Different species require different correction factors for the QT interval

Cardiovascular Toxicology

Volumn 6, Issue 2, 2006, Pages 145-157

  Soloviev, Maxim V ^a   Hamlin, Robert L ^b   Barrett, Randy M ^a   Chengelis, Christopher P ^a   Schaefer, Gerald J ^c  

^a WIL RESEARCH LABORATORIES   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Beagle dog; Cardiovascular; Cynomolgus monkey; Heart rate; QT interval; QT interval correction; Safety pharmacology

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOG; DOMESTICATION; ELECTROCARDIOGRAM; FEMALE; HEART RATE; HEART REPOLARIZATION; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; WILD ANIMAL;

ANIMALS; BODY WEIGHT; CARDIOVASCULAR AGENTS; DIET; DOGS; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; ENVIRONMENT; HEART RATE; MACACA FASCICULARIS; PHOTOPERIOD; PHYSICAL CONDITIONING, ANIMAL; REFERENCE STANDARDS; SPECIES SPECIFICITY; TELEMETRY; WATER SUPPLY;

ANIMALIA; CANIS FAMILIARIS; MACACA FASCICULARIS;

EID: 33847174126     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/CT:6:2:145     Document Type: Article

References (58)

1. Food and Drug Administration, HHS. (2005). International Conference on Harmonisation; guidance on S7B Non-clinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals; availability. Notice. Fed. Regist. 70(202):61, 133-61,134.
2. Bass, A., Kinter, L., and Williams, P. (2004). Origins, practices and future of safety pharmacology. J. Pharmacol. Toxicol. Methods 49(3):145-151.
3. Bass, A.S., Tomaselli, G., Bullingham, R. 3rd., and Kinter, L.B. (2005). Drugs effects on ventricular repolarization: a critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices. J. Pharmacol. Toxicol. Methods 52(1):12-21.
4. Davis, A.S. (1998). The pre-clinical assessment of QT interval prolongation: a comparison of in vitro and in vivo methods. Hum. Exp. Toxicol. 17(12):677-680.
5. Gralinski, M.R. (2003). The dog's role in the preclinical assessment of QT interval prolongation. Toxicol. Pathol. 31(Suppl):11-16.
6. Hammond, T.G., Carlsson, L., Davis, A.S., et al. (2001). Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey. Cardiovasc. Res. 49(4):741-750.
7. Hayes, E., Pugsley, M.K., Penz, W.P., Adaikan, G., and Walker, M.J. (1994). Relationship between QaT and RR intervals in rats, guinea pigs, rabbits, and primates. J. Pharmacol. Toxicol. 32(4):201-207.
8. Kinter, L.B. and Valentin, J.P. (2002). Safety pharmacology and risk assessment. Fundam. Clin. Pharmacol. 16(3):175-182.
9. Kinter, L.B., Siegl, P.K., and Bass, A.S. (2004). New preclinical guidelines on drug effects on ventricular repolarization: safety pharmacology comes of age. J. Pharmacol. Toxicol. Methods. 49(3):153-158.
10. Food and Drug Administration, HHS. (2001) International Conference on Harmonisation; guidance on S7A safety pharmacology studies for human pharmaceuticals; availability. Notice. Fed. Regist. 66(135):36, 791-36,792.
11. Friedrichs, G.S., Patmore, L., and Bass, A. (2005). Non-clinical evaluation of ventricular repolarization (ICH S7B): results of an interim survey of international pharmaceutical companies. J. Pharmacol. Toxicol. Methods 52(1):6-11.
12. Van der Linde, H., Van de Water, A., Loots, W., et al. (2005). A new method to calculate the beat-to-beat instability of QT duration in drug-induced long QT in anesthetized dogs. J. Pharmacol. Toxicol. Methods 52(1):168-177.
13. Lawrence, C.L., Pollard, C.E., Hammond, T.G., and Valentin, J.P. (2005). Nonclinical proarrhythmia models: predicting Torsades de Pointes. J. Pharmacol. Toxicol. 52(1):46-59.
14. Detweiler, D.K. (1988). The mammalian electrocardiogram, in Comprehensive Electrocardiography: Theory and Practice in Health and Disease (MacFarlane, P.W. and Lawrie, T.D.V., eds.). Pergamon, New York: pp. 1346-1350.
15. Osborne, B.E. and Leach, G.D. (1971). The beagle electrocardiogram. Food Cosmet. Toxicol. 9(6):857-864.
16. Tilley, L.P. (1992). Essentials of Canine and Feline Electrocardiography: Interpretation and Treatment, 3rd ed. Lippincott Williams & Wilkins, Philadelphia, PA.
17. Bazett, J.C. (1920). An analysis of time relations of electrocardiograms. Heart 7:353-367.
18. Fridericia, L.S. (1920). The duration of systole in an electrocardiogram in normal humans and in patients with heart disease. Acta Med. Scandinavica 53:469-486.
19. Van de Water, A., Verheyen, J., Xhonneux, R., and Reneman, R.S. (1989). An improved method to correct the QT interval of the electrocardiogram for changes in heart rate. J. Pharmacol. Methods 22(3):207-217.
20. Shipley, R.A. and Hallaran, W.R. (1936). The four-lead electrocardiogram in two hundred normal men and women. Am. Heart J. 11:325-336.
21. Lepeschkin, E. (1951). Modern Electrocardiography, Vol. 1. The Williams & Wilkins Co., Baltimore.
22. Spence, S., Soper, K., Hoe, C.-M., and Coleman, J. (1998). The heart rate-corrected QT interval of conscious beagle dogs: a formula based on analysis of covariance. Toxicol. Sci. 45(2):247-258.
23. National Research Council (1996). Guide for the Care and Use of Laboratory Animals, Institute of Laboratory Animal Resources, Commission on Life Sciences. National Academy Press, Washington, DC.
24. Animal Welfare Act, Amendment of, Title XVII, Subtitle F, Sections 1751 to 1759 (1985). United States Statutes at Large 99:50.
25. Pueyo, E., Smetana, P., Caminal, P., de Luna, A.B., Malik, M., and Laguna, P. (2004). Characterization of QT interval adaptation to RR interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction. IEEE Trans. Biomed. Eng. 51(9):1511-1520.
26. Browne, K.F., Prystowsky, E., Heger, J.J., Chilson, D.A., and Zipes, D.P. (1983). Prolongation of the Q-T interval in man during sleep. Am. J. Cardiol. 52(1):55-59.
27. Gillis, A.M., MacLean, K.E., and Guilleminault, C. (1988). The QT interval during wake and sleep in patients with ventricular arrhythmias. Sleep 11(4):333-339.
28. Yeragani, V.K., Berger, R., Pohl, R., and Balon, R. (2005). Effect of age on diurnal changes of 24-hour QT interval variability. Pediatr. Cardiol. 26(1):39-44.
29. Miyazaki, H. and Tagawa, M. (2002). Rate-correction technique for QT interval in long-term telemetry ECG recording in beagle dogs. Exp. Anim. 51(5):465-475.
30. Gauvin, D.V., Tilley, L.P., Smith, F.W. Jr., and Baird, T.J. (2006). Electrocardiogram, hemodynamics, and core body temperatures of the normal freely moving cynomolgus monkey by remote radiotelemetry. J. Pharmacol. Toxicol. Methods 53(2):140-151.
31. Soloviev, M.V., Hamlin, R.L., Shellhammer, L.J., et al. (2006). Variations in hemodynamic parameters and ECG in healthy conscious freely moving telemetrized beagle dogs. Cardiovasc. Toxicol. 6(1):51-62.
32. Murakawa, Y., Inoue, H., Nozaki, A., and Sugimoto, T. (1992). Role of sympathovagal interaction in diurnal variation of QT interval. Am. J. Cardiol. 69(4):339-343.
33. Bexton, R.S., Vallin, H.O., and Camm, A.J. (1986). Diurnal variation of the QT interval - influence of the autonomic nervous system. Br. Heart J. 55(3):253-258.
34. Drew, B.J., Califf, R.M., Funk, M., et al. (2004). American Heart Association. Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the Young. Practice standards for electrocardiographic monitoring in hospital settings: an American Heart Association scientific statement from the Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the Young: endorsed by the International Society of Computerized Electrocardiology and the American Association of Critical-Care Nurses. Circulation 110(17):2721-2746.
35. Luo, S., Michler, K., Johnston, P., and Macfarlane, P.W. (2004). A comparison of commonly used QT correction formulae: the effect of heart rate on the QTc of normal ECGs. J. Electrocardiol. 37(Suppl):81-90.
36. Charbit, B., Samain, E., Merckx, P., and Funck-Brentano, C. (2006). QT interval measurement: evaluation of automatic QTc measurement and new simple method to calculate and interpret corrected QT interval. Anesthesiology 104(2):255-260.
37. Davey, P. and Bateman, J. (1999). Heart rate and catecholamine contribution to QT interval shortening on exercise. Clin. Cardiol. 22(8):513-518.
38. Bortolan, G., Bressan, M., and Golferini, F. (2004). ILSA Study Group. QT dispersion in the elderly. The ILSA Study. Aging Clin. Exp. Res. 16(5):342-348.
39. Nakagawa, M., Ooie, T., Ou, B., et al. (2005). Gender differences in autonomic modulation of ventricular repolarization in humans. J. Cardiovasc. Pharmacol. 16(3):278-284.
40. Schulze-Bahr, E., Kirchhof, P., Eckardt, L., Bertrand, J., and Breithardt, G. (2005). Gender differences in cardiac arrhythmias. Herz. 30(5):390-400.
41. Bonnemeier, H., Wiegand, U.K., Braasch, W., Brandes, A., Richardt, G., and Potratz, J. (2003). Circadian profile of QT interval and QT interval variability in 172 healthy volunteers. Pacing Clin. Electrophysiol. 26(1 Pt 2):377-382.
42. Mattu, A., Brady, W.J., and Perron, A.D. (2002). Electrocardiographic manifestations of hypothermia. Am. J. Emerg. Med. 20(4):314-326.
43. Ahnve, S. and Vallin, H. (1982). Influence of heart rate and inhibition of autonomic tone on the QT interval. Circulation 65:435-459.
44. Browne, K.F., Zipes, D.P., Heger, J.J., and Prystowsky, E.N. (1982). Influence of the autonomic nervous system on the Q-T interval in man. Am. J. Cardiol. 50:1099-1103.
45. Lecocq, B., Lecocq, V., and Jaillon, P. (1989). Physiologic relation between cardiac cycle and QT duration in healthy volunteers. Am. J. Cardiol. 63:481-486.
46. Abildskov, J.A. (1976). Adrenergic effects on the QT interval of the electrocardiogram. Am. Heart J. 92:210-216.
47. Fananapazir, L., Benett, D.H., and Faragher, E.B. (1983). Contribution of heart rate to QT interval shortening during exercise. Eur. Heart J. 4:265-271.
48. Kawataki, M., Kashima, T., Toda, H., and Tanaka, H. (1984). Relation between QT interval and heart rate. applications and limitations of Bazett's formula. J. Electrocardiol. 17(4):371-375.
49. Murakawa, Y., Yamashita, T., Ajiki, K., Sezaki, K., and Omata, M. (1998). Ostensible day-night difference of QT prolongation during long-term treatment with antiarrhythmic drugs: reappraisal of the law of "regression to the mean". J. Cardiovasc. Pharmacol. 32(1):62-65.
50. Nam, G.B., Burashnikov, A., and Antzelevitch, C. (2005). Cellular mechanisms underlying the development of catecholaminergic ventricular tachycardia. Circulation. 111(21):2727-2733.
51. Roden, D.M. and Yang, T. (2005). Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve. Circulation 112(10):1376-1378.
52. Boudoulas, H., Geleris, P., Lewis, R.P., and Leier, C.V. (1981). Effect of increased adrenergic activity on the relationship between electrical and mechanical systole. Circulation 64(1):28-33.
53. Cuomo, S., De Caprio, L., Di Palma, et al. (1997). Influence of autonomic tone on QT interval duration. Cardiologia 42(10):1071-1076.
54. Yurlov, V.M. and Bogomol'nyi, B.R. (1988). Changes in electrical systole and heart rate in healthy persons after the exercise test. Kardiologiia 28(2):71-74.
55. Eckenfels, A. and Schuler, S. (1988). The normal electrocardiogram of miniature swine. Arzneimittel-Forschung 38(2):253-259.
56. Parker, G.W., Michael, L.H., and Entman, M.L. (1987). An animal model to examine the response to environmental stress as a factor in sudden cardiac death. Am. J. Cardiol. 60(18):9J-14J.
57. Pond, A.L., Scheve, B.K., et al. (2000). Expression of distinct ERG proteins in rat, mouse, and human heart. Relation to functional I(Kr) channels. J. Biol. Chem. 275(8):5997-6006.
58. Bharati, S., Levine, M., Huang, S.K., et al. (1991). The conduction system of the swine heart. Chest 100(1):207-212.