메뉴 건너뛰기




Volumn 16, Issue 11, 2010, Pages 2921-2926

New strategies for treatment of KRAS mutant metastatic colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; BEVACIZUMAB; CETUXIMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; LENALIDOMIDE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OXALIPLATIN; PANITUMUMAB; PROTEIN KINASE B; SORAFENIB;

EID: 77953105174     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-09-2029     Document Type: Review
Times cited : (68)

References (65)
  • 1
    • 67349152647 scopus 로고    scopus 로고
    • Treatment in advanced colorectal cancer: What, when and how?
    • Chau I, Cunningham D. Treatment in advanced colorectal cancer: what, when and how? Br J Cancer 2009;100:1704-1719
    • (2009) Br J Cancer , vol.100 , pp. 1704-1719
    • Chau, I.1    Cunningham, D.2
  • 3
    • 61449202998 scopus 로고    scopus 로고
    • The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
    • Hurwitz HI, Yi J, Ince W, Novotny WF, Rosen O. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist 2009;14:22-28
    • (2009) Oncologist , vol.14 , pp. 22-28
    • Hurwitz, H.I.1    Yi, J.2    Ince, W.3    Novotny, W.F.4    Rosen, O.5
  • 5
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • DOI 10.1200/JCO.2004.10.182
    • Saltz LB, Meropol NJ, Loehrer PJ, Sr., Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004;22:1201-1208 (Pubitemid 41079832)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.7 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 6
  • 7
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero AF, Maurel J, Fehrenbacher L, et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 2008;26:2311-2319
    • (2008) J Clin Oncol , vol.26 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3
  • 8
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009;360:1408-1417
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 10
    • 71249136106 scopus 로고    scopus 로고
    • Randomized phase 3 study of panitumumab with FOLFOX4 compared to FOLFOX4 alone as 1(st)- line treatment (tx) for metastatic colorectal cancer (mCRC): The PRIME trial
    • Douillard J, Siena S, Cassidy J, et al. Randomized phase 3 study of panitumumab with FOLFOX4 compared to FOLFOX4 alone as 1(st)- line treatment (tx) for metastatic colorectal cancer (mCRC): the PRIME trial. Eur J Cancer Supplements 2009;7:6.
    • (2009) Eur J Cancer Supplements , vol.7 , pp. 6
    • Douillard, J.1    Siena, S.2    Cassidy, J.3
  • 11
    • 77953084153 scopus 로고    scopus 로고
    • Randomized phase 3 study of panitumumab with FOLFIRI vs FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC)
    • Peeters M, Price T, Hotko Y, et al. Randomized phase 3 study of panitumumab with FOLFIRI vs FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC). Eur J Cancer Suppl 2009;7:10.
    • (2009) Eur J Cancer Suppl , vol.7 , pp. 10
    • Peeters, M.1    Price, T.2    Hotko, Y.3
  • 13
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • DOI 10.1038/nrc2109, PII NRC2109
    • Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 2007;7:295-308. (Pubitemid 46480970)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.4 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 14
    • 0023256456 scopus 로고
    • Prevalence of ras gene mutations in human colorectal cancers
    • Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987;327:293-297
    • (1987) Nature , vol.327 , pp. 293-297
    • Bos, J.L.1    Fearon, E.R.2    Hamilton, S.R.3
  • 15
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL. Ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-4689
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 16
    • 77953103154 scopus 로고    scopus 로고
    • Molecular markers in colon cancer have a stage specific prognostic value. Results of the translational study on the petacc 3-eortc 40883-sakk 60-00 trial
    • abstract
    • Roth A, Tejpar S, Yan P, et al. Molecular markers in colon cancer have a stage specific prognostic value. Results of the translational study on the petacc 3-eortc 40883-sakk 60-00 trial [abstract]. Ann Oncol 2009;20:7.
    • (2009) Ann Oncol , vol.20 , pp. 7
    • Roth, A.1    Tejpar, S.2    Yan, P.3
  • 17
    • 51649084560 scopus 로고    scopus 로고
    • Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer
    • Artale S, Sartore-Bianchi A, Veronese SM, et al. Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer. J Clin Oncol 2008;26:4217-4219
    • (2008) J Clin Oncol , vol.26 , pp. 4217-4219
    • Artale, S.1    Sartore-Bianchi, A.2    Veronese, S.M.3
  • 18
    • 75749102647 scopus 로고    scopus 로고
    • Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
    • Roth AD, Tejpar S, Delorenzi M, et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol 2010;28:466-474
    • (2010) J Clin Oncol , vol.28 , pp. 466-474
    • Roth, A.D.1    Tejpar, S.2    Delorenzi, M.3
  • 19
    • 73149107502 scopus 로고    scopus 로고
    • KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 9803
    • Ogino S, Meyerhardt JA, Irahara N, et al. KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 9803. Clin Cancer Res 2009;15:7322-7329
    • (2009) Clin Cancer Res , vol.15 , pp. 7322-7329
    • Ogino, S.1    Meyerhardt, J.A.2    Irahara, N.3
  • 20
    • 0035444798 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The 'RASCAL II' study
    • Andreyev HJ, Norman AR, Cunningham D, et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer 2001;85:692-696
    • (2001) Br J Cancer , vol.85 , pp. 692-696
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3
  • 22
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre A, Bachet JB, Le Corre D, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006;66:3992-3995
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 24
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • DOI 10.1158/0008-5472.CAN-06-4158
    • Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 2007;67:2643-2648 (Pubitemid 46548951)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Zanon, C.4    Moroni, M.5    Veronese, S.6    Siena, S.7    Bardelli, A.8
  • 26
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008;26:1626-1634
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 28
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359:1757-1765
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 32
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009;27:663-671
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 33
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • Allegra CJ, Jessup JM, Somerfield MR, et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol 2009;27:2091-2096
    • (2009) J Clin Oncol , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3
  • 34
    • 61449154484 scopus 로고    scopus 로고
    • KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: Practical application of patient selection
    • Jimeno A, Messersmith WA, Hirsch FR, Franklin WA, Eckhardt SG. KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. J Clin Oncol 2009;27:1130-1136
    • (2009) J Clin Oncol , vol.27 , pp. 1130-1136
    • Jimeno, A.1    Messersmith, W.A.2    Hirsch, F.R.3    Franklin, W.A.4    Eckhardt, S.G.5
  • 35
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F, Martini M, Molinari F, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008;26:5705-5712
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 36
    • 61449258442 scopus 로고    scopus 로고
    • K-ras mutations and cetuximab in colorectal cancer
    • De Roock W, Lambrechts D, Tejpar S. K-ras mutations and cetuximab in colorectal cancer. N Engl J Med 2009;360:834-836
    • (2009) N Engl J Med , vol.360 , pp. 834-836
    • De Roock, W.1    Lambrechts, D.2    Tejpar, S.3
  • 37
    • 77952092674 scopus 로고    scopus 로고
    • KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: Biological and clinical implications
    • Italiano A, Hostein I, Soubeyran I, et al. KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications. Ann Surg Oncol 2010;17:1429-1434
    • (2010) Ann Surg Oncol , vol.17 , pp. 1429-1434
    • Italiano, A.1    Hostein, I.2    Soubeyran, I.3
  • 38
    • 18044387648 scopus 로고    scopus 로고
    • Raf kinase as a target for anticancer therapeutics
    • DOI 10.1158/1535-7163.MCT-04-0297
    • Sridhar SS, Hedley D, Siu LL. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 2005;4:677-685 (Pubitemid 40601850)
    • (2005) Molecular Cancer Therapeutics , vol.4 , Issue.4 , pp. 677-685
    • Sridhar, S.S.1    Hedley, D.2    Siu, L.L.3
  • 40
    • 43749110700 scopus 로고    scopus 로고
    • Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: A report from the 11715 Study Group
    • McDermott DF, Sosman JA, Gonzalez R, et al. Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group. J Clin Oncol 2008;26:2178-2185
    • (2008) J Clin Oncol , vol.26 , pp. 2178-2185
    • McDermott, D.F.1    Sosman, J.A.2    Gonzalez, R.3
  • 41
    • 76149102749 scopus 로고    scopus 로고
    • Early efficacy signal demonstrated in advanced melanomain a phase I trial of the oncogenic BRAFselective inhibitor PLX4032
    • Chapman P, Puzanov I, Sosman J, et al. Early efficacy signal demonstrated in advanced melanomain a phase I trial of the oncogenic BRAFselective inhibitor PLX4032. Eur J Cancer Supplements 2009;7:5.
    • (2009) Eur J Cancer Supplements , vol.7 , pp. 5
    • Chapman, P.1    Puzanov, I.2    Sosman, J.3
  • 42
    • 77953101803 scopus 로고    scopus 로고
    • Bethesda (MD): U.S. National Institutes of Health. Available from
    • ClinicalTrials.gov. Bethesda (MD): U.S. National Institutes of Health. Available from: www.clinicaltrials.gov.
  • 43
    • 77953086461 scopus 로고    scopus 로고
    • A phase 1 study of XL281, a potent and selective inhibitor of RAF kinases, administered orally to patients (pts) with advanced solid tumors
    • Schwartz GK, Yazji S, Mendelson DS, et al. A phase 1 study of XL281, a potent and selective inhibitor of RAF kinases, administered orally to patients (pts) with advanced solid tumors. Eur J Cancer Supplements 2008;6:120.
    • (2008) Eur J Cancer Supplements , vol.6 , pp. 120
    • Schwartz, G.K.1    Yazji, S.2    Mendelson, D.S.3
  • 44
    • 31144453233 scopus 로고    scopus 로고
    • BRAF mutation predicts sensitivity to MEK inhibition
    • Solit DB, Garraway LA, Pratilas CA, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006;439:358-362
    • (2006) Nature , vol.439 , pp. 358-362
    • Solit, D.B.1    Garraway, L.A.2    Pratilas, C.A.3
  • 46
    • 58349091262 scopus 로고    scopus 로고
    • Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
    • Mirzoeva OK, Das D, Heiser LM, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res 2009;69:565-572
    • (2009) Cancer Res , vol.69 , pp. 565-572
    • Mirzoeva, O.K.1    Das, D.2    Heiser, L.M.3
  • 47
    • 66249116702 scopus 로고    scopus 로고
    • PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
    • Wee S, Jagani Z, Xiang KX, et al. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res 2009;69:4286-4293
    • (2009) Cancer Res , vol.69 , pp. 4286-4293
    • Wee, S.1    Jagani, Z.2    Xiang, K.X.3
  • 48
    • 72449124114 scopus 로고    scopus 로고
    • Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors
    • Duffy A, Kummar S. Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors. Target Oncol 2009;4:267-273
    • (2009) Target Oncol , vol.4 , pp. 267-273
    • Duffy, A.1    Kummar, S.2
  • 49
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
    • PII S0959804901002301
    • Yarden Y. The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001;37[Suppl 4]:S3-8. (Pubitemid 32938123)
    • (2001) European Journal of Cancer , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 50
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    • Engelman JA, Chen L, Tan X, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008;14:1351-1356
    • (2008) Nat Med , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3
  • 51
    • 62149114138 scopus 로고    scopus 로고
    • Dual-specificity phosphatases: Critical regulators with diverse cellular targets
    • Patterson KI, Brummer T, O'Brien PM, Daly RJ. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J 2009;418:475-489
    • (2009) Biochem J , vol.418 , pp. 475-489
    • Patterson, K.I.1    Brummer, T.2    O'Brien, P.M.3    Daly, R.J.4
  • 52
    • 77953107139 scopus 로고    scopus 로고
    • DUSP4 expression level in colorectal primaries predicts overall survival benefit in Kras wild-type and Kras mutant colorectal cancer after treatment with cetuximab for metastatic disease
    • De Roock W, Janssens M, Biesmans B, et al. DUSP4 expression level in colorectal primaries predicts overall survival benefit in Kras wild-type and Kras mutant colorectal cancer after treatment with cetuximab for metastatic disease. Eur J Cancer Suppl 2008;6:33.
    • (2008) Eur J Cancer Suppl , vol.6 , pp. 33
    • De Roock, W.1    Janssens, M.2    Biesmans, B.3
  • 53
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-1508
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3
  • 54
    • 0033593090 scopus 로고    scopus 로고
    • Tangled webs: Evidence of cross-talk between c-Raf-1 and Akt
    • Jun T, Gjoerup O, Roberts TM. Tangled webs: evidence of cross-talk between c-Raf-1 and Akt. Sci STKE 1999:E1.
    • (1999) Sci STKE
    • Jun, T.1    Gjoerup, O.2    Roberts, T.M.3
  • 55
    • 70349513280 scopus 로고    scopus 로고
    • Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells
    • Yoon YK, Kim HP, Han SW, et al. Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells. Mol Cancer Ther 2009;8:2526-2536
    • (2009) Mol Cancer Ther , vol.8 , pp. 2526-2536
    • Yoon, Y.K.1    Kim, H.P.2    Han, S.W.3
  • 56
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 2009;360:563-572
    • (2009) N Engl J Med , vol.360 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 57
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009;27:672-680
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 59
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002;62:200-207 (Pubitemid 34074005)
    • (2002) Cancer Research , vol.62 , Issue.1 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 60
    • 54249155585 scopus 로고    scopus 로고
    • Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor
    • Hu YP, Patil SB, Panasiewicz M, et al. Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor. Cancer Res 2008;68:8004-8013
    • (2008) Cancer Res , vol.68 , pp. 8004-8013
    • Hu, Y.P.1    Patil, S.B.2    Panasiewicz, M.3
  • 62
    • 67649365635 scopus 로고    scopus 로고
    • Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors
    • Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG. Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors. Lancet Oncol 2009;10:709-717
    • (2009) Lancet Oncol , vol.10 , pp. 709-717
    • Karamouzis, M.V.1    Konstantinopoulos, P.A.2    Papavassiliou, A.G.3
  • 63
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells
    • Wu L, Adams M, Carter T, et al. Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells. Clin Cancer Res 2008;14:4650-4657
    • (2008) Clin Cancer Res , vol.14 , pp. 4650-4657
    • Wu, L.1    Adams, M.2    Carter, T.3
  • 64
    • 0141842714 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: An overview of the results of preclinical and clinical investigations
    • Brunner TB, Hahn SM, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ. Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Res 2003;63:5656-5668
    • (2003) Cancer Res , vol.63 , pp. 5656-5668
    • Brunner, T.B.1    Hahn, S.M.2    Gupta, A.K.3    Muschel, R.J.4    McKenna, W.G.5    Bernhard, E.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.