Synthesis and biological evaluation of novel F-18 labeled pyrazolo[1,5-a]pyrimidine derivatives: Potential PET imaging agents for tumor detection

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4736-4741

  Xu, Jingli ^a   Liu, Hang ^a   Li, Guixia ^a   He, Yong ^a   Ding, Rui ^a   Wang, Xiao ^a   Feng, Man ^a   Zhang, Shuting ^a   Chen, Yurong ^a   Li, Shilei ^a   Zhao, Mingxia ^a   Qi, Chuanmin ^a   Dang, Yonghong ^b  

^a BEIJING NORMAL UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

F 18 labeled; PET imaging agents; Pyrazolo 1,5 a pyrimidine derivatives; Tumor detection

Indexed keywords

7 [2 (FLUORINE 18)FLUOROETHYLAMINO] 5 METHYLPYRAZOLO[1,5-A]PYRIMIDINE 3 CARBONITRILE; CONTRAST MEDIUM; FLUORINE 18; N[(2 (3 CYANO 5 METHYLPYRAZOLO[1,5-A]PYRIMIDIN 7 YLAMINO)ETHYL)] 2 (FLUORINE 18)FLUORO 4 NITROBENZAMIDE; PYRAZOLO[1,5-A]PYRIMIDINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DESIGN; DRUG DISCRIMINATION; DRUG DISTRIBUTION; DRUG LABELING; DRUG PURIFICATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TUMOR LEVEL; DRUG UPTAKE; EX VIVO STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; NUCLEOPHILICITY; POSITRON EMISSION TOMOGRAPHY; SUBSTITUTION REACTION;

ANIMALS; FLUORINE RADIOISOTOPES; MICE; MOLECULAR CONFORMATION; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; STEREOISOMERISM; TISSUE DISTRIBUTION;

ANIMALIA; MUS;

EID: 79960904304     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.072     Document Type: Article

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