Evaluation of cardiovascular and ECG parameters in the normal, freely moving Göttingen Minipig

Journal of Pharmacological and Toxicological Methods

Volumn 57, Issue 3, 2008, Pages 202-211

  Stubhan, Miriam ^a   Markert, Michael ^a   Mayer, Karin ^a   Trautmann, Thomas ^a   Klumpp, Anja ^a   Henke, Julia ^a   Guth, Brian ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Arterial blood pressure; Conscious minipig; Contractility; Heart rate; Hemodynamic; Methods; QT duration; Telemetry

Indexed keywords

AMOXICILLIN; FENTANYL; MELOXICAM;

ANIMAL EXPERIMENT; AORTA PRESSURE; ARTICLE; BODY TEMPERATURE; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DRUG SAFETY; ELECTROCARDIOGRAM; FEMALE; HEART HEMODYNAMICS; HEART LEFT VENTRICLE PRESSURE; HEART RATE; MALE; MINIPIG; NONHUMAN; QT INTERVAL; TELEMETRY;

ANIMALS; CARDIOVASCULAR PHYSIOLOGY; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; MALE; MODELS, ANIMAL; SWINE; SWINE, MINIATURE; TELEMETRY;

ANIMALIA;

EID: 44449126516     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2008.02.001     Document Type: Article

References (47)

1. Batey A.J., and Doe C.P.A. A method for QT correction based on beat-to-beat analysis of the QT/RR interval relationship in conscious telemetred beagle dogs. Journal of Pharmacological and Toxicological Methods 48 1 (2002) 11-19
2. Beglinger R., Becker M., Eggenberger E., and Lombard C. The Gottinger Minipig as a laboratory animal. Research in Experimental Medicine 165 3 (1975) 251-263
3. Benharkate M., Zanini V., Blanc R., Boucheix O., Coyez F., Genevois J.P., and Pairet M. Hemodynamic parameters of anesthetized pigs: A comparative study of farm piglets and Gottingen and Yucatan miniature swine. Laboratory Animal Science 43 1 (1993) 68-72
4. Bollen P., and Ellegaard L. The Göttingen minipig in pharmacology and toxicology. Pharmacology and Toxicology 80 Suppl. 2 (1997) 3-4
5. Bollen P.J.A., Hansen A.K., and Rasmussen H.J. The Laboratory Swine. A Volume in the Laboratory Animal Pocket Reference Series (2000), CRC Press
6. Bustad L.K., and McClellan R.O. Miniature swine: development, management, and utilization. Laboratory animal care 18 2 (1968) 280-287
7. Chiang A.Y., Holdsworth D.L., and Leishman D.J. A one-step approach to the analysis of the QT interval in conscious telemetrized dogs. Journal of Pharmacological and Toxicological Methods 54 2 (2006) 183-188
8. Cimini C.M., and Zambraski E.J. Non-invasive blood pressure measurement in Yucatan miniature swine using tail cuff sphygmomanometry. Laboratory Animal Science 35 4 (1985) 412-416
9. Crick S.J., Sheppard M.N., Yen Ho S., and Crick S.J. Anatomy of the pig heart: comparisons with normal human cardiac structure. Journal of Anatomy 193 1 (1998) 105-119
10. Davey P. How to correct the QT interval for the effects of heart rate in clinical studies. Journal of Pharmacological and Toxicological Methods 48 1 (2002) 3-9
11. Diederen W., and Kadatz R. Effects of AR-L 115 BS, a new cardiotonic compound, on cardiac contractility, heart rate and blood pressure in anaesthetized and conscious animals. Arzneimittel-Forschung/Drug Research 31 1A (1981) 146-150
12. Dukes T.W., and Szabuniewicz M. The electrocardiogram of conventional and miniature swine (Sus scrofa). Canadian Journal of Comparative Medicine 33 2 (1969) 118-127
13. Eckenfels A., and Schuler S. On the normal electrocardiogram of the conscious minipig. Arzneimittel-Forschung/Drug Research 38 2 (1988) 253-259
14. Fernandez-Gil T., Focant M., Elsen F., Van Hoccke A., and Vanbelle M. Effect of Finely Ground Wheat bran or Spelt Chaff on the Transit Time in Pigs. European Journal of Clinical Nutrition 49 3 (1995) 182-185
15. Gauvin D.V., Tilley L.P., Smith F.W.K., and Baird T.J. Electrocardiogram, hemodynamics, and core body temperatures of the normal freely moving laboratory beagle dog by remote radiotelemetry. Journal of Pharmacological and Toxicological Methods 53 2 (2006) 128-139
16. Georgiev S., Schoen A., and Merkenschlager M. Effect of various environmental temperatures and humidities of some physiologic parameters of the Göttinger minipig in various stages of growth. 3. Adults. Berliner und Munchener Tierarztliche Wochenschrift 85 21 (1972) 409-413
17. Glodek, P., & Oldigs, B. (1981). Das Göttinger Miniaturschwein. Beglinger, R. and Becker, M. 6. Herz und Kreislauf. Schriftenreihe Versuchstierkunde 7. Berlin und Hamburg, Paul Parey.
18. Guth B.D., Germeyer S., Kolb W., and Markert M. Developing a strategy for the nonclinical assessment of proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization. Journal of Pharmacological and Toxicological Methods 49 3 (2004) 159-169
19. Henke J., Brill T., and Feußner H. Experimentelle Medizin: Vom Tiermodell zur Computeranimation 11 (2005) 329-335
20. Hohns, H. (1970). Physiologische Untersuchungen am Herz-Kreislauf-System bei Schweinen verschiedener Rassen. Heft 51. Mariensee, Schriftenreihe des Max-Plank-Instituts für Tierzucht und Tierernährung.
21. Holzgrefe H.H., Cavero I., Gleason C.R., Warner W.A., Buchanan L.V., Gill M.W., Burkett D.E., and Durham S.K. Novel probabilistic method for precisely correcting the QT interval for heart rate in telemetered dogs and cynomolgus monkeys. Journal of Pharmacological and Toxicological Methods 55 2 (2007) 159-175
22. Hughes H.C. Swine in cardiovascular research. Laboratory animal science 36 4 (1986) 348-350
23. Jones R.D., Stuart B.P., Greufe N.P., and Landes A.M. Electrophysiology and pathology evaluation of the Yucatan pig as a non-rodent animal model for regulatory and mechanistic toxicology studies. Laboratory Animals 33 4 (1999) 356-365
24. Kano M., Toyoshi T., Iwasaki S., Dato M., Shimizu M., and Ota T. QT PRODACT: Usability of miniature pigs in safety pharmacology studies: Assessment for drug-induced QT interval prolongation. Journal of Pharmacological Sciences 99 5 (2005) 501-511
25. Khan M.A. Minipig: Advantages and disadvantages as a model in toxicity testing. Journal of the American College of Toxicology 3 6 (1984) 337-342
26. Klumpp A., Trautmann T., Markert M., and Guth B. Optimizing the experimental environment for dog telemetry studies. Journal of Pharmacological and Toxicological Methods 54 2 (2006) 141-149
27. Kuwahara M., Suzuki A., Tsutsumi H., Tanigawa M., Tsubone H., and Sugano S. Power spectral analysis of heart rate variability for assessment of diurnal variation of autonomic nervous activity in miniature swine. Laboratory animal science 49 2 (1999) 202-208
28. Kuwahara M., Tsujino Y., Tsubone H., Kumagai E., Tsutsumi H., and Tanigawa M. Effects of pair housing on diurnal rhythms of heart rate and heart rate variability in miniature swine. Experimental Animals 53 4 (2004) 303-309
29. Lal B., Bhattacharya B.K., and Dadkar N.K. Cardiovascular and antihypertensive activity of the new vasodilator 9,10-dimethoxy-2-mesitylimino-3-methyl-3,4,6,7-tetrahydro-2H-pyrimido (6,1-a) isoquinolin-4-one hydrochloride (HL 725). IRCS Medical Science 9 4 (1981) 325-326
30. Larks S.D., Wescott R.B., and Larks G.G. Electrocardiographic studies of miniature swine: normal values. Laboratory animal science 21 4 (1971) 553-557
31. Lehmann H. The minipig in general toxicology. Scandinavian Journal of Laboratory Animal Science 25 Sppl. 1 (1998) 59-62
32. Leucht W., Gregor G., and Stier H. Das Miniaturschwein. Einführung in die Versuchstierkunde. Band VI. VEB Gustav Fischer Verlag Jena (1982)
33. Lückmann, J. (1968). Die Herzfrequenz des Schweines. Hannover, Veterinary Dissertation.
34. Markert M., Klumpp A., Trautmann T., and Guth B. A novel propellant-free inhalation drug delivery system for cardiovascular drug safety evaluation in conscious dogs. Journal of Pharmacological and Toxicological Methods 50 2 (2004) 1109-1119
35. Markert M., Klumpp A., Trautmann T., Mayer K., Stubhan M., and Guth B. The value added by measuring myocardial contractility 'in vivo' in safety pharmacological profiling of drug candidates. Journal of Pharmacological and Toxicological Methods 56 2 (2007) 203-211
36. Matsunaga T., Mitsui T., Harada T., Inokuma M., Murano H., and Shibutani Y. QT corrected for heart rate and relation between QT and RR intervals in beagle dogs. Journal of Pharmacological and Toxicological Methods 38 4 (1997) 201-209
37. Meyners M., and Markert M. Correcting the QT interval for changes in HR in pre-clinical drug development. Methods of Information in Medicine 43 (2004) 445-450
38. Miyazaki H., and Tagawa M. Rate-correction technique for QT interval in long-term telemetry ECG recording in beagle dogs. Experimental Animals 51 5 (2002) 465-475
39. Nahas K., Baneux P., and Detweiler D. Electrocardiographic monitoring in the Göttingen minipig. Comparative Medicine 52 3 (2002) 258-264
40. Pugsley M.K., and Curtis M.J. Safety pharmacology in focus: new methods developed in the light of the ICH S7B guidance document. Journal of Pharmacological and Toxicological Methods 54 2 (2006) 94-98
41. Rollin B.E. Moral, social and scientific aspects of the use of swine in research. In: Tumbleson M.E. (Ed). Swine in biomedical research (1986), Plenum Press, New York 29-37
42. Ross J., Covell W., and Sonnenblick E.H. The mechanics of left ventricular contraction in acute experimental cardiac failure. Journal of Clinical Investigation 46 (1967) 299-312
43. Smith A.C., Spinale F.G., and Swindle M.M. Cardiac function and morphology of Hanford miniature swine and Yucatan miniature and micro swine. Laboratory animal science 40 1 (1990) 47-50
44. Spence S., Soper K., Hoe T.M., and Coleman J. The heart rate-corrected QT interval of conscious beagle dogs: A formula based on analysis of covariance. Toxicological Sciences 45 2 (1998) 247-258
45. Suzuki A., Tsutumi H., Kusakabe K., Kuwahara M., Sugano S., and Taniwaga M. Establishment of a 24-hour electrocardiogram recording system using a Holter recorder for miniature swine. Laboratory Animals 32 2 (1998) 165-172
46. Vainio O.M., Bloor B.C., and Kim C. Cardiovascular effects of a ketamine-medetomidine combination that produces deep sedation in Yucatan mini swine. Laboratory animal science 42 6 (1992) 582-588
47. Zambraski E.J., and Fuchs B. Resting metabolism of Yucatan miniature swine. Laboratory animal science 30 1 (1980) 51-53