An integrated cardiovascular and neurobehavioural functional assessment in the conscious telemetered cynomolgus monkey

Journal of Pharmacological and Toxicological Methods

Volumn 62, Issue 2, 2010, Pages 95-106

  Moscardo, Elena ^a   McPhie, Gordon ^b   Fasdelli, Nicola ^a   Dorigatti, Roberto ^a   Meecham, Ken ^b  

^a GSK   (Italy)

^b HUNTINGDON LIFE SCIENCES   (United Kingdom)

Author keywords

Cardiovascular; Methods; Monkey; Neurobehavioural observation battery; Numerical score; Video images

Indexed keywords

DEXAMPHETAMINE; DIAZEPAM;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BALANCE DISORDER; BODY POSTURE; BODY TEMPERATURE; CARDIOVASCULAR FUNCTION; COGNITION; CONTROLLED STUDY; COORDINATION; DIASTOLIC BLOOD PRESSURE; DRUG DOSE ESCALATION; ELECTROCARDIOGRAM; FUNCTIONAL ASSESSMENT; HEART RATE; LOCOMOTION; MALE; MEAN ARTERIAL PRESSURE; MENTAL HEALTH; MONKEY; NEUROLOGIC EXAMINATION; NONHUMAN; PR INTERVAL; QRS COMPLEX; QT INTERVAL; STEREOTYPY; SYSTOLIC BLOOD PRESSURE; TELEMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; BODY TEMPERATURE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM STIMULANTS; DEXTROAMPHETAMINE; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART RATE; MACACA FASCICULARIS; MALE; MOTOR ACTIVITY; TELEMETRY;

ANIMALIA; MACACA FASCICULARIS;

EID: 77956060281     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2010.06.006     Document Type: Article

References (40)

1. Barros M., Tomaz C. Non-human primate models for investigating fear and anxiety. Neuroscience and Biobehavioral Reviews 2002, 26:187-201.
2. Booth N.H., McDonald L.E. Veterinary pharmacology and therapeutics 1991, Ames, Iowa: Iowa State University Press. 6th ed.
3. Bradley C.M., Nicholson A.N. Behavioural responses to diazepam of drug-naive and experienced monkeys (Macaca mulatta). Psychopharmacology 1986, 88:112-114.
4. Brooks D., Horner R.L., Kozar L.F., Waddell T., Render C.L., Phillipson E.A. Validation of a telemetry system for long-term measurement of blood pressure. Journal of Applied Physiology 1996, 81:1012-1018.
5. Castner S.A., Goldman-Rakic P.S. Long-lasting psychotomimetic consequences of repeated low-dose amphetamine exposure in Rhesus monkeys. Neuropsychopharmacology 1999, 20:10-28.
6. Catalano P.J., McDaniel K.L., Moser V.C. The IPCS collaborative study on neurobehavioral screening methods: VI. Agreement and reliability of the data. Neurotoxicology 1997, 18:1057-1064.
7. El Amrani F., Martel E., Richard S. QA interval, as an index of contractility using telemetric measurement in conscious cynomolgus monkeys (Macaca fascicularis). Journal of Pharmacological and Toxicological Methods 2008, 58:158-159.
8. Gad S.C., Gad S.E. A functional observational battery for use in canine toxicity studies: Development and validation. International Journal of Toxicology 2003, 22:415-422.
9. Gauvin D.V., Tilley L.P., Smith F.W.K., Baird T.J. Electrocardiogram, hemodynamics, and core body temperatures of the normal freely moving laboratory beagle dog by remote radiotelemetry. Journal of Pharmacological and Toxicological Methods 2006, 53:128-139.
10. Gauvin D.V., Baird T.J. A functional observational battery in non-human primates for regulatory-required neurobehavioral assessments. Journal of Pharmacological and Toxicological Methods 2008, 58:88-93.
11. Gelzer A.R.M., Ball H.A. Validation of a telemetry system for measurement of blood pressure, electrocardiogram and locomotor activity in beagle dogs. Clinical and Experimental Hypertension 1997, 19:1135-1160.
12. Haggerty G.C. Strategy for and experience with neurotoxicity testing of new pharmaceuticals. Journal of the American College of Toxicology 1991, 10:677-687.
13. Hawkins P., Morton D.B., Bevan R., Heath K., Kirkwood K., Pearce J., et al. Husbandry refinements for rats, mice, dogs and non-human primates used in telemetry procedures. Laboratory Animals 2004, 38:1-10.
14. ICH S7A S7A safety pharmacology studies for human pharmaceuticals. Guidance for industry. Federal Register 2001, 66:36791-36792
15. ICH S7B S7B: the nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. Federal Register 2005, 70:61133-61134.
16. Igarashi T., Nakane S., Kitagawa T. Predictability of clinical adverse reactions of drugs by general pharmacology studies. Journal of Toxicological Science 1995, 20:77-92.
17. Irwin S. Comprehensive Observational Assessment: A systematic quantitative procedure for assessing the behavioural and physiologic state of the mouse. Psychopharmacology 1968, 13:222-257.
18. Kumar R., Palit G., Singh J.R., Dhawan B.N. Comparative behavioural effects of benzodiazepine and non-benzodiazepine anxiolytics in the Rhesus monkeys. Pharmacological Research 1999, 39(6):437-444.
19. Lukey B.J., Corcoran K.D., Solana R.P. Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys. Journal of Pharmaceutical Sciences 2006, 80:918-921.
20. Mattsson J.L., Spencer P.J., Albee R.R. A performance standard for clinical and functional observational battery examinations of rats. Journal of American College of Toxicology 1996, 15:239-254.
21. Morton W.R., Kyes K.B., Kyes R.C., Dwindler D.R., Swindler K.E. Use of the primate model in research. The laboratory primate 2005, 405-415. Academic Press, New York. S. Wolfe-Coote (Ed.).
22. Moscardo E., Giarola A. Neurobehavioural assessment in preclinical species: Rodents, dog and monkeys. Novel approaches towards primate toxicology 2006, 49-63. Waxmann Verlag, Publishing Co, Munster. G.F. Weinbauer, F. Vogel (Eds.).
23. Moscardo E., Maurin A., Dorigatti R., Champeroux P., Richard S. An optimized methodology for the neurobehavioral assessment in rodents. Journal of Pharmacological and Toxicological Methods 2007, 56:239-255.
24. Moscardo E., Fasdelli N., Giarola A., Tontodonati M., Dorigatti R. An optimised neurobehavioural observation battery integrated with the assessment of cardiovascular function in the beagle dog. Journal of Pharmacological and Toxicological Methods 2009, 60:198-209.
25. Moser V.C. Approaches for assessing the validity of a functional observational battery. Neurotoxicology and Teratology 1990, 12:483-488.
26. Moser V.C. The functional observational battery in adult and developing rats. Neurotoxicology 2000, 21:989-996.
27. NC3Rs National Centre for the Replacement, Refinement and Reduction of Animals in Research (available at www.nc3rs.org.uk).
28. O'Brien D. Neurological evaluation and development of the neonatal dog. Seminars in Veterinary Medicine & Surgery Small Animal 1994, 2:62-67.
29. O'Keeffe R.T., Lifshitz K. Nonhuman primates in neurotoxicity screening and neurobehavioral toxicity studies. Journal of American College of Toxicology 1989, 8:127-140.
30. Olson H., Betton G., Robinson D., Thomas K., Monro A., Kojala G., et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory Toxicology and Pharmacology 2000, 32:56-67.
31. Pugsley M.K., Authier S., Curtis M.J. Principles of safety pharmacology. British Journal of Pharmacology 2008, 154:1382-1399.
32. Redfern W.S., Strang I., Storey S., Heys C., Barnard C., Lawton K., et al. Spectrum of effects detected in the rat functional observational battery following oral administration of non-CNS targeted compounds. Journal of Pharmacological and Toxicological Methods 2005, 52:77-82.
33. Reinhardt V. Environmental enrichment and refinement of handling procedures. The laboratory primate 2005, 209-227. Academic Press, New York. S. Wolfe-Coote (Ed.).
34. Ridley R.M., Backer H.F., Owen F., Cross A.J., Crow T.J. Behavioural and biochemical effects of chronic amphetamine treatment in the vervet monkey. Psychopharmacology (Berlin) 1982, 78:245-251.
35. Schulze G.E., Paule M.G. Acute effects of d-amphetamine in a monkey operant behavioural test battery. Pharmacology Biochemistry & Behaviour 1990, 35:759-765.
36. Schulze G.E., Slikker W., Paule M.G. Multiple behavioral effects of diazepam in rhesus monkeys. Pharmacology, Biochemistry and Behavior 1989, 34:29-35.
37. Tardif S., Bales K., Williams L., Moeller E.L., Abbott D., Schultz-Darken N., et al. Preparing new world monkeys for laboratory research. ILAR Journal 2006, 47:307-315.
38. Tontodonati M., Fasdelli A., Moscardo E., Giarola A., Dorigatti R. A canine model to use to simultaneously assess potential neurobehavioural and cardiovascular effects of candidate drugs. Journal of Pharmacological and Toxicological Methods 2007, 56:265-275.
39. Truett A.A., West D.B. Validation of a radiotelemetry system for continuous blood pressure and heart rate monitoring in dogs. Laboratory Animal, Sciences 1995, 45:299-302.
40. Zhu Y., Wessel M.R., Liu T., Moser V.C. Analysis of neurobehavioral screening data: Dose-time-response modelling of continuous outcomes. Regulatory Toxicology and Pharmacology 2005, 41:240-255.