Thermosensitive chitosan-gelatin-glycerol phosphate hydrogel as a controlled release system of ferulic acid for nucleus pulposus regeneration

Biomaterials

Volumn 32, Issue 29, 2011, Pages 6953-6961

  Cheng, Yung Hsin ^a,b   Yang, Shu Hua ^c,d   Lin, Feng Huei ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Antioxidant; Ferulic acid; Hydrogel; Nucleus pulposus; Oxidative stress

Indexed keywords

ANTIOXIDANT; ANTIOXIDANT PROPERTIES; BLUE STAINING; CASPASE-3; CONTROLLED RELEASE SYSTEMS; DEGENERATIVE DISCS; DEGENERATIVE PROCESS; DOWN-REGULATION; FERULIC ACIDS; MRNA LEVEL; NUCLEUS PULPOSUS; POST TREATMENT; REACTIVE OXYGEN SPECIES; THERAPEUTIC EFFECTS; THERMO SENSITIVE; TYPE II COLLAGENS; UP-REGULATION;

CELL DEATH; GLYCEROL; HYDROGEN PEROXIDE; NUCLEIC ACIDS; OXIDATIVE STRESS;

HYDROGELS;

AGGRECAN; CASPASE 3; CHITOSAN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; DNA; FERULIC ACID; GELATIN; GLYCEROPHOSPHATE; GLYCOSAMINOGLYCAN; GLYCOSAMINOGLYCAN POLYSULFATE; HYDROGEN PEROXIDE; MESSENGER RNA; OSTEOGENIC PROTEIN 1; SOMATOMEDIN C; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; HEAT SENSITIVITY; HYDROGEL; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; NUCLEUS PULPOSUS; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT; TISSUE REGENERATION; UPREGULATION;

ANIMALS; CASPASE 3; CHITOSAN; COUMARIC ACIDS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; FREE RADICAL SCAVENGERS; GELATIN; GENE EXPRESSION; GLYCEROL; GLYCOSAMINOGLYCANS; HYDROGELS; HYDROGEN PEROXIDE; IN SITU NICK-END LABELING; INTERVERTEBRAL DISC; MATERIALS TESTING; OXIDANTS; OXIDATIVE STRESS; RABBITS; REACTIVE OXYGEN SPECIES; REGENERATION; TEMPERATURE; TISSUE ENGINEERING;

EID: 79960846233     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.065     Document Type: Article

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