-
1
-
-
77955978565
-
-
Accessed August 30, 2010
-
Cancer facts and figures 2010. 2010. Accessed August 30, 2010, at http://www.cancer.gov.
-
(2010)
Cancer Facts and Figures 2010
-
-
-
2
-
-
0033198035
-
CPT-11 (Irinotecan) addition to bimonthly, high-dose leucovorin and bolus and continuous-infusion 5-fluorouracil (FOLFIRI) for pretreated metastatic colorectal cancer
-
DOI 10.1016/S0959-8049(99)00150-1, PII S0959804999001501
-
Andre T, Louvet C, Maindrault-Goebel F, et al. CPT-11 (irinotecan) addition to bimonthly, high-dose leucovorin and bolus and continuous-infusion 5-fluorouracil (FOLFIRI) for pretreated metastatic colorectal cancer. GERCOR. Eur J Cancer. 1999;35:1343-7. (Pubitemid 29397434)
-
(1999)
European Journal of Cancer
, vol.35
, Issue.9
, pp. 1343-1347
-
-
Andre, T.1
Louvet, C.2
Maindrault-Goebel, F.3
Couteau, C.4
Mabro, M.5
Lotz, J.P.6
Gilles-Amar, V.7
Krulik, M.8
Carola, E.9
Izrael, V.10
De Gramont, A.11
-
3
-
-
36849052105
-
XELOX compared to FOLFOX4: Survival and response results from XELOX-1/NO16966, a randomized phase III trial of first-line treatment for patients with metastatic colorectal cancer (MCRC)
-
abstract
-
Cassidy J, Clarke S, Diaz-Rubio E, et al. XELOX compared to FOLFOX4: Survival and response results from XELOX-1/NO16966, a randomized phase III trial of first-line treatment for patients with metastatic colorectal cancer (MCRC) [abstract]. J Clin Oncol (Meeting Abstracts). 2007;25:4030.
-
(2007)
J Clin Oncol (Meeting Abstracts)
, vol.25
, pp. 4030
-
-
Cassidy, J.1
Clarke, S.2
Diaz-Rubio, E.3
-
4
-
-
0033198085
-
Oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX6)
-
DOI 10.1016/S0959-8049(99)00149-5, PII S0959804999001495
-
Maindrault-Goebel F, Louvet C, Andre T, et al. Oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX6). GERCOR. Eur J Cancer. 1999;35:1338-42. (Pubitemid 29397433)
-
(1999)
European Journal of Cancer
, vol.35
, Issue.9
, pp. 1338-1342
-
-
Maindrault-Goebel, F.1
Louvet, C.2
Andre, T.3
Carola, E.4
Lotz, J.P.5
Molitor, J.L.6
Garcia, M.L.7
Gilles-Amar, V.8
Izrael, V.9
Krulik, M.10
De Gramont, A.11
-
5
-
-
34948857445
-
Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: A final report of the AIO colorectal study group
-
DOI 10.1200/JCO.2006.09.2684
-
Porschen R, Arkenau HT, Kubicka S, et al. Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: a final report of the AIO Colorectal Study Group. J Clin Oncol. 2007;25:4217-23. (Pubitemid 47548561)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.27
, pp. 4217-4223
-
-
Porschen, R.1
Arkenau, H.-T.2
Kubicka, S.3
Greil, R.4
Seufferlein, T.5
Freier, W.6
Kretzschmar, A.7
Graeven, U.8
Grothey, A.9
Hinke, A.10
Schmiegel, W.11
Schmoll, H.-J.12
-
6
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008;26:2013-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
-
7
-
-
79251650001
-
Randomized phase III study of panitumumab (pmab) with FOLFOX4 compared to FOLFOX4 alone as first-line treatment (tx) for metastatic colorectal cancer (mCRC): PRIME trial analysis by epidermal growth factor receptor (EGFR) tumor staining
-
abstract
-
Siena S, Tabernero J, Cunningham D, et al. Randomized phase III study of panitumumab (pmab) with FOLFOX4 compared to FOLFOX4 alone as first-line treatment (tx) for metastatic colorectal cancer (mCRC): PRIME trial analysis by epidermal growth factor receptor (EGFR) tumor staining [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:3566.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 3566
-
-
Siena, S.1
Tabernero, J.2
Cunningham, D.3
-
8
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360:1408-17.
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
10
-
-
19944426509
-
Impact of EGFR expression on colorectal cancer patient prognosis and survival
-
DOI 10.1093/annonc/mdi006
-
Spano JP, Lagorce C, Atlan D, et al. Impact of EGFR expression on colorectal cancer patient prognosis and survival. Ann Oncol. 2005;16:102-8. (Pubitemid 40124486)
-
(2005)
Annals of Oncology
, vol.16
, Issue.1
, pp. 102-108
-
-
Spano, J.-P.1
Lagorce, C.2
Atlan, D.3
Milano, G.4
Domont, J.5
Benamouzig, R.6
Attar, A.7
Benichou, J.8
Martin, A.9
Morere, J.-F.10
Raphael, M.11
Penault-Llorca, F.12
Breau, J.-L.13
Fagard, R.14
Khayat, D.15
Wind, P.16
-
11
-
-
77952956887
-
Oncogenic mutations as predictive factors in colorectal cancer
-
Lievre A, Blons H, Laurent-Puig P. Oncogenic mutations as predictive factors in colorectal cancer. Oncogene. 2010;29:3033-43.
-
(2010)
Oncogene
, vol.29
, pp. 3033-3043
-
-
Lievre, A.1
Blons, H.2
Laurent-Puig, P.3
-
12
-
-
36749086904
-
Targeting the epidermal growth factor receptor in metastatic colorectal cancer
-
DOI 10.1016/j.critrevonc.2007.09.006, PII S1040842807001965
-
Ng K, Zhu AX. Targeting the epidermal growth factor receptor in metastatic colorectal cancer. Crit Rev Oncol Hematol. 2008;65:8-20. (Pubitemid 350216479)
-
(2008)
Critical Reviews in Oncology/Hematology
, vol.65
, Issue.1
, pp. 8-20
-
-
Ng, K.1
Zhu, A.X.2
-
13
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26:1626-34.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
14
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2009;27:663-71.
-
(2009)
J Clin Oncol
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
15
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
DOI 10.1200/JCO.2006.08.1620
-
Van Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol. 2007;25:1658-64. (Pubitemid 46797944)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.13
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
Canon, J.-L.7
Van Laethem, J.-L.8
Maurel, J.9
Richardson, G.10
Wolf, M.11
Amado, R.G.12
-
16
-
-
79954554297
-
Predictive molecular markers of response to epidermal growth factor receptor (EGFR) family-targeted therapies
-
Barton S, Starling N, Swanton C. Predictive molecular markers of response to epidermal growth factor receptor (EGFR) family-targeted therapies. Curr Cancer Drug Targets. 2010;8:799-812.
-
(2010)
Curr Cancer Drug Targets
, vol.8
, pp. 799-812
-
-
Barton, S.1
Starling, N.2
Swanton, C.3
-
17
-
-
36849018991
-
Role of tyrosine kinase inhibitors in the treatment of advanced colorectal cancer
-
Gravalos C, Cassinello J, Fernandez-Ranada I, Holgado E. Role of tyrosine kinase inhibitors in the treatment of advanced colorectal cancer. Clin Colorectal Cancer. 2007;6:691-9. (Pubitemid 350221366)
-
(2007)
Clinical Colorectal Cancer
, vol.6
, Issue.10
, pp. 691-699
-
-
Gravalos, C.1
Cassinello, J.2
Fernandez-Ranada, I.3
Holgado, E.4
-
18
-
-
85064293472
-
Membrane receptors as targets for therapeutic approaches in colorectal cancer
-
Govindan R, editor 2010 June 4-8, 2010. Chicago: Joy Curzio
-
Macarulla T, Markman B, Tabernero J. Membrane receptors as targets for therapeutic approaches in colorectal cancer. In: Govindan R, editor. ASCO 2010 Educational Book; 2010 June 4-8, 2010. Chicago: Joy Curzio; 2010:E52-5.
-
(2010)
ASCO 2010 Educational Book
-
-
Macarulla, T.1
Markman, B.2
Tabernero, J.3
-
19
-
-
79961001934
-
-
Accessed September 2, 2010
-
Clinical Trial Database. 2010. Accessed September 2, 2010, at http://www.clinicaltrials.gov.
-
(2010)
Clinical Trial Database
-
-
-
20
-
-
79952767715
-
Phase I PK/PD study of RO5083945 (GA201), the first glycoengineered anti-EGFR monoclonal antibody (mAb) with optimized antibody dependent cellular cytotoxicity (ADCC)
-
abstract
-
Markman B, Gomez-Roca C, Cervantes-Ruiperez A, et al. Phase I PK/PD study of RO5083945 (GA201), the first glycoengineered anti-EGFR monoclonal antibody (mAb) with optimized antibody dependent cellular cytotoxicity (ADCC) [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:2522.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 2522
-
-
Markman, B.1
Gomez-Roca, C.2
Cervantes-Ruiperez, A.3
-
21
-
-
51649123319
-
Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells
-
Wu L, Adams M, Carter T, et al. lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells. Clin Cancer Res. 2008;14:4650-7.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4650-4657
-
-
Wu, L.1
Adams, M.2
Carter, T.3
-
22
-
-
79953744107
-
Lenalidomide enhances antibody-dependent cellular cytotoxicity of solid tumor cells in vitro: Influence of host immune and tumor markers
-
Wu L, Parton A, Lu L, Adams M, Schafer P, Bartlett JB. Lenalidomide enhances antibody-dependent cellular cytotoxicity of solid tumor cells in vitro: influence of host immune and tumor markers. Cancer Immunol Immunother. 2011;1:61-73.
-
(2011)
Cancer Immunol Immunother
, vol.1
, pp. 61-73
-
-
Wu, L.1
Parton, A.2
Lu, L.3
Adams, M.4
Schafer, P.5
Bartlett, J.B.6
-
23
-
-
76549085643
-
Sym004: A novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy
-
Pedersen MW, Jacobsen HJ, Koefoed K, et al. Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy. Cancer Res. 2010;70:588-97.
-
(2010)
Cancer Res
, vol.70
, pp. 588-597
-
-
Pedersen, M.W.1
Jacobsen, H.J.2
Koefoed, K.3
-
25
-
-
76349085626
-
Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer
-
Trarbach T, Moehler M, Heinemann V, et al. Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. Br J Cancer. 2010;102:506-12.
-
(2010)
Br J Cancer
, vol.102
, pp. 506-512
-
-
Trarbach, T.1
Moehler, M.2
Heinemann, V.3
-
26
-
-
0037108712
-
Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice
-
Naka T, Sugamura K, Hylander BL, Widmer MB, Rustum YM, Repasky EA. Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. Cancer Res. 2002;62:5800-6. (Pubitemid 35204738)
-
(2002)
Cancer Research
, vol.62
, Issue.20
, pp. 5800-5806
-
-
Naka, T.1
Sugamura, K.2
Hylander, B.L.3
Widmer, M.B.4
Rustum, Y.M.5
Repasky, E.A.6
-
27
-
-
45749105225
-
First-in-human study of AMG 655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors
-
abstract
-
LoRusso P, Hong D, Heath E, et al. First-in-human study of AMG 655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2007;25:3534.
-
(2007)
J Clin Oncol (Meeting Abstracts)
, vol.25
, pp. 3534
-
-
LoRusso, P.1
Hong, D.2
Heath, E.3
-
28
-
-
72449176627
-
Safety and efficacy of AMG 655 plus modified FOLFOX6 (mFOLFOX6) and bevacizumab (B) for the first-line treatment of patients (pts) with metastatic colorectal cancer (mCRC)
-
abstract
-
Saltz L, Infante J, Schwartzberg L, et al. Safety and efficacy of AMG 655 plus modified FOLFOX6 (mFOLFOX6) and bevacizumab (B) for the first-line treatment of patients (pts) with metastatic colorectal cancer (mCRC) [abstract]. J Clin Oncol (Meeting Abstracts). 2009;27:4079.
-
(2009)
J Clin Oncol (Meeting Abstracts)
, vol.27
, pp. 4079
-
-
Saltz, L.1
Infante, J.2
Schwartzberg, L.3
-
29
-
-
79960974964
-
Phase I evaluation of the safety of conatumumab (AMG 655) in combination with AMG 479 in patients (pts) with advanced, refractory solid tumors
-
abstract
-
Chawla SP, Tabernero J, Kindler HL, et al. Phase I evaluation of the safety of conatumumab (AMG 655) in combination with AMG 479 in patients (pts) with advanced, refractory solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:3102.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 3102
-
-
Chawla, S.P.1
Tabernero, J.2
Kindler, H.L.3
-
30
-
-
79960990804
-
Panitumumab (pmab) plus AMG 102 in patients (pts) with wild-type KRAS metastatic colorectal cancer (mCRC): Updated safety results
-
abstract
-
Eng C, Tabernero J, Nowara E, et al. Panitumumab (pmab) plus AMG 102 in patients (pts) with wild-type KRAS metastatic colorectal cancer (mCRC): updated safety results [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:e14083.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
-
-
Eng, C.1
Tabernero, J.2
Nowara, E.3
-
31
-
-
73449136124
-
Metabolic syndrome and risk of subsequent colorectal cancer
-
Pais R, Silaghi H, Silaghi AC, Rusu ML, Dumitrascu DL. Metabolic syndrome and risk of subsequent colorectal cancer. World J Gastroenterol. 2009;15:5141-8.
-
(2009)
World J Gastroenterol
, vol.15
, pp. 5141-5148
-
-
Pais, R.1
Silaghi, H.2
Silaghi, A.C.3
Rusu, M.L.4
Dumitrascu, D.L.5
-
32
-
-
0037014743
-
Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer
-
Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulinlike growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst. 2002;94:972-80. (Pubitemid 34814726)
-
(2002)
Journal of the National Cancer Institute
, vol.94
, Issue.13
, pp. 972-980
-
-
Sandhu, M.S.1
Dunger, D.B.2
Giovannucci, E.L.3
-
33
-
-
0032885494
-
Expression of insulin-like growth factor-1 receptor in human colorectal cancer
-
DOI 10.1016/S0046-8177(99)90027-8
-
Hakam A, Yeatman TJ, Lu L, et al. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol. 1999;30:1128-33. (Pubitemid 29480878)
-
(1999)
Human Pathology
, vol.30
, Issue.10
, pp. 1128-1133
-
-
Hakam, A.1
Yeatman, T.J.2
Lu, L.3
Mora, L.4
Marcet, G.5
Nicosia, S.V.6
Karl, R.C.7
Coppola, D.8
-
34
-
-
41249093600
-
Role of insulin-like growth factor-1R system in colorectal carcinogenesis
-
DOI 10.1016/j.critrevonc.2007.09.003, PII S1040842807001801
-
Donovan EA, Kummar S. Role of insulin-like growth factor-1R system in colorectal carcinogenesis. Crit Rev Oncol Hematol. 2008;66:91-8. (Pubitemid 351446110)
-
(2008)
Critical Reviews in Oncology/Hematology
, vol.66
, Issue.2
, pp. 91-98
-
-
Donovan, E.A.1
Kummar, S.2
-
35
-
-
0036111682
-
Insulin-like growth factors and cancer
-
DOI 10.1016/S1470-2045(02)00731-3
-
Furstenberger G, Senn HJ. Insulin-like growth factors and cancer. Lancet Oncol. 2002;3:298-302. (Pubitemid 34546447)
-
(2002)
Lancet Oncology
, vol.3
, Issue.5
, pp. 298-302
-
-
Furstenberger, G.1
Senn, H.-J.2
-
36
-
-
77950502920
-
Effect of type 1 insulinlike growth factor receptor targeted therapy on chemotherapy in human cancer and the mechanisms involved
-
Hopkins A, Crowe PJ, Yang JL. Effect of type 1 insulinlike growth factor receptor targeted therapy on chemotherapy in human cancer and the mechanisms involved. J Cancer Res Clin Oncol. 2010;136:639-50.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 639-650
-
-
Hopkins, A.1
Crowe, P.J.2
Yang, J.L.3
-
37
-
-
56149086171
-
A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors
-
abstract
-
Atzori F, Tabernero J, Cervantes A, et al. A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2008;26:3519.
-
(2008)
J Clin Oncol (Meeting Abstracts)
, vol.26
, pp. 3519
-
-
Atzori, F.1
Tabernero, J.2
Cervantes, A.3
-
38
-
-
35148889523
-
A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors
-
abstract
-
Higano CS, Yu EY, Whiting SH, et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2007;25:3505.
-
(2007)
J Clin Oncol (Meeting Abstracts)
, vol.25
, pp. 3505
-
-
Higano, C.S.1
Yu, E.Y.2
Whiting, S.H.3
-
39
-
-
69449099663
-
Phase I dose escalation study of continuous oral dosing of OSI-906, an insulin like growth factor-1 receptor (IGF-1R) tyrosine kinase inhibitor, in patients with advanced solid tumors
-
Lindsay CR, Chan E, Evans TR, et al. Phase I dose escalation study of continuous oral dosing of OSI-906, an insulin like growth factor-1 receptor (IGF-1R) tyrosine kinase inhibitor, in patients with advanced solid tumors. J Clin Oncol (Meeting Abstracts). 2009;27:2559.
-
(2009)
J Clin Oncol (Meeting Abstracts)
, vol.27
, pp. 2559
-
-
Lindsay, C.R.1
Chan, E.2
Evans, T.R.3
-
40
-
-
73349099049
-
Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
-
Tolcher AW, Sarantopoulos J, Patnaik A, et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol. 2009;27:5800-7.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5800-5807
-
-
Tolcher, A.W.1
Sarantopoulos, J.2
Patnaik, A.3
-
41
-
-
77956227862
-
Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
-
abstract
-
Jassem J, Langer CJ, Karp DD, et al. Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:7500.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 7500
-
-
Jassem, J.1
Langer, C.J.2
Karp, D.D.3
-
42
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res. 1989;49:4682-9.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
43
-
-
0023256456
-
Prevalence of ras gene mutations in human colorectal cancers
-
Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers. Nature. 1987;327:293-7.
-
(1987)
Nature
, vol.327
, pp. 293-297
-
-
Bos, J.L.1
Fearon, E.R.2
Hamilton, S.R.3
-
44
-
-
77953105174
-
New strategies for treatment of KRAS mutant metastatic colorectal cancer
-
Prenen H, Tejpar S, Van Cutsem E. New strategies for treatment of KRAS mutant metastatic colorectal cancer. Clin Cancer Res. 2010;16:2921-6.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2921-2926
-
-
Prenen, H.1
Tejpar, S.2
Van Cutsem, E.3
-
45
-
-
5444241523
-
Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer
-
DOI 10.1200/JCO.2004.10.037
-
Rao S, Cunningham D, de Gramont A, et al. Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer. J Clin Oncol. 2004;22:3950-7. (Pubitemid 41079877)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.19
, pp. 3950-3957
-
-
Rao, S.1
Cunningham, D.2
De Gramont, A.3
Scheithauer, W.4
Smakal, M.5
Humblet, Y.6
Kourteva, G.7
Iveson, T.8
Andre, T.9
Dostalova, J.10
Illes, A.11
Belly, R.12
Perez-Ruixo, J.J.13
Park, Y.C.14
Palmer, P.A.15
-
46
-
-
0030923192
-
K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
DOI 10.1074/jbc.272.22.14459
-
Whyte DB, Kirschmeier P, Hockenberry TN, et al. K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J Biol Chem. 1997;272:14459-64. (Pubitemid 27232866)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.22
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
Nunez-Oliva, I.4
James, L.5
Catino, J.J.6
Bishop, W.R.7
Pai, J.-K.8
-
47
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F, Martini M, Molinari F, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol. 2008;26:5705-12.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
48
-
-
77956103532
-
A review of the most promising biomarkers in colorectal cancer: One step closer to targeted therapy
-
Deschoolmeester V, Baay M, Specenier P, Lardon F, Vermorken JB. A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy. Oncologist. 2010;15:699-731.
-
(2010)
Oncologist
, vol.15
, pp. 699-731
-
-
Deschoolmeester, V.1
Baay, M.2
Specenier, P.3
Lardon, F.4
Vermorken, J.B.5
-
49
-
-
77955266489
-
Cetuximab plus FOLFIRI: Final data from the CRYSTAL study on the association of KRAS and BRAF biomarker status with treatment outcome
-
abstract
-
Van Cutsem E, Lang I, Folprecht G, et al. Cetuximab plus FOLFIRI: Final data from the CRYSTAL study on the association of KRAS and BRAF biomarker status with treatment outcome [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:3570.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 3570
-
-
Van Cutsem, E.1
Lang, I.2
Folprecht, G.3
-
50
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty K, Puzanov I, Kim K, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363:809-19.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.1
Puzanov, I.2
Kim, K.3
-
51
-
-
79951498422
-
PLX4032 (RG7204), a selective mutant RAF inhibitor: Clinical and histologic characteristics of therapy-associated cutaneous neoplasms in a phase I trial
-
abstract
-
Lacouture ME, McArthur GA, Chapman PB, et al. PLX4032 (RG7204), a selective mutant RAF inhibitor: clinical and histologic characteristics of therapy-associated cutaneous neoplasms in a phase I trial [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:8592.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 8592
-
-
Lacouture, M.E.1
McArthur, G.A.2
Chapman, P.B.3
-
52
-
-
78649723255
-
PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors
-
abstract
-
Kopetz S, Desai J, Chan E, et al. PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:3534.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 3534
-
-
Kopetz, S.1
Desai, J.2
Chan, E.3
-
53
-
-
34547179997
-
MAP kinase pathways: The first twenty years
-
DOI 10.1016/j.bbamcr.2006.11.006, PII S0167488906003752
-
Avruch J. MAP kinase pathways: the first twenty years. Biochim Biophys Acta. 2007;1773:1150-60. (Pubitemid 47125973)
-
(2007)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1773
, Issue.8
, pp. 1150-1160
-
-
Avruch, J.1
-
54
-
-
14844285975
-
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer
-
DOI 10.1200/JCO.2004.01.185
-
Rinehart J, Adjei AA, Lorusso PM, et al. Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol. 2004;22:4456-62. (Pubitemid 41185111)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.22
, pp. 4456-4462
-
-
Rinehart, J.1
Adjei, A.A.2
LoRusso, P.M.3
Waterhouse, D.4
Hecht, J.R.5
Natale, R.B.6
Hamid, O.7
Varterasian, M.8
Asbury, P.9
Kaldjian, E.P.10
Gulyas, S.11
Mitchell, D.Y.12
Herrera, R.13
Sebolt-Leopold, J.S.14
Meyer, M.B.15
-
55
-
-
77949766280
-
Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers
-
LoRusso PM, Krishnamurthi SS, Rinehart JJ, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers. Clin Cancer Res. 2010;16:1924-37.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1924-1937
-
-
LoRusso, P.M.1
Krishnamurthi, S.S.2
Rinehart, J.J.3
-
56
-
-
84861528266
-
A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens
-
Bennouna J, Lang I, Valladares-Ayerbes M, et al. A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens. Invest New Drugs. 2010:1-8.
-
(2010)
Invest New Drugs
, pp. 1-8
-
-
Bennouna, J.1
Lang, I.2
Valladares-Ayerbes, M.3
-
57
-
-
78650343267
-
Phase I dose-escalation study of E6201, a MEK-1 inhibitor, in advanced solid tumors
-
abstract.
-
Borad MJ, Akerele CE, Ramanathan RK, et al. Phase I dose-escalation study of E6201, a MEK-1 inhibitor, in advanced solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:2505.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 2505
-
-
Borad, M.J.1
Akerele, C.E.2
Ramanathan, R.K.3
-
58
-
-
78650365457
-
First-in-human phase I safety, pharmacokinetic (PK), and pharmacodynamic (PD) analysis of the oral MEK-inhibitor AS703026 (two regimens [R]) in patients (pts) with advanced solid tumors
-
abstract
-
Delord J, Houede N, Awada A, et al. First-in-human phase I safety, pharmacokinetic (PK), and pharmacodynamic (PD) analysis of the oral MEK-inhibitor AS703026 (two regimens [R]) in patients (pts) with advanced solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:2504.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 2504
-
-
Delord, J.1
Houede, N.2
Awada, A.3
-
59
-
-
77958503710
-
Safety and efficacy results from the first-in-human study of the oral MEK 1/2 inhibitor GSK1120212
-
abstract
-
Infante JR, Fecher LA, Nallapareddy S, et al. Safety and efficacy results from the first-in-human study of the oral MEK 1/2 inhibitor GSK1120212 [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:2503.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 2503
-
-
Infante, J.R.1
Fecher, L.A.2
Nallapareddy, S.3
-
61
-
-
58349091262
-
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
-
Mirzoeva OK, Das D, Heiser LM, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009;69:565-72.
-
(2009)
Cancer Res
, vol.69
, pp. 565-572
-
-
Mirzoeva, O.K.1
Das, D.2
Heiser, L.M.3
-
62
-
-
77955122376
-
New strategies in colorectal cancer: Biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways
-
Dasari A, Messersmith WA. New strategies in colorectal cancer: biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways. Clin Cancer Res. 2010;16:3811-8.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3811-3818
-
-
Dasari, A.1
Messersmith, W.A.2
-
64
-
-
77956573681
-
A first-in-human phase I study of BKM120, an oral pan-class I PI3K inhibitor, in patients (pts) with advanced solid tumors
-
abstract
-
Baselga J, De Jonge MJ, Rodon J, et al. A first-in-human phase I study of BKM120, an oral pan-class I PI3K inhibitor, in patients (pts) with advanced solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:3003.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 3003
-
-
Baselga, J.1
De Jonge, M.J.2
Rodon, J.3
-
65
-
-
77956602070
-
First-in-human phase I study of the oral PI3K inhibitor BEZ235 in patients (pts) with advanced solid tumors
-
abstract
-
Burris H, Rodon J, Sharma S, et al. First-in-human phase I study of the oral PI3K inhibitor BEZ235 in patients (pts) with advanced solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:3005.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 3005
-
-
Burris, H.1
Rodon, J.2
Sharma, S.3
-
66
-
-
77956566979
-
A phase I dose-escalation study of XL147 (SAR245408), a PI3K inhibitor administered orally to patients (pts) with advanced malignancies
-
abstract
-
Edelman G, Bedell C, Shapiro G, et al. A phase I dose-escalation study of XL147 (SAR245408), a PI3K inhibitor administered orally to patients (pts) with advanced malignancies [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:3004.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 3004
-
-
Edelman, G.1
Bedell, C.2
Shapiro, G.3
-
68
-
-
79953058055
-
Final results of a randomized phase II study of perifosine in combination with capecitabine (P-CAP) versus placebo plus capecitabine (CAP) in patients (pts) with second- Or third-line metastatic colorectal cancer (mCRC)
-
abstract
-
Richards DA, Nemunaitis JJ, Vukelja SJ, et al. Final results of a randomized phase II study of perifosine in combination with capecitabine (P-CAP) versus placebo plus capecitabine (CAP) in patients (pts) with second- or third-line metastatic colorectal cancer (mCRC) [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:3531.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 3531
-
-
Richards, D.A.1
Nemunaitis, J.J.2
Vukelja, S.J.3
-
69
-
-
77956380540
-
Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics
-
He JX, Yang CH, Miao ZH. Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics. Acta Pharmacol Sin. 2010;31:1172-80.
-
(2010)
Acta Pharmacol Sin
, vol.31
, pp. 1172-1180
-
-
He, J.X.1
Yang, C.H.2
Zh, M.3
-
70
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009;361:123-34.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
-
71
-
-
77949270273
-
Microsatellite instability in colorectal cancer - The stable evidence
-
Vilar E, Gruber SB. Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol. 2010;7:153-62.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 153-162
-
-
Vilar, E.1
Gruber, S.B.2
-
72
-
-
77949261297
-
Preclinical testing of the PARP inhibitor ABT-888 in microsatellite instable colorectal cancer
-
abstract
-
Vilar Sanchez E, Chow A, Raskin L, Iniesta MD, Mukherjee B, Gruber SB. Preclinical testing of the PARP inhibitor ABT-888 in microsatellite instable colorectal cancer [abstract]. J Clin Oncol (Meeting Abstracts). 2009;27:11028.
-
(2009)
J Clin Oncol (Meeting Abstracts)
, vol.27
, pp. 11028
-
-
Vilar Sanchez, E.1
Chow, A.2
Raskin, L.3
Iniesta, M.D.4
Mukherjee, B.5
Gruber, S.B.6
-
73
-
-
33751549095
-
Targeting the Hedgehog pathway in cancer
-
DOI 10.1038/nrd2086, PII NRD2086
-
Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov. 2006;5:1026-33. (Pubitemid 44835129)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.12
, pp. 1026-1033
-
-
Rubin, L.L.1
De Sauvage, F.J.2
-
74
-
-
77953693899
-
Targeting Hedgehog - A cancer stem cell pathway
-
Merchant AA, Matsui W. Targeting Hedgehog - a cancer stem cell pathway. Clin Cancer Res. 2010;16:3130-40.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3130-3140
-
-
Merchant, A.A.1
Matsui, W.2
-
75
-
-
34248138532
-
Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas
-
Bian YH, Huang SH, Yang L, Ma XL, Xie JW, Zhang HW. Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas. World J Gastroenterol. 2007;13:1659-65. (Pubitemid 46711335)
-
(2007)
World Journal of Gastroenterology
, vol.13
, Issue.11
, pp. 1659-1665
-
-
Bian, Y.-H.1
Huang, S.-H.2
Yang, L.3
Ma, X.-L.4
Xie, J.-W.5
Zhang, H.-W.6
-
76
-
-
73449090411
-
Sonic hedgehog relates to colorectal carcinogenesis
-
Yoshikawa K, Shimada M, Miyamoto H, et al. Sonic hedgehog relates to colorectal carcinogenesis. J Gastroenterol. 2009;44:1113-7.
-
(2009)
J Gastroenterol
, vol.44
, pp. 1113-1117
-
-
Yoshikawa, K.1
Shimada, M.2
Miyamoto, H.3
-
77
-
-
68049128117
-
Paracrine Hedgehog signaling in cancer
-
Theunissen JW, de Sauvage FJ. Paracrine Hedgehog signaling in cancer. Cancer Res. 2009;69:6007-10.
-
(2009)
Cancer Res
, vol.69
, pp. 6007-6010
-
-
Theunissen, J.W.1
De Sauvage, F.J.2
-
78
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med. 2009;361:1164-72.
-
(2009)
N Engl J Med
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
LoRusso, P.M.2
Rudin, C.M.3
-
79
-
-
79961007234
-
Safety analysis of a randomized phase II trial of hedgehog pathway inhibitor (HPI) GDC-0449 versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer (mCRC)
-
abstract
-
Bendell JC, Hart LL, Firdaus I, et al. Safety analysis of a randomized phase II trial of hedgehog pathway inhibitor (HPI) GDC-0449 versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer (mCRC) [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:3530.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 3530
-
-
Bendell, J.C.1
Hart, L.L.2
Firdaus, I.3
-
81
-
-
79954577056
-
A phase I dose-escalation study of LDE225, a smoothened (Smo) antagonist, in patients with advanced solid tumors
-
abstract
-
Rodon Ahnert J, Baselga J, et al. A phase I dose-escalation study of LDE225, a smoothened (Smo) antagonist, in patients with advanced solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:2500.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 2500
-
-
Rodon Ahnert, J.1
Baselga, J.2
-
82
-
-
79954620413
-
A first-in-human, phase I study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors
-
abstract
-
Siu LL, Papadopoulos K, Alberts SR, et al. A first-in-human, phase I study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors [abstract]. J Clin Oncol (Meeting Abstracts). 2010;28:2501.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 2501
-
-
Siu, L.L.1
Papadopoulos, K.2
Alberts, S.R.3
-
83
-
-
77954215506
-
Notch signaling: Emerging molecular targets for cancer therapy
-
Yin L, Velazquez OC, Liu ZJ. Notch signaling: emerging molecular targets for cancer therapy. Biochem Pharmacol. 2010;80:690-701.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 690-701
-
-
Yin, L.1
Velazquez, O.C.2
Liu, Z.J.3
-
84
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
DOI 10.1126/science.1102160
-
Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269-71. (Pubitemid 39336870)
-
(2004)
Science
, vol.306
, Issue.5694
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris IV, J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
Blacklow, S.C.7
Look, A.T.8
Aster, J.C.9
-
85
-
-
7244250027
-
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
-
DOI 10.1083/jcb.200406140
-
Pece S, Serresi M, Santolini E, et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol. 2004;167:215-21. (Pubitemid 39435065)
-
(2004)
Journal of Cell Biology
, vol.167
, Issue.2
, pp. 215-221
-
-
Pece, S.1
Serresi, M.2
Santolini, E.3
Capra, M.4
Hulleman, E.5
Galimberti, V.6
Zurrida, S.7
Maisonneuve, P.8
Viale, G.9
Di, F.P.P.10
-
86
-
-
58349091690
-
Gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
-
Meng RD, Shelton CC, Li YM, et al. gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009;69:573-82.
-
(2009)
Cancer Res
, vol.69
, pp. 573-582
-
-
Meng, R.D.1
Shelton, C.C.2
Li, Y.M.3
-
87
-
-
59049088446
-
Activation of Notch signaling in human colon adenocarcinoma
-
Reedijk M, Odorcic S, Zhang H, et al. Activation of Notch signaling in human colon adenocarcinoma. Int J Oncol. 2008;33:1223-9.
-
(2008)
Int J Oncol
, vol.33
, pp. 1223-1229
-
-
Reedijk, M.1
Odorcic, S.2
Zhang, H.3
-
88
-
-
79551576104
-
A phase I study of RO4929097, a novel gamma secretase inhibitor, in patients with advanced solid tumors
-
abstract
-
Tolcher AW, Mikulski SM, Messersmith WA, et al. A phase I study of RO4929097, a novel gamma secretase inhibitor, in patients with advanced solid tumors [abstract]. J Clin Oncol (Meeting Abstracts) 2010;28:2502.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 2502
-
-
Tolcher, A.W.1
Mikulski, S.M.2
Messersmith, W.A.3
|