Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 29, 2011, Pages

  Iotti, Giorgio ^a   Longobardi, Elena ^a   Masella, Silvia ^a   Dardaei, Leila ^a   De Santis, Francesca ^a   Micali, Nicola ^a   Blasi, Francesco ^a  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

SATELLITE DNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PREP1 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANEUPLOIDY; ANIMAL EXPERIMENT; ARTICLE; CELL IMMORTALIZATION; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOGENETICS; DNA DAMAGE; DOWN REGULATION; GAMMA IRRADIATION; GENE EXPRESSION; GENOMIC INSTABILITY; HISTONE METHYLATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MODIFICATION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN IMMUNOPRECIPITATION; COMET ASSAY; CYTOGENETIC ANALYSIS; DNA DAMAGE; EMBRYO, MAMMALIAN; FIBROBLASTS; GAMMA RAYS; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; HETEROCHROMATIN; HOMEODOMAIN PROTEINS; HUMANS; MICE; OLIGONUCLEOTIDES; TRANSCRIPTION FACTORS;

EID: 79961068871     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1105216108     Document Type: Article

References (55)

1. Deflorian G, et al. (2004) Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Development 131:613-627. (Pubitemid 38240004)
2. Ferretti E, et al. (2006) Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol 26:5650-5662. (Pubitemid 44134323)
3. Penkov D, et al. (2005) Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Mol Cell Biol 25:10768-10781. (Pubitemid 41747122)
4. Fernandez-Diaz LC, et al. (2010) The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells. Development 137:3393-3403.
5. Ferretti E, Schulz H, Talarico D, Blasi F, Berthelsen J (1999) The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse. Mech Dev 83:53-64. (Pubitemid 29302081)
6. Ferretti E, et al. (2000) A complex site including both Pbx-Hox and Prep-Meis-responsive elements and binding a retinoic acid-inducible ternary Hoxb1-Pbx-Prep1 complex is required for HOXB2 rhombomere 4 expression. Development, 127, 155-166, 2000. Development 127:155-166.
7. Jacobs Y, Schnabel CA, Cleary ML (1999) Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol 19:5134-5142. (Pubitemid 29289551)
8. Berthelsen J, Kilstrup-Nielsen C, Blasi F, Mavilio F, Zappavigna V (1999) The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev 13:946-953. (Pubitemid 29200978)
9. Longobardi E, Blasi F (2003) Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. J Biol Chem 278:39235-39241. (Pubitemid 37221827)
10. Di Rosa P, et al. (2007) The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Dev Biol 311:324-334. (Pubitemid 350046529)
11. Micali N, Ferrai C, Fernandez-Diaz LC, Blasi F, Crippa MP (2009) Prep1 directly regulates the intrinsic apoptotic pathway by controlling Bcl-XL levels. Mol Cell Biol 29:1143-1151.
12. Longobardi E, et al. (2010) Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmMyc lymphomagenesis: A tumor suppressor role for Prep1. Mol Oncol 4:226-234.
13. Berthelsen J, et al. (1998) PKNOX-1, a gene encoding Prep1, a new regulator of pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17b/c. Genomics 47:323-324. (Pubitemid 28086861)
14. Ohgaki K, et al. (1998) Mapping of a new target region of allelic loss to a 6-cM interval at 21q21 in primary breast cancers. Genes Chromosomes Cancer 23:244-247. (Pubitemid 28465641)
15. Park WS, et al. (2000) Mapping of a new target region of allelic loss at 21q22 in primary gastric cancers. Cancer Lett 159:15-21.
16. Rajagopalan H, Lengauer C (2004) Aneuploidy and cancer. Nature 432:338-341. (Pubitemid 39551662)
17. Ganem NJ, Storchova Z, Pellman D (2007) Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 17:157-162. (Pubitemid 46551722)
18. Weaver BA, Cleveland DW (2007) Aneuploidy: Instigator and inhibitor of tumorigenesis. Cancer Res 67:10103-10105. (Pubitemid 350070779)
19. Abraham RT (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15:2177-2196.
20. Bassing CH, Alt FW (2004) H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle 3:149-153. (Pubitemid 40268686)
21. Tanaka T, et al. (2007) Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents. Cytometry A 71:648-661. (Pubitemid 47351228)
22. Banin S, et al. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281:1674-1677.
23. Canman CE, et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677-1679. (Pubitemid 28435584)
24. van Attikum H, Gasser SM (2009) Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol 19:207-217.
25. Peng JC, Karpen GH (2008) Epigenetic regulation of heterochromatic DNA stability. Curr Opin Genet Dev 18:204-211. (Pubitemid 351749828)
26. Martens JH, et al. (2005) The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J 24:800-812. (Pubitemid 40396109)
27. Guccione E, et al. (2007) Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature 449:933-937. (Pubitemid 47598605)
28. Gopalakrishnan S, Sullivan BA, Trazzi S, Della Valle G, Robertson KD (2009) DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum Mol Genet 18:3178-3193.
29. Valgardsdottir R, et al. (2008) Transcription of Satellite III non-coding RNAs is a general stress response in human cells. Nucleic Acids Res 36:423-434. (Pubitemid 351250435)
30. Lehnertz B, et al. (2003) Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol 13:1192-1200. (Pubitemid 36872941)
31. Eymery A, Callanan M, Vourc'h C (2009) The secret message of heterochromatin: New insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription. Int J Dev Biol 53:259-268.
32. Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A (2005) Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 1:143-145.
33. Kamijo T, et al. (1997) Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91:649-659. (Pubitemid 27513656)
34. Land H, Parada LF, Weinberg RA (1983) Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304:596-602. (Pubitemid 13035496)
35. Newbold RF, Overell RW (1983) Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene. Nature 304:648-651. (Pubitemid 13035507)
36. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602. (Pubitemid 27152402)
37. Lengauer C, Kinzler KW, Vogelstein B (1998) Genetic instabilities in human cancers. Nature 396:643-649. (Pubitemid 29003936)
38. Negrini S, Gorgoulis VG, Halazonetis TD (2010) Genomic instability - an evolving hallmark of cancer. Nat Rev Mol Cell Biol 11:220-228.
39. Bartkova J, et al. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434:864-870. (Pubitemid 40558993)
40. Gorgoulis VG, et al. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434:907-913. (Pubitemid 40559004)
41. Bartkova J, et al. (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444:633-637. (Pubitemid 44864442)
42. Di Micco R, et al. (2006) Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444:638-642. (Pubitemid 44864443)
43. Harvey M, et al. (1993) In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8:2457-2467. (Pubitemid 23252375)
44. Fukasawa K, Wiener F, Vande Woude GF, Mai S (1997) Genomic instability and apoptosis are frequent in p53 deficient young mice. Oncogene 15:1295-1302. (Pubitemid 27429745)
45. Salvany L, Aldaz S, Corsetti E, Azpiazu N (2009) A new role for hth in the early preblastodermic divisions in drosophila. Cell Cycle 8:2748-2755.
46. Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (1995) Meis1, a PBX1-related homeobox gene involved inmyeloid leukemia in BXH-2mice.Mol Cell Biol 15:5434-5443.
47. Lawrence HJ, et al. (1999) Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias. Leukemia 13:1993-1999.
48. Ting DT, et al. (2011) Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science 331:593-596.
49. Di Micco R, et al. (2011) Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol 13:292-302.
50. Halazonetis TD, Gorgoulis VG, Bartek J (2008) An oncogene-induced DNA damage model for cancer development. Science 319:1352-1355. (Pubitemid 351354863)
51. Nijnik A, et al. (2007) DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447:686-690. (Pubitemid 46889732)
52. Rossi DJ, et al. (2007) Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447:725-729. (Pubitemid 46889729)
53. Shen SX, et al. (1998) A targeted disruption of the murine Brca1 gene causes gammairradiation hypersensitivity and genetic instability. Oncogene 17:3115-3124.
54. Brown EJ, Baltimore D (2000) ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 14:397-402. (Pubitemid 30131885)
55. Goodarzi AA, et al. (2008) ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell 31:167-177. (Pubitemid 352001394)