Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ

Journal of the American Chemical Society

Volumn 133, Issue 29, 2011, Pages 11320-11330

  Park, Ki Duk ^a   Kim, Dongwook ^a   Reamtong, Onrapak ^b   Eyers, Claire ^b   Gaskell, Simon J ^b,c   Liu, Rihe ^a,d   Kohn, Harold ^a,e  

^a University of North Carolina   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEPILEPTIC DRUGS; BINDING AFFINITIES; BINDING INTERACTION; BINDING PARTNERS; BINDING PROTEINS; ENDOGENOUS LEVEL; INFORMATION CONCERNING; ISOTHERMAL CALORIMETRY; LOW MOLECULAR WEIGHT; LYSATES; RODENT BRAIN; SMALL MOLECULES; STEREOSPECIFIC;

BINDING ENERGY; LIGANDS; MASS SPECTROMETRY; METABOLISM; METABOLITES;

CHEMICAL DETECTION;

1 METHYLXANTHINE; 1,7 DIMETHLYLXANTHINE; 3 METHYLXANTHINE; 7 METHYLXANTHINE; CAFFEINE; HARKOSERIDE; PROTEIN 14 3 3; PROTEIN 14 3 3 DELTA; THEOBROMINE; THEOPHYLLINE; UNCLASSIFIED DRUG; URIC ACID; XANTHINE; XANTHINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYCLOADDITION; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; RAT; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

14-3-3 PROTEINS; ACETAMIDES; ANIMALS; ANTICONVULSANTS; BRAIN; MALE; MICE; MICE, INBRED ICR; MODELS, MOLECULAR; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79960569563     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2034156     Document Type: Article

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