메뉴 건너뛰기




Volumn 121, Issue 8, 2011, Pages 2972-2975

Shock and awe: Unleashing the heat shock response to treat Huntington disease

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 90 INHIBITOR; HEAT SHOCK TRANSCRIPTION FACTOR 1; HUNTINGTIN;

EID: 79961012607     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59190     Document Type: Note
Times cited : (11)

References (23)
  • 1
    • 39349083915 scopus 로고    scopus 로고
    • Adapting proteostasis for disease intervention
    • DOI 10.1126/science.1141448
    • Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science. 2008;319(5865):916-919. (Pubitemid 351263754)
    • (2008) Science , vol.319 , Issue.5865 , pp. 916-919
    • Balch, W.E.1    Morimoto, R.I.2    Dillin, A.3    Kelly, J.W.4
  • 3
    • 77951183978 scopus 로고    scopus 로고
    • Prion-like disorders: Blurring the divide between transmissibility and infectivity
    • Cushman M, Johnson BS, King OD, Gitler AD, Shorter J. Prion-like disorders: blurring the divide between transmissibility and infectivity. J Cell Sci. 2010;123(pt 8):1191-1201.
    • (2010) J Cell Sci , vol.123 , Issue.PART 8 , pp. 1191-1201
    • Cushman, M.1    Johnson, B.S.2    King, O.D.3    Gitler, A.D.4    Shorter, J.5
  • 4
    • 79952223775 scopus 로고    scopus 로고
    • Huntington's disease: Can mice lead the way to treatment?
    • Crook ZR, Housman D. Huntington's disease: can mice lead the way to treatment? Neuron. 2011;69(3):423-435.
    • (2011) Neuron , vol.69 , Issue.3 , pp. 423-435
    • Crook, Z.R.1    Housman, D.2
  • 6
    • 67649856863 scopus 로고    scopus 로고
    • Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity
    • Nekooki-Machida Y, Kurosawa M, Nukina N, Ito K, Oda T, Tanaka M. Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity. Proc Natl Acad Sci U S A. 2009;106(24):9679-9684.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.24 , pp. 9679-9684
    • Nekooki-Machida, Y.1    Kurosawa, M.2    Nukina, N.3    Ito, K.4    Oda, T.5    Tanaka, M.6
  • 7
    • 51349150684 scopus 로고    scopus 로고
    • Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease
    • Lo Bianco C, et al. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. J Clin Invest. 2008;118(9):3087-3097.
    • (2008) J Clin Invest , vol.118 , Issue.9 , pp. 3087-3097
    • Lo Bianco, C.1
  • 8
    • 50249175120 scopus 로고    scopus 로고
    • Chemical and biological approaches synergize to ameliorate protein-folding diseases
    • Mu TW, et al. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell. 2008;134(5):769-781.
    • (2008) Cell , vol.134 , Issue.5 , pp. 769-781
    • Mu, T.W.1
  • 9
    • 0032727617 scopus 로고    scopus 로고
    • Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
    • Warrick JM, Chan HYE, Gray-Board GL, Chai Y, Paulson HL, Bonini NM. Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet. 1999;23(4):425-428.
    • (1999) Nat Genet , vol.23 , Issue.4 , pp. 425-428
    • Warrick, J.M.1    Chan, H.Y.E.2    Gray-Board, G.L.3    Chai, Y.4    Paulson, H.L.5    Bonini, N.M.6
  • 10
    • 79961013560 scopus 로고    scopus 로고
    • Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease
    • Labbadia J, et al. Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease. J Clin Invest. 2011;121(8):3306-3319.
    • (2011) J Clin Invest , vol.121 , Issue.8 , pp. 3306-3319
    • Labbadia, J.1
  • 12
    • 25844466597 scopus 로고    scopus 로고
    • Heat shock response modulators as therapeutic tools for diseases of protein conformation
    • DOI 10.1074/jbc.R500010200
    • Westerheide SD, Morimoto RI. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem. 2005;280(39):33097-33100. (Pubitemid 41397104)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.39 , pp. 33097-33100
    • Westerheide, S.D.1    Morimoto, R.I.2
  • 14
    • 51649130437 scopus 로고    scopus 로고
    • Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease
    • Steele AD, et al. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A. 2008;105(36):13626- 13631.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.36 , pp. 13626-13631
    • Steele, A.D.1
  • 15
    • 0036852712 scopus 로고    scopus 로고
    • Pharmacological prevention of Parkinson disease in Drosophila [1]
    • DOI 10.1038/nm1102-1185
    • Auluck PK, Bonini NM. Pharmacological prevention of Parkinson disease in Drosophila. Nat Med. 2002;8(11):1185-1186. (Pubitemid 35373534)
    • (2002) Nature Medicine , vol.8 , Issue.11 , pp. 1185-1186
    • Auluck, P.K.1    Bonini, N.M.2
  • 17
    • 57749116408 scopus 로고    scopus 로고
    • Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
    • Duennwald ML, Lindquist S. Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev. 2008;22(23):3308-3319.
    • (2008) Genes Dev , vol.22 , Issue.23 , pp. 3308-3319
    • Duennwald, M.L.1    Lindquist, S.2
  • 19
    • 77953579937 scopus 로고    scopus 로고
    • Emergence and natural selection of drug-resistant prions
    • Shorter J. Emergence and natural selection of drug-resistant prions. Mol Biosyst. 2010;6(7):1115-1130.
    • (2010) Mol Biosyst , vol.6 , Issue.7 , pp. 1115-1130
    • Shorter, J.1
  • 20
    • 78149452881 scopus 로고    scopus 로고
    • Protein homeostasis and the phenotypic manifestation of genetic diversity: Principles and mechanisms
    • Jarosz DF, Taipale M, Lindquist S. Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Annu Rev Genet. 2010;44:189-216.
    • (2010) Annu Rev Genet , vol.44 , pp. 189-216
    • Jarosz, D.F.1    Taipale, M.2    Lindquist, S.3
  • 21
    • 0141794540 scopus 로고    scopus 로고
    • Hsp90 and chromatin: Where is the link?
    • Sangster TA, Queitsch C, Lindquist S. Hsp90 and chromatin: where is the link? Cell Cycle. 2003;2(3):166-168.
    • (2003) Cell Cycle , vol.2 , Issue.3 , pp. 166-168
    • Sangster, T.A.1    Queitsch, C.2    Lindquist, S.3
  • 22
    • 0037228526 scopus 로고    scopus 로고
    • Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution
    • DOI 10.1038/ng1067
    • Sollars V, Lu X, Xiao L, Wang X, Garfinkel MD, Ruden DM. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. Nat Genet. 2003;33(1):70-74. (Pubitemid 36068685)
    • (2003) Nature Genetics , vol.33 , Issue.1 , pp. 70-74
    • Sollars, V.1    Lu, X.2    Xiao, L.3    Wang, X.4    Garfinkel, M.D.5    Ruden, D.M.6
  • 23
    • 75749136948 scopus 로고    scopus 로고
    • Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease
    • Neef DW, Turski ML, Thiele DJ. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol. 2010;8(1):e1000291.
    • (2010) PLoS Biol , vol.8 , Issue.1
    • Neef, D.W.1    Turski, M.L.2    Thiele, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.