Respiratory safety pharmacology: Positive control drug responses in Sprague-Dawley rats, Beagle dogs and cynomolgus monkeys

Regulatory Toxicology and Pharmacology

Volumn 55, Issue 2, 2009, Pages 229-235

  Authier, Simon ^a,b   Legaspi, Margarita ^a,b   Gauvin, Dominique ^b   Troncy, Eric ^b  

^a LAB Research Inc   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Conscious; Dog; ICH S7A; Minute volume; Monkey; Rat; Respiratory rate; Respiratory safety; Tidal volume

Indexed keywords

METHACHOLINE; REMIFENTANIL; SALBUTAMOL; SODIUM CHLORIDE;

ACCLIMATIZATION; AIRFLOW; ARTICLE; BREATHING RATE; BRONCHODILATATION; BRONCHOSPASM; CONTROLLED STUDY; DOG; DRUG RESPONSE; DRUG SAFETY; EXPERIMENTAL MODEL; FACE MASK; FEMALE; HELMET; HYPERVENTILATION; HYPOTHESIS; HYPOVENTILATION; LUNG MINUTE VOLUME; LUNG VENTILATION; MALE; MEDICAL ASSESSMENT; MONKEY; NONHUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RAT; RESPIRATION DEPRESSION; SPECIES DIFFERENCE; TIDAL VOLUME;

ALBUTEROL; ANIMALS; BRONCHOCONSTRICTOR AGENTS; BRONCHODILATOR AGENTS; DOGS; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; HYPERVENTILATION; HYPOVENTILATION; MACACA FASCICULARIS; MALE; METHACHOLINE CHLORIDE; PHARMACEUTICAL PREPARATIONS; PIPERIDINES; RATS; RESPIRATION; RESPIRATORY FUNCTION TESTS; RESPIRATORY INSUFFICIENCY; SPECIES SPECIFICITY;

ANIMALIA; CANIS FAMILIARIS; MACACA FASCICULARIS; RATTUS;

EID: 70349557785     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.07.010     Document Type: Article

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