Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea

Sleep Medicine

Volumn 12, Issue 7, 2011, Pages 666-671

  Bhushan, Bharat ^a   Khalyfa, Abdelnaby ^a   Spruyt, Karen ^a   Kheirandish Gozal, Leila ^a   Capdevila, Oscar Sans ^a   Bhattacharjee, Rakesh ^a   Kim, Jinkwan ^a   Keating, Brendan ^b   Hakonarson, Hakon ^b   Gozal, David ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Atherosclerosis; Cholesterol; Gene polymorphisms; Hyperlipidemia; Metabolic syndrome; Sleep apnea

Indexed keywords

CHOLESTEROL; FATTY ACID BINDING PROTEIN 4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

APNEA HYPOPNEA INDEX; ARTICLE; BODY MASS; CHILD; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; OBESITY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN POLYMORPHISM; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP APNEA SYNDROME; TRIACYLGLYCEROL BLOOD LEVEL;

CHILD; CHILD, PRESCHOOL; FATTY ACID-BINDING PROTEINS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYSOMNOGRAPHY; RISK FACTORS; SLEEP APNEA, OBSTRUCTIVE;

EID: 79960630916     PISSN: 13899457     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2010.12.014     Document Type: Article

References (36)

1. Gozal D. Obstructive sleep apnea in children: implications for the developing central nervous system. Semin Pediatr Neurol 2008, 15(2):100-106.
2. Capdevila O.S., Dayyat E., Kheirandish-Gozal L., Gozal D. Prevalence of epileptiform activity in healthy children during sleep. Sleep Med 2008, 9(3):303-309.
3. Dayyat E., Kheirandish-Gozal L., Gozal D. Childhood obstructive sleep apnea: one or two distinct disease entities?. Sleep Med Clin 2007, 2(3):433-444.
4. Gozal D., Capdevila O.S., Kheirandish-Gozal L. Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children. Am J Respir Crit Care Med 2008, 177(10):1142-1149.
5. Kwok K.L., Ng D.K., Chan C.H. Cardiovascular changes in children with snoring and obstructive sleep apnoea. Ann Acad Med Singapore 2008, 37(8):715-721.
6. Gozal D. Sleep, sleep disorders and inflammation in children. Sleep Med 2009, 10(Suppl. 1):S12-S16.
7. Suheyl Ezgu F., Hasanoglu A., Tumer L., Ozbay F., Aybay C., Gunduz M. Endothelial activation and inflammation in prepubertal obese Turkish children. Metabolism 2005, 54(10):1384-1389.
8. Tauman R., Ivanenko A., O'Brien L.M., Gozal D. Plasma C-reactive protein levels among children with sleep-disordered breathing. Pediatrics 2004, 113(6):e564-e569.
9. Tauman R., O'Brien L.M., Gozal D. Hypoxemia and obesity modulate plasma C-reactive protein and interleukin-6 levels in sleep-disordered breathing. Sleep Breath 2007, 11(2):77-84.
10. O'Brien L.M., Serpero L.D., Tauman R., Gozal D. Plasma adhesion molecules in children with sleep-disordered breathing. Chest 2006, 129(4):947-953.
11. Kheirandish-Gozal L., Capdevila O.S., Tauman R., Gozal D. Plasma C-reactive protein in nonobese children with obstructive sleep apnea before and after adenotonsillectomy. J Clin Sleep Med 2006, 2(3):301-304.
12. Gozal D., Crabtree V.M., Sans Capdevila O., Witcher L.A., Kheirandish-Gozal L. C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged children. Am J Respir Crit Care Med 2007, 176(2):188-193.
13. Gozal D., Serpero L.D., Sans Capdevila O., Kheirandish-Gozal L. Systemic inflammation in non-obese children with obstructive sleep apnea. Sleep Med 2008, 9(3):254-259.
14. Kim J., Bhattacharjee R., Snow A.B., Capdevila O.S., Kheirandish-Gozal L., Gozal D. Myeloid-related protein 8/14 levels in children with obstructive sleep apnoea. Eur Respir J 2010, 35(4):843-850.
15. Khalyfa A., Capdevila O.S., Buazza M.O., Serpero L.D., Kheirandish-Gozal L., Gozal D. Genome-wide gene expression profiling in children with non-obese obstructive sleep apnea. Sleep Med 2009, 10(1):75-86.
16. Kim J., Lee S., Bhattacharjee R., Khalyfa A., Kheirandish-Gozal L., Gozal D. Leukocyte telomere length and plasma catestatin and myeloid related protein 8/14 concentrations in children with obstructive sleep apnea. Chest 2010, 138(1):91-99.
17. Zimmerman A.W., Veerkamp J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 2002, 59(7):1096-1116.
18. Furuhashi M., Hotamisligil G.S. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov 2008, 7(6):489-503.
19. Furuhashi M., Fucho R., Gorgun C.Z., Tuncman G., Cao H., Hotamisligil G.S. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest 2008, 118(7):2640-2650.
20. Yun K.E., Kim S.M., Choi K.M., Park H.S. Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children. Metabolism 2009, 58(6):798-802.
21. Reinehr T., Stoffel-Wagner B., Roth C.L. Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss. J Clin Endocrinol Metab 2008, 93(6):2287-2293.
22. Khalyfa A., Bhushan B., Hegazi M., Kim J., Kheirandish-Gozal L., Bhattacharjee R., et al. Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. Lipids Health Dis. 2010, 9:18.
23. Montgomery-Downs H.E., O'Brien L.M., Gulliver T.E., Gozal D. Polysomnographic characteristics in normal preschool and early school-aged children. Pediatrics 2006, 117(3):741-753.
24. Standards and indications for cardiopulmonary sleep studies in children. American Thoracic Society. Am J Respir Crit Care Med 1996.
25. Silber M.H., Ancoli-Israel S., Bonnet M.H., Chokroverty S., Grigg-Damberger M.M., Hirshkowitz M., et al. The visual scoring of sleep in adults. J Clin Sleep Med 2007, 3(2):121-131.
26. Maeda K., Cao H., Kono K., Gorgun C.Z., Furuhashi M., Uysal K.T., et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab 2005, 1(2):107-119.
27. Cabre A., Lazaro I., Girona J., Manzanares J.M., Marimon F., Plana N., et al. Fatty acid binding protein 4 is increased in metabolic syndrome and with thiazolidinedione treatment in diabetic patients. Atherosclerosis 2007, 195(1):e150-e158.
28. Karakas S.E., Almario R.U., Kim K. Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers. Metabolism 2009, 58(7):1002-1007.
29. Lam D.C., Xu A., Lam K.S., Lam B., Lam J.C., Lui M.M., et al. Serum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance. Eur Respir J 2009, 33(2):346-351.
30. Reinehr T., Stoffel-Wagner B., Roth C.L. Adipocyte fatty acid-binding protein in obese children before and after weight loss. Metabolism 2007, 56(12):1735-1741.
31. Tuncman G., Erbay E., Hom X., De Vivo I., Campos H., Rimm E.B., et al. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci USA 2006, 103(18):6970-6975.
32. Damcott C.M., Moffett S.P., Feingold E., Barmada M.M., Marshall J.A., Hamman R.F., et al. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. Metabolism 2004, 53(3):303-309.
33. Fu Y., Luo N., Lopes-Virella M.F. Oxidized LDL induces the expression of ALBP/aP2 mRNA and protein in human THP-1 macrophages. J Lipid Res 2000, 41(12):2017-2023.
34. Liu Q.Y., Quinet E., Nambi P. Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells. Mol Cell Biochem 2007, 302(1-2):203-213.
35. Boord J.B., Maeda K., Makowski L., Babaev V.R., Fazio S., Linton M.F., et al. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol 2002, 22(10):1686-1691.
36. Visser M., Bouter L.M., McQuillan G.M., Wener M.H., Harris T.B. Low-grade systemic inflammation in overweight children. Pediatrics 2001, 107(1):E13.