Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and l-carnitine: Implications in cardiovascular and non-alcoholic fatty liver diseases

Food and Chemical Toxicology

Volumn 49, Issue 9, 2011, Pages 2453-2458

  Kang, Jong Soon ^a   Lee, Won Kyung ^b   Lee, Chang Woo ^a   Yoon, Won Kee ^a   Kim, Nayang ^b   Park, Sang Ki ^b   Lee, Heon Sik ^b   Park, Hyoung Kook ^b   Han, Sang Bae ^c   Yun, Jieun ^a   Lee, Kiho ^a   Lee, Ki Hoon ^a   Park, Song Kyu ^d   Kim, Hwan Mook ^d  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b LG Household and Healthcare Ltd   (South Korea)

^c Chungbuk National University   (South Korea)

^d Korea University   (South Korea)

Author keywords

L Carnitine; Obesity; Red grape; Soy isoflavone

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOBESITY AGENT; ASPARTATE AMINOTRANSFERASE; CARNITINE PLUS RED GRAPE EXTRACT PLUS SOY ISOFLAVONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MIXTURE; DRUG RESPONSE; EPIDIDYMIS FAT; HORMONE BLOOD LEVEL; LIPID STORAGE; LIVER WEIGHT; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; SUBCUTANEOUS FAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; CARDIOVASCULAR DISEASES; CARNITINE; DIETARY FATS; FATTY LIVER; ISOFLAVONES; LIPIDS; MICE; MICE, INBRED C57BL; OBESITY; ORGAN SIZE; PLANT EXTRACTS; SOYBEANS; VITIS;

MUS; VITACEAE;

EID: 79960847322     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.06.071     Document Type: Article

References (37)

1. Achike F.I., To N.H., Wang H., Kwan C.Y. Obesity, metabolic syndrome, adipocytes and vascular function: a holistic viewpoint. Clin. Exp. Pharmacol. Physiol. 2011, 38:1-10.
2. Amin K.A., Nagy M.A. Effect of carnitine and herbal mixture extract on obesity induced by high fat diet in rats. Diabetol. Metab. Syndr. 2009, 1:17.
3. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., Pistell P.J., Poosala S., Becker K.G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K.W., Spencer R.G., Lakatta E.G., Le Couteur D., Shaw R.J., Navas P., Puigserver P., Ingram D.K., de Cabo R., Sinclair D.A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
4. Bertelli A.A., Das D.K. Grapes, wines, resveratrol, and heart health. J. Cardiovasc. Pharmacol. 2009, 54:468-476.
5. Bhathena S.J., Velasquez M.T. Beneficial role of dietary phytoestrogens in obesity and diabetes. Am. J. Clin. Nutr. 2002, 76:1191-1201.
6. Brennan A.M., Mantzoros C.S. Drug Insight: the role of leptin in human physiology and pathophysiology-emerging clinical applications. Nat. Clin. Pract. Endocrinol. Metab. 2006, 2:318-327.
7. Brisdelli F., D'Andrea G., Bozzi A. Resveratrol: a natural polyphenol with multiple chemopreventive properties. Curr. Drug Metab. 2009, 10:530-546.
8. Bujanda L., Hijona E., Larzabal M., Beraza M., Aldazabal P., Garcia-Urkia N., Sarasqueta C., Cosme A., Irastorza B., Gonzalez A., Arenas J.I. Resveratrol inhibits nonalcoholic fatty liver disease in rats. BMC Gastroenterol. 2008, 8:40.
9. Couillard C., Mauriege P., Imbeault P., Prud'homme D., Nadeau A., Tremblay A., Bouchard C., Despres J.P. Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia. Int. J. Obes. Relat. Metab. Disord. 2000, 24:782-788.
10. Dulloo A.G., Duret C., Rohrer D., Girardier L., Mensi N., Fathi M., Chantre P., Vandermander J. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clin. Nutr. 1999, 70:1040-1045.
11. Duncan A.M., Phipps W.R., Kurzer M.S. Phyto-oestrogens. Best Pract. Res. Clin. Endocrinol. Metab. 2003, 17:253-271.
12. Foretz M., Guichard C., Ferre P., Foufelle F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc. Natl. Acad. Sci. USA 1999, 96:12737-12742.
13. Glass C.K., Witztum J.L. Atherosclerosis: the road ahead. Cell 2001, 104:503-516.
14. Herrera B.M., Keildson S., Lindgren C.M. Genetics and epigenetics of obesity. Maturitas 2011, 69:41-49.
15. Hwang J.T., Park I.J., Shin J.I., Lee Y.K., Lee S.K., Baik H.W., Ha J., Park O.J. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem. Biophys. Res. Commun. 2005, 338:694-699.
16. Kim Y.J., Kim K.Y., Kim M.S., Lee J.H., Lee K.P., Park T. A mixture of the aqueous extract of Garcinia cambogia, soy peptide and l-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr. 2008, 2:353-358.
17. Kim M.H., Park J.S., Seo M.S., Jung J.W., Lee Y.S., Kang K.S. Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis. Cell Prolif. 2010, 43:594-605.
18. Kohjima M., Enjoji M., Higuchi N., Kato M., Kotoh K., Yoshimoto T., Fujino T., Yada M., Yada R., Harada N., Takayanagi R., Nakamuta M. Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int. J. Mol. Med. 2007, 20:351-358.
19. Kopelman P.G. Obesity as a medical problem. Nature 2000, 404:635-643.
20. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 2006, 127:1109-1122.
21. Lee M.S., Lee H.J., Lee H.S., Kim Y. l-Carnitine stimulates lipolysis via induction of the lipolytic gene expression and suppression of the adipogenic gene expression in 3T3-L1 adipocytes. J. Med. Food 2006, 9:468-473.
22. Lee Y.M., Choi J.S., Kim M.H., Jung M.H., Lee Y.S., Song J. Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets. Nutrition 2006, 22:956-964.
23. Lois K., Kumar S. Obesity and diabetes. Endocrinol. Nutr. 2009, 56(Suppl. 4):38-42.
24. Matteoni C.A., Younossi Z.M., Gramlich T., Boparai N., Liu Y.C., McCullough A.J. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999, 116:1413-1419.
25. Murosaki S., Lee T.R., Muroyama K., Shin E.S., Cho S.Y., Yamamoto Y., Lee S.J. A combination of caffeine, arginine, soy isoflavones, and l-carnitine enhances both lipolysis and fatty acid oxidation in 3T3-L1 and HepG2 cells in vitro and in KK mice in vivo. J. Nutr. 2007, 137:2252-2257.
26. Orgaard A., Jensen L. The effects of soy isoflavones on obesity. Exp. Biol. Med. (Maywood) 2008, 233:1066-1080.
27. Ososki A.L., Kennelly E.J. Phytoestrogens: a review of the present state of research. Phytother. Res. 2003, 17:845-869.
28. Park H.J., Yang J.Y., Ambati S., Della-Fera M.A., Hausman D.B., Rayalam S., Baile C.A. Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. J. Med. Food 2008, 11:773-783.
29. Rayalam S., Yang J.Y., Ambati S., Della-Fera M.A., Baile C.A. Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Phytother. Res. 2008, 22:1367-1371.
30. Ryokkynen A., Kukkonen J.V., Nieminen P. Effects of dietary genistein on mouse reproduction, postnatal development and weight-regulation. Anim. Reprod. Sci. 2006, 93:337-348.
31. Shang J., Chen L.L., Xiao F.X., Sun H., Ding H.C., Xiao H. Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase. Acta Pharmacol. Sin. 2008, 29:698-706.
32. Staiger H., Haring H.U. Adipocytokines: fat-derived humoral mediators of metabolic homeostasis. Exp. Clin. Endocrinol. Diabetes 2005, 113:67-79.
33. Tian W.X. Inhibition of fatty acid synthase by polyphenols. Curr. Med. Chem. 2006, 13:967-977.
34. Yang J.Y., Lee S.J., Park H.W., Cha Y.S. Effect of genistein with carnitine administration on lipid parameters and obesity in C57Bl/6J mice fed a high-fat diet. J. Med. Food 2006, 9:459-467.
35. Yang J.Y., Della-Fera M.A., Rayalam S., Ambati S., Hartzell D.L., Park H.J., Baile C.A. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. 2008, 82:1032-1039.
36. Yun J.W. Possible anti-obesity therapeutics from nature - a review. Phytochemistry 2010, 71:1625-1641.
37. Zhang M., Ikeda K., Xu J.W., Yamori Y., Gao X.M., Zhang B.L. Genistein suppresses adipogenesis of 3T3-L1 cells via multiple signal pathways. Phytother. Res. 2009, 23:713-718.