Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line

American Journal of Physiology - Cell Physiology

Volumn 294, Issue 6, 2008, Pages

  Lin, Alan L ^a   Zhu, Bing ^a   Zhang, WanKe ^a   Dang, Howard ^a   Zhang, Bin Xian ^a,b   Katz, Michael S ^a,b   Yeh, Chih Ko ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Epidermal growth factor receptor; Muscarinic receptor; Protein kinase C

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CALCIUM ION; CARBACHOL; EGTAZIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR ANTAGONIST; MUSCARINIC M3 RECEPTOR ANTAGONIST; N (3 CHLOROPROPYL) 4 PIPERIDINYL DIPHENYLACETATE; PHORBOL 13 ACETATE 12 MYRISTATE; PILOCARPINE; PIRENZEPINE; PROTEIN KINASE C; RECEPTOR SUBTYPE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UO 126; CALCIUM; CHELATING AGENT; CHRM1 PROTEIN, HUMAN; EGFR PROTEIN, HUMAN; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL CULTURE; CHOLINERGIC SYSTEM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; NONHUMAN; PAROTID GLAND; PRIORITY JOURNAL; RAT; SALIVARY GLAND; SALIVATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; XEROSTOMIA; ANIMAL; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE; SPRAGUE DAWLEY RAT;

ANIMALS; CALCIUM; CARBACHOL; CELL LINE; CHELATING AGENTS; ENZYME ACTIVATION; HUMANS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; PAROTID GLAND; PHOSPHORYLATION; PILOCARPINE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; RNA INTERFERENCE; SALIVARY GLANDS; SRC-FAMILY KINASES;

EID: 47249106538     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00151.2007     Document Type: Article

References (47)

1. Amos S, Martin PM, Polar GA, Parsons SJ, Hussaini IM. Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cδ/c-Src pathways in glioblastoma cells. J Biol Chem 280: 7729-7738, 2005.
2. 1-adrenoceptor. Mol Pharmacol 63: 1312-1321, 2003.
3. Baum BJ. Principles of saliva secretion. Ann NY Acad Sci 694: 17-23, 1993.
4. Berkeley JL, Decker MJ, Levey AI. The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures. J Neurochem 82: 192-201, 2002.
5. Berkeley JL, Levey AI. Muscarinic activation of mitogen-activated protein kinase in PC12 cells. J Neurochem 75: 487-493, 2000.
6. Calandrella SO, Barrett KE, Keely SJ. Transactivation of the epidermal growth factor receptor mediates muscarinic stimulation of focal adhesion kinase in intestinal epithelial cells. J Cell Physiol 203: 103-110, 2005.
7. 3 muscarinic receptors in rat parotid gland couple to two second messenger systems. Am J Physiol Cell Physiol 261: C1063-C1073, 1991.
8. Dowd FJ, Zeng W, Watson EL, DiJulio D. Carbachol and the ERK pathway in the mouse parotid gland (Abstract) [Online]. http://iadr.confex.com/ iadr/2005Balt/techprogram/abstract_61511.htm.
9. Fox RI, Konttinen Y, Fisher A. Use of muscarinic agonists in the treatment of Sjögren's syndrome. Clin Immunol 101: 249-263, 2001.
10. 2-adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol 70: 1575-1584, 2006.
11. Gornitsky M, Shenouda G, Sultanem K, Katz H, Hier M, Black M, Velly AM. Double-blind randomized, placebo-controlled study of pilocarpine to salvage salivary gland function during radiotherapy of patients with head and neck cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98: 45-52, 2004.
12. Gorsky M, Epstein JB, Parry J, Epstein MS, Le ND, Silverman S Jr. The efficacy of pilocarpine and bethanechol upon saliva production in cancer patients with hyposalivation following radiation therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97: 190-195, 2004.
13. Grimes CA, Jope RS. Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells. J Neurochem 73: 1384-1392, 1999.
14. 1 muscarinic acetylcholine receptors to the activation of ERK1/2. J Biol Chem 276: 25568-25581, 2001.
15. 1 receptor by several muscarinic ligands. Eur J Pharmacol 267: 21-31, 1994.
16. 1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons. J Biol Chem 276: 15850-15853, 2001.
17. Hug H, Sarre TF. Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291: 329-343, 1993.
18. Jaken S. Protein kinase C isozymes and substrates. Curr Opin Cell Biol 8: 168-173, 1996.
19. Jimenez E, Gamez MI, Bragado MJ, Montiel M. Muscarinic activation of mitogen-activated protein kinase in rat thyroid epithelial cells. Cell Signal 14: 665-672, 2002.
20. Jimenez E, Montiel M. Activation of MAP kinase by muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells. J Cell Physiol 204: 678-686, 2005.
21. Kanno H, Horikawa Y, Hodges RR, Zoukhri D, Shatos MA, Rios JD, Dartt DA. Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. Am J Physiol Cell Physiol 284: C988-C998, 2003.
22. 2+, PKY-2 and p60Src. J Biol Chem 275: 12619-12625, 2000.
23. Keely SJ, Uribe JM, Barrett KE. Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion. J Biol Chem 273: 27111-27117, 1998.
24. 3 muscarinic receptor. Biochem J 337: 275-280, 1999.
25. Kitten AM, Hymer TK, Katz MS. Bidirectional modulation of parathyroid hormone-responsive adenylyl cyclase by protein kinase C. Am J Physiol Endocrinol Metab 266: E897-E904, 1994.
26. 3 muscarinic receptors in sublingual glands. Am J Physiol Cell Physiol 280: C884-C896, 2001.
27. Luttrell LM. G protein-coupled receptor signalling in neuroendocrine systems. "Location, location, location": activation and targeting of MAP kinases by G protein-coupled receptors. J Mol Endocrinol 30: 117-126, 2003.
28. Olsen JG, Salih MA, Harrison JL, Herrera I, Luther MF, Kalu DK, Lifschitz MD, Katz MS, Yeh CK. Modulation by food restriction of intracellular calcium signaling in parotid acinar cells of aging Fischer 344 rats. J Gerontol 52A: B152-B158, 1997.
29. Proctor GB, Carpenter GH. Regulation of salivary gland function by autonomic nerves. Auton Neurosci 133: 3-18, 2007.
30. Putney JW Jr. Identification of cellular activation mechanisms associated with salivary secretion. Annu Rev Physiol 48: 75-88, 1986.
31. 3 cotransport activity in renal epithelial cells. Am J Physiol Renal Physiol 280: F844-F850, 2001.
32. Rosenblum K, Futter M, Jones M, Hulme EC, Bliss TV. ERKI/II regulation by the muscarinic acetylcholine receptors in neurons. J Neurosci 20: 977-985, 2000.
33. Rothermel JD, Parker Botelho LH. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3′,5′-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J 251: 757-762, 1988.
34. Ryberg AT, Warfvinge G, Axelsson L, Soukup O, Gotrick B, Tobin G. Expression of muscarinic receptor subtypes in salivary glands of rats, sheep and man. Arch Oral Biol 53: 66-74, 2008.
35. 3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase. Biochem J 348: 381-387, 2000.
36. Takagi K, Yamaguchi K, Sakurai T, Asari T, Hashimoto K, Terakawa S. Secretion of saliva in X-irradiated rat submandibular glands. Radiat Res 159: 351-360, 2003.
37. Tobin G, Ryberg AT, Gentle S, Edwards AV. Distribution and function of muscarinic receptor subtypes in the ovine submandibular gland. J Appl Physiol 100: 1215-1223, 2006.
38. Ukegawa JI, Takeuchi Y, Kusayanagi S, Mitamura K. Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells. J Cancer Res Clin Oncol 129: 272-278, 2003.
39. Watcharasit P, Tucholski J, Jope RS. Src family kinase involvement in muscarinic receptor-induced tyrosine phosphorylation in differentiated SH-SY5Y cells. Neurochem Res 26: 809-816, 2001.
40. Watson EL, Abel PW, DiJulio D, Zeng W, Makoid M, Jacobson KL, Potter LT, Dowd FJ. Identification of muscarinic receptor subtypes in mouse parotid gland. Am J Physiol Cell Physiol 271: C905-C913, 1996.
41. 5 muscarinic receptors stimulate mitogen-activated protein kinase. Pharmacology 56: 175-186, 1998.
42. Wylie PG, Challiss RA, Blank JL. Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors. Biochem J 338: 619-628, 1999.
43. Wynn RL. Oral pilocarpine (Salagen) - a recently approved salivary stimulant. Gen Dent 44: 26-30, 1996.
44. Yagle K, Lu H, Guizzetti M, Moller T, Costa LG. Activation of mitogen-activated protein kinase by muscarinic receptors in astroglial cells: role in DNA synthesis and effect of ethanol. Glia 35: 111-120, 2001.
45. Yanagawa T, Hayashi Y, Nagamine S, Yoshida H, Yura Y, Sato M. Generation of cells with phenotypes of both intercalated duct-type and myoepithelial cells in human parotid gland adenocarcinoma clonal cells grown in athymic nude mice. Virchows Arch B Cell Pathol Incl Mol Pathol 51: 187-195, 1986.
46. Yeh CK, Ghosh PM, Dang H, Liu Q, Lin AL, Zhang BX, Katz MS. β-Adrenergic-responsive activation of extracellular signal-regulated protein kinases in salivary cells: role of epidermal growth factor receptor and cAMP. Am J Physiol Cell Physiol 288: C1357-C1366, 2005.
47. Zhang BX, Yeh CK, Hymer TK, Lifschitz MD, Katz MS. EGF inhibits muscarinic receptor-mediated calcium signaling in a human salivary cell line. Am J Physiol Cell Physiol 279: C1024-C1033, 2000.