Effects of muscarinic receptor antagonism on the phosphatidylinositol bisphosphate signal transduction pathway after experimental brain injury

Brain Research

Volumn 742, Issue 1-2, 1996, Pages 63-70

  Lyeth, Bruce G ^a   Gong, Qin Zhi ^a   Dhillon, H S ^b   Prasad, M Renuka ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

arachidonic acid; diacylglycerol; fluid percussion; free fatty acid; muscarinic; phosphatidylinositol bisphosphate; rat; scopolamine; traumatic brain injury

Indexed keywords

ARACHIDONIC ACID; DIACYLGLYCEROL; MUSCARINIC RECEPTOR BLOCKING AGENT; PHOSPHOLIPASE C; SCOPOLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN INJURIES; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; MUSCARINIC ANTAGONISTS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; RATS; RATS, SPRAGUE-DAWLEY; SCOPOLAMINE; SIGNAL TRANSDUCTION;

EID: 0030566694     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01002-5     Document Type: Article

References (42)

1. Delahunty T.M., Jiang J.Y., Black R.T., Lyeth B.G. Differential modulation of carbachol and phosphoinositide turnover following traumatic brain injury. Neurochem. Res. 20:1995;335-341.
2. Delahunty T.M., Jiang J.Y., Gong Q.Z., Black R.T., Lyeth B.G. Differential consequences of lateral and central fluid percussion brain injury on receptor coupling in rat hippocampus. J. Neurotrauma. 12:1995;1045-1057.
3. 2 levels in rats. J. Neurotrauma. 5:1988;303-313.
4. Dhillon H.S., Donaldson D., Dempsey R.J., Prasad M.R. Regional levels of free fatty acids and Evans Blue extravasation after experimental brain injury. J. Neurotrauma. 11:1994;405-415.
5. Dhillon H.S., Carbary T., Dose J., Dempsey R.J., Prasad M.R. Activation of phosphatidylinositol bisphosphate signal transduction pathway after experimental brain injury: a lipid study. Brain Res. 698:1995;100-106.
6. Dixon C.E., Lyeth B.G., Povlishock J.T., Findling R.L., Hamm R.J., Marmarou A., Young H.F., Hayes R.L. A fluid percussion model of experimental brain injury in the rat. J. Neurosurg. 67:1987;110-119.
7. Ellis E.F., Wright K.F., Wei E.P., Kontos H.A. Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury. J. Neurochem. 37:1981;892-896.
8. Faden A.I., Demediuk P., Panter S.S., Vink R. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science. 244:1989;798-800.
9. Frandsen A., Schousboe A. Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons. J. Neurochem. 60:1993;1202-1211.
10. Gorman L.K., Fu K., Hovda D.A., Becker D.P., Katayama Y. Analysis of acetylcholine release following concussive brain injury in the rat. J. Neurotrauma. 6:1989;203-210.
11. Hall E.D., Andrus P.K., Yonkers P.A. Brain hydroxyl radical generation in acute experimental head injury. J. Neurochem. 60:1993;588-594.
12. Hamm R.J., O'Dell D.M., Pike B.R., Lyeth B.G. Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801. Cognitive Brain Res. 1:1993;223-226.
13. Hayes R.L., Jenkins L.W., Lyeth B.G. Neurotransmitter-mediated mechanisms of traumatic brain injury: acetylcholine and excitatory amino acids. J. Neurotrauma. 9:1992;S173-S187.
14. Hicks R., Soares H., Smith D., McIntosh T. Temporal and spatial characterization of neuronal injury following lateral fluid-percussion brain injury in the rat. Acta Neuropathol. 91:1996;236-246.
15. Hovda D.A., Becker D.P., Katayama Y. Secondary injury and acidosis. J. Neurotrauma. 9:1992;S47-S60.
16. Jiang J.Y., Lyeth B.G., Clifton G.L., Jenkins L.W., Hamm R.J., Hayes R.L. Relationship between body and brain temperature in traumatically brain injured rodents. J. Neurosurg. 74:1991;492-496.
17. Joyce J.N., Gibbs R.B., Cotman C.W., Marshall J.F. Regulation of muscarinic receptors in hippocampus following cholinergic denervation and reinnervation by septal and striatal transplants. J. Neurosci. 9:1989;2776-2791.
18. Katayama Y., Becker D.P., Tamura T., Hovda D.A. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J. Neurosurg. 73:1990;889-900.
19. Kawamata T., Katayama Y., Hovda D.A., Yoshino A., Becker D.P. Administration of excitatory amino acid antagonists via microdialysis attenuates the increase in glucose utilization seen following concussive brain injury. J. Cereb. Blood Flow Metab. 12:1992;12-24.
20. Kawamata T., Katayama Y., Hovda D.A., Yoshino A., Becker D.P. Lactate accumulation following concussive brain injury: the role of ion fluxes induced by excitatory amino acids. Brain Res. 674:1995;196-204.
21. Kontos H.A., Wei E.P., Ellis E.F., Jenkins L.W., Povlishock J.T., Rowe G.T., Hess M.L. Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats. Circ. Res. 57:1985;142-151.
22. Kuhr W.G., Korf J. Extracellular lactic acid as an indicator of brain metabolism: continuous on-line measurement on conscious, freely moving rats with interstriatal dialysis. J. Cereb. Blood Flow Metab. 8:1988;130-137.
23. Lapetina E.G., Siess W. Measurement of inositol phospholipid turnover in platelets. Methods Enzymol. 141:1987;176-192.
24. Lyeth B.G., Dixon C.E., Hamm R.J., Jenkins L.W., Young H.f., Stonnington H.H., Hayes R.L. Effects of anticholinergic treatment on transient behavioral suppression and physiological responses following concussive brain injury to the rat. Brain Res. 448:1988;88-97.
25. Lyeth B.G., Dixon C.E., Jenkins L.W., Hamm R.J., Alberico A., Young H.F., Stonnington H.H., Hayes R.L. Effects of scopolamine treatment on long-term behavioral deficits following concussive brain injury to the rat. Brain Res. 452:1988;39-48.
26. Lyeth B.G., Ray M., Hamm R.J., Schnabel J., Saady J.J., Poklis A., Jenkins L.W., Gudeman S.K., Hayes R.L. Post-injury scopolamine administration in experimental traumatic brain injury. Brain Res. 569:1992;281-286.
27. Lyeth B.G., Hayes R.L. Cholinergic and opioid mediation of traumatic brain injury. J. Neurotrauma. 9((Suppl. 2)):1992;S463-S474.
28. Lyeth B.G., Jiang J.Y., Robinson S.E., Guo H., Jenkins L.W. Hypothermia blunts acetylcholine increase in CSF of traumatically brain injured rats. Mol. Chem. Neuropathol. 18:1993;247-256.
29. 31P nuclear magnetic resonance. J. Neurochem. 49:1987;1530-1540.
30. Nilsson P., Hillered L., Ponten U., Ungerstedt U. Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. J. Cereb. Blood Flow Metab. 10:1990;631-637.
31. Palmer A.M., Marion D.W., Botscheller M.L., Swedlow P.E., Styren S.D., DeKosky S.T. Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. J. Neurochem. 61:1993;2015-2024.
32. Prasad M.R., Ramaiah C., McIntosh T.K., Dempsey R.J., Hipkens S., Yurek D. Regional levels of lactate and norepinephrine after experimental brain injury. J. Neurochem. 63:1994;1086-1094.
33. Prasad M.R., Dhillon H.S., Carbary T., Dempsey R.J., Scheff S.W. Enhanced phosphodiestric breakdown of phosphatidylinositol bisphosphate after experimental brain injury. J. Neurochem. 63:1994;773-776.
34. Robinson S.E., Martin R.M., Davis T.R., Gyenes C.A., Ryland J.E., Enters E.K. The effect of acetylcholine depletion on behavior following traumatic brain injury. Brain Res. 509:1990;41-46.
35. 1 muscarinic blockade on behavior following traumatic brain injury in the rat. Brain Res. 511:1990;141-148.
36. Seisjo B.K. Acidosis and ischemic brain damage. Neurochem. Pathol. 9:1988;31-88.
37. Shohami E., Shapira Y., Sidi A., Cotev S. Head injury induces increased prostaglandin synthesis in the rat brain. J. Cereb. Blood Flow Metab. 7:1987;58-63.
38. Somjen G.G. Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression. Brain Res. 311:1984;186-188.
39. Tzigaret C., McIntosh T.K., Okiyama K., Jenkins L.W., Prasad M.R. Measurement of hippocampal levels of cellular second messengers following in situ freezing. J. Neurochem. 60:1993;827-834.
40. Vink R., Head V.A., Rogers P.J., McIntosh T.K., Faden A.I. Mitochondrial metabolism following traumatic brain injury in rats. J. Neurotrauma. 7:1990;21-27.
41. Wei E.P., Lamb R.G., Kontos H.A. Increased phospholipase C activity after experimental brain injury. J. Neurosurg. 56:1982;695-698.
42. Yang M.S., DeWitt D.S., Becker D.P., Hayes R.L. Regional brain metabolite levels following mild experimental head injury in the cat. J. Neurosurg. 63:1985;617-621.