Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2

Cellular and Molecular Life Sciences

Volumn 68, Issue 16, 2011, Pages 2769-2784

  Chou, Shang Min ^a   Huang, Ting Hsiang ^a   Chen, Hsiang Chin ^a   Li, Tsai Kun ^a,b  

^a School of Medicine   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Calcium; Calpain; Nucleocytoplasmic shuttling; Proteolysis; Topoisomerase

Indexed keywords

CALPAIN 2; DNA TOPOISOMERASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM TRANSPORT; CELL FRACTIONATION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DNA CLEAVAGE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PROTEIN DEGRADATION; RNA INTERFERENCE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; CALCIUM; CALCIUM-BINDING PROTEINS; CALPAIN; CAMPTOTHECIN; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; DNA TOPOISOMERASES, TYPE I; GENE KNOCKDOWN TECHNIQUES; HUMANS; IONOMYCIN; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PHOSPHOPROTEINS; RNA-BINDING PROTEINS;

EID: 79960951874     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0591-4     Document Type: Article

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