Eriobotrya japonica leaf and its triterpenes inhibited lipopolysaccharide-induced cytokines and inducible enzyme production via the nuclear factor-κB signaling pathway in lung epithelial cells

American Journal of Chinese Medicine

Volumn 36, Issue 6, 2008, Pages 1185-1198

  Lee, Chang Hsien ^a   Wu, Shih Lu ^a   Chen, Jaw Chyun ^a   Li, Chia Cheng ^a   Lo, Hsin Yi ^a   Cheng, Wen Yu ^a   Lin, Jaung Geng ^a   Chang, Yung Hsien ^a   Hsiang, Chien Yun ^a   Ho, Tin Yun ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Eriobotrya japonica; Lung Inflammation; Nuclear Factor B; Ursolic Acid

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; ERIOBOTRYA JAPONICA EXTRACT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; OLEANOLIC ACID; PLANT EXTRACT; TRITERPENE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; URSOLIC ACID;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INHIBITION KINETICS; LOQUAT; LUNG ALVEOLUS EPITHELIUM; PLANT LEAF; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT INFLAMMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL LINE; CYTOKINES; DRUGS, CHINESE HERBAL; EPITHELIAL CELLS; ERIOBOTRYA; GENE EXPRESSION; HUMANS; LIPOPOLYSACCHARIDES; LUNG; NF-KAPPA B; PLANT LEAVES; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 57349132885     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X0800651X     Document Type: Article

References (37)

1. Baldwin, A.S. Jr. The NF-κB and IκB proteins: New discoveries and insights. Annu. Rev. Immunol. 14: 649-683, 1996.
2. Banno, N., T. Akihisa, H. Tokuda, K. Yasukawa, H. Higashihara, M. Ukiya, K.Watanabe, Y. Kimura, J. Hasegawa and H. Nishino. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci. Biotechnol. Biochem. 68: 85-90, 2004.
3. Barnes, P.J. and M. Karin. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases. New Engl. J. Med. 336: 1066-1071, 1997.
4. Blasi, F. Atypical pathogens and respiratory tract infections. Eur. Respir. J. 24: 171-181, 2004.
5. Calixto, J.B., M.F. Otuki and A.S. Santos. Anti-inflammtory compounds of plant origin. Part 1. Action on the arachidonic acid pathway, nitric oxide and nuclear factor (NF-κB). Planta Med. 69: 973-983, 2003.
6. Chen, Y.C., L.L. Yang and T.J. Lee. Oroxylin A inhibition of lipopolysaccharide induced iNOS and COX-2 gene expression via suppression of nuclear factor-κB activation. Biochem. Pharmacol. 59: 1445-1457, 2000.
7. Cheng, W.Y., C.Y. Hsiang, D.T. Bau, J.C. Chen, W.S. Shen, C.C. Li, H.Y. Lo, S.L. Wu, S.Y. Chiang and T.Y. Ho. Microarray analysis of vanillin-regulated gene expression profile in human hepatocarcinoma cells. Pharmacol. Res. 56: 474-482, 2007.
8. Chung, K.F. Cytokines in chronic obstructive pulmonary disease. Eur. Respir. J. Suppl. 34: 50s-59s, 2001.
9. Covert, M.W., T.H. Leung, J.E. Gaston and D. Baltimore. Achieving stability of lipopolysaccharide-induced NF-κB activation. Science 309: 1854-1857, 2005.
10. De Tommasi, N., F. De Simone, C. Pizza, N. Mahmood, P.S. Moore, C. Conti, N. Orsi and M.L. Stein. Constituents of Eriobotrya japonica A study of their antiviral properties. J. Nat. Prod. 55: 1067-1073, 1992.
11. Ganz, T. and J. Weiss. Antimicrobial peptides of phagocytes and epithelia. Semin. Hematol. 34: 343-354, 1997.
12. Haddad, J.J. and S.C. Land. Amiloride blockades lipopolysaccharide-induced proinflammatory cytokine biosynthesis in an IκB-α/NF-κB-dependent mechanism. Evidence for the amplification of an antiinflammatory pathway in the alveolar epithelium. Am. J. Respir. Cell Mol. Biol. 26: 114-126, 2002.
13. Hamada, A., S. Yoshioka, D. Takuma, J. Yokota, T. Cui, M. Kusunose, M. Miyamura, S. Kyotani and Y. Nishioka. The effect of Eriobotrya japonica seed extract on oxidative stress in adriamycin-induced nephropathy in rats. Biol. Pharm. Bull. 27: 1961-1964, 2004.
14. Hsiang, C.Y., I.L. Lai, D.C. Chao and T.Y. Ho. Differential regulation of activator protein 1 activity by glycyrrhizin. Life Sci. 70: 1643-1656, 2002.
15. Hsiang, C.Y., S.L. Wu and T.Y. Ho. Activation of activator protein 1 and extracellular signal-regulated kinases in human hepatocellular transformation. Tumor Biol. 25: 313-320, 2004.
16. Hsiang, C.Y., S.L. Wu and T.Y. Ho. Morin inhibited 12-O tetradecanoylphorbol-13- acetate0ubduced hepatocellular transformation via activator protein 1 signaling pathway and cell cycle progression. Biochem. Pharmacol. 69: 1603-1611, 2005a.
17. Hsiang, C.Y., S.L. Wu, S.E. Cheng and T.Y. Ho. Acetaldehyde-induced interleukin-1β and tumor necrosis factor-α production is inhibited by berberine through nuclear factor-κB signaling pathway in HepG2 cells. J. Biomed. Sci. 12: 791-801, 2005b.
18. Hsiang, C.Y., S.L. Wu, J.C. Chen, H.Y. Lo, C.C. Li, S.Y. Chiang, H.C. Wu and T.Y. Ho. Acetaldehyde induces matrix metalloproteinase-9 gene expression via nuclear factor-κB and activator protein 1 signaling pathways in human hepatocellular carcinoma cells: Association with the invasive potential. Toxicol. Lett. 171: 78-86, 2007.
19. Hsu, Y.L., P.L. Kuo and C.C. Lin. Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells. Life Sci. 75: 2303-2316, 2004.
20. Huang, Y., J. Li, Q. Cao, S.C. Yu, X.W. Lv, Y. Jin, L. Zhang, Y.H. Zou and J.F. Ge. Anti-oxidative effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in chronic bronchitis rats. Life Sci. 78: 2749-2757, 2006.
21. Huang, Y., J. Li, R. Wang, Q. Wu, Y.H. Li, S.C. Yu, W.M. Cheng and Y.Y. Wang. Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf on inflammatory cytokine and mediator induction from alveolar macrophages of chronic bronchitic rats. Inflamm. Res. 56: 76-82, 2007.
22. Jung, H.A., J.C. Park, H.Y. Chung, J. Kim and J.S. Choi. Antioxidant flavonoids and chlorogenic acid from the leaves of Eriobotrya japonica. Arch. Pharm. Res. 22: 213-218, 1999.
23. Junko, Y., T. Daisuke, H. Atsuhide, O. Masahide, Y. Saburo, K. Masahiko, M. Mitsuhiko, K. Shojiro and N. Yutaka. Scavenging of reactive oxygen species by Eriobotrya japonica seed extract. Biol. Pharm. Bull. 29: 467-471, 2006.
24. Kawahara N., M. Satake and Y. Goda. A new acylated flavonol glycoside from the leaves of Eriobotrya japonica. Chem. Pharm. Bull. 50: 1619-1620, 2002.
25. Khair, O.A., R.J. Davies and J.L. Devalia. Bacterial-induced release of inflammatory mediators by bronchial epithelial cells. Eur. Respir. J. 9: 1913-1922, 1996.
26. Kwon, H.J., M.J. Kang, H.J. Kim, J.S. Choi, K.J. Paik and H.Y. Chung. Inhibition of NF-κB by methyl chlorogenate from Eriobotrya japonica. Mol. Cells 10: 241-246, 2000.
27. Lee, C.H., J.C. Chen, C.Y. Hsiang, S.L. Wu, H.C. Wu and T.Y. Ho. Berberine suppresses inflammatory agents-induced interleukin-1β and tumor necrosis factor-α productions via the inhibition of IκB degradation in human lung cells. Pharmacol. Res. 56: 193-201, 2007.
28. Nakanaga, T., J.A. Nadel, I.F. Ueki, J.L. Koff and M.X. Shao. Regulation of interleukin-8 via an airway epithelial signaling cascade. Am. J. Physiol. Lung Cell Mol. Physiol. 292: L1289-L1296, 2007.
29. Paola, P.B. and D.A. Daniele. Chemokines and their receptors in asthma and chronic obstructive pulmonary disease. Curr. Opin. Pulm. Med. 9: 104-110, 2003.
30. Passàli, D., R. Ferri, G. Becchini, G.C. Passàli and L. Bellussi. Alterations of nasal mucociliary transport in patients with hypertrophy of the inferior turbinates, deviations of the nasal septum and chronic sinusitis. Eur. Arch. Otorhinolaryngol 256: 335-337, 1999.
31. Pharmacopoeia Commission of People's Republic of China (ChPC). Pharmacopoeia of People's Republic of China (ChP), Vol. 1. Chemical Industry Press, Beijing, 2005, p. 142 (in Chinese).
32. Shimizu, M., H. Fukumura, H. Tsuji, S. Tanaami, T. Hayashi and N. Morita. Anti-inflammatory constituents of topically applied crude drugs. I. Constituents and anti-inflammatory effect of Eriobotrya japonica LINDL. Chem. Pharm. Bull. 34: 2614-2617, 1986.
33. Shishodia, S., S. Majumdar, S. Banerjee and B.B. Aggarwal. Ursolic acid inhibits nuclear factor-κB activation induced by carcinogenic agents through suppression of IκB-α kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res. 63: 4375-4383, 2003.
34. Standiford, T.J., S.L. Kunkel, M.A. Basha, S.W. Chensue, J.P. 3rd. Lynch, G.B. Toews, J. Westwick and R.M. Strieter. Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J. Clin. Invest. 86: 1945-1953, 1990.
35. Taniguchi, S., Y. Imayoshi, E. Kobayashi, Y. Takamatsu, H. Ito, T. Hatano, H. Sakagami, H. Tokuda, H. Nishino, D. Sugita, S. Shimura and T. Yoshida. Production of bioactive triterpenes by Eriobotrya japonica calli. Phytochemistry 59: 315-323, 2002.
36. Tashkin, D.P., G.C. Baldwin, T. Sarafian, S. Dubinett and M.D. Roth. Respiratory and immunologic consequences of marijuana smoking. J. Clin. Pharmacol. 42: 71S-81S, 2002.
37. Watkins, D.N., D.J. Peroni, J.C. Lenzo, D.A. Knight, M.J. Garlepp and P.J. Thompson. Expression and localization of COX-2 in human airways and cultured airway epithelial cells. Eur. Respir. J. 13: 999-1007, 1999.