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Volumn 122, Issue 1, 2011, Pages 198-210

Cadmium induces anemia through interdependent progress of hemolysis, body iron accumulation, and insufficient erythropoietin production in rats

Author keywords

Anemia; Cadmium; Erythropoietin; Hemolysis; Iron; Rat

Indexed keywords

CADMIUM; ERYTHROPOIETIN; FERRITIN; IRON;

EID: 79961009460     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr100     Document Type: Article
Times cited : (99)

References (37)
  • 1
    • 4143051431 scopus 로고    scopus 로고
    • Transferrin receptor 1
    • Aisen, P. (2004). Transferrin receptor 1. Int. J. Biochem. Cell Biol. 36, 2137-2143.
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 2137-2143
    • Aisen, P.1
  • 2
    • 70349306677 scopus 로고    scopus 로고
    • Recycling iron in normal and pathological states
    • Beaumont, C., and Delaby, C. (2009). Recycling iron in normal and pathological states. Semin. Hematol. 46, 328-338.
    • (2009) Semin. Hematol. , vol.46 , pp. 328-338
    • Beaumont, C.1    Delaby, C.2
  • 3
    • 0014510315 scopus 로고
    • The renal handling of hemoglobin. II. Catabolism
    • Bunn, H. F., and Jandl, J. H. (1969). The renal handling of hemoglobin. II. Catabolism. J. Exp. Med. 129, 925-934.
    • (1969) J. Exp. Med. , vol.129 , pp. 925-934
    • Bunn, H.F.1    Jandl, J.H.2
  • 5
    • 0033568576 scopus 로고    scopus 로고
    • Regulation of the erythropoietin gene
    • Ebert, B. L., and Bunn, H. F. (1999). Regulation of the erythropoietin gene. Blood 94, 1864-1877.
    • (1999) Blood , vol.94 , pp. 1864-1877
    • Ebert, B.L.1    Bunn, H.F.2
  • 9
    • 0016263590 scopus 로고
    • Relationship between cadmium and iron absorption
    • Hamilton, D. L., and Valberg, L. S. (1974). Relationship between cadmium and iron absorption. Am. J. Physiol. 227, 1033-1037.
    • (1974) Am. J. Physiol. , vol.227 , pp. 1033-1037
    • Hamilton, D.L.1    Valberg, L.S.2
  • 10
    • 0030608152 scopus 로고    scopus 로고
    • The ferritins: molecular properties, iron storage function and cellular regulation
    • Harrison, P. M., and Arosio, P. (1996). The ferritins: molecular properties, iron storage function and cellular regulation. Biochim. Biophys. Acta. 1275, 161-203.
    • (1996) Biochim. Biophys. Acta. , vol.1275 , pp. 161-203
    • Harrison, P.M.1    Arosio, P.2
  • 11
    • 78649328682 scopus 로고    scopus 로고
    • Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River Basin in Toyama, Japan, after restoration of rice paddies
    • Horiguchi, H., Aoshima, K., Oguma, E., Sasaki, S., Miyamoto, K., Hosoi, Y., Katoh, T., and Kayama, F. (2010). Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River Basin in Toyama, Japan, after restoration of rice paddies. Int. Arch. Occup. Environ. Health 83, 953-970.
    • (2010) Int. Arch. Occup. Environ. Health , vol.83 , pp. 953-970
    • Horiguchi, H.1    Aoshima, K.2    Oguma, E.3    Sasaki, S.4    Miyamoto, K.5    Hosoi, Y.6    Katoh, T.7    Kayama, F.8
  • 12
    • 0034554803 scopus 로고    scopus 로고
    • Cadmium and platinum suppression of erythropoietin production in cell culture: clinical implications
    • Horiguchi, H., Kayama, F., Oguma, E., Willmore, W. G., Hradecky, P., and Bunn, H. F. (2000). Cadmium and platinum suppression of erythropoietin production in cell culture: clinical implications. Blood 96, 3743-3747.
    • (2000) Blood , vol.96 , pp. 3743-3747
    • Horiguchi, H.1    Kayama, F.2    Oguma, E.3    Willmore, W.G.4    Hradecky, P.5    Bunn, H.F.6
  • 13
    • 22044452931 scopus 로고    scopus 로고
    • The effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats: implications of pregnancy-related anemia
    • Horiguchi, H., Oguma, E., and Kayama, F. (2005). The effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats: implications of pregnancy-related anemia. Blood 106, 67-74.
    • (2005) Blood , vol.106 , pp. 67-74
    • Horiguchi, H.1    Oguma, E.2    Kayama, F.3
  • 14
    • 33748680317 scopus 로고    scopus 로고
    • Cadmium and cisplatin damage erythropoietin-producing proximal renal tubular cells
    • Horiguchi, H., Oguma, E., and Kayama, F. (2006). Cadmium and cisplatin damage erythropoietin-producing proximal renal tubular cells. Arch. Toxicol. 80, 680-686.
    • (2006) Arch. Toxicol. , vol.80 , pp. 680-686
    • Horiguchi, H.1    Oguma, E.2    Kayama, F.3
  • 15
    • 0029823743 scopus 로고    scopus 로고
    • Long-term cadmium exposure induces anemia in rats through hypoinduction of erythropoietin in the kidneys
    • Horiguchi, H., Sato, M., Konno, N., and Fukushima, M. (1996). Long-term cadmium exposure induces anemia in rats through hypoinduction of erythropoietin in the kidneys. Arch. Toxicol. 71, 11-19.
    • (1996) Arch. Toxicol. , vol.71 , pp. 11-19
    • Horiguchi, H.1    Sato, M.2    Konno, N.3    Fukushima, M.4
  • 16
    • 0027943676 scopus 로고
    • Hypoproduction of erythropoietin contributes to anemia in chronic cadmium intoxication: clinical study on Itaiitai disease in Japan
    • Horiguchi, H., Teranishi, H., Niiya, K., Aoshima, K., Katoh, T., Sakuragawa, N., and Kasuya, M. (1994). Hypoproduction of erythropoietin contributes to anemia in chronic cadmium intoxication: clinical study on Itaiitai disease in Japan. Arch. Toxicol. 68, 632-636.
    • (1994) Arch. Toxicol. , vol.68 , pp. 632-636
    • Horiguchi, H.1    Teranishi, H.2    Niiya, K.3    Aoshima, K.4    Katoh, T.5    Sakuragawa, N.6    Kasuya, M.7
  • 17
    • 0029122626 scopus 로고
    • Cadmiuminduced renal damage and proinflammatory cytokines: possible role of IL-6 in tubular epithelial cell regeneration
    • Kayama, F., Yoshida, T., Elwell, M. R., and Luster, M. I. (1995). Cadmiuminduced renal damage and proinflammatory cytokines: possible role of IL-6 in tubular epithelial cell regeneration. Toxicol. Appl. Pharmacol. 134, 26-34.
    • (1995) Toxicol. Appl. Pharmacol. , vol.134 , pp. 26-34
    • Kayama, F.1    Yoshida, T.2    Elwell, M.R.3    Luster, M.I.4
  • 18
    • 0021948638 scopus 로고
    • An apparent acceleration of age-related changes of rat red blood cells by cadmium
    • Kunimoto, M., Miura, T., and Kubota, K. (1985). An apparent acceleration of age-related changes of rat red blood cells by cadmium. Toxicol. Appl. Pharmacol. 77, 451-457.
    • (1985) Toxicol. Appl. Pharmacol. , vol.77 , pp. 451-457
    • Kunimoto, M.1    Miura, T.2    Kubota, K.3
  • 20
    • 0022974110 scopus 로고
    • Effect of cadmium on essential metal concentrations in testis, liver and kidney of five inbred strains of mice
    • Maitani, T., and Suzuki, K. T. (1986). Effect of cadmium on essential metal concentrations in testis, liver and kidney of five inbred strains of mice. Toxicology 42, 121-130.
    • (1986) Toxicology , vol.42 , pp. 121-130
    • Maitani, T.1    Suzuki, K.T.2
  • 22
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., and Ganz, T. (2004a). IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113, 1271-1276.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 23
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., and Kaplan, J. (2004b). Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306, 2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 24
    • 0021278162 scopus 로고
    • Iron concentrations in liver and kidney of cadmium-exposed human subjects
    • Nogawa, K., Honda, R., Yamada, Y., Kido, T., Tsuritani, I., and Ishizaki, M. (1984). Iron concentrations in liver and kidney of cadmium-exposed human subjects. Toxicol. Lett. 21, 209-212.
    • (1984) Toxicol. Lett. , vol.21 , pp. 209-212
    • Nogawa, K.1    Honda, R.2    Yamada, Y.3    Kido, T.4    Tsuritani, I.5    Ishizaki, M.6
  • 25
    • 84882891103 scopus 로고    scopus 로고
    • Cadmium
    • 3rd ed. (G. F. Nordberg, B. A. Fowler, M. Nordberg, and L. T. Friberg, Eds.), Academic Press, Burlington, MA
    • Nordberg, G. F., Nogawa, K., Nordberg, M., and Friberg, L. T. (2007). Cadmium. In Handbook on the Toxicology of Metals, 3rd ed. (G. F. Nordberg, B. A. Fowler, M. Nordberg, and L. T. Friberg, Eds.), pp. 445-486. Academic Press, Burlington, MA.
    • (2007) Handbook on the Toxicology of Metals , pp. 445-486
    • Nordberg, G.F.1    Nogawa, K.2    Nordberg, M.3    Friberg, L.T.4
  • 27
    • 33846494990 scopus 로고    scopus 로고
    • Correlation between serum ferritin levels and liver iron concentration determined by MR imaging: impact of hematologic disease and inflammation
    • Olthof, A. W., Sijens, P. E., Kreeftenberg, H. G., Kappert, P., Irwan, R., van der Jagt, E. J., and Oudkerk, M. (2007). Correlation between serum ferritin levels and liver iron concentration determined by MR imaging: impact of hematologic disease and inflammation. Magn. Reson. Imaging 25, 228-231.
    • (2007) Magn. Reson. Imaging , vol.25 , pp. 228-231
    • Olthof, A.W.1    Sijens, P.E.2    Kreeftenberg, H.G.3    Kappert, P.4    Irwan, R.5    van der Jagt, E.J.6    Oudkerk, M.7
  • 28
    • 78649491998 scopus 로고    scopus 로고
    • Cadmium increases ferroportin-1 gene expression in J774 macrophage cells via the production of reactive oxygen species
    • Park, B. Y., and Chung, J. (2009). Cadmium increases ferroportin-1 gene expression in J774 macrophage cells via the production of reactive oxygen species. Nutr. Res. Pract. 3, 192-199.
    • (2009) Nutr. Res. Pract. , vol.3 , pp. 192-199
    • Park, B.Y.1    Chung, J.2
  • 29
    • 0034680828 scopus 로고    scopus 로고
    • Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool
    • Picard, V., Govoni, G., Jabado, N., and Gros, P. (2000). Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J. Biol. Chem. 275, 35738-35745.
    • (2000) J. Biol. Chem. , vol.275 , pp. 35738-35745
    • Picard, V.1    Govoni, G.2    Jabado, N.3    Gros, P.4
  • 30
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., and Loréal, O. (2001). A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276, 7811-7819.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loréal, O.7
  • 31
    • 0029960279 scopus 로고    scopus 로고
    • Ferritin translation by interleukin-1 and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes
    • Rogers, J. T. (1996). Ferritin translation by interleukin-1 and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes. Blood 87, 2525-2537.
    • (1996) Blood , vol.87 , pp. 2525-2537
    • Rogers, J.T.1
  • 32
    • 0034643632 scopus 로고    scopus 로고
    • The blood in systemic disorders
    • Spivak, J. L. (2000). The blood in systemic disorders. Lancet 355, 1707-1712.
    • (2000) Lancet , vol.355 , pp. 1707-1712
    • Spivak, J.L.1
  • 33
    • 0017057717 scopus 로고
    • Influence of dietary cadmium on the distribution of the essential metals copper, zinc and iron in tissues of the rat
    • Stonard, M. D., and Webb, M. (1976). Influence of dietary cadmium on the distribution of the essential metals copper, zinc and iron in tissues of the rat. Chem. Biol. Interact. 15, 349-363.
    • (1976) Chem. Biol. Interact. , vol.15 , pp. 349-363
    • Stonard, M.D.1    Webb, M.2
  • 34
    • 0021686850 scopus 로고
    • Effects of subcutaneous and oral cadmium on iron metabolism: role of ceruloplasmin and metallothionein
    • Sugawara, N., Sugawara, C., and Miyake,H. (1984). Effects of subcutaneous and oral cadmium on iron metabolism: role of ceruloplasmin and metallothionein. Arch. Toxicol. 56, 25-28.
    • (1984) Arch. Toxicol. , vol.56 , pp. 25-28
    • Sugawara, N.1    Sugawara, C.2    Miyake, H.3
  • 35
    • 0035918904 scopus 로고    scopus 로고
    • DMT1 gene expression and cadmium absorption in human absorptive enterocytes
    • Tallkvist, J., Bowlus, C. L., and Lönnerdal, B. (2001). DMT1 gene expression and cadmium absorption in human absorptive enterocytes. Toxicol. Lett. 122, 171-177.
    • (2001) Toxicol. Lett. , vol.122 , pp. 171-177
    • Tallkvist, J.1    Bowlus, C.L.2    Lönnerdal, B.3
  • 36
    • 0032909207 scopus 로고    scopus 로고
    • Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
    • Vulpe, C. D., Kuo, Y. M., Murphy, T. L., Cowley, L., Askwith, C., Libina, N., Gitschier, J., and Anderson, G. J. (1999). Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat. Genet. 21, 195-199.
    • (1999) Nat. Genet. , vol.21 , pp. 195-199
    • Vulpe, C.D.1    Kuo, Y.M.2    Murphy, T.L.3    Cowley, L.4    Askwith, C.5    Libina, N.6    Gitschier, J.7    Anderson, G.J.8
  • 37
    • 0027136260 scopus 로고
    • Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction
    • Wang, G. L., and Semenza,G. L. (1993). Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82, 3610-3615.
    • (1993) Blood , vol.82 , pp. 3610-3615
    • Wang, G.L.1    Semenza, G.L.2


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