Inhibitory effects of the extracts of garcinia species on human low-density lipoprotein peroxidation and platelet aggregation in relation to their total phenolic contents

Journal of Medicinal Plants Research

Volumn 5, Issue 13, 2011, Pages 2699-2709

  Jantan, Ibrahim ^a   Jumuddin, Farra Aidah ^a   Saputri, Fadlina Chany ^a   Rahman, Khalid ^b  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Antiplatelet activity; Garcinia species; LDL antioxidant activity; Low density lipoprotein; Total phenolic contents

Indexed keywords

ANTIOXIDANT; ARACHIDONIC ACID; GALLIC ACID; GARCINIA ATROVIRIDIS EXTRACT; GARCINIA CANTLEYANA EXTRACT; GARCINIA COWA EXTRACT; GARCINIA EUGENIFOLIA EXTRACT; GARCINIA GRIFFITHII EXTRACT; GARCINIA HOMBRONIANA EXTRACT; GARCINIA MANGOSTANA EXTRACT; GARCINIA NERVOSA EXTRACT; GARCINIA PRAINIANA EXTRACT; LOW DENSITY LIPOPROTEIN; METHANOL; PLANT EXTRACT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; GARCINIA; GARCINIA ATROVIRIDIS; GARCINIA CANTLEYANA; GARCINIA COWA; GARCINIA EUGENIFOLIA; GARCINIA GRIFFITHII; GARCINIA HOMBRONIANA; GARCINIA NERVOSA; GARCINIA PRAINIANA; HUMAN; IC 50; IMPEDANCE; LIPID PEROXIDATION; PHYTOCHEMISTRY; SPECIES DIFFERENCE; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

GARCINIA; GARCINIA MANGOSTANA;

EID: 79961099566     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Bradford MM (1976). A rapid and sensitive method for the quantitation of micrograms quantities of protein utilizing the principle of protein dye binding. Anal. Biochem., 72: 248-254.
2. Buege JA, Aust SD (1978). Microsomal lipid peroxidation. Meth. Enzymol., 52: 302-310.
3. Chung MI, Weng JR, Wang JP, Teng CM, Lin CN (2002). Antiplatelet and anti-inflammatory constituents and new oxygenated xanthones from Hypericum geminiflorum. Planta Med., 68: 25-29.
4. Dillon SA, Burmi RS, Lowe GM, Billington D, Rahman K (2003). Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density lipoprotein. Life Sci., 72: 1583-1594.
5. Dong H, Chen S-X (1998). A new antiplatelet diarylheptanoid from Alpinia blepharocalyx. J. Nat. Prod., 61: 142-144.
6. Finkel T, Holbrook NJ (2000). Oxidant, oxidative stress and biology of ageing. Nature, 40: 239-247.
7. Galle J, Wanner C (1998). Oxidized LDL and Lp(a). Meth. Mol. Biol., 108: 119-130.
8. Gibbins JM (2004). Platelet adhesion signaling and the regulation of thrombus formation. J. Cell Sci., 117: 3415-3425.
9. Graham JM, Higgins JA, Gillot T, Taylor T, Wilkinson J, Ford T, Billington D (1996). A novel method for the rapid separation of plasma lipoproteins using self-generating gradients of iodixanol. Atherosclerosis, 124: 125-135.
10. Han QB, Yang NY, Tian HL, Qiao CF, Song JZ, Chang DC, Chen SL, Luo KQ, Xu HX (2008). Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis. Phytochem., 69: 2187-2192.
11. Heinecke JW (1998). Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis, Atherosclerosis, 141: 1-15.
12. Hodzic Z, Pasalic H, Memisevic A, Srabovic M, Saletovic M, Poljakovic M (2009). The Influence of total phenols content on antioxidant capacity in the whole grain extract. Eur. J. Sc. Res., 3: 471-477.
13. Hughes, DA (2005). Plant polyphenols: Modifiers of immune function and risk of cardiovascular disease. Nutr., 21: 422-423.
14. Ingerman-Wojenski CM, Silver MJ (1984). A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer. Thromb. Haemostas, 2: 154-156.
15. Jantan I, Raweh SM, Yasin YH, Murad S (2006). Antiplatelet activity of aporphine and phenantherenoid alkaloids from Aromadendron elegans Blume. Phytother. Res., 20: 493-496.
16. Jantan I, Mohd Yasin, YH, Jalil J, Murad S, Idris MS (2009). Antiplatelet aggregation activity of compounds isolated from Guttiferae species in human whole blood. Pharm. Biol., 47: 1090-1095.
17. Ji X, Avula B, Khan IA (2007). Quantitative and qualitative determinationof six xanthones in Garcinia mangostana L. by LP-PDA and LC-ESI-MS. J. Pharm. Biomed. Anal., 43: 1270-1276.
18. Jiang F, Dusting GJ (2003). Natural phenolic compounds as cardiovascular therapeutics: Potential role of their anti-inflammatory effects. Curr. Vas. Pharmacol., 1: 135-156.
19. Joseph GS, Jayaprakasha GK, Selvi AT, Jena BS, Sakariah KK (2005). Antiaflatoxigenic and antioxidant activities of Garcinia extracts. Int. J. Food Microbiol., 101: 153-160.
20. Kolodziejczyk J, Masullo M, Olas B, Piacente S, Wachowicz B (2009). Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma. Platelets, 20: 487-492.
21. Liao CH, Ko FN, Wu CL, Teng CM (2000). Antiplatelet effect of marchatinquinone, isolated from Reboulia hemisphaerica, in rabbit washed platelets. J. Pharm. Pharmacol., 52: 353-359.
22. Lin CN, Shieh WL, Ko FN, Teng CM (1993). Antiplatelet activity of some prenylflavonoids. Biochem. Pharmacol., 45: 509-512.
23. Lloyd J, Bochner F (1996). Aspirin: How low is the dose? Aust. Prescr., 19: 79-81.
24. Morimitsu Y, Hayashi K, Nakagawa Y, Fujii H, Horio F, Uchida K, Osawa T (2000). Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi. Mech. Ageing Dev., 116: 125-134.
25. Naldoni FJ, Claudino ALR, Cruz JW, Chavasco JK, Faria E, Silva PM, Veloso MP, Dos Santos MH (2009). Antimicrobial activity of benzophenones and extracts from the fruits of Garcinia brasiliensis. J. Med. Food, 12: 403-407.
26. Noble RP (1968). Electrophoretic separation of plasma lipoproteins in agarose gel. J. Lipid Res., 9: 693-700.
27. Nurtjahja-Tjendraputra E, Ammit AJ, Roufogalis BD, Tran VH, Duke CC (2003). Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb. Res., 111: 259-265.
28. Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M (2009). Garcinia mangostana L.: A phytochemical and pharmacological review. Phytother. Res., 23: 1047-1065.
29. Odabasoglu F, Aslan A, Cakir A, Suleyman H, Karaqoz Y, Halici M, Bayir Y (2004). Comparison of antioxidant activity and phenolic content of three lichen species. Phytother. Res., 11: 938-941.
30. Okoko T (2009). In vitro antioxidant and free radical scavenging activities of Garcinia kola seeds. Food Chem. Toxicol., 47: 2620-2623.
31. Parthasarathy S, Young SG, Witztum JL, Pittman RC, Steinberg D (1986). Probucol inhibits oxidative modification of low-density lipoprotein. J. Clin. Invest., 77: 641-644.
32. Patthamakanokporn O, Puwastien P, Nitithamyong A, Sirichakwal PP (2008). Changes of antioxidant activity and total phenolic compounds during storage of selected fruits. J. Food Comp. Anal., 21: 241-248.
33. Pedraza-Chaverri J, Cardenas-Rodriguez, Orozco-Ibarra, Perez-Rojas JM (2008). Medicinal properties of mangosteen (Garcinia mangostana). Food Chem. Toxicol., 46: 3227-3239.
34. Perry LM (1980). Medicinal Plants of East and South East Asia. Massachusetts Institute of Technology Press, Cambridge, UK.
35. Rice-Evans CA, Miller NJ, Paganga G (1997). Antioxidant properties of phenolic compounds. Trends Plant Sci., 2: 152-159.
36. Scalzo J, Politi A, Pellegrini N, Mezzetti B., Battino M (2005). Plant genotype affects total antioxidant capacity and phenolic contents in fruits. Nutr., 21: 207-213.
37. Shen Z, Chen Z, Li L, Lei W, Hao X (2000). Antiplatelet and antithrombotic effects of the diterpene spiramine Q from Spirae japonica var. incise. Planta Med., 66: 287-289.
38. Singleton VL, Orthofer R, Raventos RML (1999). Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Meth. Enzymol., 299: 152-178.
39. Tsai IL, Wun MF, Teng CM, Ishikawa T, Chen IS (1998). Anti-platelet aggregation constituents from Formosan Toddalia asiatica. Phytochemistry, 48: 1377-1382.
40. Velioglu YS, Mazza G, Gao L, Oomah BD (1998). Antioxidant activity and total phenolics in selected fruits, vegetables and grain products. J. Agric. Food Chem., 46: 4113-4117.
41. Wollin SD, Jones PJH (2001). Alcohol, red wine and cardiovascular disease. J. Nutr., 131: 1401-1404.
42. Zhao H, Fan W, Dong J, Lu J, Chen J, Shan L, Lin Y, Kong W (2008). Evaluation of antioxidant activities and total phenolic contents of typical malting barley varieties. Food Chem., 107: 296-304.