Regulation of fat storage and reproduction by Krüppel-like transcription factor KLF3 and fat-associated genes in Caenorhabditis elegans

Journal of Molecular Biology

Volumn 411, Issue 3, 2011, Pages 537-553

  Zhang, Jun ^a   Bakheet, Razan ^a,d   Parhar, Ranjit S ^a,d   Huang, Cheng Han ^a   Hussain, M Mahmood ^b   Pan, Xiaoyue ^b   Siddiqui, Shahid S ^c   Hashmi, Sarwar ^a  

^a NEW YORK BLOOD CENTER   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

C. elegans; genetic interaction; Kr ppel like transcription factors; lipid metabolism; oxidation

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A OXIDASE; KRUPPEL LIKE FACTOR; LONG CHAIN FATTY ACID COENZYME A LIGASE; PROTEIN KLF3; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACS 1 GENE; ACS 2 GENE; ARTICLE; CAENORHABDITIS ELEGANS; CYTOSOL; FAT 7 GENE; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FERTILITY; GENE; GENE INTERACTION; GENE MUTATION; INTESTINE; KLF 3 GENE; LARVAL DEVELOPMENT; LIPID METABOLISM; LIPID STORAGE; METABOLIC REGULATION; MITOCHONDRION; MUTANT; NONHUMAN; PEROXISOME; PHENOTYPE; PRIORITY JOURNAL; REPRODUCTION; RNA INTERFERENCE;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 79960929525     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.06.011     Document Type: Article

References (49)

1. Bhathena S.J. Relationship between fatty acids and the endocrine system Biofactors 13 2000 35 39 (Pubitemid 32107342)
2. Agatha G., Hafer R., and Zintl F. Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia Cancer Lett. 173 2001 139 144 (Pubitemid 32971931)
3. Ntambi M., Miyazaki M., and Dobrzyn A. Regulation of stearoyl-CoA desaturase expression Lipids 39 2004 1061 1065 (Pubitemid 40129048)
4. Schwartz W., Woods C., Porte D. Jr, Seeley J., and Baskin D.G. Central nervous system control of food intake Nature 404 2000 661 671 (Pubitemid 30205071)
5. Reddy J.K., and Hashimoto T. Peroxisomal beta-oxidation and peroxisome proliferators-activated receptor alpha: an adaptive metabolic system Annu. Rev. Nutr. 21 2001 193 230 (Pubitemid 32695270)
6. Turner J., and Crossley M. Mammalian Krüppel-like transcription factors: more than just a pretty finger Trends Biochem. Sci. 24 1999 236 240
7. van Vliet J., Crofts A., Quinlan G., Czolij R., Perkins C., and Crossley M. Human KLF17 is a new member of the Sp/KLF family of transcription factors Genomics 87 2006 474 482
8. Wu J., Srinivasan V., Neumann C., and Lingrel J.B. The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes Biochemistry 44 2005 11098 11105.8
9. Li D., Yea S., Li S., Chen Z., Narla G., and Banck M. Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1 J. Biol. Chem. 280 2005 26941 26952 (Pubitemid 41040730)
10. Birsoy K., Chen Z., and Friedman J. Transcriptional regulation of adipogenesis by KLF4 Cell Metab. 7 2008 339 347 (Pubitemid 351455215)
11. Mori T., Sakaue H., Iguchi H., Gomi H., Okada Y., and Takashima Y. Role of Krüppel-like transcription factor 15 (KLF15) in transcriptional regulation of adipogenesis J. Biol. Chem. 280 2005 12867 12875
12. Sue N., Jack B.H., Eaton S.A., Pearson R.C., Funnell A.P., and Turner J. Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis Mol. Cell. Biol. 28 2008 3967 3978 (Pubitemid 351812983)
13. The MuTHER Consortium The GIANT Consortium The MAGIC Investigators The DIAGRAM Consortium Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes Nat. Genet. 43 2011 561 564
14. Hashmi S., Ji Q., Zhang J., Parhar R., Huang C.H., Brey C., and Gaugler R. A Krüppel-like factor in Caenorhabditis elegans with essential roles in fat regulation, cell death and phagocytosis DNA Cell Biol. 27 2008 545 551
15. Zhang J., Yang C., Brey C., Rodriguez M., Oksov Y., and Gaugler R. Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition Exp. Cell Res. 315 2009 2568 2580
16. Brey C., Nelder M., Gaugler R., and Hashmi S. Krüppel-like family of transcription factors: an emerging new frontier in lipid biology Int. J. Biol. Sci. 5 2009 622 636
17. White J. The anatomy W.B. Wood, The Nematode Caenorhabditis elegans 1988 Cold Spring Harbor Laboratory Cold Spring Harbor, NY 81 122
18. McKay J.P., Raizen D.M., Gottschalk A., Schafer W.R., and Avery L. Eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx Genetics 166 2004 161 169 (Pubitemid 38364711)
19. Zhang O., Box C., Xu N., Le Men J., Yu J., and Guo F. Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans Proc. Natl Acad. Sci. USA 107 2010 4640 4645
20. Soukas A., Socci N.D., Saatkamp B.D., Novelli S., and Friedman J.M. Distinct transcriptional profiles of adipogenesis in vivo and in vitro J. Biol. Chem. 276 2001 34167 34174
21. Mak Y., Nelson S., Basson M., Johnson D., and Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage Nat. Genet. 38 2006 363 368
22. Grant B., and Hirsh D. Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte Mol. Biol. Cell. 10 1999 4311 4326
23. Sundaram M., and Greenwald I. Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans Genetics 135 1993 765 783 (Pubitemid 23324820)
24. Van Gilst M.R., Hadjivassiliou H., Jolly A., and Yamamoto K.R. Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans PLoS Biol. 3 2005 301 312
25. Sonnichsen B., Koski L.B., Walsh A., Marschall P., Neumann B., and Brehm M. Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans Nature 434 2005 462 469 (Pubitemid 40477050)
26. Horvitz H.R., and Sulston J. Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans Genetics 96 1980 435 454
27. Brock T.J., Browse J., and Watts J.L. Genetic regulation of unsaturated fatty acid composition in C. elegans PLoS Genet. 2 2006 997 1005
28. Ntambi J.M. The regulation of stearoyl-CoA desaturase (SCD) Prog. Lipid Res. 34 1995 139 150
29. Dobrzyn P., Dobrzyn A., Miyazaki M., Cohen P., Asilmaz E., and Hardie D.G. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver Proc. Natl Acad. Sci. USA 101 2004 6409 6414 (Pubitemid 38585987)
30. Gurvitz A., Langer S., Piskacek M., Hamilton B., Ruis H., and Hartig A. Predicting the function and sub-cellular location of Caenorhabditis elegans proteins similar to Saccharomyces cerevisiae beta-oxidation enzymes Yeast 17 2000 188 200
31. Osumi T., Hashimoto T., and Ui N. Purification and properties of acyl-CoA oxidase from rat liver J. Biochem. 87 1980 1735 1746
32. Watts J.L., and Browse J. A palmitoyl-CoA-specific Δ9 Biochem. Biophys. Res. Commun. 272 2000 263 269
33. Cohen P., and Friedman J.M. Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1) J. Nutr. 134 2004 2455S 2463S (Pubitemid 39201621)
34. Cohen P., Ntambi J.M., and Friedman J.M. Stearoyl-CoA desaturase-1 and the metabolic syndrome Endocr. Metab. Disord. 3 2003 271 280
35. Faust I.M., Johnson P.R., Stern J.S., and Hirsch J. Diet induced adipocyte number increase in adult rats: a new model of obesity Am. J. Physiol. 235 1978 E279 E286
36. Rodeheffer S., Birsoy K., and Friedman J.M. Identification of white adipocyte progenitor cells in vivo Cell 135 2008 240 249
37. Reddy K., and Mannaerts G.P. Peroximal lipid metabolism Annu. Rev. Nutr. 14 1994 343 370
38. Sulston J., and Hodgkin J. Method W.B. Wood, The Nematode Caenorhabditis elegans 1998 Cold Spring Harbor Laboratory Cold Spring Harbor, NY 587 606
39. Brenner S. The genetics of Caenorhabditis elegans Genetics 77 1974 71 94
40. Mello C.C., Kramer J.M., Stinchcomb D., and Ambros V. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences EMBO J. 10 1991 3959 3970 (Pubitemid 21905425)
41. Kimura K.D., Tissenbaum H.A., Liu Y., and Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans Science Y277 1997 942 946 (Pubitemid 27366677)
42. Ogg S., Paradis S., Gottlieb S., Patterson G.I., Lee L., Tissenbaum H.A., and Ruvkun G. The Forkhead transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature 389 1997 994 999 (Pubitemid 27485694)
43. Ashrafi K., Chang Y., Watts L., Fraser G., Kamath S., Ahringer J., and Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes Nature 421 2003 268 272 (Pubitemid 36139130)
44. Mullaney B.C., Blind R.D., Lemieux G.A., Perez C.L., Elle I.C., and Faergeman N.J. Regulation of C. elegans fat uptake and storage by acyl CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25 Cell Metab. 12 2010 398 410
45. Soukas A., Kane A., Carr E., Mello A., and Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans Genes Dev. 23 2009 496 511
46. 4-induced steatosis J. Biol. Chem. 282 2007 17078 17089 (Pubitemid 47093224)
47. Hashmi S., Zhang J., Oksov Y., and Lustigman S. The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development J. Biol. Chem. 279 2004 6035 6045 (Pubitemid 38220636)
48. Tabara H., Grishok A., and Mello C.C. RNAi in C. elegans: soaking in the genome sequence Science 282 1998 430 431 (Pubitemid 28483660)
49. You J., Kim J., Raizen M., and Avery L. Insulin, cGMP, and TGF-β signals regulate food intake and quiescence in C. elegans: a model for satiety Cell Metab. 7 2008 249 257 (Pubitemid 351285528)