BRCA2 heterozygosity delays cytokinesis in primary human fibroblasts

Cellular Oncology

Volumn 31, Issue 3, 2009, Pages 191-201

  Jonsdottir, Asta Björk ^a,b   Vreeswijk, Maaike P G ^b   Wolterbeek, Ron ^b   Devilee, Peter ^b   Tanke, Hans J ^b   Eyfjörd, Jorunn E ^a   Szuhai, Karoly ^b  

^a UNIVERSITY OF ICELAND   (Iceland)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

BRCA2; Cytokinesis; Heterozygous phenotype; Live cell imaging; Primary human fibroblasts

Indexed keywords

AURORA B KINASE; BRCA2 PROTEIN; MESSENGER RNA;

ARTICLE; BRCA 2 GENE; CELL DIVISION; CONTROLLED STUDY; CYTOKINESIS; FIBROBLAST; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE MUTATION; GENOTYPE; HETEROZYGOSITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; TUMOR SUPPRESSOR GENE;

BRCA2 PROTEIN; CELLS, CULTURED; CYTOKINESIS; FIBROBLASTS; HETEROZYGOTE; HUMANS; MUTATION;

EID: 67650236397     PISSN: 15705870     EISSN: None     Source Type: Journal    
DOI: 10.3233/CLO-2009-0465     Document Type: Article

References (32)

1. K. Arnold, M.K. Kim, K. Frerk, L. Edler, L. Savelyeva,P. Schmezer and R. Wiedemeyer, Lower level of BRCA2 protein in heterozygous mutation carriers is correlated with an increase in DNA double strand breaks and an impaired DSB repair, Cancer Lett. 243(2006), 90-100.
2. M.J. Daniels, Y. Wang, M. Lee and A.R. Venkitaraman, Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2, Science 306(2004), 876-879.
3. A.A. Davies, J.Y. Masson, M.J. Mcllwraith, A.Z. Stasiak, A. Stasiak, A.R. Venkitaraman and S.C.West, Role of BRCA2 in control of the RAD51 recombination and DNA repair protein, Mol. Cell. 7 (2001), 273-282.
4. F. Esashi, V.E. Galkin, X.Yu, E.H. Egelman and S.C. West, Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2, Nat. Struct. Mol. Biol. 14(2007), 468-474.
5. M. Glotzer, The molecular requirements for cytokinesis, Science 307(2005), 1735-1739.
6. D.M. Glover, Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles, Oncogene 24(2005), 230-237.
7. S. Gretarsdottir, S. Thorlacius, R. Valgardsdottir, S. Gud- laugsdottir, S. Sigurdsson, M.Steinarsdottir, J.G. Jonasson, K. Anamthawat-Jonsson and J.E. Eyfjord, BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability, Cancer Res. 58(1998), 859-862.
8. X. Han, H. Saito, Y. Miki and A. Nakanishi, A CRM1- mediated nuclear export signal governs cytoplasmic localization of BRCA2 and is essential for centrosomal localization of BRCA2, Oncogene 27(2007), 2969-2977.
9. M.J. Higgins, H.S. Wang, I. Shtromas, T. Haliotis, J.C. Roder, J.J. Holden and B.N. White, Organization of a repetitive human 1.8 kb KpnI sequence localized in the heterochromatin of chromosome 15, Chromosoma 93(1985), 77-86.
10. M. Levitus, H. Joenje and J.P. de Winter, The Fanconi anemia pathway of genomic maintenance, Cell. Oncol. 28(2006), 329.
11. H.R. Lin, N.S. Ting, J. Qin and W.H. Lee, M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex, J. Biol.Chem. 278(2003), 35979-35987.
12. M. Lomonosov, S. Anand, M. Sangrithi, R. Davies and A.R. Venkitaraman, Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein, Genes Dev. 17(2003), 3017-3022.
13. E.K. Mikaelsdottir, S. Valgeirsdottir, J.E. Eyfjord and T. Raf- nar, The Icelandic founder mutation BRCA2 999del5: analysis of expression, Breast Cancer Res. 6 (2004), R284-R290.
14. Y. Miki, J. Swensen, D. Shattuck-Eidens, P.A. Futreal,K. Harshman, S. Tavtigian, Q. Liu, C. Cochran, L.M. Bennett and W. Ding, A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1, Science 266(1994), 66-71.
15. A. Nakanishi, X. Han, H. Saito, K. Taguchi, Y. Ohta, S. Imajoh- Ohmi and Y. Miki, Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division, Biochem. Biophys. Res. Commun. 355(2007), 34-40.
16. B. Nieuwenhuis, A.J. Assen-Bolt, M.A. Waarde-Verhagen,R.H. Sijmons, A.H. Van der Hout, T. Bauch, C. Streffer and H.H. Kampinga, BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage, Int. J. Radiat. Biol. 78(2002), 285-295.
17. K.J. Patel, V.P. Yu, H. Lee, A. Corcoran, F.C. Thistlethwaite, M.J. Evans, W.H. Colledge, L.S. Friedman, B.A. Ponder and A.R. Venkitaraman, Involvement of BRCA2 in DNA repair,Mol. Cell. 1(1998), 347-357.
18. Y.S. Seong, K. Kamijo, J.S. Lee, E. Fernandez, R. Kuriyama, T. Miki and K.S. Lee, A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells, J. Biol. Chem. 277 (2002), 32282-32293.
19. Q. Shi and R.W. King, Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines, Nature 437 (2005), 1038-1042.
20. I.S. Smirnova, N.D. Aksenov, E.V. Kashuba, P. Payakurel, V.V. Grabovetsky, A.D. Zaberezhny, M.S. Vonsky, L. Buchinska, P. Biberfeld, J. Hinkula and M.G. Isaguliants, Hepatitis C virus core protein transforms murine fibroblasts by promoting genomic instability, Cell. Oncol. 28 (2006), 177-190.
21. L. Song, C.A. Varma, J.W. Verhoeven and H.J. Tanke, Influence of the triplet excited state on the photobleaching kinetics of fluorescein in microscopy, Biophys. J. 70 (1996), 2959-2968.
22. H.J. Tanke, J. Wiegant, R.P. van Gijlswijk, V. Bezrookove, H. Pattenier, R.J. Heetebrij, E.G. Talman, A.K. Raap and J. Vrolijk, New strategy for multi-colour fluorescence in situhybridisation: COBRA: COmbined Binary RAtio labelling, Eur. J. Hum. Genet. 7 (1999), 2-11.
23. S.V. Tavtigian, J. Simard, J. Rommens, F. Couch, D. Shattuck- Eidens, S. Neuhausen, S. Merajver, S. Thorlacius, K. Offit, D. Stoppa-Lyonnet, C. Belanger, R. Bell, S. Berry, R. Bogden,Q. Chen, T. Davis, M. Dumont, C. Frye, T. Hattier, S. Jam- mulapati, T. Janecki, P. Jiang, R. Kehrer, J.F. Leblanc, J.T. Mitchell, J. McArthur-Morrison, K. Nguyen, Y. Peng, C. Samson, M. Schroeder, S.C. Snyder, L. Steele, M. Stringfellow, C. Stroup, B. Swedlund, J. Swense, D. Teng, A. Thomas, T. Tran, M. Tranchant, J. Weaver-Feldhaus, A.K. Wong, H. Shizuya, J.E. Eyfjord, L. Cannon-Albright, M. Tranchant, F. Labrie, M.H. Skolnick, B. Weber, A. Kamb and D.E. Goldgar, The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds, Nat. Genet. 12 (1996), 333-337.
24. S. Thorlacius, G. Olafsdottir, L. Tryggvadottir, S. Neuhausen, J.G. Jonasson, S.V. Tavtigian, H. Tulinius, H.M. Ogmundsdot- tir and J.E. Eyfjord, A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes, Nat. Genet. 13 (1996), 117-119.
25. H. Tulinius, G.H. Olafsdottir, H. Sigvaldason, A. Arason, R.B. Barkardottir, V. Egilsson, H.M. Ogmundsdottir, L. Tryggvadot- tir, S. Gudlaugsdottir and J.E. Eyfjord, The effect of a single BRCA2 mutation on cancer in Iceland, J. Med. Genet. 39(2002), 457-462.
26. A. Tutt, A. Gabriel, D. Bertwistle, F. Connor, H. Paterson, J. Peacock, G. Ross and A. Ashworth, Absence of BRCA2 causes genome instability by chromosome breakage and loss associated with centrosome amplification, Curr. Biol. 9 (1999), 1107-1110.
27. M. van Engeland, F.C. Ramaekers, B. Schutte and C.P. Reutel- ingsperger, A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture, Cytometry 24 (1996), 131-139.
28. J. Vandesompele, K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, A. De Paepe and F. Speleman, Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes, Genome Biol. 3 (2002), RE-SEARCH0034.
29. A.R. Venkitaraman, Cancer susceptibility and the functions of BRCA1 and BRCA2, Cell 108 (2002), 171-182.
30. M. Warren, C.J. Lord, J. Masabanda, D. Griffin and A. Ash- worth, Phenotypic effects of heterozygosity for a BRCA2 mutation, Hum. Mol. Genet. 12 (2003), 2645-2656.
31. R. Wooster, G. Bignell, J. Lancaster, S. Swift, S. Seal, J. Man- gion, N. Collins, S. Gregory, C. Gumbs and G. Micklem, Identification of the breast cancer susceptibility gene BRCA2, Nature 378(1995), 789-792.
32. V.P. Yu, M. Koehler, C. Steinlein, M. Schmid, L.A. Hanakahi, A.J. van Gool, S.C. West and A.R. Venkitaraman, Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation, Genes Dev. 14(2000), 1400-1406.