-
1
-
-
77953644244
-
-
Available at: Accessed February 2010
-
Available at: http://seer.cancer.gov. Accessed February 2010.
-
-
-
-
2
-
-
72449176846
-
Molecular origins of cancer: Molecular basis of colorectal cancer
-
Markowitz SD, Bertagnolli MM. Molecular origins of cancer: molecular basis of colorectal cancer. N Engl J Med. 2009;361:2449-2460.
-
(2009)
N Engl J Med
, vol.361
, pp. 2449-2460
-
-
Markowitz, S.D.1
Bertagnolli, M.M.2
-
5
-
-
62449205665
-
Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
-
Dallas NA, Xia L, Fan F, et al. Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res. 2009;69:1951-1957.
-
(2009)
Cancer Res
, vol.69
, pp. 1951-1957
-
-
Dallas, N.A.1
Xia, L.2
Fan, F.3
-
6
-
-
20244364227
-
Inhibition of insulin-like growth factor i receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells
-
Benini S, Manara MC, Baldini N, et al. Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells. Clin Cancer Res. 2001;7:1790-1797.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1790-1797
-
-
Benini, S.1
Manara, M.C.2
Baldini, N.3
-
7
-
-
65249162840
-
Sequencing of type i insulin-like growth factor receptor inhibition affects chemotherapy response in vitro and in vivo
-
Zeng X, Sachdev D, Zhang H, et al. Sequencing of type I insulin-like growth factor receptor inhibition affects chemotherapy response in vitro and in vivo. Clin Cancer Res. 2009;15:2840-2849.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2840-2849
-
-
Zeng, X.1
Sachdev, D.2
Zhang, H.3
-
8
-
-
69949106121
-
Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: Rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma
-
Desbois-Mouthon C, Baron A, Blivet-Van Eggelpoel MJ, et al. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin Cancer Res. 2009; 15:5445-5456.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5445-5456
-
-
Desbois-Mouthon, C.1
Baron, A.2
Blivet-Van Eggelpoel, M.J.3
-
9
-
-
66149092327
-
Hyperactivation of the insulinlike growth factor receptor i signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells
-
Eckstein N, Servan K, Hildebrandt B, et al. Hyperactivation of the insulinlike growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res. 2009;69:2996-3003.
-
(2009)
Cancer Res
, vol.69
, pp. 2996-3003
-
-
Eckstein, N.1
Servan, K.2
Hildebrandt, B.3
-
10
-
-
0033888984
-
Insulin-like growth factor I (IGF-I), IGF-binding protein-3 and the risk of colorectal adenoma and cancer in the nurses' health study
-
DOI 10.1016/S1096-6374(00)90014-5
-
Giovannucci E, Pollak M, Platz EA, et al. Insulin-like growth factor I (IGF-I), IGF-binding protein-3 and the risk of colorectal adenoma and cancer in the Nurses' Health Study. Growth Horm IGF Res. 2000; 10(suppl A):S30-S31. (Pubitemid 30641925)
-
(2000)
Growth Hormone and IGF Research
, vol.10
, Issue.SUPPL. A
-
-
Giovannucci, E.1
Pollak, M.2
Platz, E.A.3
Willett, W.C.4
Stampfer, M.J.5
Majeed, N.6
Colditz, G.A.7
Speizer, F.E.8
Hankinson, S.E.9
-
12
-
-
1842866389
-
A prospective study of plasma C-peptide and colorectal cancer risk in men
-
Ma J, Giovannucci E, Pollak M, et al. A prospective study of plasma C-peptide and colorectal cancer risk in men. J Natl Cancer Inst. 2004;96: 546-553. (Pubitemid 38559579)
-
(2004)
Journal of the National Cancer Institute
, vol.96
, Issue.7
, pp. 546-553
-
-
Ma, J.1
Giovannucci, E.2
Pollak, M.3
Leavitt, A.4
Tao, Y.5
Gaziano, J.M.6
Stampfer, M.J.7
-
13
-
-
0036112482
-
Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: A prospective study in northern Sweden
-
Palmqvist R, Hallmans G, Rinaldi S, et al. Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden. Gut. 2002;50:642-646.
-
(2002)
Gut
, vol.50
, pp. 642-646
-
-
Palmqvist, R.1
Hallmans, G.2
Rinaldi, S.3
-
14
-
-
0032885494
-
Expression of insulin-like growth factor-1 receptor in human colorectal cancer
-
Hakam A, Yeatman TJ, Lu L, et al. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol. 1999;30:1128-1133.
-
(1999)
Hum Pathol
, vol.30
, pp. 1128-1133
-
-
Hakam, A.1
Yeatman, T.J.2
Lu, L.3
-
15
-
-
0037110602
-
Overexpression of the insulin-like growth factor i receptor in human colon carcinomas
-
Weber MM, Fottner C, Liu SB, et al. Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. Cancer. 2002;95: 2086-2095.
-
(2002)
Cancer
, vol.95
, pp. 2086-2095
-
-
Weber, M.M.1
Fottner, C.2
Liu, S.B.3
-
16
-
-
0030962307
-
Gene expression profiles in normal and cancer cells
-
Zhang L, Zhou W, Velculescu VE, et al. Gene expression profiles in normal and cancer cells. Science. 1997;276:1268-1272.
-
(1997)
Science
, vol.276
, pp. 1268-1272
-
-
Zhang, L.1
Zhou, W.2
Velculescu, V.E.3
-
17
-
-
56749184290
-
Insulin and insulin-like growth factor signalling in neoplasia
-
Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer. 2008;8:915-928.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 915-928
-
-
Pollak, M.1
-
18
-
-
54049108939
-
Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials
-
Rodon J, DeSantos V, Ferry RJ Jr, et al. Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials. Mol Cancer Ther. 2008;7:2575-2588.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2575-2588
-
-
Rodon, J.1
Desantos, V.2
Ferry Jr., R.J.3
-
19
-
-
54249157471
-
Addiction to elevated insulin-like growth factor i receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody
-
Cao L, Yu Y, Darko I, et al. Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody. Cancer Res. 2008;68:8039-8048.
-
(2008)
Cancer Res
, vol.68
, pp. 8039-8048
-
-
Cao, L.1
Yu, Y.2
Darko, I.3
-
20
-
-
68849128275
-
Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
-
Zha J, O'Brien C, Savage H, et al. Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer. Mol Cancer Ther. 2009;8:2110-2121.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2110-2121
-
-
Zha, J.1
O'Brien, C.2
Savage, H.3
-
21
-
-
58249101005
-
The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS- 536924) and rationale for combining with EGFR/HER2 inhibitors
-
Huang F, Greer A, Hurlburt W, et al. The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS- 536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res. 2009;69:161-170.
-
(2009)
Cancer Res
, vol.69
, pp. 161-170
-
-
Huang, F.1
Greer, A.2
Hurlburt, W.3
-
22
-
-
33750453743
-
Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells
-
Byron SA, Horwitz KB, Richer JK, et al. Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells. Br J Cancer. 2006;95:1220-1228.
-
(2006)
Br J Cancer
, vol.95
, pp. 1220-1228
-
-
Byron, S.A.1
Horwitz, K.B.2
Richer, J.K.3
-
23
-
-
67649628084
-
Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression
-
Mukohara T, Shimada H, Ogasawara N, et al. Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression. Cancer Lett. 2009;282:14-24.
-
(2009)
Cancer Lett
, vol.282
, pp. 14-24
-
-
Mukohara, T.1
Shimada, H.2
Ogasawara, N.3
-
24
-
-
84975255462
-
Development and validation of an integrated genomic classifier to predict sensitivity to the IGF-1R/IR tyrosine kinase inhibitor, OSI-906, in colorectal cancer
-
Pitts TM, Tan AC, Kulikowski GN, et al. Development and validation of an integrated genomic classifier to predict sensitivity to the IGF-1R/IR tyrosine kinase inhibitor, OSI-906, in colorectal cancer. Mol Cancer Ther. 2009;8(12 suppl):A39.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.12 SUPPL.
-
-
Pitts, T.M.1
Tan, A.C.2
Kulikowski, G.N.3
-
25
-
-
77953640609
-
Analysis of biomarkers during early phase clinical development of AMG 479, an investigational fully human monoclonal antibody antagonist of type 1 insulin-like growth factor receptor (IGF-1R)
-
McCaffery I, Tolcher A, Puzanov I, et al. Analysis of biomarkers during early phase clinical development of AMG 479, an investigational fully human monoclonal antibody antagonist of type 1 insulin-like growth factor receptor (IGF-1R). J Clin Oncol. 2009;27(15 suppl):Abstract 3545.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
, pp. 3545
-
-
McCaffery, I.1
Tolcher, A.2
Puzanov, I.3
-
26
-
-
35148889523
-
A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors
-
Presented at 2007 ASCO Annual Meeting Proceedings
-
Higano CS, Yu EY, Whiting SH, et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. Presented at 2007 ASCO Annual Meeting Proceedings. J Clin Oncol. 2007;25:3505.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3505
-
-
Higano, C.S.1
Yu, E.Y.2
Whiting, S.H.3
-
27
-
-
73349099049
-
Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
-
Tolcher AW, Sarantopoulos J, Patnaik A, et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol. 2009;27: 5800-5807.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5800-5807
-
-
Tolcher, A.W.1
Sarantopoulos, J.2
Patnaik, A.3
-
28
-
-
35348815620
-
Phase i dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors
-
Haluska P, Shaw HM, Batzel GN, et al. Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res. 2007;13:5834-5840.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5834-5840
-
-
Haluska, P.1
Shaw, H.M.2
Batzel, G.N.3
-
29
-
-
75749102231
-
Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma
-
Haluska P, Worden F, Olmos D, et al. Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma. Cancer Chemother Pharmacol. 2009;65:765-773.
-
(2009)
Cancer Chemother Pharmacol
, vol.65
, pp. 765-773
-
-
Haluska, P.1
Worden, F.2
Olmos, D.3
-
30
-
-
56149086171
-
A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors
-
Atzori F, Tabernero J, Cervantes A, et al. A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors. Clin Oncol. 2008;26(20 suppl):Abstract 3519.
-
(2008)
Clin Oncol
, vol.26
, Issue.20 SUPPL.
, pp. 3519
-
-
Atzori, F.1
Tabernero, J.2
Cervantes, A.3
-
31
-
-
69449099663
-
Phase i dose escalation study of continuous oral dosing of OSI-906, an insulin like growth factor-1 receptor (IGF-1R) tyrosine kinase inhibitor, in patients with advanced solid tumors
-
Lindsay CR, Chan E, Campell S, et al. Phase I dose escalation study of continuous oral dosing of OSI-906, an insulin like growth factor-1 receptor (IGF-1R) tyrosine kinase inhibitor, in patients with advanced solid tumors. J Clin Oncol. 2009;27:Abstract 2559.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2559
-
-
Lindsay, C.R.1
Chan, E.2
Campell, S.3
-
32
-
-
69449097339
-
Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
-
Gualberto A, Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene. 2009;28:3009-3021.
-
(2009)
Oncogene
, vol.28
, pp. 3009-3021
-
-
Gualberto, A.1
Pollak, M.2
-
33
-
-
17544367410
-
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
-
DOI 10.1074/jbc.271.22.12687
-
Pitti RM, Marsters SA, Ruppert S, et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem. 1996;271:12687-12690. (Pubitemid 26175834)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.22
, pp. 12687-12690
-
-
Pitti, R.M.1
Marsters, S.A.2
Ruppert, S.3
Donahue, C.J.4
Moore, A.5
Ashkenazi, A.6
-
34
-
-
13344285339
-
Identification and characterization of a new member of the TNF family that induces apoptosis
-
Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995;3:673-682.
-
(1995)
Immunity
, vol.3
, pp. 673-682
-
-
Wiley, S.R.1
Schooley, K.2
Smolak, P.J.3
-
35
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 2001;15:3059-3087.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
36
-
-
0036598992
-
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
-
Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer. 2002;2:420-430.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 420-430
-
-
Ashkenazi, A.1
-
37
-
-
0030892234
-
Apoptosis by death factor
-
Nagata S. Apoptosis by death factor. Cell. 1997;88:355-365.
-
(1997)
Cell
, vol.88
, pp. 355-365
-
-
Nagata, S.1
-
39
-
-
0030762815
-
An antagonist decoy receptor and a death domain-containing receptor for TRAIL
-
Pan G, Ni J, Wei YF, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science. 1997;277:815-818.
-
(1997)
Science
, vol.277
, pp. 815-818
-
-
Pan, G.1
Ni, J.2
Wei, Y.F.3
-
40
-
-
0030996297
-
The receptor for the cytotoxic ligand TRAIL
-
Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science. 1997;276:111-113.
-
(1997)
Science
, vol.276
, pp. 111-113
-
-
Pan, G.1
O'Rourke, K.2
Chinnaiyan, A.M.3
-
41
-
-
0030792712
-
Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
-
Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science. 1997;277: 818-821.
-
(1997)
Science
, vol.277
, pp. 818-821
-
-
Sheridan, J.P.1
Marsters, S.A.2
Pitti, R.M.3
-
42
-
-
0030880548
-
TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL
-
Walczak H, Degli-Esposti MA, Johnson RS, et al. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 1997;16:5386-5397.
-
(1997)
EMBO J
, vol.16
, pp. 5386-5397
-
-
Walczak, H.1
Ma, D.2
Johnson, R.S.3
-
43
-
-
0037108712
-
Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice
-
Naka T, Sugamura K, Hylander BL, et al. Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. Cancer Res. 2002;62:5800-5806.
-
(2002)
Cancer Res
, vol.62
, pp. 5800-5806
-
-
Naka, T.1
Sugamura, K.2
Hylander, B.L.3
-
44
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
-
Walczak H, Miller RE, Ariail K, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999;5: 157-163.
-
(1999)
Nat Med
, vol.5
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
-
45
-
-
33644832724
-
Targeted induction of apoptosis in cancer management: The emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents
-
Rowinsky EK. Targeted induction of apoptosis in cancer management: the emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents. J Clin Oncol. 2005;23:9394-9407.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9394-9407
-
-
Rowinsky, E.K.1
-
46
-
-
34948894931
-
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/ TRAIL
-
Wagner KW, Punnoose EA, Januario T, et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/ TRAIL. Nat Med. 2007;13:1070-1077.
-
(2007)
Nat Med
, vol.13
, pp. 1070-1077
-
-
Wagner, K.W.1
Punnoose, E.A.2
Januario, T.3
-
47
-
-
52649109485
-
Application of pharmacodynamics assays in a phase Ia trial of Apo2L/TRAIL in patients with advanced tumors
-
Presented at 2007 ASCO Annual Meeting Proceedings
-
Pan Y, Xu R, Peach M, et al. Application of pharmacodynamics assays in a phase Ia trial of Apo2L/TRAIL in patients with advanced tumors. Presented at 2007 ASCO Annual Meeting Proceedings. J Clin Oncol. 2007;25:3535.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3535
-
-
Pan, Y.1
Xu, R.2
Peach, M.3
-
48
-
-
77951923134
-
Biomarkers for predicting the sensitivity of cancer cells to TRAIL-R1 agonistic monoclonal antibody
-
Araki S, Nakayama Y, Hori A, et al. Biomarkers for predicting the sensitivity of cancer cells to TRAIL-R1 agonistic monoclonal antibody. Cancer Lett. 2010;292:269-279.
-
(2010)
Cancer Lett
, vol.292
, pp. 269-279
-
-
Araki, S.1
Nakayama, Y.2
Hori, A.3
-
49
-
-
50349092260
-
A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies
-
Hotte SJ, Hirte HW, Chen EX, et al. A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies. Clin Cancer Res. 2008;14:3450-3455.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3450-3455
-
-
Hotte, S.J.1
Hirte, H.W.2
Chen, E.X.3
-
50
-
-
72449141229
-
Phase i and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors
-
Wakelee HA, Patnaik A, Sikic BI, et al. Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors. Ann Oncol. 2010;21:376-381.
-
(2010)
Ann Oncol
, vol.21
, pp. 376-381
-
-
Wakelee, H.A.1
Patnaik, A.2
Sikic, B.I.3
-
51
-
-
50549105199
-
HGS-ETR1, an antibody targeting TRAIL, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies. Results of a phase i and PK study
-
Presented at 2006 ASCO Annual Meeting Proceedings
-
Chow LQ, Eckhardt SG, Gustafson DL. HGS-ETR1, an antibody targeting TRAIL, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies. Results of a phase I and PK study. Presented at 2006 ASCO Annual Meeting Proceedings. J Clin Oncol. 2006;24:2515.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2515
-
-
Chow, L.Q.1
Eckhardt, S.G.2
Gustafson, D.L.3
-
52
-
-
70349318434
-
Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: Results of a phase i and pharmacokinetic study
-
Leong S, Cohen RB, Gustafson DL, et al. Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study. J Clin Oncol. 2009;27:4413-4421.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4413-4421
-
-
Leong, S.1
Cohen, R.B.2
Gustafson, D.L.3
-
53
-
-
69949110775
-
Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: A phase i study
-
Mom CH, Verweij J, Oldenhuis CN, et al. Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: a phase I study. Clin Cancer Res. 2009;15:5584-5590.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5584-5590
-
-
Ch, M.1
Verweij, J.2
Oldenhuis, C.N.3
-
54
-
-
57049122507
-
A Phase i study with the agonistic TRAIL-R1 antibody, mapatumumab, in combination with gemcitabine and cisplatin
-
Oldenhuis C, Mom C, Sleijfer A, et al. A Phase I study with the agonistic TRAIL-R1 antibody, mapatumumab, in combination with gemcitabine and cisplatin. J Clin Oncol. 2008;26:Abstract 3540.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3540
-
-
Oldenhuis, C.1
Mom, C.2
Sleijfer, A.3
-
55
-
-
45749149222
-
Results of a phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed or refractory colorectal cancer (CRC)
-
Presented at
-
Kanzler S, Trarabach T, Heinemann V, et al. Results of a phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed or refractory colorectal cancer (CRC). Presented at European Cancer Conference. 2005;13:Abstract 630.
-
(2005)
European Cancer Conference
, vol.13
, pp. 630
-
-
Kanzler, S.1
Trarabach, T.2
Heinemann, V.3
-
56
-
-
76349085626
-
Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer
-
Trarbach T, Moehler M, Heinemann V, et al. Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. Br J Cancer. 2010;102:506-512.
-
(2010)
Br J Cancer
, vol.102
, pp. 506-512
-
-
Trarbach, T.1
Moehler, M.2
Heinemann, V.3
-
57
-
-
33751549095
-
Targeting the Hedgehog pathway in cancer
-
Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov. 2006;5:1026-1033.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 1026-1033
-
-
Rubin, L.L.1
De Sauvage, F.J.2
-
58
-
-
9244221172
-
Tissue repair and stem cell renewal in carcinogenesis
-
Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature. 2004;432:324-331.
-
(2004)
Nature
, vol.432
, pp. 324-331
-
-
Beachy, P.A.1
Karhadkar, S.S.2
Berman, D.M.3
-
59
-
-
0242669237
-
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
-
Watkins DN, Berman DM, Burkholder SG, et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature. 2003;422:313-317.
-
(2003)
Nature
, vol.422
, pp. 313-317
-
-
Watkins, D.N.1
Berman, D.M.2
Burkholder, S.G.3
-
60
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell. 1996;85:841-851.
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
-
61
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
-
Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003;425:846-851.
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
-
62
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003;425:851-856.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
-
63
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature. 2004;431:707-712.
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
-
64
-
-
0031913524
-
Activating smoothened mutations in sporadic basal-cell carcinoma
-
Xie J, Murone M, Luoh SM, et al. Activating smoothened mutations in sporadic basal-cell carcinoma. Nature. 1998;391:90-92.
-
(1998)
Nature
, vol.391
, pp. 90-92
-
-
Xie, J.1
Murone, M.2
Luoh, S.M.3
-
65
-
-
33846237601
-
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
-
Clement V, Sanchez P, de Tribolet N, et al. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol. 2007;17:165-172.
-
(2007)
Curr Biol
, vol.17
, pp. 165-172
-
-
Clement, V.1
Sanchez, P.2
De Tribolet, N.3
-
66
-
-
67650289584
-
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
-
Scales SJ, de Sauvage FJ. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009;30:303-312.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 303-312
-
-
Scales, S.J.1
De Sauvage, F.J.2
-
67
-
-
35348837163
-
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
-
Bar EE, Chaudhry A, Lin A, et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells. 2007;25:2524-2533.
-
(2007)
Stem Cells
, vol.25
, pp. 2524-2533
-
-
Bar, E.E.1
Chaudhry, A.2
Lin, A.3
-
68
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
Rudin CM, Hann CL, Laterra J, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med. 2009;361:1173-1178.
-
(2009)
N Engl J Med
, vol.361
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
-
69
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med. 2009;361:1164-1172.
-
(2009)
N Engl J Med
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
Lorusso, P.M.2
Rudin, C.M.3
-
71
-
-
0345601083
-
Met, metastasis, motility and more
-
Birchmeier C, Birchmeier W, Gherardi E, et al. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 2003;4:915-925.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 915-925
-
-
Birchmeier, C.1
Birchmeier, W.2
Gherardi, E.3
-
73
-
-
33746504571
-
Invasive growth: A MET-driven genetic programme for cancer and stem cells
-
Boccaccio C, Comoglio PM. Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer. 2006;6:637-645.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 637-645
-
-
Boccaccio, C.1
Comoglio, P.M.2
-
74
-
-
0034720310
-
The cytokine hepatocyte growth factor/ scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3′ kinase
-
Fan S, Ma YX, Wang JA, et al. The cytokine hepatocyte growth factor/ scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3′ kinase. Oncogene. 2000;19:2212-2223.
-
(2000)
Oncogene
, vol.19
, pp. 2212-2223
-
-
Fan, S.1
Ma, Y.X.2
Wang, J.A.3
-
75
-
-
0037399323
-
The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma
-
Derksen PW, de Gorter DJ, Meijer HP, et al. The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma. Leukemia. 2003;17:764-774.
-
(2003)
Leukemia
, vol.17
, pp. 764-774
-
-
Derksen, P.W.1
De Gorter, D.J.2
Meijer, H.P.3
-
76
-
-
38649119730
-
Signaling networks assembled by oncogenic EGFR and c-Met
-
Guo A, Villen J, Kornhauser J, et al. Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A. 2008;105:692-697.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 692-697
-
-
Guo, A.1
Villen, J.2
Kornhauser, J.3
-
77
-
-
0035102323
-
Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo
-
Xin X, Yang S, Ingle G, et al. Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am J Pathol. 2001;158:1111-1120.
-
(2001)
Am J Pathol
, vol.158
, pp. 1111-1120
-
-
Xin, X.1
Yang, S.2
Ingle, G.3
-
78
-
-
0345722740
-
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas
-
Park WS, Dong SM, Kim SY, et al. Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res. 1999;59:307-310.
-
(1999)
Cancer Res
, vol.59
, pp. 307-310
-
-
Park, W.S.1
Dong, S.M.2
Kim, S.Y.3
-
79
-
-
0031858674
-
Serum hepatocyte growth factor as an index of disease status of patients with colorectal carcinoma
-
Fukuura T, Miki C, Inoue T, et al. Serum hepatocyte growth factor as an index of disease status of patients with colorectal carcinoma. Br J Cancer. 1998;78:454-459.
-
(1998)
Br J Cancer
, vol.78
, pp. 454-459
-
-
Fukuura, T.1
Miki, C.2
Inoue, T.3
-
80
-
-
0034131506
-
Functional expression of HGF and its receptor in human colorectal cancer
-
Otte JM, Schmitz F, Kiehne K, et al. Functional expression of HGF and its receptor in human colorectal cancer. Digestion. 2000;61:237-246. (Pubitemid 30418224)
-
(2000)
Digestion
, vol.61
, Issue.4
, pp. 237-246
-
-
Otte, J.-M.1
Schmitz, F.2
Kiehne, K.3
Stechele, H.U.4
Banasiewicz, T.5
Krokowicz, P.6
Nakamura, T.7
Folsch, U.R.8
Herzig, K.-H.9
-
81
-
-
17344373892
-
Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas
-
Zhuang Z, Park WS, Pack S, et al. Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas. Nat Genet. 1998;20:66-69.
-
(1998)
Nat Genet
, vol.20
, pp. 66-69
-
-
Zhuang, Z.1
Park, W.S.2
Pack, S.3
-
82
-
-
0142248852
-
A novel germline mutation in the MET extracellular domain in a Korean patient with the diffuse type of familial gastric cancer
-
Kim IJ, Park JH, Kang HC, et al. A novel germline mutation in the MET extracellular domain in a Korean patient with the diffuse type of familial gastric cancer. J Med Genet. 2003;40:e97.
-
(2003)
J Med Genet
, vol.40
-
-
Kim, I.J.1
Park, J.H.2
Kang, H.C.3
-
83
-
-
31544462584
-
Somatic mutations lead to an oncogenic deletion of met in lung cancer
-
Kong-Beltran M, Seshagiri S, Zha J, et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res. 2006;66:283-289.
-
(2006)
Cancer Res
, vol.66
, pp. 283-289
-
-
Kong-Beltran, M.1
Seshagiri, S.2
Zha, J.3
-
84
-
-
37149032108
-
A phase II study of the c-Met RTK inhibitor XL880 in patient (pts) with papillary renal-cell carcinoma (PRC)
-
Presented at 2007 ASCO Annual Meeting Proceedings
-
Ross RW, Stein M, Sarantopoulos J, et al. A phase II study of the c-Met RTK inhibitor XL880 in patient (pts) with papillary renal-cell carcinoma (PRC). Presented at 2007 ASCO Annual Meeting Proceedings. J Clin Oncol. 2007;18S(20 suppl):Abstract 15601.
-
(2007)
J Clin Oncol
, vol.18
, Issue.20 SUPPL.
, pp. 15601
-
-
Ross, R.W.1
Stein, M.2
Sarantopoulos, J.3
-
85
-
-
70350140489
-
Clinical activity observed in a phase i dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066
-
Kwak EL, Camidge DR, Clark J, et al. Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J Clin Oncol. 2009;27(15 suppl):Abstract 3509.
-
(2009)
J Clin Oncol
, vol.27
, Issue.115 SUPPL.
, pp. 3509
-
-
Kwak, E.L.1
Camidge, D.R.2
Clark, J.3
-
86
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A. 2007;104:20932-20937.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
87
-
-
68949201629
-
Activating and resistance mutations of EGFR in non-small-cell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors
-
Gazdar AF. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene. 2009;1(28 suppl):S24-S31.
-
(2009)
Oncogene
, vol.1
, Issue.28 SUPPL.
-
-
Gazdar, A.F.1
-
88
-
-
62449250134
-
MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors
-
Kubo T, Yamamoto H, Lockwood WW, et al. MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors. Int J Cancer. 2009;124:1778-1784.
-
(2009)
Int J Cancer
, vol.124
, pp. 1778-1784
-
-
Kubo, T.1
Yamamoto, H.2
Lockwood, W.W.3
-
89
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer. 2007;7:295-308.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
90
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
De Roock W, Piessevaux H, De Schutter J, et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol. 2008;19:508-515.
-
(2008)
Ann Oncol
, vol.19
, pp. 508-515
-
-
De Roock, W.1
Piessevaux, H.2
De Schutter, J.3
-
91
-
-
42149083899
-
Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
-
Barault L, Veyrie N, Jooste V, et al. Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. Int J Cancer. 2008;122:2255-2259.
-
(2008)
Int J Cancer
, vol.122
, pp. 2255-2259
-
-
Barault, L.1
Veyrie, N.2
Jooste, V.3
-
92
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008;359:1757-1765.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
93
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
Lievre A, Bachet JB, Boige V, et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol. 2008;26:374-379.
-
(2008)
J Clin Oncol
, vol.26
, pp. 374-379
-
-
Lievre, A.1
Bachet, J.B.2
Boige, V.3
-
94
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360:563-572.
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
-
95
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2009;27:663-671.
-
(2009)
J Clin Oncol
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
96
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 2003;3:11-22.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
97
-
-
0023256456
-
Prevalence of ras gene mutations in human colorectal cancers
-
Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers. Nature. 1987;327:293-297.
-
(1987)
Nature
, vol.327
, pp. 293-297
-
-
Bos, J.L.1
Fearon, E.R.2
Hamilton, S.R.3
-
98
-
-
0037805547
-
RAS oncogenes: The first 30 years
-
Malumbres M, Barbacid M. RAS oncogenes: the first 30 years. Nat Rev Cancer. 2003;3:459-465.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 459-465
-
-
Malumbres, M.1
Barbacid, M.2
-
99
-
-
36049048292
-
Biochemical and functional characterization of germ line KRAS mutations
-
Schubbert S, Bollag G, Lyubynska N, et al. Biochemical and functional characterization of germ line KRAS mutations. Mol Cell Biol. 2007;27: 7765-7770.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7765-7770
-
-
Schubbert, S.1
Bollag, G.2
Lyubynska, N.3
-
100
-
-
33745307617
-
Ras PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441:424-430.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
101
-
-
0030920821
-
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients
-
Zhu D, Keohavong P, Finkelstein SD, et al. K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients. Cancer Res. 1997;57:2485-2492.
-
(1997)
Cancer Res
, vol.57
, pp. 2485-2492
-
-
Zhu, D.1
Keohavong, P.2
Finkelstein, S.D.3
-
102
-
-
0001674319
-
Randomized doubleblind placebo-controlled trial of the farnesyltransferase inhibitor R115777 (Zarnestra) in advanced refractory colon cancer
-
Cunningham C, de Gramont A, Scheithauer W, et al. Randomized doubleblind placebo-controlled trial of the farnesyltransferase inhibitor R115777 (Zarnestra) in advanced refractory colon cancer. Proc Am Soc Clin Oncol. 2002;21:Abstract 502.
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 502
-
-
Cunningham, C.1
De Gramont, A.2
Scheithauer, W.3
-
103
-
-
1342331479
-
Opinion: Searching for the elusive targets of farnesyltransferase inhibitors
-
Sebti SM, Der CJ. Opinion: searching for the elusive targets of farnesyltransferase inhibitors. Nat Rev Cancer. 2003;3:945-951.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 945-951
-
-
Sebti, S.M.1
Der, C.J.2
-
104
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417:949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
105
-
-
5444227865
-
Guilty as charged: B-RAF is a human oncogene
-
Garnett MJ, Marais R. Guilty as charged: B-RAF is a human oncogene. Cancer Cell. 2004;6:313-319.
-
(2004)
Cancer Cell
, vol.6
, pp. 313-319
-
-
Garnett, M.J.1
Marais, R.2
-
106
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan PT, Garnett MJ, Roe SM, et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004;116:855-867.
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
-
107
-
-
73949134204
-
Quantitative evaluation of CpG island methylation in hyperplastic polyps
-
Vaughn CP, Wilson AR, Samowitz WS: Quantitative evaluation of CpG island methylation in hyperplastic polyps. Mod Pathol. 23:151-156.
-
Mod Pathol
, vol.23
, pp. 151-156
-
-
Vaughn, C.P.1
Wilson, A.R.2
Samowitz, W.S.3
-
108
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F, Martini M, Molinari F, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol. 2008;26:5705-5712.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
109
-
-
73349094741
-
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
-
Laurent-Puig P, Cayre A, Manceau G, et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol. 2009;27:5924-5930.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5924-5930
-
-
Laurent-Puig, P.1
Cayre, A.2
Manceau, G.3
-
110
-
-
75749102647
-
Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
-
Roth AD, Tejpar S, Delorenzi M, et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol. 2010; 28:466-474.
-
(2010)
J Clin Oncol
, vol.28
, pp. 466-474
-
-
Roth, A.D.1
Tejpar, S.2
Delorenzi, M.3
-
111
-
-
77949466716
-
Cetuximab plus FOLFIRI in the treatment of metastatic colorectal cancer (mCRC): The influence of KRAS and BRAF biomarkers on outcome: Updated from the CRYSTAL trial
-
Presented at
-
Cutsem EV, Lang I, Folpretcht G, et al. Cetuximab plus FOLFIRI in the treatment of metastatic colorectal cancer (mCRC): The influence of KRAS and BRAF biomarkers on outcome: Updated from the CRYSTAL trial. Presented at 2010 Gastrointestinal Cancers Symposium. 2010:Abstract 281.
-
(2010)
2010 Gastrointestinal Cancers Symposium
, pp. 281
-
-
Cutsem, E.V.1
Lang, I.2
Folpretcht, G.3
-
112
-
-
77952949918
-
Efficacy of PLX4032, a selective V600EB-Raf inhibitor, as monotherapy or in combination with capecitabine± bevacizumab in a colorectal cancer xenograft model
-
Presented at
-
Kolinsky KD, Su F, Bollag G, et al. Efficacy of PLX4032, a selective V600EB-Raf inhibitor, as monotherapy or in combination with capecitabine± bevacizumab in a colorectal cancer xenograft model. Presented at 2009 Gastrointestinal Cancers Symposium. 2009;Abstract 591.
-
(2009)
2009 Gastrointestinal Cancers Symposium
, pp. 591
-
-
Kolinsky, K.D.1
Su, F.2
Bollag, G.3
-
113
-
-
67651246671
-
Phase i study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer
-
Flaherty K, Puzanov I, Sosman J, et al. Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer. J Clin Oncol. 2009;27(15 suppl):Abstract 9000.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
, pp. 9000
-
-
Flaherty, K.1
Puzanov, I.2
Sosman, J.3
-
114
-
-
68949106943
-
A phase i study of XL281, a selective oral RAF kinase inhibitor, in patients (pts) with advanced solid tumors
-
Schwartz GK, Robertson S, Shen A, et al. A phase I study of XL281, a selective oral RAF kinase inhibitor, in patients (pts) with advanced solid tumors. J Clin Oncol. 2009;27(15 suppl):Abstract 3513.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
, pp. 3513
-
-
Schwartz, G.K.1
Robertson, S.2
Shen, A.3
-
115
-
-
19944422076
-
A phase II trial of ISIS 3521 in patients with metastatic colorectal cancer
-
Marshall JL, Eisenberg SG, Johnson MD, et al. A phase II trial of ISIS 3521 in patients with metastatic colorectal cancer. Clin Colorectal Cancer. 2004; 4:268-274.
-
(2004)
Clin Colorectal Cancer
, vol.4
, pp. 268-274
-
-
Marshall, J.L.1
Eisenberg, S.G.2
Johnson, M.D.3
-
116
-
-
0035992350
-
Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: A National Cancer Institute of Canada clinical trials group study
-
Cripps MC, Figueredo AT, Oza AM, et al. Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study. Clin Cancer Res. 2002;8:2188-2192.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2188-2192
-
-
Cripps, M.C.1
Figueredo, A.T.2
Oza, A.M.3
-
117
-
-
0032984348
-
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
-
Sebolt-Leopold JS, Dudley DT, Herrera R, et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med. 1999;5:810-816.
-
(1999)
Nat Med
, vol.5
, pp. 810-816
-
-
Sebolt-Leopold, J.S.1
Dudley, D.T.2
Herrera, R.3
-
118
-
-
23944439944
-
Phase i and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies
-
LoRusso PM, Adjei AA, Varterasian M, et al. Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies. J Clin Oncol. 2005;23:5281-5293.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5281-5293
-
-
Lorusso, P.M.1
Adjei, A.A.2
Varterasian, M.3
-
119
-
-
14844285975
-
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer
-
Rinehart J, Adjei AA, Lorusso PM, et al. Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol. 2004;22:4456-4462.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4456-4462
-
-
Rinehart, J.1
Adjei, A.A.2
Lorusso, P.M.3
-
120
-
-
10344258041
-
Targeting the mitogen-activated protein kinase cascade to treat cancer
-
Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer. 2004;4:937-947.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 937-947
-
-
Sebolt-Leopold, J.S.1
Herrera, R.2
-
121
-
-
58449129131
-
Clinical aspects of a phase i study of PD-0325901, a selective oral MEK inhibitor, in patients with advanced cancer
-
LoRusso P, Krishnamurthi S, Rinehart J, et al. Clinical aspects of a phase I study of PD-0325901, a selective oral MEK inhibitor, in patients with advanced cancer. Mol. Cancer Ther. 2007;6(3649s):Abstract 113.
-
(2007)
Mol. Cancer Ther
, vol.6
, Issue.3649 S
, pp. 113
-
-
Lorusso, P.1
Krishnamurthi, S.2
Rinehart, J.3
-
122
-
-
31544450194
-
A phase 1-2 clinical study of a second generation oral MEK inhibitor, PD 0325901 in patients with advanced cancer
-
LoRusso P, Krishnamurthi S, Rinehart J, et al. A phase 1-2 clinical study of a second generation oral MEK inhibitor, PD 0325901 in patients with advanced cancer. J Clin Oncol. 2005;23:Abstract 3011.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3011
-
-
Lorusso, P.1
Krishnamurthi, S.2
Rinehart, J.3
-
123
-
-
33947401129
-
Biological characterization of ARRY- 142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor
-
Yeh TC, Marsh V, Bernat BA, et al. Biological characterization of ARRY- 142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin Cancer Res. 2007;13:1576-1583.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1576-1583
-
-
Yeh, T.C.1
Marsh, V.2
Bernat, B.A.3
-
124
-
-
43749103335
-
Phase i pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
-
Adjei AA, Cohen RB, Franklin W, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol. 2008;26:2139-2146.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2139-2146
-
-
Adjei, A.A.1
Cohen, R.B.2
Franklin, W.3
-
125
-
-
84855487013
-
A phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens
-
In press
-
Bennouna J, Lang I, Valladares-Ayerbes M, et al. A phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens. Invest New Drugs. In press.
-
Invest New Drugs
-
-
Bennouna, J.1
Lang, I.2
Valladares-Ayerbes, M.3
-
126
-
-
33244460258
-
Validation and use of a biomarker for clinical development of the MEK1/2 inhibitor ARRY-142886 (AZD6244)
-
Presented at 2005 ASCO Annual Meeting Proceedings
-
Doyle MP, Yeh TC, Suzy B, et al. validation and use of a biomarker for clinical development of the MEK1/2 inhibitor ARRY-142886 (AZD6244). Presented at 2005 ASCO Annual Meeting Proceedings. J Clin Oncol. 2005;23:3075.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3075
-
-
Doyle, M.P.1
Yeh, T.C.2
Suzy, B.3
-
127
-
-
77953623084
-
Members of the non-canonical WNT pathway confer resistance to the MEK 1/2 inhibitor AZD6244 in colorectal cancer (CRC) cell lines
-
Tenter JJ, Nallapreddy S, Tan AC, et al. Members of the non-canonical WNT pathway confer resistance to the MEK 1/2 inhibitor AZD6244 in colorectal cancer (CRC) cell lines. Mol Cancer Ther. 2009;8(12 suppl):A38.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.12 SUPPL.
-
-
Tenter, J.J.1
Nallapreddy, S.2
Tan, A.C.3
-
128
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, et al. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005;4:988-1004.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
-
129
-
-
68249093818
-
Targeting the phosphoinositide 3-kinase pathway in cancer
-
Liu P, Cheng H, Roberts TM, et al. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009;8:627-644.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 627-644
-
-
Liu, P.1
Cheng, H.2
Roberts, T.M.3
-
130
-
-
13944284494
-
Oncogenic mutations of PIK3CA in human cancers
-
Samuels Y, Velculescu VE. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle. 2004;3:1221-1224.
-
(2004)
Cell Cycle
, vol.3
, pp. 1221-1224
-
-
Samuels, Y.1
Velculescu, V.E.2
-
131
-
-
23844445836
-
Colorectal cancer: Mutations in a signalling pathway
-
Parsons DW, Wang TL, Samuels Y, et al. Colorectal cancer: mutations in a signalling pathway. Nature. 2005;436:792.
-
(2005)
Nature
, vol.436
, pp. 792
-
-
Parsons, D.W.1
Wang, T.L.2
Samuels, Y.3
-
132
-
-
70350176755
-
A phase i dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765, a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced solid tumors
-
Lo Russo PM, Markman B, Tabernero J, et al. A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765, a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced solid tumors. J Clin Oncol. 2009;27(15 suppl):Abstract 3502.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
, pp. 3502
-
-
Lo Russo, P.M.1
Markman, B.2
Tabernero, J.3
-
133
-
-
76749171098
-
Phase i dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors
-
Shapiro GI, Kwak EL, Baselga J, et al. Phase I dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors. J Clin Oncol. 2009;27(15 suppl):Abstract 3500.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
, pp. 3500
-
-
Shapiro, G.I.1
Kwak, E.L.2
Baselga, J.3
-
134
-
-
76749136608
-
A first-in-human phase i study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors
-
Wagner AJ, Von Hoff DD, Lo Russo PM, et al. A first-in-human phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors. J Clin Oncol. 2009;27(15 suppl):Abstract 3501.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
, pp. 3501
-
-
Wagner, A.J.1
Von Hoff, D.D.2
Lo Russo, P.M.3
-
135
-
-
67649814136
-
PI3K/PTEN signaling in angiogenesis and tumorigenesis
-
Jiang BH, Liu LZ. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res. 2009;102:19-65.
-
(2009)
Adv Cancer Res
, vol.102
, pp. 19-65
-
-
Jiang, B.H.1
Liu, L.Z.2
-
136
-
-
0141919562
-
PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells
-
Zhou M, Gu L, Findley HW, et al. PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells. Cancer Res. 2003;63:6357-6362.
-
(2003)
Cancer Res
, vol.63
, pp. 6357-6362
-
-
Zhou, M.1
Gu, L.2
Findley, H.W.3
-
137
-
-
0035914258
-
Cross-talk between signalling pathways and the multidrug resistant protein MDR-1
-
Ding S, Chamberlain M, McLaren A, et al. Cross-talk between signalling pathways and the multidrug resistant protein MDR-1. Br J Cancer. 2001; 85:1175-1184.
-
(2001)
Br J Cancer
, vol.85
, pp. 1175-1184
-
-
Ding, S.1
Chamberlain, M.2
McLaren, A.3
-
138
-
-
70449518977
-
Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway
-
Tang J, Wang J, Kong X, et al. Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway. Exp Cell Res. 2009;315:3521-3531.
-
(2009)
Exp Cell Res
, vol.315
, pp. 3521-3531
-
-
Tang, J.1
Wang, J.2
Kong, X.3
-
139
-
-
70349758510
-
Src kinases as therapeutic targets for cancer
-
Kim LC, Song L, Haura EB. Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol. 2009;6:587-595.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 587-595
-
-
Kim, L.C.1
Song, L.2
Haura, E.B.3
-
140
-
-
0036544562
-
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling
-
Eliceiri BP, Puente XS, Hood JD, et al. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002;157:149-160.
-
(2002)
J Cell Biol
, vol.157
, pp. 149-160
-
-
Eliceiri, B.P.1
Puente, X.S.2
Hood, J.D.3
-
141
-
-
34548065791
-
Non-receptor protein-tyrosine kinases as molecular targets for antiangiogenic therapy (Review)
-
Kanda S, Miyata Y, Kanetake H, et al. Non-receptor protein-tyrosine kinases as molecular targets for antiangiogenic therapy (Review). Int J Mol Med. 2007;20:113-121.
-
(2007)
Int J Mol Med
, vol.20
, pp. 113-121
-
-
Kanda, S.1
Miyata, Y.2
Kanetake, H.3
-
142
-
-
0028865988
-
Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression
-
Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res. 1995;55:6161-6165.
-
(1995)
Cancer Res
, vol.55
, pp. 6161-6165
-
-
Mukhopadhyay, D.1
Tsiokas, L.2
Sukhatme, V.P.3
-
143
-
-
0023522557
-
Analysis of pp60(c-src) in human colon carcinoma and normal human colon mucosal cells
-
Bolen JB, Veillette A, Schwartz AM, et al. Analysis of pp60c-src in human colon carcinoma and normal human colon mucosal cells. Oncogene Res. 1987;1:149-168. (Pubitemid 18072623)
-
(1987)
Oncogene Research
, vol.1
, Issue.2
, pp. 149-168
-
-
Bolen, J.B.1
Veillette, A.2
Schwartz, A.M.3
Deseau, V.4
Rosen, N.5
-
144
-
-
0027469402
-
Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer
-
Talamonti MS, Roh MS, Curley SA, et al. Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J Clin Invest. 1993;91:53-60.
-
(1993)
J Clin Invest
, vol.91
, pp. 53-60
-
-
Talamonti, M.S.1
Roh, M.S.2
Curley, S.A.3
-
146
-
-
0037080135
-
Activation of Src kinase in primary colorectal carcinoma: An indicator of poor clinical prognosis
-
Aligayer H, Boyd DD, Heiss MM, et al. Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer. 2002;94:344-351.
-
(2002)
Cancer
, vol.94
, pp. 344-351
-
-
Aligayer, H.1
Boyd, D.D.2
Heiss, M.M.3
-
147
-
-
77953636968
-
Inhibition of colon tumor metastasis in an orthotopic nude mouse model with the dual selective Src/Abl kinase inhibitor, AZD0530
-
Presented at 2007 ASCO Annual Meeting Proceedings
-
Phillips K, Parikh N, Kuwai T, et al. Inhibition of colon tumor metastasis in an orthotopic nude mouse model with the dual selective Src/Abl kinase inhibitor, AZD0530. Presented at 2007 ASCO Annual Meeting Proceedings. J Clin Oncol. 2007;18S:14032.
-
(2007)
J Clin Oncol
, vol.18 S
, pp. 14032
-
-
Phillips, K.1
Parikh, N.2
Kuwai, T.3
-
148
-
-
20444500171
-
SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models
-
Golas JM, Lucas J, Etienne C, et al. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res. 2005;65:5358-5364.
-
(2005)
Cancer Res
, vol.65
, pp. 5358-5364
-
-
Golas, J.M.1
Lucas, J.2
Etienne, C.3
-
149
-
-
37549004527
-
Bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor: Preliminary results from a phase 1 study in patients with advanced malignant solid tumors
-
Presented at 2007 ASCO Annual Meeting Proceedings
-
Messersmith WA, Krishnamurthi S, Hewes BA, et al. Bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor: preliminary results from a phase 1 study in patients with advanced malignant solid tumors. Presented at 2007 ASCO Annual Meeting Proceedings. J Clin Oncol. 2007;18S:3552.
-
(2007)
J Clin Oncol
, vol.18 S
, pp. 3552
-
-
Messersmith, W.A.1
Krishnamurthi, S.2
Hewes, B.A.3
-
150
-
-
70349673597
-
Phase i dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors
-
Demetri GD, Lo Russo P, MacPherson IR, et al. Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors. Clin Cancer Res. 2009;15:6232-6240.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6232-6240
-
-
Demetri, G.D.1
Lo Russo, P.2
MacPherson, I.R.3
-
151
-
-
0020621890
-
Aberration of poly(adenosine diphosphateribose) metabolism in human colon adenomatous polyps and cancers
-
Hirai K, Ueda K, Hayaishi O. Aberration of poly(adenosine diphosphateribose) metabolism in human colon adenomatous polyps and cancers. Cancer Res. 1983;43:3441-3446.
-
(1983)
Cancer Res
, vol.43
, pp. 3441-3446
-
-
Hirai, K.1
Ueda, K.2
Hayaishi, O.3
-
152
-
-
0025770287
-
Enhanced expression of poly(ADPribose) synthetase gene in malignant lymphoma
-
Tomoda T, Kurashige T, Moriki T, et al. Enhanced expression of poly(ADPribose) synthetase gene in malignant lymphoma. Am J Hematol. 1991;37: 223-227.
-
(1991)
Am J Hematol
, vol.37
, pp. 223-227
-
-
Tomoda, T.1
Kurashige, T.2
Moriki, T.3
-
153
-
-
0018149712
-
Synthesis of DNA and poly(adenosine diphosphate ribose) in normal and chronic lymphocytic leukemia lymphocytes
-
Berger NA, Adams JW, Sikorski GW, et al. Synthesis of DNA and poly(adenosine diphosphate ribose) in normal and chronic lymphocytic leukemia lymphocytes. J Clin Invest. 1978;62:111-118.
-
(1978)
J Clin Invest
, vol.62
, pp. 111-118
-
-
Berger, N.A.1
Adams, J.W.2
Sikorski, G.W.3
-
154
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009;361:123-134.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
-
155
-
-
73449091519
-
DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome
-
Poulogiannis G, Frayling IM, Arends MJ: DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome. Histopathology. 56:167-179.
-
Histopathology
, vol.56
, pp. 167-179
-
-
Poulogiannis, G.1
Frayling, I.M.2
Arends, M.J.3
-
156
-
-
30944446883
-
Lessons from phase III clinical trials on anti-VEGF therapy for cancer
-
Jain RK, Duda DG, Clark JW, et al. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol. 2006;3:24-40.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 24-40
-
-
Jain, R.K.1
Duda, D.G.2
Clark, J.W.3
-
157
-
-
36048992408
-
Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
-
Saltz LB, Rosen LS, Marshall JL, et al. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol. 2007;25:4793-4799.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4793-4799
-
-
Saltz, L.B.1
Rosen, L.S.2
Marshall, J.L.3
|