Respiratory safety pharmacology: Concurrent validation of volume, rate, time, flow and ratio variables in conscious male Sprague-Dawley rats

Regulatory Toxicology and Pharmacology

Volumn 58, Issue 3, 2010, Pages 444-450

  Legaspi, Margarita ^a,b   Authier, Simon ^a,b   Gauvin, Dominique ^b   Moreau, Maxim ^b   Beauchamp, Guy ^b   Chaurand, Fernando ^a   Troncy, Eric ^b  

^a INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Conscious; ICH S7A; Monitoring qualifications; Rat; Respiratory function; Validation

Indexed keywords

METHACHOLINE; REMIFENTANIL; SALBUTAMOL; METHACHOLINE CHLORIDE; PIPERIDINE DERIVATIVE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREATHING RATE; BRONCHODILATATION; CONTROLLED STUDY; DRUG SAFETY; DUNNETT TEST; LUNG VOLUME; MALE; NONHUMAN; PEAK EXPIRATORY FLOW; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RAT; RESPIRATION DEPRESSION; RESPIRATORY SYSTEM; SENSITIVITY ANALYSIS; SPRAGUE DAWLEY RAT; TIDAL VOLUME; TOXICITY TESTING; VALIDATION STUDY; ANIMAL; BREATHING; BRONCHOSPASM; CHEMICALLY INDUCED DISORDER; CONSCIOUSNESS; DOSE RESPONSE; DRUG EFFECT; INSPIRATORY CAPACITY; LUNG FUNCTION TEST; REPRODUCIBILITY; RESPIRATORY FAILURE;

RATTUS;

ALBUTEROL; ANIMALS; BRONCHOCONSTRICTION; CONSCIOUSNESS; DOSE-RESPONSE RELATIONSHIP, DRUG; INSPIRATORY CAPACITY; MALE; METHACHOLINE CHLORIDE; PIPERIDINES; PLETHYSMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RESPIRATION; RESPIRATORY FUNCTION TESTS; RESPIRATORY INSUFFICIENCY; RESPIRATORY RATE; RESPIRATORY SYSTEM; SODIUM CHLORIDE; TIDAL VOLUME;

EID: 79959516489     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2010.08.014     Document Type: Article

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