Antiplatelet and antithrombotic effects of the diterpene spiramine Q from Spiraea japonica var. incisa

Planta Medica

Volumn 66, Issue 3, 2000, Pages 287-289

  Shen, Zhiqiang ^a   Chen, Zhihe ^a   Ling, Li ^a   Lei, Weiya ^a   Hao, Xiaojiang ^b  

^a KUNMING MEDICAL UNIVERSITY   (China)

^b KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; DITERPENE; PLANT EXTRACT; SEROTONIN; SPIRAEA JAPONICA EXTRACT; SPIRAMINE Q; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; FEMALE; MALE; MOUSE; NONHUMAN; PLANT ROOT; RABBIT; SEROTONIN RELEASE; SUDDEN DEATH; THROMBOCYTE AGGREGATION; THROMBOSIS;

ANIMALS; FIBRINOLYTIC AGENTS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; MICE; PLATELET AGGREGATION INHIBITORS; RABBITS; THROMBOSIS;

ANIMALIA; JAPONICA; ORYCTOLAGUS CUNICULUS; SPIRAEA JAPONICA;

EID: 0034011502     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2000-8571     Document Type: Article

References (8)

1. 1 Zhang XS, Wang BD. Chinese medicine dictionary (Edited by Jiangsu Medical College). Shanghai Science and Technology House. 1993: 4057-64
2. 2 Hao XJ, Hong X, Yang XS, Zhao BT. Diterpene alkaloids from roots of Spiraea japonica. Phytochemistry 1995; 38: 545-7
3. 3 Masakado M, Umeda F, Yamauchi T, Ishii H, Ono Y, Nawata H. Human fibroblast cells produce a factor that stimulates prostacyclin synthesis by vascular endothelia cells. Thromb. Res. 1994; 76: 513-24
4. 2. Fed. Proc. 1987; 46: 133-8
5. 5 Kohler C, Wooding W, Ellenbogen L. Intravenous arachidonate in the mouse: A model for evaluation of antithrombotic drugs.-Thromb. Res. 1976; 9: 67-80
6. 6 Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194: 927-9
7. 7 Wan HY, Chen H, Xi XD, Ruan CG. Fluorophotometry for platelet 5-HT. Jiangsu Medicine 1985; 11: 24-5
8. 8 Myers AK, Forman G, Torrs Duarte AP, Penhos J, Ramwell P. Comparision of verapamil and nifedipine in thrombosis models. Proc. Soc. Exp. Biol. Med. 1986; 183: 86-91