Effect of cyclosporine and tacrolimus on cytochrome P450 activities in human liver microsomes

Yakugaku Zasshi

Volumn 127, Issue 1, 2007, Pages 209-216

  Niwa, Toshiro ^a   Yamamoto, Sachiko ^a   Saito, Miho ^a   Shiraga, Toshifumi ^a   Takagi, Akira ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Calcineurin inhibitor; Cyclosporine; Cytochrome P450; Human liver microsomes; Tacrolimus

Indexed keywords

ATORVASTATIN; CHLORZOXAZONE; CYCLOSPORIN; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEBRISOQUINE; DILTIAZEM; ETHOXYRESORUFIN; MICAFUNGIN; NIFEDIPINE; PHENYTOIN DERIVATIVE; REPAGLINIDE; S MEPHENYTOIN; TACROLIMUS; TESTOSTERONE; TOLBUTAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN EXPERIMENT; HYDROXYLATION; IN VIVO STUDY; LIVER MICROSOME; MAXIMUM ALLOWABLE CONCENTRATION; OXIDATION;

CELLS, CULTURED; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; MICROSOMES, LIVER; TACROLIMUS;

EID: 33846180686     PISSN: 00316903     EISSN: 13475231     Source Type: Journal    
DOI: 10.1248/yakushi.127.209     Document Type: Article

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