Regulated hypoxia/reperfusion-dependent modulation of ERK1/2, cPLA2, and Bcl-2/Bax: A potential mechanism of neuroprotective effect of penehyclidine hydrochloride

International Journal of Neuroscience

Volumn 121, Issue 8, 2011, Pages 442-449

  Wang, Yun ^a   Ma, Tengfei ^a   Li, Mei ^a   Sun, Xiaojing ^a   Wang, Yigang ^a   Gu, Shuling ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Bcl 2 Bax; CPLA2; ERK1 2; Hypoxia reoxygenation; Muscarinic receptors; Penehyclidine hydrochloride

Indexed keywords

CHOLINERGIC RECEPTOR BLOCKING AGENT; CYTOSOLIC PHOSPHOLIPASE A2; MITOGEN ACTIVATED PROTEIN KINASE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M3 RECEPTOR; PENEHYCLIDINE HYDROCHLORIDE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN HYPOXIA; BRAIN SLICE; ENZYME ACTIVATION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; REOXYGENATION; REPERFUSION; STROKE; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CYCLOPENTANES; DOWN-REGULATION; HIPPOCAMPUS; MALE; MAP KINASE SIGNALING SYSTEM; NEUROPROSTANES; PHOSPHOLIPASES A2, CYTOSOLIC; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINUCLIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION;

EID: 79960811641     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2011.570611     Document Type: Article

References (49)

1. Bazan, N. G. (2005).Lipid signaling in neural plasticity, brain repair, and neuroprotection. Molecular Neurobiology, 32(1), 89-103.
2. Bonventre, J. V., Huang, Z., Taheri, M. R., OLeary, E., Li, E., Moskowitz, M. A., et al. (1997).Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature, 390(6660), 622-625.
3. Bright, R. & Mochly-Rosen, D. (2005).The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke, 36(12), 2781-2790.
4. Brunelle, J.K., & Letai, A. (2009).Control of mitochondrial apoptosis by the Bcl-2 family. Journal of Cell Science, 122(Pt 4), 437-441.
5. Burke, J. E., & Dennis, E. A. (2009).Phospholipase A2 structure/ function, mechanism, and signaling. Journal of Lipid Research, 50 Suppl, S237-S242.
6. Caulfield,M. P. (1993).Muscarinic receptors: Characterization, coupling and function. Pharmacology Therapeutics, 58(3), 319-379.
7. Chen, S., Xu, X. Y., Qu, X. G., & Yang, X. B. (2009).Effects of penehyclidine hydrochloride on the expression of cytochrome C and caspase-3 in rat s brain after acute focal cerebral ischemia/ reperfusion. Medical Journal of Wuhan University, 30(1), 47-51.
8. Chung, E., Iwasaki, K., Mishima, K., Egashira, N., & Fujiwara, M. (2002).Repeated cerebral ischemia induced hippocampal cell death and impairments of spatial cognition in the rat. Life Sciences, 72(4-5), 609-619.
9. Eglen, R. M. (2006).Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function. Autonomous Autacoid Pharmacology, 26(3), 219-233.
10. Fields, T. A., & Casey, P. J. (1997).Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. Biochemistry Journal, 321(Pt 3), 561-571.
11. Figueredo, L. Z., Moreira, K. M., Ferreira, T. L., Fornari, R. V., & Oliveira, M. G. (2008).Interaction between glutamatergic- NMDA and cholinergic-muscarinic systems in classical fear conditioning. Brain Research Bulletin, 77(2-3), 71-76.
12. Fisher, M., & Brott, T. G., (2003).Emerging therapies for acute ischemic stroke: New therapies on trial. Stroke, 34(2), 359-361.
13. Ghavami, S., Hashemi, M., Ande, S. R., Yeganeh, B., Xiao, W., Eshraghi, M., et al. (2009).Apoptosis and cancer: Mutations within caspase genes. Journal of Medical Genetics, 46(8), 497-510.
14. Gulledge, A. T., & Stuart, G. J. (2005).Cholinergic inhibition of neocortical pyramidal neurons. Journal of Neuroscience, 25(44), 10308-10320.
15. Haddad, J. J. (2007).The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion-dependent regulation of MAPK(ERK): Discordant proteomic effect of MAPK(p38).Protein & Peptide Letters, 14(4), 361-371.
16. Hamilton, S. E., & Nathanson, N. M. (2001).The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons. Journal of Biological Chemistry, 276(19), 15850-15853.
17. Han, X. Y., Liu, H., Liu, C. H., Wu, B., Chen, L. F., Zhong, B. H., et al. (2005).Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride (8018).Bioorganic and Medicinal Chemistry Letters, 15(8), 1979-1982.
18. Hetman, M., & Gozdz, A. (2004).Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. European Journal of Biochemistry, 271(11), 2050-2055.
19. Janicke, R. U., Sprengart,M. L.,Wati,M. R., & Porter, A. G. (1998). Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. Journal of Biological Chemistry, 273(16), 9357-9360.
20. Jiang, L., Wang, J. K., & Li, E. Y. (2007).Effects of penehyclidine hydrochloride pretreatment on transient focal cerebral ischemia/ reperfusion injury and expression of caspase-3 in rats. Journal of Jilin University (Medicine Edition), 33(4), 626-629.
21. Jiang, Z. W., Gong, Q. Z., Di, X., Zhu, J., & Lyeth, B. G. (2000). Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model. Brain Research, 852(1), 37-44.
22. Jones, C. K., Brady, A. E., Davis, A. A., Xiang, Z., Bubser, M., Tantawy, M. N., et al. (2008).Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. Journal of Neuroscience, 28(41), 10422-10433.
23. Kishimoto, K., Li, R. C., Zhang, J., Klaus, J. A., Kibler, K. K., Dore, S., et al. (2010).Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice. Journal Neuroinflammation, 7, 42.
24. Korsmeyer, S. J. (1999).BCL-2 gene family and the regulation of programmed cell death. Cancer Research, 59(7 Suppl), 1693s-1700s.
25. Leber, B., Lin, J., & Andrews, D. W. (2010).Still embedded together binding to membranes regulates Bcl-2 protein interactions. Oncogene, 29(38), 5221-5230.
26. Li, D. W., Liu, J. P., Mao, Y. W., Xiang, H., Wang, J., Ma, W. Y., et al., (2005).Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. Molecular Biology Cell, 16(9), 4437-4453.
27. Lin, A. L., Zhu, B., Zhang, W., Dang, H., Zhang, B. X., Katz, M. S., et al. (2008).Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line. American Journal of Cellular Physiology, 294(6), C1454-C1464.
28. Lo, E. H., Dalkara, T., & Moskowitz, M. A. (2003).Mechanisms, challenges and opportunities in stroke. Nature Reviews Neuroscience, 4(5), 399-415.
29. Lu, Z., & Xu, S. (2006).ERK1/2 MAP kinases in cell survival and apoptosis. IUBMB Life, 58(11), 621-631.
30. Lyeth, B.G.,Gong, Q. Z.,Dhillon, H. S.,&Prasad,M. R., (1996).Effects ofmuscarinic receptor antagonism on the phosphatidylinositol bisphosphate signal transduction pathway after experimental brain injury. Brain Research, 742(1-2), 63-70.
31. Ma, T. F., Jin, R., Zhang, J., Gu, S. L., & Duan, S. M. (2006).Protective effects of penehyclidine hydrochloride on transient forebrain ischemia reperfusion injury in gerbils. Chinese Journal of Clinical Pharmacology and Therapeutics, 11(4), 453-457.
32. Mattson, M. P., (1989).Acetylcholine potentiates glutamate-induced neurodegeneration in cultured hippocampal neurons. Brain Research, 497(2), 402-406.
33. Nito, C., Kamada, H., Endo, H., Niizuma, K., Myer, D. J., & Chan, P. H. (2008).Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in bloodbrain barrier disruption after focal cerebral ischemia and reperfusion. Journal of Cerebral Blood Flow & Metabolism, 28(10), 1686-1696.
34. Niu, W. Z., Zhao, D. L., & Liu, C. G. (1990).The effects of a new cholinolytic-8018-and its optical isomers on the central muscarinic and nicotinic receptors. Architecture International Pharmacodyn Therapeutics, 304, 64-74.
35. Phillis, J. W., Smith-Barbour, M., Perkins, L. M., & ORegan, M. H. (1993).Acetylcholine output from the ischemic rat cerebral cortex: Effects of adenosine agonists. Brain Research, 613(2), 337-340.
36. Porter, A. G., & Janicke, R. U. (1999).Emerging roles of caspase-3 in apoptosis. Cell Death and Differentiation, 6(2), 99-104.
37. Reed, J. C. (1997).Double identity for proteins of the Bcl-2 family. Nature, 387(6635), 773-776.
38. Reed, J. C. (1999).Dysregulation of apoptosis in cancer. Journal of Clinical Oncology, 17(9), 2941-2953.
39. Rose, C. R., & Konnerth, A. (2001).Stores not just for storage. Intracellular calcium release and synaptic plasticity. Neuron, 31(4), 519-522.
40. Rosse, T., Olivier, R., Monney, L., Rager, M ., Conus, S., Fellay, I., et al. (1998).Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature, 391(6666), 496-499.
41. Saluja, I., ORegan, M. H., Song, D., & Phillis, J. W. (1999).Activation of cPLA2, PKC, and ERKs in the rat cerebral cortex during ischemia/reperfusion. Neurochemical Research, 24(5), 669-677.
42. Sapirstein, A., Saito, H., Texel, S. J., Samad, T. A., OLeary, E., & Bonventre, J. V. (2005).Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mousemodel of inflammation. American Journal of Physiology Regulation Integrated Comparative Physiology, 288(6), R1774-R1782.
43. Sawe, N., Steinberg, G., & Zhao, H. (2008).Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke. Journal of Neuroscience Research, 86(8), 1659-1669.
44. Subramaniam, S., & Unsicker, K., (2010).ERK and cell death: ERK1/2 in neuronal death. FEBS Journal, 277(1), 22-29.
45. Sun, G. Y., Shelat, P. B., Jensen, M. B., He, Y., Sun, A. Y., & Simonyi, A. (2010).Phospholipases A2 and inflammatory responses in the central nervous system. Neuromolecular Medicine, 12(2), 133-148.
46. Xu, J., Weng, Y. I., Simonyi, A., Krugh, B. W., Liao, Z., Weisman, G. A., et al. (2002).Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes. Journal of Neurochemistry, 83(2), 259-270.
47. Yoshihiro, K., & Yoshiki, M. (1991).Output, tissue levels, and synthesis of acetylcholine during and after transient forebrain ischemical in the rat. Journal of Neurochemistry, 56(4), 1169-1173.
48. Zhao, H., Yenari, M. A., Cheng, D., Sapolsky, R. M., & Steinberg, G. K. (2003).Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity. Journal of Neurochemistry, 85(4), 1026-1036.
49. Zhuang, S., & Schnellmann, R. G. (2006).A death-promoting role for extracellular signal-regulated kinase. Journal of Pharmacology and Experimental Therapeutics, 319(3), 991-997.