Antiplatelet aggregation activity of compounds isolated from Guttiferae species in human whole blood

Pharmaceutical Biology

Volumn 47, Issue 11, 2009, Pages 1090-1095

  Jantan, Ibrahim ^a   Mohd Yasin, Yusyila Harlina ^a   Jalil, Juriyati ^a   Murad, Shahnaz ^b   Idris, Muhammad Sum ^c  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b INSTITUTE FOR MEDICAL RESEARCH   (Malaysia)

^c UNIVERSITI TEKNOLOGI MALAYSIA   (Malaysia)

Author keywords

Antiplatelet aggregation; Guttiferae; Human whole blood

Indexed keywords

1,3,7 TRIHYDROXYXANTHONE; 2 (3 HYDROXY 3 METHYLBUTYL) 1,3,5,6 TETRAHYDROXYXANTHONE; 2 (3 METHYLBUT 2 ENYL) 1,3,5 TRIHYDROXYXANTHONE; 2 (3 METHYLBUT 2 ENYL) 1,3,5,6 TETRAHYDROXYXANTHONE; 2,3 DIMETHYL 5 HYDROXY 6 (3 METHYLBUT 2 ENYL) 7 METHOXY 8 (2 CARBOXYL 1 PHENYLETHYL) 2,3 DIHYDROBENZOPYRAN; 4 HYDROXYXANTHONE; 5,7,4',5'',7'',4''' HEXAHYDROXY[3' 8'']BIFLAVANONE; 6 DEOXYJACAREUBIN; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; AMENTOFLAVONE; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; CANOPHYLLOL; COLLAGEN; FRIEDELIN; ISOCOWANOL; KAEMPFEROL 3 O RHAMNOSIDE; MACLURAXANTHONE; NORATHYRIOL; PYRANOAMENTOFLAVONE; QUERCETIN; QUERCETIN 3 O RHAMNOSIDE; RUBRAXANTHONE; SITOSTEROL; UNCLASSIFIED DRUG;

ARTICLE; BLOOD; CALOPHYLLUM INOPHYLLOIDES; CALOPHYLLUM INOPHYLLUM; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; GARCINIA BANCANA; GARCINIA OPACA; GARCINIA PARVIFOLIA; GUTTIFERAE; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

CALOPHYLLUM INOPHYLLUM; CLUSIACEAE; GARCINIA OPACA;

EID: 70350335772     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880200903008641     Document Type: Article

References (26)

1. Arita H, Nakano T, Hansaki K (1989): Thromboxane A2, its generation and role in platelet activation. Prog Lipid Res 28: 273-301.
2. Challen A, Branch WJ, Cummings JH (1982): Quantitation of platelet mass during aggregation in the electronic (Wellcome) whole blood aggregometer. J Pharmacol Meth 8: 115-122.
3. Chung MI, Weng JR, Wang JP, Teng CM, Lin CN (2002): Antiplatelet and anti-inflammatory constituents and new oxygenated xanthones from Hypericum geminiflorum. Planta Med 68: 25-29.
4. Dong H, Chen S-X (1998): A new antiplatelet diarylheptanoid from Alpinia blepharocalyx. J Nat Prod 61: 142-144.
5. Gibbins JM (2004): Platelet adhesion signaling and the regulation of thrombus formation. J Cell Sci 117: 3415-3425.
6. Goh SH, Jantan I (1991): A xanthone from Calophyllum inophyllum. Phytochemistry 30: 366-367.
7. Goh SH, Jantan I, Gray AI, Waterman PG (1992a): Prenylated xanthones of Garcinia opaca. Phytochemistry 31: 1383-1386.
8. Goh SH, Jantan I, Waterman PG (1992b): Neoflavonoid and biflavonoid constituents of Calophyllum inophylloide. J Nat Prod 55: 1415-1420.
9. Gresele P, Agnelli G (2002): Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci 23: 25-32.
10. Guglielmone HA, Agnese AM, Nunez Montoya SC, Cabrera JL (2005): Inhibitory effects of sulphated flavonoids isolated from Flaveria bidentis on platelet aggregation. Throm Res 115: 495-502.
11. Harker LA, Mann KG (1992): Thrombosis and fibrinolysis. In: Fuster V, Verstraete M, eds., Thrombosis in Cardiovascular Disorders. Philadelphia, PA, WB Saunders, pp. 1-16.
12. Ingerman-Wojenski CM, Silver MJ (1984): A quick method for screening platelet dysfunctions using the whole blood lumi- aggregometer. Thromb Haemost 2: 154-156.
13. Jantan I, Goh SH (1995): Flavonoids, xanthones and triterpenes of the leaves and heartwood of Garcinia bancana Miq. Sains Malaysiana 24: 23-30.
14. Jantan I, Jalil J, Warif NA (2001a): Inhibitory effects of xanthones on platelet activating factor receptor binding in vitro. J Ethnopharmacol 75: 287-290.
15. Jantan I, Jalil J, Warif NA (2001b): Platelet activating factor (PAF) antagonistic activities of compounds isolated from Guttiferae species. Pharm Biol 39: 243-246.
16. Jantan I, Pisar M, Idris MS, Taher M, Mohd AR (2002): Inhibitory effect of rubraxanthone isolated from Garcinia parvifolia Miq. on platelet activating factor receptor binding. Planta Med 68: 1133-1134.
17. Jantan I, Raweh SM, Yassin YH, Murad S (2006): Antiplatelet activity of aporphine and phenanthrene alkaloids from Aromadendron elegans Blume. Phytother Res 20: 493-496.
18. Liao CH, Ko FN, Wu CL, Teng CM (2000): Antiplatelet effect of marchatinquinone, isolated from Reboulia hemisphaerica, in rabbit washed platelets. J Pharm Pharmacol 52: 353-359.
19. Lin CN, Shieh WL, Ko FN, Teng CM (1993a): Antiplatelet activity of some prenylflavonoids. Biochem Pharmacol 45: 509-512.
20. Lin CN, Liou SS, Ko FN, Teng CM (1993b): Gamma-pyrone compounds. IV: Synthesis and antiplatelet effects of mono- and deoxygenated xanthones and xanthonoxypropanolamine. J Pharm Sci 82: 11-16.
21. Lloyd J, Bochner F (1996): Aspirin: how low is the dose? Aust Prescr 19: 79-81.
22. Morimitsu Y, Hayashi K, Nakagawa Y, Fujii H, Horio F, Uchida K, Osawa T (2000): Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi. Mech Ageing Dev 116: 125-134.
23. Nurtjahja-Tjendraputra E, Ammit AJ, Roufogalis BD, Tran VH, Duke CC (2003): Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res 111: 259-265.
24. Shen Z, Chen Z, Li L, Lei W, Hao X (2000): Antiplatelet and antithrombotic effects of the diterpene spiramine Q from Spirae japonica var. incise. Planta Med 66: 287-289.
25. Teng CM, Lin CN, Ko FN, Cheng KL, Huang TF (1989): Novel inhibitory actions on platelet thromboxane and inositolphosphate formation by xanthones and their glycosides. Biochem Pharmacol 38: 3791-3795.
26. Tsai I-L, Wun M-F, Teng C-M, Ishikawa T, Chen I-S (1998): Antiplatelet aggregation constituents from Formosan Toddalia asiatica. Phytochemistry 48: 1377-1382.