-
1
-
-
54949102358
-
Reversal of P-glycoprotein-mediated multidrug resistance in human sarcoma MES-SA/Dx-5 cells by nonsteroidal anti-inflammatory drugs
-
Angelini A, Iezzi M, Di Febbo C, Di Ilio C, Cuccurullo F, Porreca E (2008) Reversal of P-glycoprotein-mediated multidrug resistance in human sarcoma MES-SA/Dx-5 cells by nonsteroidal anti-inflammatory drugs. Oncol Rep 20:731-735
-
(2008)
Oncol Rep
, vol.20
, pp. 731-735
-
-
Angelini, A.1
Iezzi, M.2
Di Febbo, C.3
Di Ilio, C.4
Cuccurullo, F.5
Porreca, E.6
-
2
-
-
27544479318
-
Role of tyrosine kinase inhibitors in cancer therapy
-
Arora A, Scholar EM (2005) Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Therapeutics 315:971-979
-
(2005)
J Pharmacol Exp Therapeutics
, vol.315
, pp. 971-979
-
-
Arora, A.1
Scholar, E.M.2
-
3
-
-
56149086171
-
A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor- 1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors
-
Atzori F, Tabernero J, Cervantes A, Botero M, Hsu K, Brown H et al (2008) A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor- 1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors. ASCO Meet Abstr 26:3519
-
(2008)
ASCO Meet Abstr
, vol.26
, pp. 3519
-
-
Atzori, F.1
Tabernero, J.2
Cervantes, A.3
Botero, M.4
Hsu, K.5
Brown, H.6
-
4
-
-
0242288111
-
Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment
-
Bohula EA, Playford MP, Macaulay VM (2003) Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment. Anticancer Drugs 14:669-682
-
(2003)
Anticancer Drugs
, vol.14
, pp. 669-682
-
-
Bohula, E.A.1
Playford, M.P.2
MacAulay, V.M.3
-
5
-
-
0029937307
-
Antisense RNA to the type 1 insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo
-
Burfeind P, Chernicky C, Rininsland F, Ilan J, Ilan J (1996) Antisense RNA to the type 1 insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. Proc Natl Acad Sci USA 93:7263-7268
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7263-7268
-
-
Burfeind, P.1
Chernicky, C.2
Rininsland, F.3
Ilan, J.4
-
6
-
-
1542285155
-
Expression of insulin-like growth factor mitogenic signals in adult soft-tissue sarcomas: SigniWcant correlation with malignant potential
-
Busund L, Ow K, Russell P, Crowe PJ, Yang J (2004) Expression of insulin-like growth factor mitogenic signals in adult soft-tissue sarcomas: signiWcant correlation with malignant potential. Virchows Arch 444:142-148
-
(2004)
Virchows Arch
, vol.444
, pp. 142-148
-
-
Busund, L.1
Ow, K.2
Russell, P.3
Crowe, P.J.4
Yang, J.5
-
7
-
-
20944440088
-
Tumor development by transgenic expression of a constitutively active insulin-like growth factor 1 receptor
-
Carboni JM, Lee AV, Hadsell DL, Rowley BR, Lee FY, Bol DK et al (2005) Tumor development by transgenic expression of a constitutively active insulin-like growth factor 1 receptor. Cancer Res 65:3781-3787
-
(2005)
Cancer Res
, vol.65
, pp. 3781-3787
-
-
Carboni, J.M.1
Lee, A.V.2
Hadsell, D.L.3
Rowley, B.R.4
Lee, F.Y.5
Bol, D.K.6
-
8
-
-
42649104659
-
The type i insulin-like growth factor receptor pathway: A key player in cancer therapeutic resistance
-
Casa AJ, Dearth RK, Litzenburger BC, Lee AV, Cui X (2008) The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance. Front Biosci 13:3273-3287
-
(2008)
Front Biosci
, vol.13
, pp. 3273-3287
-
-
Casa, A.J.1
Dearth, R.K.2
Litzenburger, B.C.3
Lee, A.V.4
Cui, X.5
-
9
-
-
0034115368
-
Treatment of human breast cancer cells with antisense RNA to the type 1 insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo
-
Chernicky C, Yi L, Tan H, Gan S, Ilan J (2000) Treatment of human breast cancer cells with antisense RNA to the type 1 insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo. Cancer Gene Ther 7:385-395
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 385-395
-
-
Chernicky, C.1
Yi, L.2
Tan, H.3
Gan, S.4
Ilan, J.5
-
11
-
-
34247140280
-
Ionising radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism
-
Cosaceanu D, Budiu RA, Carapancea M, Castro J, Lewensohn R, Dricu A (2007) Ionising radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism. Oncogene 26:2423-2434
-
(2007)
Oncogene
, vol.26
, pp. 2423-2434
-
-
Cosaceanu, D.1
Budiu, R.A.2
Carapancea, M.3
Castro, J.4
Lewensohn, R.5
Dricu, A.6
-
12
-
-
17144414465
-
Delayed activation of the insulin-like growth factor-1 receptro/ Src/MAPL/Egr-1 signaling regulates clusterin expression, a pro-survival factor
-
Criswell T, Beman M, Araki S, Leskov K, Cataldo E, Mayo LD et al (2005) Delayed activation of the insulin-like growth factor-1 receptro/ Src/MAPL/Egr-1 signaling regulates clusterin expression, a pro-survival factor. J Biol Chem 280:14212-14221
-
(2005)
J Biol Chem
, vol.280
, pp. 14212-14221
-
-
Criswell, T.1
Beman, M.2
Araki, S.3
Leskov, K.4
Cataldo, E.5
Mayo, L.D.6
-
14
-
-
0037090527
-
IGF-1 in gynaecology and obstetrics
-
Druckman R, Rohr U (2002) IGF-1 in gynaecology and obstetrics. Maturitas 41:S65-S83
-
(2002)
Maturitas
, vol.41
-
-
Druckman, R.1
Rohr, U.2
-
15
-
-
0036138625
-
Insulin-like growth factor-1 receptor in uveal melanoma: A predictor for metastatic disease and a potential therapeutic target
-
Ericsson C, Girnita L, Seregard S, Bartolazzi A, Jager M, Larsson O (2002) Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target. Invest Opthalmol Vis Sci 43:1-8
-
(2002)
Invest Opthalmol Vis Sci
, vol.43
, pp. 1-8
-
-
Ericsson, C.1
Girnita, L.2
Seregard, S.3
Bartolazzi, A.4
Jager, M.5
Larsson, O.6
-
16
-
-
0033006852
-
Ku, a DNA repair protein with multiple cellular functions
-
Featherstone C, Jackson SP (1999) Ku, a DNA repair protein with multiple cellular functions? Mutat Res 434:3-15
-
(1999)
Mutat Res
, vol.434
, pp. 3-15
-
-
Featherstone, C.1
Jackson, S.P.2
-
17
-
-
77953231967
-
-
Garcia M, Jemal A, Ward EM, Center MM, Hao Y, Siegel RL et al (2007) American Cancer Society, Atlanta, GA
-
Garcia M, Jemal A, Ward EM, Center MM, Hao Y, Siegel RL et al (2007) American Cancer Society, Atlanta, GA
-
-
-
-
18
-
-
69149084571
-
Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer
-
Ge J, Chen Z, Wu S, Chen J, Li X, Li J et al (2009) Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer. Digestion 80:148-158
-
(2009)
Digestion
, vol.80
, pp. 148-158
-
-
Ge, J.1
Chen, Z.2
Wu, S.3
Chen, J.4
Li, X.5
Li, J.6
-
19
-
-
0033374830
-
Insulin like growth factor 1 (IGF-1R) antagonises apoptosis induced by serum deWciency and doxorubicin in neuronal cell culture
-
Gil-Ad I, Shtaif B, Luria D, Karp L, Fridman Y, Weizman A (1999) Insulin like growth factor 1 (IGF-1R) antagonises apoptosis induced by serum deWciency and doxorubicin in neuronal cell culture. Growth Horm IGF Res 9:458-464
-
(1999)
Growth Horm IGF Res
, vol.9
, pp. 458-464
-
-
Gil-Ad, I.1
Shtaif, B.2
Luria, D.3
Karp, L.4
Fridman, Y.5
Weizman, A.6
-
20
-
-
0035160628
-
Insulin, insulin-like growth factors and colon cancer: A review of the evidence
-
Giovannucci E (2001) Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr 131:3109S-3120S
-
(2001)
J Nutr
, vol.131
-
-
Giovannucci, E.1
-
21
-
-
1642494838
-
Cyclolignans as inhibitors of the insulin-like growth factor- 1 receptor and malignant cell growth
-
Girnita L, Girnita A, Prete F, Bartolazzi A, Larrson O, Axelson M (2004) Cyclolignans as inhibitors of the insulin-like growth factor- 1 receptor and malignant cell growth. Cancer Res 64:236-242
-
(2004)
Cancer Res
, vol.64
, pp. 236-242
-
-
Girnita, L.1
Girnita, A.2
Prete, F.3
Bartolazzi, A.4
Larrson, O.5
Axelson, M.6
-
22
-
-
0032850369
-
Insulin-like growth factor 1 (IGF-1) rescues breast cancer cells from chemotherapy-induced cell death-proliferative and anti-apoptotic effects
-
Gooch JL, Van Den Berg CL, Yee D (1999) Insulin-like growth factor 1 (IGF-1) rescues breast cancer cells from chemotherapy-induced cell death-proliferative and anti-apoptotic effects. Breast Cancer Res Treat 56:1-10
-
(1999)
Breast Cancer Res Treat
, vol.56
, pp. 1-10
-
-
Gooch, J.L.1
Van Den Berg, C.L.2
Yee, D.3
-
23
-
-
0032885494
-
Expression of insulin-like growth factor-1 receptor in human colorectal cancer
-
Hakam A, Yeatman T, Lu L, Mora L, Marcet G, Nicosia S et al (1999) Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol 30:1128-1133
-
(1999)
Hum Pathol
, vol.30
, pp. 1128-1133
-
-
Hakam, A.1
Yeatman, T.2
Lu, L.3
Mora, L.4
Marcet, G.5
Nicosia, S.6
-
24
-
-
36148953021
-
Phase i dose escalation study of the anti-IGF-1R monoclonal antibody CP-751,871 in patients with refractory solid tumors
-
Haluska P, Shaw H, Batzel GN, Molife LR, Adjei AA, Yap TA et al (2007) Phase I dose escalation study of the anti-IGF-1R monoclonal antibody CP-751,871 in patients with refractory solid tumors. ASCO Meet Abstr 25:3586
-
(2007)
ASCO Meet Abstr
, vol.25
, pp. 3586
-
-
Haluska, P.1
Shaw, H.2
Batzel, G.N.3
Molife, L.R.4
Adjei, A.A.5
Yap, T.A.6
-
25
-
-
33947246109
-
Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer
-
Harris LN, You F, Schnitt SJ, Witkiewicz A, Lu X, Sgroi D et al (2007) Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin Cancer Res 13:1198-1207
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1198-1207
-
-
Harris, L.N.1
You, F.2
Schnitt, S.J.3
Witkiewicz, A.4
Lu, X.5
Sgroi, D.6
-
26
-
-
34548018304
-
The insulin-like growth factor 1 receptor in cancer: Old focus, new future
-
Hartog H, Wesseling J, Boezen HM, van der Graaf WT (2007) The insulin-like growth factor 1 receptor in cancer: old focus, new future. Eur J Cancer 43:1895-1904
-
(2007)
Eur J Cancer
, vol.43
, pp. 1895-1904
-
-
Hartog, H.1
Wesseling, J.2
Boezen, H.M.3
Van Der Graaf, W.T.4
-
27
-
-
53549121511
-
A phase i trial of nordihydroguareacetic acid (NDGA) in patients with non-metastatic prostate cancer and rising PSA
-
Harzstark AL, Ryan C, Diamond M, Jones J, Zavodovskaya M, Maddux B et al (2007) A phase I trial of nordihydroguareacetic acid (NDGA) in patients with non-metastatic prostate cancer and rising PSA. J Clin Oncol 25:15500
-
(2007)
J Clin Oncol
, vol.25
, pp. 15500
-
-
Harzstark, A.L.1
Ryan, C.2
Diamond, M.3
Jones, J.4
Zavodovskaya, M.5
Maddux, B.6
-
28
-
-
62749203737
-
Insulin-like growth factor 1 receptor targeted therapeutics: Novel compounds and novel treatment strategies for cancer medicine
-
Hewish M, Chau I, Cunningham D (2009) Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine. Recent Pat Anticancer Drug Discov 4:54-72
-
(2009)
Recent Pat Anticancer Drug Discov
, vol.4
, pp. 54-72
-
-
Hewish, M.1
Chau, I.2
Cunningham, D.3
-
29
-
-
57149124243
-
A phase i study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF1R) in advanced solid tumor patients in a q2 wk schedule
-
Hidalgo M, Tirado Gomez M, Lewis N, Vuky JL, Taylor G, Hayburn JL et al (2008) A phase I study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF1R) in advanced solid tumor patients in a q2 wk schedule. ASCO Meet Abstr 26:3520
-
(2008)
ASCO Meet Abstr
, vol.26
, pp. 3520
-
-
Hidalgo, M.1
Tirado Gomez, M.2
Lewis, N.3
Vuky, J.L.4
Taylor, G.5
Hayburn, J.L.6
-
30
-
-
35148889523
-
A phase I, Wrst in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors
-
Higano CS, Yu EY, Whiting SH, Gordon MS, LoRusso P, Fox F et al (2007) A phase I, Wrst in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. ASCO Meet Abstr 25:3505
-
(2007)
ASCO Meet Abstr
, vol.25
, pp. 3505
-
-
Higano, C.S.1
Yu, E.Y.2
Whiting, S.H.3
Gordon, M.S.4
Lorusso, P.5
Fox, F.6
-
31
-
-
0036420545
-
Mechanisms of steroid impairment of growth
-
Hochberg Z (2002) Mechanisms of steroid impairment of growth. Horm Res 58:33-38
-
(2002)
Horm Res
, vol.58
, pp. 33-38
-
-
Hochberg, Z.1
-
32
-
-
58249101005
-
The mechanisms of diVerential sensitivity to an insulinlike growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
-
Huang F, Greer A, Hurlburt W, Han X, Hafezi R, Wittenberg GM et al (2009) The mechanisms of diVerential sensitivity to an insulinlike growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res 69:161-170
-
(2009)
Cancer Res
, vol.69
, pp. 161-170
-
-
Huang, F.1
Greer, A.2
Hurlburt, W.3
Han, X.4
Hafezi, R.5
Wittenberg, G.M.6
-
33
-
-
33645526144
-
Cancer statistics
-
Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C et al (2006) Cancer statistics. CA Cancer J Clin 56:106-130
-
(2006)
CA Cancer J Clin
, vol.56
, pp. 106-130
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Murray, T.4
Xu, J.5
Smigal, C.6
-
34
-
-
0033613356
-
Induction of tumor suppression and glandular diVerentiation of A549 lung carcinoma cells by dominant-negative IGF-1 receptor
-
Jiang Y, Rom WN, Yie TA, Chi CX, Tchou-Wong KM (1999) Induction of tumor suppression and glandular diVerentiation of A549 lung carcinoma cells by dominant-negative IGF-1 receptor. Oncogene 18:6071-6077
-
(1999)
Oncogene
, vol.18
, pp. 6071-6077
-
-
Jiang, Y.1
Rom, W.N.2
Yie, T.A.3
Chi, C.X.4
Tchou-Wong, K.M.5
-
35
-
-
36348954086
-
Efficacy of the anti-insulin like growth factor i receptor (IGF-IR) antibody CP-751871 in combination with paclitaxel and carboplatin as Wrst-line treatment for advanced non-small cell lung cancer (NSCLC)
-
Karp DD, Paz-Ares LG, Blakely LJ, Kreisman H, Eisenberg PD, Cohen RB et al (2007) Efficacy of the anti-insulin like growth factor I receptor (IGF-IR) antibody CP-751871 in combination with paclitaxel and carboplatin as Wrst-line treatment for advanced non-small cell lung cancer (NSCLC). ASCO Meet Abstr 25:7506
-
(2007)
ASCO Meet Abstr
, vol.25
, pp. 7506
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Blakely, L.J.3
Kreisman, H.4
Eisenberg, P.D.5
Cohen, R.B.6
-
36
-
-
66349091290
-
Phase II study of the efficacy of the anti-insulin-like growth factor type 1 receptor antibody CP-751, 871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small cell lung cancer
-
Karp DD, Paz-Ares LG, Novello S, Haluska P, Garland L, Cardenal F et al (2009) Phase II study of the efficacy of the anti-insulin-like growth factor type 1 receptor antibody CP-751, 871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small cell lung cancer. J Clin Oncol 27:2516-2522
-
(2009)
J Clin Oncol
, vol.27
, pp. 2516-2522
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Novello, S.3
Haluska, P.4
Garland, L.5
Cardenal, F.6
-
37
-
-
33847290787
-
Novel treatment strategies for soft tissue sarcoma
-
Kasper B, Gil T, D'Hondt V, Gebhart M, Awada A (2007) Novel treatment strategies for soft tissue sarcoma. Crit Rev Oncol Hematol 62:9-15
-
(2007)
Crit Rev Oncol Hematol
, vol.62
, pp. 9-15
-
-
Kasper, B.1
Gil, T.2
D'hondt, V.3
Gebhart, M.4
Awada, A.5
-
38
-
-
0031934765
-
Role of growth factors in pancreatic cancer
-
Korc M (1998) Role of growth factors in pancreatic cancer. Surg Oncol Clin N Am 7:25-41
-
(1998)
Surg Oncol Clin N Am
, vol.7
, pp. 25-41
-
-
Korc, M.1
-
39
-
-
0032939970
-
Activation of the insulin like growth factor-1 receptor promotes the survival o human keratinocytes following ultraviolet B irradiation
-
Kuhn C, Hurwitz SA, Kumar MG, Cotton J, Spandau DF (1999) Activation of the insulin like growth factor-1 receptor promotes the survival o human keratinocytes following ultraviolet B irradiation. Int J Cancer 80:431-438
-
(1999)
Int J Cancer
, vol.80
, pp. 431-438
-
-
Kuhn, C.1
Hurwitz, S.A.2
Kumar, M.G.3
Cotton, J.4
Spandau, D.F.5
-
40
-
-
35348815424
-
Phase 1 Wrst-in-human dose escalation study of cp-751,871, a speciWc monoclonal antibody against the insulin like growth factor 1 receptor
-
Lacy M, Alsina M, Melvin CL, Roberts L, Yin D, Petersen A et al (2006) Phase 1 Wrst-in-human dose escalation study of cp-751,871, a speciWc monoclonal antibody against the insulin like growth factor 1 receptor. J Clin Oncol 24:7609
-
(2006)
J Clin Oncol
, vol.24
, pp. 7609
-
-
Lacy, M.1
Alsina, M.2
Melvin, C.L.3
Roberts, L.4
Yin, D.5
Petersen, A.6
-
41
-
-
49249125421
-
Phase i pharmacokinetic and pharmacodynamic study of the anti-insulin like growth factor type 1 Receptor monoclonal antibody CP-751, 871 in patients with multiple myeloma
-
Lacy MQ, Alsina M, Fonseca R, Paccagnella ML, Melvin CL, Yin D et al (2008) Phase I pharmacokinetic and pharmacodynamic study of the anti-insulin like growth factor type 1 Receptor monoclonal antibody CP-751, 871 in patients with multiple myeloma. J Clin Oncol 26:3196-3203
-
(2008)
J Clin Oncol
, vol.26
, pp. 3196-3203
-
-
Lacy, M.Q.1
Alsina, M.2
Fonseca, R.3
Paccagnella, M.L.4
Melvin, C.L.5
Yin, D.6
-
42
-
-
54249104991
-
Autophagy: A novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model
-
Lambert LA, Qiao N, Hunt KK, Lambert DH, Mills GB, Meijer L et al (2008) Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. Cancer Res 68:7966-7974
-
(2008)
Cancer Res
, vol.68
, pp. 7966-7974
-
-
Lambert, L.A.1
Qiao, N.2
Hunt, K.K.3
Lambert, D.H.4
Mills, G.B.5
Meijer, L.6
-
43
-
-
22044434446
-
Role of insulin-like growth factor 1 receptor signaling in cancer
-
Larrson O, Girnita A, Girnita L (2005) Role of insulin-like growth factor 1 receptor signaling in cancer. Br J Cancer 92:2097-2101
-
(2005)
Br J Cancer
, vol.92
, pp. 2097-2101
-
-
Larrson, O.1
Girnita, A.2
Girnita, L.3
-
44
-
-
0029895283
-
Antitumor eVects of an adenovirus expressing antisense insulin-like growth factor i receptor on human lung cancer cell lines
-
Lee C, Wu S, Gabrilovich D, Chen H, Nadaf-Rahrov S, Ciernik I et al (1996) Antitumor eVects of an adenovirus expressing antisense insulin-like growth factor I receptor on human lung cancer cell lines. Cancer Res 56:3038-3041
-
(1996)
Cancer Res
, vol.56
, pp. 3038-3041
-
-
Lee, C.1
Wu, S.2
Gabrilovich, D.3
Chen, H.4
Nadaf-Rahrov, S.5
Ciernik, I.6
-
45
-
-
34748830273
-
Induction of glutathione transferase in insulin-like growth factor 1 receptor-overexpressed hepatoma cells
-
Lee JY, Han CY, Yang JW, Smith C, Kim SK, Lee EY et al (2007) Induction of glutathione transferase in insulin-like growth factor 1 receptor- overexpressed hepatoma cells. Mol Pharmacol 72:1082-1093
-
(2007)
Mol Pharmacol
, vol.72
, pp. 1082-1093
-
-
Lee, J.Y.1
Han, C.Y.2
Yang, J.W.3
Smith, C.4
Kim, S.K.5
Lee, E.Y.6
-
46
-
-
0032401879
-
Inhibition of insulinlike growth factor 1 receptor expression in neuroblastoma cells induces the regression of established tumors in mice
-
Liu X, Turbyville T, Fritz A, Whitesell L (1998a) Inhibition of insulinlike growth factor 1 receptor expression in neuroblastoma cells induces the regression of established tumors in mice. Cancer Res 58:5432-5438
-
(1998)
Cancer Res
, vol.58
, pp. 5432-5438
-
-
Liu, X.1
Turbyville, T.2
Fritz, A.3
Whitesell, L.4
-
47
-
-
0032006082
-
Expression of the insulin like growth factor 1 receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells
-
Liu Y, Lehar S, Corvi C, Payne G, O'Connor R (1998b) Expression of the insulin like growth factor 1 receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells. Cancer Res 58:570-576
-
(1998)
Cancer Res
, vol.58
, pp. 570-576
-
-
Liu, Y.1
Lehar, S.2
Corvi, C.3
Payne, G.4
O'connor, R.5
-
48
-
-
34250213241
-
IGF-1R expression in localised cervical carcinoma patients treated by radiochemotherapy
-
Lloret M, Lara PC, Bordon E, Pinar B, Rev A, Falcon O et al (2007) IGF-1R expression in localised cervical carcinoma patients treated by radiochemotherapy. Gynecol Oncol 106:8-11
-
(2007)
Gynecol Oncol
, vol.106
, pp. 8-11
-
-
Lloret, M.1
Lara, P.C.2
Bordon, E.3
Pinar, B.4
Rev, A.5
Falcon, O.6
-
49
-
-
0036559535
-
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
-
Lopez T, Hanahan D (2002) Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 1:339-353
-
(2002)
Cancer Cell
, vol.1
, pp. 339-353
-
-
Lopez, T.1
Hanahan, D.2
-
50
-
-
16544373519
-
The IGF receptor as anticancer treatment target
-
discussion 243-246
-
Macaulay VM (2004) The IGF receptor as anticancer treatment target. Novartis Found Symp 262:235-243 (discussion 243-246)
-
(2004)
Novartis Found Symp
, vol.262
, pp. 235-243
-
-
MacAulay, V.M.1
-
51
-
-
0042515293
-
An anti-insulin-like growth factor 1 receptor antibody that is a potent inhibitor of cancer cell proliferation
-
Maloney E, McLaughlin J, Dagdigian N, Garrett L, Connors K, Zhou XH et al (2003) An anti-insulin-like growth factor 1 receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res 63:5073-5083
-
(2003)
Cancer Res
, vol.63
, pp. 5073-5083
-
-
Maloney, E.1
McLaughlin, J.2
Dagdigian, N.3
Garrett, L.4
Connors, K.5
Zhou, X.H.6
-
52
-
-
33845914051
-
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
-
Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E et al (2006) A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444:1038-1043
-
(2006)
Nature
, vol.444
, pp. 1038-1043
-
-
Niedernhofer, L.J.1
Garinis, G.A.2
Raams, A.3
Lalai, A.S.4
Robinson, A.R.5
Appeldoorn, E.6
-
53
-
-
0029951491
-
Radiosensitive target in the mouse embryo chimera assay: Implications that the target involves autocrine growth factor function
-
Peters JM, Tsark EC, Wiley LM (1996) Radiosensitive target in the mouse embryo chimera assay: implications that the target involves autocrine growth factor function. Radiat Res 175:722-729
-
(1996)
Radiat Res
, vol.175
, pp. 722-729
-
-
Peters, J.M.1
Tsark, E.C.2
Wiley, L.M.3
-
54
-
-
0034082039
-
Insulin-like growth factor physiology and cancer risk
-
DOI 10.1016/S0959-8049(00)00102-7, PII S0959804900001027
-
Pollak M (2000) Insulin-like growth factor physiology and cancer risk. Eur J Cancer 36:1224-1228 (Pubitemid 30407009)
-
(2000)
European Journal of Cancer
, vol.36
, Issue.10
, pp. 1224-1228
-
-
Pollak, M.1
-
55
-
-
0028050256
-
Growth inhibition of human melanoma cells in nude mice by antisense strategies to type 1 insulin-like growth factor receptor
-
ResnicoV M, Coppola D, Sell C, Rubin R, Ferrone S, Baserga R (1994a) Growth inhibition of human melanoma cells in nude mice by antisense strategies to type 1 insulin-like growth factor receptor. Cancer Res 54:4848-4850
-
(1994)
Cancer Res
, vol.54
, pp. 4848-4850
-
-
Resnico, V.M.1
Coppola, D.2
Sell, C.3
Rubin, R.4
Ferrone, S.5
Baserga, R.6
-
56
-
-
0028271497
-
Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1R) receptor are nontumorigenic and induce regression of wild-type tumors
-
ResnicoV M, Sell C, Rubini M, Coppola D, Ambrose D, Baserga R et al (1994b) Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1R) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res 54:2218-2222
-
(1994)
Cancer Res
, vol.54
, pp. 2218-2222
-
-
Resnico, V.M.1
Sell, C.2
Rubini, M.3
Coppola, D.4
Ambrose, D.5
Baserga, R.6
-
57
-
-
33847284924
-
Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells
-
Riedemann J, Sohail M, Macaulay VM, Riedemann J, Sohail M, Macaulay VM (2007) Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells. Biochem Biophys Res Commun 355:700-706
-
(2007)
Biochem Biophys Res Commun
, vol.355
, pp. 700-706
-
-
Riedemann, J.1
Sohail, M.2
MacAulay, V.M.3
Riedemann, J.4
Sohail, M.5
MacAulay, V.M.6
-
58
-
-
10844296820
-
Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wildtype and mutant human prostate cancer
-
Rochester MA, Riedemann J, Hellawell GO, Brewster SF, Macaulay VM, Rochester MA et al (2005) Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wildtype and mutant human prostate cancer. Cancer Gene Ther 12:90-100
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 90-100
-
-
Rochester, M.A.1
Riedemann, J.2
Hellawell, G.O.3
Brewster, S.F.4
MacAulay, V.M.5
Rochester, M.A.6
-
59
-
-
36148981957
-
A phase i study of q3W R1507, a human monoclonal antibody IGF-1R antagonist in patients with advanced cancer
-
Rodon J, Patnaik A, Stein M, Tolcher A, Ng C, Dias C (2007) A phase I study of q3W R1507, a human monoclonal antibody IGF-1R antagonist in patients with advanced cancer. ASCO Meet Abstr 25:3590
-
(2007)
ASCO Meet Abstr
, vol.25
, pp. 3590
-
-
Rodon, J.1
Patnaik, A.2
Stein, M.3
Tolcher, A.4
Ng, C.5
Dias, C.6
-
60
-
-
0034788985
-
The IGF system and breast cancer
-
Sachdev D, Yee D (2001) The IGF system and breast cancer. Endocr Relat Cancer 8:197-209
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 197-209
-
-
Sachdev, D.1
Yee, D.2
-
61
-
-
0347356289
-
Development of molecular agents for IGF receptor targeting
-
Salisbury AJ, Macaulay VM (2003) Development of molecular agents for IGF receptor targeting. Horm Metab Res 35:843-849
-
(2003)
Horm Metab Res
, vol.35
, pp. 843-849
-
-
Salisbury, A.J.1
MacAulay, V.M.2
-
62
-
-
33846874575
-
The role of the IGF system in cancer growth and metastasis: Overview and recent insights
-
Samani A, Yakar S, LeRoith D, Brodt P (2007) The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 28:20-47
-
(2007)
Endocr Rev
, vol.28
, pp. 20-47
-
-
Samani, A.1
Yakar, S.2
Leroith, D.3
Brodt, P.4
-
63
-
-
56149094007
-
A phase IB study of AMG 479, a type 1 insulin-like growth factor receptor (IGF1R) antibody, in combination with panitumumab (P) or gemcitabine (G)
-
Sarantopoulos J, Mita AC, Mulay M, Romero O, Lu J, Capilla F et al (2008) A phase IB study of AMG 479, a type 1 insulin-like growth factor receptor (IGF1R) antibody, in combination with panitumumab (P) or gemcitabine (G). ASCO Meet Abstr 26:3583
-
(2008)
ASCO Meet Abstr
, vol.26
, pp. 3583
-
-
Sarantopoulos, J.1
Mita, A.C.2
Mulay, M.3
Romero, O.4
Lu, J.5
Capilla, F.6
-
65
-
-
36348970313
-
Targeted therapies in Ewing's sarcoma
-
Scotlandi K (2006) Targeted therapies in Ewing's sarcoma. Adv Exp Med Biol 587:13-22
-
(2006)
Adv Exp Med Biol
, vol.587
, pp. 13-22
-
-
Scotlandi, K.1
-
66
-
-
20944447905
-
Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors
-
Scotlandi K, Manara MC, Nicoletti G, Lollini PL, Lukas S, Benini S et al (2005) Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors. Cancer Res 65:3868-3876
-
(2005)
Cancer Res
, vol.65
, pp. 3868-3876
-
-
Scotlandi, K.1
Manara, M.C.2
Nicoletti, G.3
Lollini, P.L.4
Lukas, S.5
Benini, S.6
-
67
-
-
0027366338
-
Simian virus 40 large tumor antigen is unable to transform mouse embryonic Wbroblasts lacking type 1 insulin-like growth factor receptor
-
Sell C, Rubini M, Rubin R, Liu JP, Efstratiadis A, Baserga R (1993) Simian virus 40 large tumor antigen is unable to transform mouse embryonic Wbroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci USA 90:11217-11221
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11217-11221
-
-
Sell, C.1
Rubini, M.2
Rubin, R.3
Liu, J.P.4
Efstratiadis, A.5
Baserga, R.6
-
68
-
-
0033838566
-
Function of the IGF-1 Receptor in breast cancer
-
Surmacz E (2000) Function of the IGF-1 Receptor in breast cancer. J Mammary Gland Biol Neoplasia 5:95-105
-
(2000)
J Mammary Gland Biol Neoplasia
, vol.5
, pp. 95-105
-
-
Surmacz, E.1
-
69
-
-
0242624594
-
Growth factor receptors as therapeutic targets: Strategies to inhibit the insulin-like growth factor 1 receptor
-
Surmacz E (2003) Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor 1 receptor. Oncogene 22:6589-6597
-
(2003)
Oncogene
, vol.22
, pp. 6589-6597
-
-
Surmacz, E.1
-
70
-
-
58149299317
-
Molecularly targeted therapy for hepatocellular carcinoma
-
Tanaka S, Arii S (2009) Molecularly targeted therapy for hepatocellular carcinoma. Cancer Sci 100:1-8
-
(2009)
Cancer Sci
, vol.100
, pp. 1-8
-
-
Tanaka, S.1
Arii, S.2
-
71
-
-
36148976199
-
A phase i pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody against insulin-like growth factor type 1 receptor (IGF-1R), in advanced solid tumors
-
Tolcher AW, Rothenberg ML, Rodon J, Delbeke D, Patnaik A, Nguyen L et al (2007) A phase I pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody against insulin-like growth factor type 1 receptor (IGF-1R), in advanced solid tumors. ASCO Meet Abstr 25:3002
-
(2007)
ASCO Meet Abstr
, vol.25
, pp. 3002
-
-
Tolcher, A.W.1
Rothenberg, M.L.2
Rodon, J.3
Delbeke, D.4
Patnaik, A.5
Nguyen, L.6
-
72
-
-
57149130704
-
A phase i study of AVE1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor1 receptor) antagonist, in patients (pts) with advanced solid tumor
-
Tolcher AW, Patnaik A, Till E, Takimoto CH, Papadopoulos KP, Massard C et al (2008) A phase I study of AVE1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor1 receptor) antagonist, in patients (pts) with advanced solid tumor. ASCO Meet Abstr 26:3582
-
(2008)
ASCO Meet Abstr
, vol.26
, pp. 3582
-
-
Tolcher, A.W.1
Patnaik, A.2
Till, E.3
Takimoto, C.H.4
Papadopoulos, K.P.5
Massard, C.6
-
73
-
-
0037399412
-
Tyrosine kinases as targets in cancer therapy-successes and failures
-
Traxler P (2003) Tyrosine kinases as targets in cancer therapy-successes and failures. Oncol Res 7:215-234
-
(2003)
Oncol Res
, vol.7
, pp. 215-234
-
-
Traxler, P.1
-
74
-
-
16944364325
-
Insulin-like growth factor-1 receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation
-
Turner B, Haffty B, Narayanan L, Yuan J, Havre P, Gumbs A et al (1997) Insulin-like growth factor-1 receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res 57:3079-3083
-
(1997)
Cancer Res
, vol.57
, pp. 3079-3083
-
-
Turner, B.1
Haffty, B.2
Narayanan, L.3
Yuan, J.4
Havre, P.5
Gumbs, A.6
-
75
-
-
7644223079
-
The cyclolignan PPP induces activation loop-speciWc inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway
-
Vasilcanu D, Girnita A, Girnita L, Vasilcanu R, Axelson M, Larsson O (2004) The cyclolignan PPP induces activation loop-speciWc inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Oncogene 23:7854-7862
-
(2004)
Oncogene
, vol.23
, pp. 7854-7862
-
-
Vasilcanu, D.1
Girnita, A.2
Girnita, L.3
Vasilcanu, R.4
Axelson, M.5
Larsson, O.6
-
76
-
-
2342586777
-
New therapeutic strategies for soft tissue sarcomas
-
Von Mehren M (2003) New therapeutic strategies for soft tissue sarcomas. Curr Opin Oncol 4:441-451
-
(2003)
Curr Opin Oncol
, vol.4
, pp. 441-451
-
-
Von Mehren, M.1
-
77
-
-
77953230391
-
New concepts in regulation and function of the insulin-like growth factors: Implications for understanding normal growth and neoplasia
-
Werner H, Le Roith D (2000) New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Proc Natl Acad Sci USA 93:8318-8323
-
(2000)
Proc Natl Acad Sci USA
, vol.93
, pp. 8318-8323
-
-
Werner, H.1
Le Roith, D.2
-
78
-
-
57149127369
-
IGF-1 receptor inhibitors in clinical trials- early lessons
-
Weroha SJ, Haluska P (2008) IGF-1 receptor inhibitors in clinical trials- early lessons. J Mammary Gland Biol Neoplasia 13:471-483
-
(2008)
J Mammary Gland Biol Neoplasia
, vol.13
, pp. 471-483
-
-
Weroha, S.J.1
Haluska, P.2
-
79
-
-
34249723214
-
Opportunities for improving the therapeutic ratio for patients with sarcoma
-
Wunder J, Nielsen T, Maki R, O'Sullivan B, Alman B (2007) Opportunities for improving the therapeutic ratio for patients with sarcoma. Lancet Oncol 8:513-524
-
(2007)
Lancet Oncol
, vol.8
, pp. 513-524
-
-
Wunder, J.1
Nielsen, T.2
Maki, R.3
O'sullivan, B.4
Alman, B.5
-
80
-
-
0033179378
-
Expression of insulin-like growth factor-1 receptor in synovial sarcoma: Association with an aggressive phenotype
-
Xie Y, Skytting B, Nilsson G, Brodin B, Larsson O (1999) Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype. Cancer Res 59:3588-3591
-
(1999)
Cancer Res
, vol.59
, pp. 3588-3591
-
-
Xie, Y.1
Skytting, B.2
Nilsson, G.3
Brodin, B.4
Larsson, O.5
-
81
-
-
22544461679
-
The role of the growth hormone/ insulin-like growth factor axis in tumor growth and progression: Lessons from animal models
-
Yakar S, LeRoith D, Brodt P (2005) The role of the growth hormone/ insulin-like growth factor axis in tumor growth and progression: lessons from animal models. Cytokine Growth Factor Rev 16:407-420
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 407-420
-
-
Yakar, S.1
Leroith, D.2
Brodt, P.3
-
82
-
-
33847204624
-
Targeted therapies in adult soft tissue sarcomas
-
Yang JL, Crowe PJ (2007) Targeted therapies in adult soft tissue sarcomas. J Surg Oncol 95:183-184
-
(2007)
J Surg Oncol
, vol.95
, pp. 183-184
-
-
Yang, J.L.1
Crowe, P.J.2
|