Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake

BMC Microbiology

Volumn 8, Issue , 2008, Pages

  Brown, Amanda C ^a   Parish, Tanya ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; FOSMIDOMYCIN; ISOMERASE; 1 DEOXY D XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; CARRIER PROTEIN; DRUG DERIVATIVE; FOSFOMYCIN; MULTIENZYME COMPLEX; OXIDOREDUCTASE; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG UPTAKE; ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; BACTERIAL GENE; CROSSING OVER; DRUG DETOXIFICATION; DRUG EFFECT; ESSENTIAL GENE; GENE DELETION; GENETICS; METABOLISM; OPERON;

CORYNEBACTERINEAE; ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

ALDOSE-KETOSE ISOMERASES; ANTIBIOTICS, ANTITUBERCULAR; CROSSING OVER, GENETIC; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; FOSFOMYCIN; GENE DELETION; GENES, BACTERIAL; GENES, ESSENTIAL; MEMBRANE TRANSPORT PROTEINS; METABOLIC DETOXICATION, DRUG; MULTIENZYME COMPLEXES; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; OPERON; OXIDOREDUCTASES;

EID: 44849135047     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-8-78     Document Type: Article

References (41)

1. 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin. RK Dhiman ML Schaeffer AM Bailey CA Testa H Scherman DC Crick, J Bacteriol 2005 187 24 8395 8402 16321944 10.1128/JB.187.24.8395-8402.2005
2. Global burden of tuberculosis. Estimated incidence, prevalence, and mortality by country. C Dye S Scheele P Dolin V Pathania MC Raviglione, Journal of American Medical Association 1999 282 677 686 10.1001/jama.282.7.677
3. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. ST Cole R Brosch J Parkhill T Garnier C Churcher D Harris SV Gordon K Eiglmeier S Gas CE Barry, Nature 1998 393 6685 537 544 10.1038/31159 9634230
4. Porins in the cell wall of mycobacteria. J Trias V Jarlier R Benz, Science 1992 258 5087 1479 1481 10.1126/science.1279810 1279810
5. A tetrameric porin limits the cell wall permeability of Mycobacterium smegmatis. H Engelhardt C Heinz M Niederweis, J Biol Chem 2002 277 40 37567 37572 10.1074/jbc.M206983200 12130659
6. Characterization of a porin from Mycobacterium smegmatis. S Mukhopadhyay D Basu P Chakrabarti, J Bacteriol 1997 179 19 6205 6207 9324274
7. The growth rate of Mycobacterium smegmatis depends on sufficient porin-mediated influx of nutrients. J Stephan J Bender F Wolschendorf C Hoffmann E Roth C Mailander H Engelhardt M Niederweis, Molecular Microbiology 2005 58 3 714 730 10.1111/j.1365-2958.2005.04878.x 16238622
8. Foundations of antibiotic resistance in bacterial physiology: the mycobacterial paradigm. L Nguyen CJ Thompson, Trends in Microbiology 2006 14 7 304 312 10.1016/j.tim.2006.05.005 16759863
9. Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis. DC Crick MC Schulbach EE Zink M Macchia S Barontini GS Besra PJ Brennan, J Bacteriol 2000 182 20 5771 5778 11004176 10.1128/JB.182.20.5771-5778.2000
10. Fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis. T Kuzuyama T Shimizu S Takahashi H Seto, Tetrahedron Letters 1998 39 43 7913 7916 10.1016/S0040-4039(98)01755-9
11. In vitro and in vivo antibacterial activity of FR-3 a phosphonic acid antimicrobial agent. HC Neu T Kamimura, Antimicrob Agents Chemother 1564 19 6 1013 1023
12. Synergy of fosmidomycin (FR-31564) and other antimicrobial agents. HC Neu T Kamimura, Antimicrob Agents Chemother 1982 22 4 560 563 7181471
13. Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli. Y Sakamoto S Furukawa H Ogihara M Yamasaki, Biosci Biotechnol Biochem 2003 67 9 2030 2033 10.1271/bbb.67.2030 14519998
14. Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification. S Fujisaki S Ohnuma T Horiuchi I Takahashi S Tsukui Y Nishimura T Nishino M Kitabatake H Inokuchi, Gene 1996 175 1-2 83 87 10.1016/0378-1119(96)00128-X 8917080
15. Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis. SM Halling BD Peterson-Burch BJ Bricker RL Zuerner Z Qing L-L Li V Kapur DP Alt SC Olsen, J Bacteriol 2005 187 8 2715 2726 15805518 10.1128/JB.187.8.2715-2726.2005
16. Plasmodium falciparum: detection of the deoxyxylulose 5- phosphate reductoisomerase activity. J Wiesner M Hintz B Altincicek S Sanderbrand C Weidemeyer E Beck H Jomaa, Exp Parasitol 2000 96 3 182 186 10.1006/expr.2000. 4566 11162369
17. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. H Jomaa J Wiesner S Sanderbrand B Altincicek C Weidemeyer M Hintz I Turbachova M Eberl J Zeidler HK Lichtenthaler, Science 1999 285 5433 1573 1576 10.1126/science.285.5433.1573 10477522
18. Fosmidomycin for malaria. MA Missinou S Borrmann A Schindler S Issifou AA Adegnika P-B Matsiegui R Binder B Lell J Wiesner T Baranek, The Lancet 2002 360 9349 1941 1942 10.1016/S0140-6736(02)11860-5
19. Distribution of mevalonate and glyceraldehyde 3- phosphate/pyruvate routes for isoprenoid biosynthesis in some Gram-negative bacteria and mycobacteria. SR Putra A Disch JM Bravo M Rohmer, FEMS Microbiol Lett 1998 164 1 169 175 10.1111/j.1574-6968.1998.tb13082.x 9675863
20. Genes required for mycobacterial growth defined by high density mutagenesis. CM Sassetti DH Boyd EJ Rubin, Molecular Microbiology 2003 48 1 77 84 10.1046/j.1365-2958.2003.03425.x 12657046
21. Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement. T Parish NG Stoker, Microbiology 2000 146 Pt 8 1969 1975 10931901
22. Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides. A Weihofen B Martoglio, Trends Cell Biol 2003 13 71 78 10.1016/S0962-8924(02)00041-7 12559757
23. Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis. H Makinoshima MS Glickman, Nature 2005 436 7049 406 409 16034419 10.1038/nature03713
24. Use of the mycobacteriophage L5 excisionase in Mycobacterium tuberculosis to demonstrate gene essentiality. T Parish J Lewis NG Stoker, Tuberculosis 2001 81 5-6 359 364 10.1054/tube.2001.0312 11800587
25. Efficient switching of mycobacteriophage L5-based integrating plasmids in Mycobacterium tuberculosis. CA Pashley T Parish, FEMS Microbiol Lett 2003 229 2 211 215 10.1016/S0378-1097(03)00823-1 14680701
26. Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG, but not Escherichia coli fabG. T Parish G Roberts F Laval M Schaeffer M Daffe K Duncan, J Bacteriol 2007 189 3721 3728 17337570 10.1128/JB.01740-06
27. Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis. MR Pasca P Guglierame F Arcesi M Bellinzoni E De Rossi G Riccardi, Antimicrob Agents Chemother 2004 48 8 3175 3178 15273144 10.1128/AAC.48.8.3175-3178.2004
28. Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. X-Z Li L Zhang H Nikaido, Antimicrob Agents Chemother 2004 48 7 2415 2423 15215089 10.1128/AAC.48.7.2415-2423.2004
29. mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis. MR Pasca P Guglierame E De Rossi F Zara G Riccardi, Antimicrob Agents Chemother 2005 49 11 4775 4777 16251328 10.1128/AAC.49.11.4775-4777.2005
30. Isoniazid accumulation in Mycobacterium smegmatis is modulated by proton motive force-driven and ATP-dependent extrusion systems. BS Choudhuri S Sen P Chakrabarti, Biochemical and Biophysical Research Communications 1999 256 3 682 684 10.1006/bbrc.1999.0357
31. Role of mycobacterial efflux transporters in drug resistance: an unresolved question. ED Rossi JA Ainsa G Riccardi, FEMS Microbiology Reviews 2006 30 1 36 52 10.1111/j.1574-6976.2005.00002.x 16438679
32. Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitum. S Ramon-Garcia C Martin J Ainsa E De Rossi, J Antimicrob Chemother 2006 57 2 252 259 10.1093/jac/dki436 16373429
33. Bioassay for determination of fosmidomycin in plasma and urine: Application for pharmacokinetic dose optimisation. A Cheoymang D Hudchinton D Kioy K Na-Bangchang, Journal of Microbiological Methods 2007 69 1 65 69 10.1016/j.mimet.2006.11.018 17258829
34. FR-31564 a new phosphonic acid antibiotic: bacterial resistance and membrane permeability. H Kojo Y Shigi M Nishida, J Antibiot (Tokyo) 1980 33 1 44 48 7378171
35. Antibacterial research and development in the 21st Century - an industry perspective of the challenges. CJ Thomson E Power H Ruebsamen-Waigmann H Labischinski, Current Opinion in Microbiology 2004 7 5 445 450 10.1016/j.mib.2004.08.009 15451498
36. Tetracycline-inducible gene regulation in mycobacteria. MCJ Blokpoel HN Murphy R O'Toole S Wiles ESC Runn GR Stewart DB Young BD Robertson, Nucleic Acids Res 2005 33 2:art. no.-e22. 15687380
37. Use of a tetracycline-inducible system for conditional expression in Mycobacterium tuberculosis and Mycobacterium smegmatis. P Carroll DG Muttucumaru T Parish, Appl Environ Microbiol 2005 71 6 3077 3084 15933004 10.1128/AEM.71.6.3077-3084.2005
38. Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. S Ehrt XV Guo CM Hickey M Ryou M Monteleone LW Riley D Schnappinger, Nucleic Acids Res 2005 33 2 e21 15687379 10.1093/nar/gni013
39. Control of the acetamidase gene of Mycobacterium smegmatis by multiple regulators. G Roberts DGN Muttucumaru T Parish, FEMS Microbiol Lett 2003 221 1 131 136 10.1016/S0378-1097(03)00177-0 12694921
40. Electroporation of mycobacteria. T Parish NG Stoker, Methods Mol Biol 1998 101 129 144 9921475
41. Site-directed mutagenesis of the 19-kilodalton lipoprotein antigen reveals no essential role for the protein in the growth and virulence of Mycobacterium intracellulare. E Mahenthiralingam B-I Marklund LA Brooks DA Smith GJ Bancroft RW Stokes, Infect Immun 1998 66 8 3626 34 9673242