Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1518, Issue 1-2, 2001, Pages 27-35

  Cherry, James A ^a   Thompson, Barbara E ^a   Pho, Vanee ^a  

^a BOSTON UNIVERSITY   (United States)

Author keywords

Diazepam; Enzyme kinetics; Phosphodiesterase inhibitor; Rolipram; Type IV phosphodiesterase

Indexed keywords

CYCLIC AMP; DIAZEPAM; ISOENZYME; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DNA LIBRARY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBUNIT; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; KIDNEY CELL; MICHAELIS CONSTANT; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; CYCLIC AMP; DIAZEPAM; DNA, COMPLEMENTARY; HUMANS; IMMUNOBLOTTING; MICE; MILRINONE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PURINONES; RATS; ROLIPRAM; SEQUENCE HOMOLOGY, AMINO ACID;

MAMMALIA;

EID: 0035911641     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4781(01)00164-6     Document Type: Article

References (45)

1. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
2. Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts
3. Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene
4. Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases
5. Differential modulation of tissue function and the therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isozymes
6. The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: Intracellular targeting regulation and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions
7. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors
8. Rat homologs of the Drosophila dunce gene code for cyclic AMP phosphodiesterases sensitive to rolipram and RO 20-1724
9. A cyclic AMP-specific phosphodiesterase expressed in yeast
10. Results of a phase II study of the antidepressant effect of rolipram
11. A multicenter double-blind study of three different doses of the new cAMP-phosphodiesterase inhibitor rolipram in patients with major depressive disorder
12. Effects of therapeutic agents on cyclic AMP metabolism in vitro
13. Regional cyclic nucleotide phosphodiesterase activity in cat central nervous system: Effects of benzodiazepines
14. Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor
15. Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase
16. Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene
17. Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement movement and affect
18. A mouse homolog of dunce a gene important for learning and memory in Drosophila is preferentially expressed in olfactory receptor neurons
19. An improved assay of cyclic 3′5′-nucleotide phosphodiesterases with QAE-Sephadex columns
20. Multiple cyclic nucleotide phosphodiesterase activities from rat brain
21. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
22. Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2
23. Physical mapping and promoter structure of the murine cAMP-specific phosphodiesterase pde4a gene
24. Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species
25. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3
26. Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram
27. Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum
28. Isolation and characterization of cDNAs corresponding to two human calcium calmodulin-regulated 3′ 5′-cyclic nucleotide phosphodiesterases
29. The determination of enzyme inhibitor constant
30. 50) of an enzymatic reaction
31. Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice
32. The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram
33. Effects of rolipram, a novel antidepressant, on monoamine metabolism in rat brain
34. Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors
35. Clinical and biochemical effects of the selective phosphodiesterase inhibitor rolipram in depressed inpatients controlled by determination of plasma level
36. Pharmacokinetics of (+)-rolipram and (-)-rolipram in healthy volunteers
37. Pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differences
38. Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy
39. High dose diazepam in schizophrenia
40. Massive benzodiazepine requirements during acute alcohol withdrawal
41. Comparison of single- and repeated-dose pharmacokinetics of diazepam
42. The pathomorphology of schizophrenia and mood disorders: Similarities and differences
43. Functional neuropathology in Parkinson's disease