Long-term cadmium exposure induces anemia in rats through hypoinduction of erythropoietin in the kidneys

Archives of Toxicology

Volumn 71, Issue 1-2, 1996, Pages 11-19

  Horiguchi, Hyogo ^a   Sato, Masao ^a   Konno, Nobuhiro ^a   Fukushima, Masaaki ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Anemia; Cadmium; Erythropoietin; Kidney; Rat

Indexed keywords

CADMIUM; ERYTHROPOIETIN; HEAVY METAL; MESSENGER RNA;

ANEMIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG TISSUE LEVEL; ENVIRONMENTAL EXPOSURE; FEMALE; HISTOLOGY; INTOXICATION; KIDNEY; KIDNEY INJURY; LIVER; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; RNA ANALYSIS;

ANEMIA; ANIMALS; BLOTTING, NORTHERN; BODY WEIGHT; BONE MARROW; CADMIUM CHLORIDE; ERYTHROPOIETIN; FEMALE; HEMATOLOGIC TESTS; KIDNEY; ORGAN SIZE; RATS; RATS, WISTAR; RNA, MESSENGER;

ANIMALIA;

EID: 0029823743     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050352     Document Type: Article

References (20)

1. Caro J, Zon LI, Silver R, Miller O, Erslev AJ (1983) Erythropoietin in liver tissue extracts and in liver perfusates from hypoxic rats. Am J Physiol 244: E431 E434
2. Eckardt K-U, Kurtz A, Bauer C (1984) Regulation of erythropoietin production is related to proximal tubular function. Am J Physiol 256: F942 F947
3. Friberg L, Kjellstrom T, Nordberg GF (1986) Cadmium. In: Friberg L, Nordberg GF, Youk VB (eds) Handbook on the toxicology of metals, 2nd edn. Elsevier, Amsterdam, pp 130 184
4. Hir ML, Eckardt K-U, Kaissling B, Koury ST, Kurtz A (1991) Structure-function correlations in erythropoietin formation and oxyeen sensing in the kidneys. Klinisch Wochenschr 69: 567 575
5. Horiguchi H, Mukaida N, Okamolo S, Teranishi H, Kasuya M, Matsushima K (1993) Cadmium induces interleukin-8 production in human peripheral blood mononuclear cells with the concomitant generation of superoxide radicals. Lymphokine Cytokine Res 12: 421 428
6. Horiguchi H, Teranishi H, Niiya K, Aoshima K, Katoh T, Sakuragawa N, Kasuya M (1994) Hypoproduction of erythropoietin contributes to anemia in chronic cadmium intoxication: clinical study on Hai-Itai disease in Japan. Arch Toxicol 68: 632-636
7. Kasuya M, Teranishi H, Aoshima K, Katoh T, Horiguchi H, Morikawa Y, Nishijo M, Iwata K (1992) Water pollution by cadmium and the onset of Itai-itai disease. Water Sci Technol 25: 149 156
8. Koury ST, Bondurant MC, Koury MJ (1988) Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71: 524 527
9. Lacombe C, Silva J-L D, Bruneval P, Fournier J-G, Welding F, Casadevall N, Camilleri J-P, Bariety J, Varet B, Tambourin P (1988) Peritubular cells are the site of the erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest 81: 620 623
10. Lowry OH, Rosebrough NJ, Farr AL, Kandall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265 275
11. Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
12. Maxwell AP, Lappin TRJ, Johnston CF, Bridges JM, McGeown MG (1990) Erythropoietin production in kidney tubular cells. Br J Haematol 74: 535-539
13. Nagao M, Suga H, Okano M, Masuda S, Narita H, Ikura K, Sasaki R (1992) Nucleotide sequence of rat erythropoietin. Biochem Biophys Acta 1171: 99 102
14. Nicholson JK, Kendall MD, Osborn D (1983) Cadmium and mercury nephrotoxicity. Nature 304: 633-635
15. Satake K, Okuyama T, Ohashi M, Shinoda T (1960) The spectro-photometric determination of amine, amino acid and peptide with 2,4,6-trinitrobenzene 2-sulfonic acid. J Biochem 47: 654-660
16. Sato M, Nagai Y (1980) Mode of existence of cadmium in rat liver and kidney after prolonged subcutaneous administration. Toxicol Appl Pharmacol 54: 90-99
17. Sherwood JB, Goldwasser E (1979) A radioimmunoassuy for erythropoietin. Blood 54: 885-893
18. Spivak JL (1990) Serum immunoreactive erythropoietin in health and disease, Int J Cell Clon 8 (Suppl 1): 211-226
19. Yasuda M, Miwa A, Kitagawa M (1995) Morphometric studies of renal lesions in Itai-itai disease: chronic cadmium nephropathy. Nephron 69: 14-19
20. Yiangou M, Ge X, Carter KC. Papaconstantinou J (1991) Induction of several acute-phase protein genes by heavy metals: a new class of metal-responsive genes. Biochemistry 30: 3798 3806