The fission yeast git5 gene encodes a Gβ subunit required for glucose- triggered adenylate cyclase activation

Genetics

Volumn 154, Issue 4, 2000, Pages 1463-1471

  Landry, Sheila ^a   Pettit, Maria T ^a,b   Apolinario, Ethel ^a,c   Hoffman, Charles S ^a  

^a BOSTON COLLEGE   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; ENZYME ACTIVATION; GENE DISRUPTION; GENE SEQUENCE; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; SEXUAL DEVELOPMENT; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; BASE SEQUENCE; CLONING, MOLECULAR; CODON; CYCLIC AMP; DNA PRIMERS; DNA, RECOMBINANT; ENZYME ACTIVATION; GLUCOSE; GTP-BINDING PROTEIN BETA SUBUNITS; HETEROTRIMERIC GTP-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PHENOTYPE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

MAMMALIA; SCHIZOSACCHAROMYCES POMBE;

EID: 0034075620     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. + gene as a new selectable marker for molecular genetic studies. Curr. Genet. 24: 491-495.
2. AUSUBEL, F. M., R. BRENT, R. E. KINGSTON, D. D. MOORE, J. G. SEIDMAN et al. 1998 Current Protocols in Molecular Biology. Wiley-Interscience, New York.
3. BYRNE, S. M., and C. S. HOFFMAN, 1993 Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe. J. Cell Sci. 105: 1095-1100.
4. CLAPHAM, D. E., and E. J. NEER, 1993 New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature 365: 403-406.
5. DAL SANTO, P., B. BLANCHARD and C. S. HOFFMAN, 1996 The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways. J. Cell Sci. 109: 1919-1925.
6. FEDERMAN, A. D., B. R. CONKLIN, K. A. SCHRADER, R. R. REED and H. R. BOURNE, 1992 Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature 356: 159-161.
7. GAO, B. N., and A. G. GILMAN. 1991 Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc. Natl. Natl. Acad. Sci. USA 88: 10178-10182.
8. GARCIA-HIGUERA, I., J. FENOGLIO, Y. LI, C. LEWIS, M. P. PANCHENKO et al., 1996 Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit. Biochemistry 35: 13985-13994.
9. GARRITSEN, A., P. J. VAN GALEN and W. F. SIMONDS, 1993 The N-terminal coiled-coil domain of beta is essential for gamma association: a model for G-protein beta gamma subunit interaction. Proc. Natl. Acad. Sci. USA 90: 7706-7710.
10. GILMAN, A. G., 1984 G proteins and dual control of adenylate cyclase. Cell 36: 577-579.
11. GILMAN, A. G., 1987 G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56: 615-649.
12. GUTZ, H., H. HESLOT, U. LEUPOLD and N. LOPRIENO, 1974 Schizosaccharomyces pombe, pp. 395-446 in Handbook of Genetics, edited by R. C. KING. Plenum, New York.
13. HOFFMAN, C. S., and H. WINSTON, 1990 Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe. Genetics 124: 807-816.
14. HOFFMAN, C. S., and F. WINSTON, 1991 Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway. Genes Dev. 5: 561-571.
15. ISSHIKI, T., N. MOCHIZUKI, T. MAEDA and M. YAMAMOTO, 1992 Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition. Genes Dev. 6: 2455-2462.
16. JIN, M., M. FUJITA, B. M. CULLEY, E. APOLINARIO, M. YAMAMOTO et al., 1995 sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase. Genetics 140: 457-467.
17. KAWAMUKAI, M., K. FERGUSON, M. WIGLER and D. YOUNG, 1991 Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Cell Regul. 2: 155-164.
18. KIM, D. U., S. K. PARK, K. S. CHUNG, M. U. CHOI and H. S. YOO, 1996 The G protein beta subunit Gpb1 of Schizosaccharomyces pombe is a negative regulator of sexual development. Mol. Gen. Genet. 252: 20-32.
19. KOHLI, J., 1987 Genetic nomenclature and gene list of the fission yeast Schizosaccharomyces pombe. Curr. Genet. 11: 575-589.
20. LAMBRIGHT, D. G., J. SONDEK, A. BOHM, N. P. SKIBA, H. E. HAMM et al., 1996 The 2.0 A crystal structure of a heterotrimeric G protein. Nature 379: 311-319.
21. LEVITZKI, A., and A. BAR-SINAI, 1991 The regulation of adenylyl cyclase by receptor-operated G proteins. Pharmacol. Ther. 50: 271-283.
22. MAEDA, T., N. MOCHIZUKI and M. YAMAMOTO, 1990 Adenylyl cyclase is dispensable for vegetative cell growth in the fission yeast Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 87: 7814-7818.
23. MAEDA, T., Y. WATANABE, H. KUNITOMO and M. YAMAMOTO, 1994 cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe. J. Biol. Chem. 269: 9632-9637.
24. + gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. EMBO J. 6: 729-736.
25. MOCHIZUKI, N., and M. YAMAMOTO, 1992 Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast. Mol. Gen. Genet. 233: 17-24.
26. MOLZ, L., R. BOOHER, P. YOUNG and D. BEACH 1989 cdc2 and the regulation of mitosis: six interacting mcs genes. Genetics 122: 773-782.
27. NOCERO, M., T. ISSHIKI, M. YAMAMOTO and C. S. HOFTMAN, 1994 Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8). Genetics 138: 39-45.
28. NOMOTO, S., N. NAKAYAMA, K. ARAI and K. MATSUMOTO, 1990 Regulation of the yeast pheromone response pathway by G protein subunits. EMBO J. 9: 691-696.
29. OBARA, T., M. NAKAFUKU, M. YAMAMOTO and Y. KAZIRO, 1991 Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: involvement in mating and sporulation pathways. Proc. Natl. Acad. Sci. USA 88: 5877-5881.
30. PELLEGRINO, S., S. ZHANG, A. GARRITSEN and W. F. SIMONDS, 1997 The coiled-coil region of the G protein beta subunit. Mutational analysis of G gamma and effector interactions. J. Biol. Chem. 272: 25360-25366.
31. PIDOUX, A. L., M. LEDIZET and W. Z. CANDE. 1996. Fission yeast pkl1 is a kinesin-related protein involved in mitotic spindle function. Mol. Biol. Cell 7: 1639-1655.
32. SIMON, M. I., M. P. STRATHMANN and N. GAUTAM, 1991 Diversity of G proteins in signal transduction. Science 252: 802-808.
33. SONDEK, J., A. BOHM, D. G. LAMBRIGHT, H. E. HAMM and P. B. SIGLER, 1996 Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature 379: 369-:374.
34. STERNWEIS, P. C., 1994 The active role of beta gamma in signal transduction. Curr. Opin. Cell Biol. 6: 198-203.
35. TANG, W. J., and A. G. GILMAN, 1991 Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science 254: 1500-1503.
36. THOMPSON, J. D., D. G. HIGGINS and T. J. GIBSON, 1994 CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22: 4673-4680.
37. WALL, M. A., D. E. COLEMAN, E. LEE, J. A. INIGUEZ-LLUHI, B. A. POSNER et al., 1995 The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell 83: 1047-1058.
38. WATANABE, Y., Y. LINO, K. FURUHATA, C. SHIMODA and M. YAMAMOTO, 1988 The S. pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP. EMBO J. 7: 761-767.
39. WHITEWAY, M., L. HOUGAN, D. DIGNARD, L. BELL, G. SAARI et al., 1988 Function of the STE4 and STE18 genes in mating pheromone signal transduction in Saccharomyces cerevisiae. Cold Spring Harbor Symp. Quant. Biol. 53: 585-590.
40. YAMAWAKI-KATAOKA, Y., T. TAMAOKI, H. R. CHOE, H. TANAKA and T. KATAOKA, 1989 Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae. Proc. Nat. Acad. Sci. USA 86: 5693-5697.
41. YOUNG, D., M. RIGGS, J. FIELD, A. VOJTEK, D. BROEK et al., 1989 The adenylyl cyclase gene from Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 86: 7989-7993.