A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor

Oncogene

Volumn 30, Issue 30, 2011, Pages 3360-3369

  Lee, M ^a   Daniels, M J ^a   Garnett, M J ^a   Venkitaraman, A R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

BRC repeats; BRCA2; cytokinesis; HMG20b; mitosis

Indexed keywords

HIGH MOBILITY GROUP PROTEIN; RAD51 PROTEIN;

ARTICLE; CHROMOSOME STRUCTURE; CONTROLLED STUDY; CYTOKINESIS; DNA BINDING; DNA DAMAGE; DNA RECOMBINATION; GENE INACTIVATION; HUMAN; HUMAN CELL; MITOSIS; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; RNA INTERFERENCE; TUMOR SUPPRESSOR GENE;

AMINO ACID MOTIFS; ANIMALS; BRCA2 PROTEIN; CELL NUCLEUS; CONSERVED SEQUENCE; CYTOKINESIS; DNA-BINDING PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; MITOSIS; PROTEIN BINDING; RAD51 RECOMBINASE; RNA INTERFERENCE;

EID: 79960843926     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.55     Document Type: Article

References (34)

1. Breast Cancer Linkage Consortium (1999). Cancer risks in BRCA2 mutation carriers. The breast cancer linkage consortium. J Natl Cancer Inst 91: 1310-1316.
2. Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL et al. (2003). Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72: 1117-1130. (Pubitemid 36530000)
3. Ayoub N, Rajendra E, Su X, Jeyasekharan AD, Mahen R, Venkitara-man AR. (2009). The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry. Curr Biol 19: 1075-1085.
4. Bork P, Blomberg N, Nilges M. (1996). Internal repeats in the BRCA2 protein sequence. Nat Genet 13: 22-23.
5. Carreira A, Hilario J, Amitani I, Baskin RJ, Shivji MK, Venkitaraman AR et al. (2009). The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51. Cell 136: 1032-1043.
6. Chen CF, Chen PL, Zhong Q, Sharp ZD, Lee WH. (1999). Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control. J Biol Chem 274: 32931-32935. (Pubitemid 129535331)
7. Daniels MJ, Wang Y, Lee M, Venkitaraman AR. (2004). Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science 306: 876-879. (Pubitemid 39446997)
8. Jonsdottir AB, Vreeswijk MP, Wolterbeek R, Devilee P, Tanke HJ, Eyfjord JE et al. (2009). BRCA2 heterozygosity delays cytokinesis in primary human fibroblasts. Cell Oncol 31: 191-201.
9. King TA, Li W, Brogi E, Yee CJ, Gemignani ML, Olvera N et al. (2007). Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis. Ann Surg Oncol 14: 2510-2518. (Pubitemid 47389559)
10. Lee M, Daniels MJ, Venkitaraman AR. (2004). Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression. Oncogene 23: 865-872. (Pubitemid 38250931)
11. Lee YM, Kim W. (2003). Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. Biochem J 374: 497-503. (Pubitemid 37094109)
12. Lekomtsev S, Guizetti J, Pozniakovsky A, Gerlich DW, Petronczki M. (2010). Evidence that the tumor-suppressor protein BRCA2 does not regulate cytokinesis in human cells. J Cell Sci 123: 1395-1400.
13. Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA et al. (2001). A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. Cell 104: 247-257. (Pubitemid 32174840)
14. Meng X, Fan J, Shen Z. (2007). Roles of BCCIP in chromosome stability and cytokinesis. Oncogene 26: 6253-6260. (Pubitemid 47462109)
15. Nathanson KL, Wooster R, Weber BL. (2001). Breast cancer genetics: what we know and what we need. Nat Med 7: 552-556. (Pubitemid 32448321)
16. Patel KJ, Yu VP, Lee H, Corcoran A, Thistlethwaite FC, Evans MJ et al. (1998). Involvement of Brca2 in DNA repair. Mol Cell 1: 347-357. (Pubitemid 128378883)
17. Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL et al. (2002). Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature 420: 287-293. (Pubitemid 35398178)
18. Rahman N, Stratton MR. (1998). The genetics of breast cancer susceptibility. Annu Rev Genet 32: 95-121. (Pubitemid 29045309)
19. Rajendra E, Venkitaraman AR. (2010). Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase. Nucleic Acids Res 38: 82-96.
20. Rowley M, Ohashi A, Mondal G, Mills L, Yang L, Zhang L et al. (2011). Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice. Gastroenterology (e-pub ahead of print; doi:10.1053/j.gastro. 2010.12.039).
21. Shivji MK, Davies OR, Savill JM, Bates DL, Pellegrini L, Venkitaraman AR. (2006). A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange. Nucleic Acids Res 34: 4000-4011. (Pubitemid 44399123)
22. Shivji MK, Mukund SR, Rajendra E, Chen S, Short JM, Savill J et al. (2009). The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single-versus double-stranded DNA to stimulate strand exchange. Proc Natl Acad Sci USA 106: 13254-13259.
23. Straight AF, Field CM, Mitchison TJ. (2005). Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell 16: 193-201. (Pubitemid 40024302)
24. Sumoy L, Carim L, Escarceller M, Nadal M, Gratacos M, Pujana MA et al. (2000). HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. Cytogenet Cell Genet 88: 62-67. (Pubitemid 30175597)
25. Tutt A, Gabriel A, Bertwistle D, Connor F, Paterson H, Peacock J et al. (1999). Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification. Curr Biol 9: 1107-1110. (Pubitemid 29504480)
26. Venkitaraman AR. (2002). Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108: 171-182. (Pubitemid 34161138)
27. Vinciguerra P, Godinho SA, Parmar K, Pellman D, DAndrea AD. (2010). Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest 120: 3834-3842.
28. Wang W, Chi T, Xue Y, Zhou S, Kuo A, Crabtree GR. (1998). Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. Proc Natl Acad Sci USA 95: 492-498. (Pubitemid 28083770)
29. Welcsh PL, King MC. (2001). BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hum Mol Genet 10: 705-713. (Pubitemid 32331579)
30. Wong AK, Pero R, Ormonde PA, Tavtigian SV, Bartel PL. (1997). RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J Biol Chem 272: 31941-31944. (Pubitemid 28011857)
31. Yu VP, Koehler M, Steinlein C, Schmid M, Hanakahi LA, van Gool AJ et al. (2000). Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation. Genes Dev 14: 1400-1406. (Pubitemid 30397083)
32. Yuan SS, Lee SY, Chen G, Song M, Tomlinson GE, Lee EY. (1999). BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo. Cancer Res 59: 3547-3551. (Pubitemid 29381849)
33. Zhao WM, Fang G. (2005). Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. J Biol Chem 280: 33516-33524. (Pubitemid 41397151)
34. Zhu C, Jiang W. (2005). Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. Proc Natl Acad Sci USA 102: 343-348. (Pubitemid 40116769)