Cardiovascular and respiratory safety pharmacology in Göttingen minipigs: Pharmacological characterization

Journal of Pharmacological and Toxicological Methods

Volumn 64, Issue 1, 2011, Pages 53-59

  Authier, S ^a,b   Gervais, J ^a,b   Fournier, S ^a   Gauvin, D ^b   Maghezzi, S ^a   Troncy, E ^b  

^a LAB Research North America   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Cardiovascular; Methods; Minipig; Respiratory; Safety pharmacology; Telemetry

Indexed keywords

DOPAMINE; ESMOLOL; MEDETOMIDINE; REMIFENTANIL; SOTALOL;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BRADYCARDIA; CARDIOVASCULAR SYSTEM; DOSE RESPONSE; DRUG MEGADOSE; DRUG SAFETY; HYPERTENSION; HYPOTENSION; LUNG MINUTE VOLUME; MALE; MINIPIG; NONHUMAN; PHARMACOLOGICAL SCIENCE; QT PROLONGATION; RESPIRATORY SYSTEM; RISK ASSESSMENT; SAFETY PHARMACOLOGY; SHORT QT INTERVAL; SYSTOLIC BLOOD PRESSURE; TACHYPNEA; TIDAL VOLUME; TOXICITY TESTING;

ANIMALS; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; DOPAMINE; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; MALE; MEDETOMIDINE; MODELS, ANIMAL; PIPERIDINES; PROPANOLAMINES; RESPIRATORY SYSTEM; SOTALOL; SWINE; SWINE, MINIATURE; TELEMETRY; TOXICITY TESTS;

RODENTIA; SUIDAE;

EID: 79960989812     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2011.04.007     Document Type: Article

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