Structure-function analysis of diacylglycerol acyltransferase sequences from 70 organisms

BMC Research Notes

Volumn 4, Issue , 2011, Pages

  Cao, Heping ^a  

^a SOUTHERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; EUKARYOTA; FUNGI;

EID: 79960556294     PISSN: None     EISSN: 17560500     Source Type: Journal    
DOI: 10.1186/1756-0500-4-249     Document Type: Article

References (52)

1. Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic protein. Cao H, Tuttle JS, Blackshear PJ, J Biol Chem 2004 279 21489 21499 10.1074/jbc.M400900200 15010466 (Pubitemid 38656559)
2. Temperature-sensitive post-translational regulation of plant omega-3 fatty-acid desaturases is mediated by the endoplasmic reticulum-associated degradation pathway. O'Quin JB, Bourassa L, Zhang D, Shockey JM, Gidda SK, Fosnot S, Chapman KD, Mullen RT, Dyer JM, J Biol Chem 2010 285 21781 21796 10.1074/jbc.M110.135236 20452984
3. Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. Cao H, Deterding LJ, Venable JD, Kennington EA, Yates JR, Tomer KB, Blackshear PJ, Biochem J 2006 394 285 297 10.1042/BJ20051316 16262601 (Pubitemid 43259679)
4. Phosphorylation site analysis of the anti-inflammatory and mRNA-destabilizing protein tristetraprolin. Cao H, Deterding LJ, Blackshear PJ, Expert Rev Proteomics 2007 4 711 726 10.1586/14789450.4.6.711 18067411 (Pubitemid 350261438)
5. Brittle-1, an adenylate translocator, facilitates transfer of extraplastidial synthesized ADP - glucose into amyloplasts of maize endosperms. Shannon JC, Pien FM, Cao H, Liu KC, Plant Physiol 1998 117 1235 1252 10.1104/pp.117.4.1235 9701580 (Pubitemid 128652897)
6. Identification of the soluble starch synthase activities of maize endosperm. Cao H, Imparl-Radosevich J, Guan H, Keeling PL, James MG, Myers AM, Plant Physiol 1999 120 205 216 10.1104/pp.120.1.205 10318698
7. Evidence for essential arginine residues at the active sites of maize branching enzymes. Cao H, Preiss J, J Protein Chem 1996 15 291 304 10.1007/BF01887118 8804577 (Pubitemid 26179089)
8. Site-directed mutagenesis evidence for arginine-384 residue at the active site of maize branching enzyme II. Cao H, Preiss J, J Protein Chem 1999 18 379 386 10.1023/A:1021003915810 10395456 (Pubitemid 29293211)
9. Purification and molecular genetic characterization of ZPU1, a pullulanase-type starch-debranching enzyme from maize. Beatty MK, Rahman A, Cao H, Woodman W, Lee M, Myers AM, James MG, Plant Physiol 1999 119 255 266 10.1104/pp.119.1.255 9880368 (Pubitemid 29384603)
10. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV Jr, Proc Natl Acad Sci USA 1998 95 13018 13023 10.1073/pnas.95.22.13018 9789033 (Pubitemid 28509516)
11. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. Cases S, Stone SJ, Zhou P, Yen E, Tow B, Lardizabal KD, Voelker T, Farese RV Jr, J Biol Chem 2001 276 38870 38876 10.1074/jbc.M106219200 11481335
12. DGAT2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activity. Lardizabal KD, Mai JT, Wagner NW, Wyrick A, Voelker T, Hawkins DJ, J Biol Chem 2001 276 38862 38869 10.1074/jbc.M106168200 11481333
13. Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum. Shockey JM, Gidda SK, Chapital DC, Kuan JC, Dhanoa PK, Bland JM, Rothstein SJ, Mullen RT, Dyer JM, Plant Cell 2006 18 2294 2313 10.1105/tpc.106.043695 16920778 (Pubitemid 44484727)
14. A distinct DGAT with sn-3 acetyltransferase activity that synthesizes unusual, reduced-viscosity oils in Euonymus and transgenic seeds. Durrett TP, McClosky DD, Tumaney AW, Elzinga DA, Ohlrogge J, Pollard M, Proc Natl Acad Sci USA 2010 107 9464 9469 10.1073/pnas.1001707107 20439724
15. Cytosolic triacylglycerol biosynthetic pathway in oilseeds. Molecular cloning and expression of peanut cytosolic diacylglycerol acyltransferase. Saha S, Enugutti B, Rajakumari S, Rajasekharan R, Plant Physiol 2006 141 1533 1543 10.1104/pp.106.082198 16798944 (Pubitemid 44223302)
16. Defective in cuticular ridges (DCR) of Arabidopsis thaliana, a gene associated with surface cutin formation, encodes a soluble diacylglycerol acyltransferase. Rani SH, Krishna TH, Saha S, Negi AS, Rajasekharan R, J Biol Chem 2010 285 38337 38347 10.1074/jbc.M110.133116 20921218
17. The Arabidopsis thaliana TAG1 mutant has a mutation in a diacylglycerol acyltransferase gene. Zou J, Wei Y, Jako C, Kumar A, Selvaraj G, Taylor DC, Plant J 1999 19 645 653 10.1046/j.1365-313x.1999.00555.x 10571850 (Pubitemid 29492544)
18. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV Jr, Nat Genet 2000 25 87 90 10.1038/75651 10802663 (Pubitemid 30257043)
19. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM, Farese RV Jr, J Biol Chem 2004 279 11767 11776 10.1074/jbc.M311000200 14668353 (Pubitemid 38401682)
20. Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. Chen HC, Rao M, Sajan MP, Standaert M, Kanoh Y, Miura A, Farese RV, Farese RV, Diabetes 2004 53 1445 1451 10.2337/diabetes.53.6.1445 15161747 (Pubitemid 38697655)
21. Tobacco as a production platform for biofuel: overexpression of Arabidopsis DGAT and LEC2 genes increases accumulation and shifts the composition of lipids in green biomass. Andrianov V, Borisjuk N, Pogrebnyak N, Brinker A, Dixon J, Spitsin S, Flynn J, Matyszczuk P, Andryszak K, Laurelli M, Golovkin M, Koprowski H, Plant Biotechnol J 2010 8 277 287 10.1111/j.1467-7652. 2009.00458.x 20051035
22. Metabolic engineering of hydroxy fatty acid production in plants: RcDGAT2 drives dramatic increases in ricinoleate levels in seed oil. Burgal J, Shockey J, Lu C, Dyer J, Larson T, Graham I, Browse J, Plant Biotechnol J 2008 6 819 831 10.1111/j.1467-7652.2008.00361.x 18643899
23. Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight. Jako C, Kumar A, Wei Y, Zou J, Barton DL, Giblin EM, Covello PS, Taylor DC, Plant Physiol 2001 126 861 874 10.1104/pp.126.2.861 11402213 (Pubitemid 32568815)
24. Expression of Umbelopsis ramanniana DGAT2A in seed increases oil in soybean. Lardizabal K, Effertz R, Levering C, Mai J, Pedroso MC, Jury T, Aasen E, Gruys K, Bennett K, Plant Physiol 2008 148 89 96 10.1104/pp.108.123042 18633120 (Pubitemid 352847578)
25. Cloning and characterization of an acyl-CoA-dependent diacylglycerol acyltransferase 1 (DGAT1) gene from Tropaeolum majus, and a study of the functional motifs of the DGAT protein using site-directed mutagenesis to modify enzyme activity and oil content. Xu J, Francis T, Mietkiewska E, Giblin EM, Barton DL, Zhang Y, Zhang M, Taylor DC, Plant Biotechnol J 2008 6 799 818 10.1111/j.1467-7652.2008.00358.x 18631243
26. Expression in yeast and tobacco of plant cDNAs encoding acyl CoA:diacylglycerol acyltransferase. Bouvier-Nave P, Benveniste P, Oelkers P, Sturley SL, Schaller H, Eur J Biochem 2000 267 85 96 10.1046/j.1432-1327.2000. 00961.x 10601854 (Pubitemid 30029741)
27. Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. Liu L, Zhang Y, Chen N, Shi X, Tsang B, Yu YH, J Clin Invest 2007 117 1679 1689 10.1172/JCI30565 17510710 (Pubitemid 46871352)
28. DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content. Roorda BD, Hesselink MK, Schaart G, Moonen-Kornips E, Martinez-Martinez P, Losen M, De Baets MH, Mensink RP, Schrauwen P, J Lipid Res 2005 46 230 236 15576838 (Pubitemid 40271086)
29. Activation of diacylglycerol acyltransferase expressed in Saccharomyces cerevisiae: overexpression of Dga1p lacking the N-terminal region in the Deltasnf2 disruptant produces a significant increase in its enzyme activity. Kamisaka Y, Kimura K, Uemura H, Shibakami M, Appl Microbiol Biotechnol 2010 88 105 115 10.1007/s00253-010-2725-x 20567816
30. DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity. Liu L, Shi X, Bharadwaj KG, Ikeda S, Yamashita H, Yagyu H, Schaffer JE, Yu YH, Goldberg IJ, J Biol Chem 2009 284 36312 36323 10.1074/jbc.M109.049817 19778901
31. DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Deltasnf2 disruptant of Saccharomyces cerevisiae. Kamisaka Y, Tomita N, Kimura K, Kainou K, Uemura H, Biochem J 2007 408 61 68 10.1042/BJ20070449 17688423 (Pubitemid 350158403)
32. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV Jr, J Clin Invest 2002 109 1049 1055 11956242 (Pubitemid 34413589)
33. Functional and Topological Analysis of Yeast Acyl-CoA:Diacylglycerol Acyltransferase 2, an Endoplasmic Reticulum Enzyme Essential for Triacylglycerol Biosynthesis. Liu Q, Siloto RM, Snyder CL, Weselake RJ, J Biol Chem 2011 286 13115 13126 10.1074/jbc.M110.204412 21321129
34. Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2. Stone SJ, Levin MC, Farese RV Jr, J Biol Chem 2006 281 40273 40282 10.1074/jbc.M607986200 17035227 (Pubitemid 46041832)
35. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria- associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV Jr, J Biol Chem 2009 284 5352 5361 19049983
36. Mutation of F417 but not of L418 or L420 in the lipid binding domain decreases the activity of triacylglycerol hydrolase. Alam M, Gilham D, Vance DE, Lehner R, J Lipid Res 2006 47 375 383 16282638 (Pubitemid 43276923)
37. Role of cysteine residues in thiol modification of acyl-CoA: diacylglycerol acyltransferase 2 from yeast. Liu Q, Siloto RM, Weselake RJ, Biochemistry 2010 49 3237 3245 10.1021/bi9020499 20225889
38. A phenylalanine in DGAT is a key determinant of oil content and composition in maize. Zheng P, Allen WB, Roesler K, Williams ME, Zhang S, Li J, Glassman K, Ranch J, Nubel D, Solawetz W, Bhattramakki D, Llaca V, Deschamps S, Zhong GY, Tarczynski MC, Shen B, Nat Genet 2008 40 367 372 10.1038/ng.85 18278045 (Pubitemid 351311769)
39. Characterization of cDNAs encoding diacylglycerol acyltransferase from cultures of Brassica napus and sucrose-mediated induction of enzyme biosynthesis. Nykiforuk CL, Furukawa-Stoffer TL, Huff PW, Sarna M, Laroche A, Moloney MM, Weselake RJ, Biochim Biophys Acta 2002 1580 95 109 11880235 (Pubitemid 34203865)
40. BT1, a protein critical for in vivo starch accumulation in maize endosperm, is not detected in maize endosperm suspension cultures. Cao H, Shannon JC, Physiol Plant 1996 97 665 673 10.1111/j.1399-3054.1996.tb00530.x (Pubitemid 27093659)
41. Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Winter A, Kramer W, Werner FA, Kollers S, Kata S, Durstewitz G, Buitkamp J, Womack JE, Thaller G, Fries R, Proc Natl Acad Sci USA 2002 99 9300 9305 10.1073/pnas.142293799 12077321 (Pubitemid 34764608)
42. Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets. Kuerschner L, Moessinger C, Thiele C, Traffic 2008 9 338 352 10.1111/j.1600-0854.2007.00689.x 18088320 (Pubitemid 351188994)
43. Expression of tung tree diacylglycerol acyltransferase 1 in E. coli. Cao H, Chapital DC, Shockey JM, Klasson KT, BMC Biotechnology 2011 11 73 10.1186/1472-6750-11-73 21745386
44. Purification of recombinant tung tree diacylglycerol acyltransferases from E. coli. Cao H, Chapital DC, Howard OD, Jiang XN, Shockey JM, Klasson KT, FASEB J 2011 25 765.8
45. Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation. McFie PJ, Stone SL, Banman SL, Stone SJ, J Biol Chem 2010 285 37377 37387 10.1074/jbc.M110.163691 20876538
46. Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Grisart B, Farnir F, Karim L, Cambisano N, Kim JJ, Kvasz A, Mni M, Simon P, Frere JM, Coppieters W, Georges M, Proc Natl Acad Sci USA 2004 101 2398 2403 10.1073/pnas.0308518100 14983021 (Pubitemid 38269323)
47. Basic local alignment search tool. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ, J Mol Biol 1990 215 403 410 2231712
48. Protein database searches for multiple alignments. Altschul SF, Lipman DJ, Proc Natl Acad Sci USA 1990 87 5509 5513 10.1073/pnas.87.14.5509 2196570 (Pubitemid 20260210)
49. The characterization of amino acid sequences in proteins by statistical methods. Zimmerman JM, Eliezer N, Simha R, J Theor Biol 1968 21 170 201 10.1016/0022-5193(68)90069-6 5700434
50. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Saitou N, Nei M, Mol Biol Evol 1987 4 406 425 3447015
51. Clustal W and Clustal × version 2.0. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG, Bioinformatics 2007 23 2947 2948 10.1093/bioinformatics/btm404 17846036 (Pubitemid 350162903)
52. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Thompson JD, Higgins DG, Gibson TJ, Nucleic Acids Res 1994 22 4673 4680 10.1093/nar/22.22.4673 7984417 (Pubitemid 24354800)