Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger

Thrombosis Research

Volumn 111, Issue 4-5, 2003, Pages 259-265

  Nurtjahja Tjendraputra, Effie ^a   Ammit, Alaina J ^a   Roufogalis, Basil D ^a   Tran, Van H ^a   Duke, Colin C ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Arachidonic acid; Aspirin; Cyclooxygenase 1; Ginger; Human whole blood; Platelet aggregation

Indexed keywords

(10) GINGEROL; (12) GINGEROL; (6) GINGERDIOL; (6) GINGEROL; (8) GINGERDIOL; (8) GINGEROL; (8) PARADOL; (8) SHOGAOL; (9) GINGEROL; 1,7 BIS(4 HYDROXY 3 METHOXYPHENYL)HEPT 4,6 DIEN 3 ONE; 1,7 BIS(4 HYDROXY 3 METHOXYPHENYL)HEPTAN 3 ONE; 2 HYDROXY 1 (4 HYDROXY 3 METHOXYPHENYL)DODECANE; 3 HYDROXY 1 (4 HYDROXY 3 METHOXYPHENYL)DEC 4 ENE; 3 HYDROXY 1 (4 HYDROXY 3 METHOXYPHENYL)DECANE; 3 HYDROXY 1 (4 HYDROXY 3 METHOXYPHENYL)DODECANE; 3 HYDROXY 1,7 BIS(4 HYDROXY 3 METHOXYPHENYL)HEPTANE; 5 HYDROXY 1 (4 HYDROXY 3 METHOXYPHENYL)DODECANE; 5 HYDROXY 1,7 BIS(4 HYDROXY 3 METHOXYPHENYL)HEPT 6 EN 3 ONE; ACETYLSALICYLIC ACID; ALKANE DERIVATIVE; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; GINGER EXTRACT; GINGEROL; SHOGAOL; SYNTHETASE; UNCLASSIFIED DRUG;

ANALYTICAL EQUIPMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; GINGER; HUMAN; HYDROPHOBICITY; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE KINETICS; THROMBOSIS;

EID: 0345802676     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2003.09.009     Document Type: Article

References (22)

1. Arita H., Nakano T., Hansaki K. Thromboxane A2, its generation and role in platelet activation. Prog. Lipid Res. 28:1989;273-301.
2. Rao G.H. Physiology of blood platelet activation. Indian J. Physiol. Pharmacol. 37:1993;263-275.
3. Rao G.H.R., Rao A.T. Pharmacology of platelet activation-inhibitory drugs. Indian J. Physiol. Pharmacol. 38:1994;69-84.
4. Lloyd J., Bochner F. Aspirin: how low is low dose? Aust. Prescr. 19:1996;79-81.
5. Hau IN, Dingjiang Y, Yuqi B, Yuzhen Z. Effect of dry and roasted ginger on experimental gastric ulcer in rats. Chungkuo Chung Yao Tsa Chih J. Chinese Materia Medica 1990;15:270-80, 317-18.
6. Al-Yahya M.A., Rafatullah S., Mossa J.S., Ageel A.M., Parmar N.S., Tariq M. Gastroprotective activity of ginger (Zingiber officinale) in albino rats. Am. J. Chin. Med. 17:1989;51-56.
7. Yahamara J., Miki K., Chisaka T., Sawada T., Fujimura H., Tomimatsu T.et al. Cholagic effect of ginger and its active constituents. J. Ethnopharmacol. 13:1985;217-225.
8. Yamahara J., Mochizuki M., Rong H.Q., Matsuda H., Fujimura H. The anti-ulcer effect in rats of ginger constituents. J. Ethnopharmacol. 23:1988;299-304.
9. Guh J.H., Ko F.N., Jong T.T., Tenf C.M. Antiplatelet effect of gingerol isolated from Zingiber officinale. J. Pharm. Pharmacol. 47:1995;329-332.
10. Venkateshwarlu V. Cyclooxygenase inhibitors from spices. Indian Drugs J. 34:1997;427-432.
11. Koo K.L.K., Ammit A.J., Tran V.H., Duke C.C., Roufogalis B.D. Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation. Thromb. Res. 103:2001;387-397.
12. Hamasaki Y., Miyazaki S., Tai H.-H. Regulatory mechanism of arachidonic acid metabolism in rat basophilic leukemia (RBL)-2H3 cells. Acta Haematol. Jpn. 50:1987;813-818.
13. Denniff P., Macleod I., Whitting D.A. Syntheses of the (±)-[n]-gingerols (pungent principles of ginger) and related compounds through regioselective aldol condensation: relative pungency assays. J. Chem. Soc., Perkin Trans. 1(1):1981;82-87.
14. Roufogalis BD, Duke CC, Tran VH. Preparation and pharmaceutical uses of phenylalkanols. PCT Int Appl CODEN: PIXXD2 WO 9920589 A1 19990429 CAN 130: 325046 AN1999:282187 1999.
15. Tanaka M, Urani F, Tani T. [6]-Gingerol or [6]-shogaol prepared from phenolic ketone derivatives. Jpn. Kokai Tokyo Koho Vol. JP61137834 A2 19860625. Japan 1986:10.
16. Boudeville P., Bona M., Burgot J.L. Correlations between n-octanol/water partition coefficients and RP-HPLC capacity factors of 1,2-dithiole-3-thiones and 1,2-dithiol-3-ones. J. Pharm. Sci. 85:1996;990-998.
17. McCall J. Liquid-liquid partition coefficients by high pressure liquid chromatography. J. Med. Chem. 18:1975;549-552.
18. Ingerman-Wojenski C.M., Silver M.J. A quick method for screening platelet dysfunction using whole blood lumi aggregometer. Thromb. Haemost. 51:1984;154-156.
19. Lehuu B., Curtis-Prior P.B. Effect of dimethyl sulphoxide (DMSO) on aggregation of human blood platelets. J. Pharm. Pharmacol. 39:1987;62-63.
20. De la Cruz J.P., Bellido I., Camara S., Martos F., Sanchez de la Cuesta F. Effects of acetylsalicylic acid on platelet aggregation in male and female whole blood: an in vitro study. Hematol. J. 36:1986;394-397.
21. Ali M.A., Routh J.I. The protein binding of acetylsalicylic acid and salicylic acid. J. Clin. Chem. 15:1969;1027-1038.
22. Kramer E., Routh J.I. The binding of acetylsalicylic acid and salicylic acid to human serum albumin. J. Clin. Biochem. 6:1973;98-105.