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Volumn 31, Issue 6, 2011, Pages 2283-2290

Endoglin (CD105): A review of its role in angiogenesis and tumor diagnosis, progression and therapy

Author keywords

Angiogenesis; Cancer; CD105; Endoglin; Review; Tumor

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ANTIENDOGLIN MONOCLONAL ANTIBODY; ANTINEOPLASTIC AGENT; ARGINYLGLYCYLASPARTIC ACID; CCAAT ENHANCER BINDING PROTEIN; CD31 ANTIGEN; CYCLOOXYGENASE 2 INHIBITOR; ENDOGLIN; INTERLEUKIN 1 RECEPTOR; MESSENGER RNA; MONOCLONAL ANTIBODY; SMAD PROTEIN; STAT1 PROTEIN; TATA BINDING PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 79960462574     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (243)

References (104)
  • 1
    • 0021912390 scopus 로고
    • Identification of several cell surface proteins of non-T, non-B acute lymphoblastic leukemia by using monoclonal antibodies
    • Quackenbush EJ and Letarte M: Identification of several cell surface proteins of non-T, non-B acute lymphoblastic leukemia by using monoclonal antibodies. J Immunol 134: 1276-1285, 1985. (Pubitemid 15158627)
    • (1985) Journal of Immunology , vol.134 , Issue.2 , pp. 1276-1285
    • Quackenbush, E.J.1    Letarte, M.2
  • 2
    • 0033851028 scopus 로고    scopus 로고
    • Endoglin expression on human microvascular endothelial cells association with betaglycan and formation of higher order complexes with TGF-beta signalling receptors
    • Wong SH, Hamel L, Chevalier S and Philip A: Endoglin expression on human microvascular endothelial cells association with betaglycan and formation of higher order complexes with TGF-beta signalling receptors. Eur J Biochem 267: 5550-5560, 2000.
    • (2000) Eur J Biochem , vol.267 , pp. 5550-5560
    • Wong, S.H.1    Hamel, L.2    Chevalier, S.3    Philip, A.4
  • 4
    • 0032908133 scopus 로고    scopus 로고
    • Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells
    • DOI 10.1002/(SICI)1097-0215(19990517)81:4<568::AID-IJC11>3.0.CO;2-X
    • Miller DW, Graulich W, Karges B, Stahl S, Ernst M, Ramaswamy A, Sedlacek HH, Muller R and Adamkiewicz J: Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells. Int J Cancer 81: 568-572, 1999. (Pubitemid 29203054)
    • (1999) International Journal of Cancer , vol.81 , Issue.4 , pp. 568-572
    • Miller, D.W.1    Graulich, W.2    Karges, B.3    Stahl, S.4    Ernst, M.5    Ramaswamy, A.6    Sedlacek, H.-H.7    Muller, R.8    Adamkiewicz, J.9
  • 5
    • 0036591699 scopus 로고    scopus 로고
    • Endoglin (CDI05) is expressed on immature blood vessels and is a marker for survival in prostate cancer
    • DOI 10.1002/pros.10083
    • Wikstrom P, Lissbrant IF, Stattin P, Egevad L and Bergh A: Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer. Prostate 51: 268-275, 2002. (Pubitemid 34556377)
    • (2002) Prostate , vol.51 , Issue.4 , pp. 268-275
    • Wikstrom, P.1    Lissbrant, I.F.2    Stattin, P.3    Egevad, L.4    Bergh, A.5
  • 7
    • 0033557520 scopus 로고    scopus 로고
    • Breast carcinoma: Vascular density determined using CD105 antibody correlates with tumor prognosis
    • Kumar S, Ghellal A, Li C, Byrne G, Haboubi N, Wang JM and Bundred N: Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis. Cancer Res 59: 856-861, 1999. (Pubitemid 29086739)
    • (1999) Cancer Research , vol.59 , Issue.4 , pp. 856-861
    • Kumar, S.1    Ghellal, A.2    Li, C.3    Byrne, G.4    Haboubi, N.5    Wang, J.M.6    Bundred, N.7
  • 9
    • 0025093973 scopus 로고
    • Vascular attack as a therapeutic strategy for cancer
    • Denekamp J: Vascular attack as a therapeutic strategy for cancer. Cancer Metastasis Rev 9: 267-282, 1990.
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 267-282
    • Denekamp, J.1
  • 10
    • 0242708765 scopus 로고    scopus 로고
    • Endoglin (CD105): A powerful therapeutic target on tumor-associated angiogenetic blood vessels
    • Fonsatti E, Altomonte M, Nicotra MR, Natali PG and Maio M: Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels. Oncogene 22: 6557-6563, 2003. (Pubitemid 37372335)
    • (2003) Oncogene , vol.22 , Issue.43 , pp. 6557-6563
    • Fonsatti, E.1    Altomonte, M.2    Nicotra, M.R.3    Natali, P.G.4    Maio, M.5
  • 11
    • 0023784185 scopus 로고
    • Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line
    • Gougos A and Letarte M: Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line. J Immunol 141: 1925-1933, 1988.
    • (1988) J Immunol , vol.141 , pp. 1925-1933
    • Gougos, A.1    Letarte, M.2
  • 12
    • 0025310515 scopus 로고
    • Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells
    • Gougos A and Letarte M: Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J Biol Chem 265: 8361-8364, 1990.
    • (1990) J Biol Chem , vol.265 , pp. 8361-8364
    • Gougos, A.1    Letarte, M.2
  • 13
    • 0028023647 scopus 로고
    • Localization of endoglin, a transforming growth factor-beta binding protein, and of CD44 and integrins in placenta during the first trimester of pregnancy
    • St-Jacques S, Forte M, Lye SJ and Letarte M: Localization of endoglin, a transforming growth factor-beta binding protein, and of CD44 and integrins in placenta during the first trimester of pregnancy. Biol Reprod 51: 405-413, 1994. (Pubitemid 24297612)
    • (1994) Biology of Reproduction , vol.51 , Issue.3 , pp. 405-413
    • St-Jacques, S.1    Forte, M.2    Lye, S.J.3    Letarte, M.4
  • 14
    • 33748749625 scopus 로고    scopus 로고
    • Endoglin structure and function: Determinants of endoglin phosphorylation by transforming growth factor-beta receptors
    • DOI 10.1074/jbc.M601288200
    • Koleva RI, Conley BA, Romero D, Riley KS, Marto JA, Lux A and Vary CP: Endoglin structure and function: Determinants of endoglin phosphorylation by transforming growth factor-beta receptors. J Biol Chem 281: 25110-25123, 2006. (Pubitemid 44401898)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.35 , pp. 25110-25123
    • Koleva, R.I.1    Conley, B.A.2    Romero, D.3    Riley, K.S.4    Marto, J.A.5    Lux, A.6    Vary, C.P.H.7
  • 16
    • 0026646785 scopus 로고
    • Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    • Cheifetz S, Bellon T, Cales C, Vera S, Bernabeu C, Massague J and Letarte M: Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem 267: 19027-19030, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 19027-19030
    • Cheifetz, S.1    Bellon, T.2    Cales, C.3    Vera, S.4    Bernabeu, C.5    Massague, J.6    Letarte, M.7
  • 17
    • 0037047426 scopus 로고    scopus 로고
    • Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II
    • Guerrero-Esteo M, Sanchez-Eisner T, Letamendia A and Bernabeu C: Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. J Biol Chem 277: 29197-29209, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 29197-29209
    • Guerrero-Esteo, M.1    Sanchez-Eisner, T.2    Letamendia, A.3    Bernabeu, C.4
  • 18
    • 0028170145 scopus 로고
    • Phosphorylation of the human-transforming growth factor-beta-binding protein endoglin
    • Lastres P, Martin-Perez J, Langa C and Bernabeu C: Phosphorylation of the human-transforming growth factor-beta-binding protein endoglin. Biochem J 301(Pt 3): 765-768, 1994.
    • (1994) Biochem J , vol.301 , Issue.PART 3 , pp. 765-768
    • Lastres, P.1    Martin-Perez, J.2    Langa, C.3    Bernabeu, C.4
  • 19
    • 0035017536 scopus 로고    scopus 로고
    • Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies
    • DOI 10.1002/jcp.1095
    • Fonsatti E, Del Vecchio L, Altomonte M, Sigalotti L, Nicotra MR, Coral S, Natali PG and Maio M: Endoglin: An accessory component of the TGF-beta-binding receptor complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies. J Cell Physiol 188: 1-7, 2001. (Pubitemid 32476491)
    • (2001) Journal of Cellular Physiology , vol.188 , Issue.1 , pp. 1-7
    • Fonsatti, E.1    Del, V.L.2    Altomonte, M.3    Sigalotti, L.4    Nicotra, M.R.5    Coral, S.6    Natali, P.G.7    Maio, M.8
  • 20
    • 0034688954 scopus 로고    scopus 로고
    • Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer
    • Li C, Guo B, Wilson PB, Stewart A, Byrne G, Bundred N and Kumar S: Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer. Int J Cancer 89: 122-126, 2000.
    • (2000) Int J Cancer , vol.89 , pp. 122-126
    • Li, C.1    Guo, B.2    Wilson, P.B.3    Stewart, A.4    Byrne, G.5    Bundred, N.6    Kumar, S.7
  • 23
  • 25
    • 0032535394 scopus 로고    scopus 로고
    • Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1
    • Rius C, Smith JD, Almendro N, Langa C, Botella LM, Marchuk DA, Vary CP and Bernabeu C: Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. Blood 92: 4677-4690, 1998. (Pubitemid 29005870)
    • (1998) Blood , vol.92 , Issue.12 , pp. 4677-4690
    • Rius, C.1    Smith, J.D.2    Almendro, N.3    Langa, C.4    Botella, L.M.5    Marchuk, D.A.6    Vary, C.P.H.7    Bernabeu, C.8
  • 27
    • 0037113959 scopus 로고    scopus 로고
    • Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways
    • DOI 10.1074/jbc.M207160200
    • Sanchez-Eisner T, Botella LM, Velasco B, Langa C and Bernabeu C: Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem 277: 43799-43808, 2002. (Pubitemid 36157800)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.46 , pp. 43799-43808
    • Sanchez-Elsner, T.1    Botella, L.M.2    Velasco, B.3    Langa, C.4    Bernabeu, C.5
  • 28
    • 0036888627 scopus 로고    scopus 로고
    • Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells
    • Ota T, Fujii M, Sugizaki T, Ishii M, Miyazawa K, Aburatani H and Miyazono K: Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells. J Cell Physiol 193: 299-318, 2002.
    • (2002) J Cell Physiol , vol.193 , pp. 299-318
    • Ota, T.1    Fujii, M.2    Sugizaki, T.3    Ishii, M.4    Miyazawa, K.5    Aburatani, H.6    Miyazono, K.7
  • 29
    • 0038239184 scopus 로고    scopus 로고
    • TNF alpha down-regulates CD105 expression in vascular endothelial cells: A comparative study with TGF beta 1
    • Li C, Guo B, Ding S, Rius C, Langa C, Kumar P, Bernabeu C and Kumar S: TNF alpha down-regulates CD105 expression in vascular endothelial cells: a comparative study with TGF beta 1. Anticancer Res 23: 1189-1196, 2003. (Pubitemid 36754077)
    • (2003) Anticancer Research , vol.23 , Issue.2 B , pp. 1189-1196
    • Li, C.1    Guo, B.2    Ding, S.3    Rius, C.4    Langa, C.5    Kumar, P.6    Bernabeu, C.7    Kumar, S.8
  • 30
    • 0035895073 scopus 로고    scopus 로고
    • Expression and function of CD105 during the onset of hematopoiesis from Flk1(+) precursors
    • Cho SK, Bourdeau A, Letarte M and Zuniga-Pflucker JC: Expression and function of CD105 during the onset of hematopoiesis from Flk1(+) precursors. Blood 98: 3635-3642, 2001.
    • (2001) Blood , vol.98 , pp. 3635-3642
    • Cho, S.K.1    Bourdeau, A.2    Letarte, M.3    Zuniga-Pflucker, J.C.4
  • 33
    • 0029035687 scopus 로고
    • Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow
    • Rokhlin OW, Cohen MB, Kubagawa H, Letarte M and Cooper MD: Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow. J Immunol 154: 4456-4465, 1995.
    • (1995) J Immunol , vol.154 , pp. 4456-4465
    • Rokhlin, O.W.1    Cohen, M.B.2    Kubagawa, H.3    Letarte, M.4    Cooper, M.D.5
  • 35
    • 77958455429 scopus 로고    scopus 로고
    • Endoglin (CD105) expression and angiogenesis status in small cell lung cancer
    • Takase Y, Kai K, Masuda M, Akashi M and Tokunaga O: Endoglin (CD105) expression and angiogenesis status in small cell lung cancer. Pathol Res Pract 206: 725-730, 2010.
    • (2010) Pathol Res Pract , vol.206 , pp. 725-730
    • Takase, Y.1    Kai, K.2    Masuda, M.3    Akashi, M.4    Tokunaga, O.5
  • 36
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human disease
    • Blobe GC, Schiemann WP and Lodish HF: Role of transforming growth factor beta in human disease. N Engl J Med 342: 1350-1358, 2000.
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 37
    • 0037407769 scopus 로고    scopus 로고
    • Genealogy, expression, and cellular function of transforming growth factor-beta
    • DOI 10.1016/S0163-7258(03)00035-4
    • Govinden R and Bhoola KD: Genealogy, expression, and cellular function of transforming growth factor-beta. Pharmacol Ther 98: 257-265, 2003. (Pubitemid 36513779)
    • (2003) Pharmacology and Therapeutics , vol.98 , Issue.2 , pp. 257-265
    • Govinden, R.1    Bhoola, K.D.2
  • 38
    • 0035196734 scopus 로고    scopus 로고
    • Regulation of transforming growth factor-beta signaling
    • Zhu HJ and Burgess AW: Regulation of transforming growth factor-beta signaling. Mol Cell Biol Res Commun 4: 321-330, 2001.
    • (2001) Mol Cell Biol Res Commun , vol.4 , pp. 321-330
    • Zhu, H.J.1    Burgess, A.W.2
  • 39
    • 0344625381 scopus 로고    scopus 로고
    • TGF-beta signaling and cancer: Structural and functional consequences of mutations in Smads
    • Hata A, Shi Y and Massague J: TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. Mol Med Today 4: 257-262, 1998.
    • (1998) Mol Med Today , vol.4 , pp. 257-262
    • Hata, A.1    Shi, Y.2    Massague, J.3
  • 40
    • 0031106404 scopus 로고    scopus 로고
    • Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
    • Pepper MS: Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev 8: 21-43, 1997.
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 21-43
    • Pepper, M.S.1
  • 41
    • 0033534572 scopus 로고    scopus 로고
    • Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily
    • Barbara NP, Wrana JL and Letarte M: Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem 274: 584-594, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 584-594
    • Barbara, N.P.1    Wrana, J.L.2    Letarte, M.3
  • 42
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • Massague J and Wotton D: Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19: 1745-1754, 2000. (Pubitemid 30204386)
    • (2000) EMBO Journal , vol.19 , Issue.8 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 44
    • 58149230979 scopus 로고    scopus 로고
    • TGF-beta signaling in vascular biology and dysfunction
    • Goumans MJ, Liu Z and ten Dijke P: TGF-beta signaling in vascular biology and dysfunction. Cell Res 19: 116-127, 2009.
    • (2009) Cell Res , vol.19 , pp. 116-127
    • Goumans, M.J.1    Liu, Z.2    Ten Dijke, P.3
  • 45
    • 77950880642 scopus 로고    scopus 로고
    • ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration
    • Ray BN, Lee NY, How T and Blobe GC: ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration. Carcinogenesis 31: 435-441, 2010.
    • (2010) Carcinogenesis , vol.31 , pp. 435-441
    • Ray, B.N.1    Lee, N.Y.2    How, T.3    Blobe, G.C.4
  • 49
    • 0001421509 scopus 로고    scopus 로고
    • CD105 antagonizes the inhibitory signaling of transforming growth factor beta1 on human vascular endothelial cells
    • Li C, Hampson IN, Hampson L, Kumar P, Bernabeu C and Kumar S: CD105 antagonizes the inhibitory signaling of transforming growth factor beta1 on human vascular endothelial cells. FASEB J 14: 55-64, 2000. (Pubitemid 30051523)
    • (2000) FASEB Journal , vol.14 , Issue.1 , pp. 55-64
    • Chenggang, L.1    Hampson, I.N.2    Hampson, L.3    Kumar, P.4    Bernabeu, C.5    Kumar, S.6
  • 52
    • 77950538520 scopus 로고    scopus 로고
    • Dynamic expression of Endoglin, a TGF-beta co-receptor, during pre-circulation vascular development in chick
    • Alev C, McIntyre BA, Ota K and Sheng G: Dynamic expression of Endoglin, a TGF-beta co-receptor, during pre-circulation vascular development in chick. Int J Dev Biol 54: 737-742, 2010.
    • (2010) Int J Dev Biol , vol.54 , pp. 737-742
    • Alev, C.1    McIntyre, B.A.2    Ota, K.3    Sheng, G.4
  • 53
    • 0029986771 scopus 로고    scopus 로고
    • Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease): New insights in pathogenesis, complications, and treatment
    • DOI 10.1001/archinte.156.7.714
    • Haitjema T, Westermann CJ, Overtoom TT, Timmer R, Disch F, Mauser H and Lammers JW: Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease): new insights in pathogenesis, complications, and treatment. Arch Intern Med 156: 714-719, 1996. (Pubitemid 26108192)
    • (1996) Archives of Internal Medicine , vol.156 , Issue.7 , pp. 714-719
    • Haitjema, T.1    Westermann, C.J.J.2    Overtoom, T.T.C.3    Timmer, R.4    Disch, F.5    Mauser, H.6    Lammers, J.-W.J.7
  • 55
    • 0035875091 scopus 로고    scopus 로고
    • Analysis of several endoglin mutants reveals no endogenous mature or secreted protein capable of interfering with normal endoglin function
    • Paquet ME, Pece-Barbara N, Vera S, Cymerman U, Karabegovic A, Shovlin C and Letarte M: Analysis of several endoglin mutants reveals no endogenous mature or secreted protein capable of interfering with normal endoglin function. Hum Mol Genet 10: 1347-1357, 2001. (Pubitemid 32640663)
    • (2001) Human Molecular Genetics , vol.10 , Issue.13 , pp. 1347-1357
    • Paquet, M.-E.1    Pece-Barbara, N.2    Vera, S.3    Cymerman, U.4    Karabegovic, A.5    Shovlin, C.6    Letarte, M.7
  • 56
    • 0032742527 scopus 로고    scopus 로고
    • Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1
    • Pece-Barbara N, Cymerman U, Vera S, Marchuk DA and Letarte M: Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1. Hum Mol Genet 82171-82181, 1999.
    • (1999) Hum Mol Genet , pp. 82171-82181
    • Pece-Barbara, N.1    Cymerman, U.2    Vera, S.3    Marchuk, D.A.4    Letarte, M.5
  • 57
    • 0032720393 scopus 로고    scopus 로고
    • A murine model of hereditary hemorrhagic telangiectasia
    • Bourdeau A, Dumont DJ and Letarte M: A murine model of hereditary hemorrhagic telangiectasia. J Clin Invest 104: 1343-1351, 1999.
    • (1999) J Clin Invest , vol.104 , pp. 1343-1351
    • Bourdeau, A.1    Dumont, D.J.2    Letarte, M.3
  • 58
    • 0034970744 scopus 로고    scopus 로고
    • Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia
    • Bourdeau A, Faughnan ME, McDonald ML, Paterson AD, Wanless IR and Letarte M: Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia. Am J Pathol 158: 2011-2020, 2001.
    • (2001) Am J Pathol , vol.158 , pp. 2011-2020
    • Bourdeau, A.1    Faughnan, M.E.2    McDonald, M.L.3    Paterson, A.D.4    Wanless, I.R.5    Letarte, M.6
  • 59
    • 0034090097 scopus 로고    scopus 로고
    • Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
    • Griffioen AW and Molema G: Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 52: 237-268, 2000. (Pubitemid 30368433)
    • (2000) Pharmacological Reviews , vol.52 , Issue.2 , pp. 237-268
    • Griffioen, A.W.1    Molema, G.2
  • 60
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • DOI 10.1038/339058a0
    • Folkman J, Watson K, Ingber D and Hanahan D: Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339: 58-61, 1989. (Pubitemid 19115892)
    • (1989) Nature , vol.339 , Issue.6219 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 61
    • 0030932552 scopus 로고    scopus 로고
    • In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11
    • Maier JA, Delia D, Thorpe PE and Gasparini G: In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11. Anticancer Drugs 8: 238-244, 1997.
    • (1997) Anticancer Drugs , vol.8 , pp. 238-244
    • Maier, J.A.1    Delia, D.2    Thorpe, P.E.3    Gasparini, G.4
  • 66
    • 0034060755 scopus 로고    scopus 로고
    • Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin
    • DOI 10.1016/S0959-8049(99)00335-4, PII S0959804999003354
    • Bredow S, Lewin M, Hofmann B, Marecos E and Weissleder R: Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin. Eur J Cancer 36: 675-681, 2000. (Pubitemid 30156855)
    • (2000) European Journal of Cancer , vol.36 , Issue.5 , pp. 675-681
    • Bredow, S.1    Lewin, M.2    Hofmann, B.3    Marecos, E.4    Weissleder, R.5
  • 67
    • 0038725471 scopus 로고    scopus 로고
    • CD105 is important for angiogenesis: Evidence and potential applications
    • DOI 10.1096/fj.02-0634rev
    • Duff SE, Li C, Garland JM and Kumar S: CD105 is important for angiogenesis: evidence and potential applications. FASEB J 17: 984-992, 2003. (Pubitemid 36676386)
    • (2003) FASEB Journal , vol.17 , Issue.9 , pp. 984-992
    • Duff, S.E.1    Li, C.2    Garland, J.M.3    Kumar, S.4
  • 68
    • 0026497186 scopus 로고
    • Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer
    • Horak ER, Leek R, Klenk N, LeJeune S, Smith K, Stuart N, Greenall M, Stepniewska K and Harris AL: Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet 340: 1120-1124, 1992.
    • (1992) Lancet , vol.340 , pp. 1120-1124
    • Horak, E.R.1    Leek, R.2    Klenk, N.3    LeJeune, S.4    Smith, K.5    Stuart, N.6    Greenall, M.7    Stepniewska, K.8    Harris, A.L.9
  • 69
    • 0024208863 scopus 로고
    • The prognostic significance of tumor vascularity in intermediate- thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study
    • Srivastava A, Laidler P, Davies RP, Horgan K and Hughes LE: The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study. Am J Pathol 133: 419-423, 1988. (Pubitemid 19017504)
    • (1988) American Journal of Pathology , vol.133 , Issue.2 , pp. 419-423
    • Srivastava, A.1    Laidler, P.2    Davies, R.P.3    Horgan, K.4    Hughes, L.E.5
  • 70
    • 0031058177 scopus 로고    scopus 로고
    • Association of tumour vasculature with tumour progression and overall survival of patients with non-early gastric carcinomas
    • Tanigawa N, Amaya H, Matsumura M and Shimomatsuya T: Association of tumour vasculature with tumour progression and overall survival of patients with non-early gastric carcinomas. Br J Cancer 75: 566-571, 1997. (Pubitemid 27085301)
    • (1997) British Journal of Cancer , vol.75 , Issue.4 , pp. 566-571
    • Tanigawa, N.1    Amaya, H.2    Matsumura, M.3    Shimomatsuya, T.4
  • 72
    • 0029411167 scopus 로고
    • Angiogenesis in human breast carcinoma: What is the question?
    • Page DL and Jensen RA: Angiogenesis in human breast carcinoma: What is the question? Hum Pathol 26: 1173-1174, 1995.
    • (1995) Hum Pathol , vol.26 , pp. 1173-1174
    • Page, D.L.1    Jensen, R.A.2
  • 74
    • 0036163111 scopus 로고    scopus 로고
    • Estimation of angiogenesis with anti-CD 105 immunostaining in the process of colorectal cancer development
    • DOI 10.1067/msy.2002.119361
    • Akagi K, Ikeda Y, Sumiyoshi Y, Kimura Y, Kinoshita J, Miyazaki M and Abe T: Estimation of angiogenesis with anti-CD105 immunostaining in the process of colorectal cancer development. Surgery 131(1 Suppl): S109-S113, 2002. (Pubitemid 34118625)
    • (2002) Surgery , vol.131 , Issue.1 SUPPL.
    • Akagi, K.1    Ikeda, Y.2    Sumiyoshi, Y.3    Kimura, Y.4    Kinoshita, J.5    Miyazaki, M.6    Abe, T.7
  • 75
    • 18844413509 scopus 로고    scopus 로고
    • Endoglin is a better marker than CD31 in evaluation of angiogenesis in glioblastoma
    • Behrem S, Zarkovic K, Eskinja N and Jonjic N: Endoglin is a better marker than CD31 in evaluation of angiogenesis in glioblastoma. Croat Med J 46: 417-422, 2005. (Pubitemid 40686486)
    • (2005) Croatian Medical Journal , vol.46 , Issue.3 , pp. 417-422
    • Behrem, S.1    Zarkovic, K.2    Eskinja, N.3    Jonjic, N.4
  • 76
    • 27244431905 scopus 로고    scopus 로고
    • Prognostic significance of microvessel density determined by an anti-CD105/endoglin monoclonal antibody in astrocytic tumors: Comparison with an anti-CD31 monoclonal antibody
    • Yao Y, Kubota T, Takeuchi H and Sato K: Prognostic significance of microvessel density determined by an anti-CD105/endoglin monoclonal antibody in astrocytic tumors: comparison with an anti-CD31 monoclonal antibody. Neuropathology 25: 201-206, 2005.
    • (2005) Neuropathology , vol.25 , pp. 201-206
    • Yao, Y.1    Kubota, T.2    Takeuchi, H.3    Sato, K.4
  • 77
    • 0033609719 scopus 로고    scopus 로고
    • Antiangiogenic radioimmunotherapy of human solid tumors in SCID mice using (125)I-labeled anti-endoglin monoclonal antibodies
    • Tabata M, Kondo M, Haruta Y and Seon BK: Antiangiogenic radioimmunotherapy of human solid tumors in SCID mice using (125)I-labeled anti-endoglin monoclonal antibodies. Int J Cancer 82: 737-742, 1999.
    • (1999) Int J Cancer , vol.82 , pp. 737-742
    • Tabata, M.1    Kondo, M.2    Haruta, Y.3    Seon, B.K.4
  • 79
    • 33847660487 scopus 로고    scopus 로고
    • Endoglin (CD105) expression in angiogenesis of primary hepatocellular carcinomas: Analysis using tissue microarrays and comparisons with CD34 and VEGF
    • Yao Y, Pan Y, Chen J, Sun X, Qiu Y and Ding Y: Endoglin (CD105) expression in angiogenesis of primary hepatocellular carcinomas: analysis using tissue microarrays and comparisons with CD34 and VEGF. Ann Clin Lab Sci 37: 39-48, 2007. (Pubitemid 46350612)
    • (2007) Annals of Clinical and Laboratory Science , vol.37 , Issue.1 , pp. 39-48
    • Yao, Y.1    Pan, Y.2    Chen, J.3    Sun, X.4    Qiu, Y.5    Ding, Y.6
  • 80
    • 0036152351 scopus 로고    scopus 로고
    • Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity
    • Schimming R and Marme D: Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity. Head Neck 24: 151-156, 2002.
    • (2002) Head Neck , vol.24 , pp. 151-156
    • Schimming, R.1    Marme, D.2
  • 81
    • 0033939222 scopus 로고    scopus 로고
    • Endoglin expression as a measure of microvessel density in cervical cancer
    • DOI 10.1016/S0029-7844(00)00864-4, PII S0029784400008644
    • Brewer CA, Setterdahl JJ, Li MJ, Johnston JM, Mann JL and McAsey ME: Endoglin expression as a measure of microvessel density in cervical cancer. Obstet Gynecol 96: 224-228, 2000. (Pubitemid 30447343)
    • (2000) Obstetrics and Gynecology , vol.96 , Issue.2 , pp. 224-228
    • Brewer, C.A.1    Setterdahl, J.J.2    Li, M.J.3    Johnston, J.M.4    Mann, J.L.5    McAsey, M.E.6
  • 83
    • 12344254785 scopus 로고    scopus 로고
    • Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver
    • Ho JW, Poon RT, Sun CK, Xue WC and Fan ST: Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver. World J Gastroenterol 11: 176-181, 2005. (Pubitemid 40125199)
    • (2005) World Journal of Gastroenterology , vol.11 , Issue.2 , pp. 176-181
    • Ho, J.W.1    Poon, R.T.2    Sun, C.K.3    Xue, W.-C.4    Fan, S.-T.5
  • 84
    • 0034907326 scopus 로고    scopus 로고
    • Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin
    • Takahashi N, Kawanishi-Tabata R, Haba A, Tabata M, Haruta Y, Tsai H and Seon BK: Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin. Clin Cancer Res 7: 524-532, 2001. (Pubitemid 32707974)
    • (2001) Clinical Cancer Research , vol.7 , Issue.3 , pp. 524-532
    • Takahashi, N.1    Kawanishi-Tabata, R.2    Haba, A.3    Tabata, M.4    Haruta, Y.5    Tsai, H.6    Seon, B.K.7
  • 85
    • 73549089305 scopus 로고    scopus 로고
    • Combined perioperative plasma endoglin and VEGF - A assessment in colorectal cancer patients
    • Mysliwiec P, Pawlak K, Kuklinski A and Kedra B: Combined perioperative plasma endoglin and VEGF - a assessment in colorectal cancer patients. Folia Histochem Cytobiol 47: 231-236, 2009.
    • (2009) Folia Histochem Cytobiol , vol.47 , pp. 231-236
    • Mysliwiec, P.1    Pawlak, K.2    Kuklinski, A.3    Kedra, B.4
  • 86
    • 77951288738 scopus 로고    scopus 로고
    • CD105 is a marker of tumour vasculature and a potential target for the treatment of head and neck squamous cell carcinoma
    • Marioni G, D'Alessandro E, Giacomelli L and Staffieri A: CD105 is a marker of tumour vasculature and a potential target for the treatment of head and neck squamous cell carcinoma. J Oral Pathol Med 39: 361-367, 2010.
    • (2010) J Oral Pathol Med , vol.39 , pp. 361-367
    • Marioni, G.1    D'Alessandro, E.2    Giacomelli, L.3    Staffieri, A.4
  • 87
    • 34447130180 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (Avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer
    • Cohen MH, Gootenberg J, Keegan P and Pazdur R: FDA drug approval summary: bevacizumab (Avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer. Oncologist 12: 713-718, 2007.
    • (2007) Oncologist , vol.12 , pp. 713-718
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 88
    • 34147190880 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer
    • DOI 10.1634/theoncologist.12-3-356
    • Cohen MH, Gootenberg J, Keegan P and Pazdur R: FDA drug approval summary: bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer. Oncologist 12: 356-361, 2007. (Pubitemid 46556802)
    • (2007) Oncologist , vol.12 , Issue.3 , pp. 356-361
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 89
    • 27944490875 scopus 로고    scopus 로고
    • VEGF as a therapeutic target in cancer
    • Ferrara N: VEGF as a therapeutic target in cancer. Oncology 69(Suppl): 11-16, 2005.
    • (2005) Oncology , vol.69 , Issue.SUPPL. , pp. 11-16
    • Ferrara, N.1
  • 90
    • 20544455330 scopus 로고    scopus 로고
    • Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy
    • DOI 10.1016/j.bbrc.2005.05.132, PII S0006291X05011344
    • Ferrara N, Hillan KJ and Novotny W: Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 333: 328-335, 2005. (Pubitemid 40848295)
    • (2005) Biochemical and Biophysical Research Communications , vol.333 , Issue.2 , pp. 328-335
    • Ferrara, N.1    Hillan, K.J.2    Novotny, W.3
  • 92
    • 1442286971 scopus 로고    scopus 로고
    • Bispecific Single-Chain Diabody-Mediated Killing of Endoglin-Positive Endothelial Cells by Cytotoxic T Lymphocytes
    • Korn T, Muller R and Kontermann RE: Bispecific single-chain diabody-mediated killing of endoglin-positive endothelial cells by cytotoxic T lymphocytes. J Immunother 27: 99-106, 2004. (Pubitemid 38282729)
    • (2004) Journal of Immunotherapy , vol.27 , Issue.2 , pp. 99-106
    • Korn, T.1    Muller, R.2    Kontermann, R.E.3
  • 93
    • 54249167046 scopus 로고    scopus 로고
    • Production and characterization of a high-affinity nanobody against human endoglin
    • Larchmt
    • Ahmadvand D, Rasaee MJ, Rahbarizadeh F and Mohammadi M: Production and characterization of a high-affinity nanobody against human endoglin. Hybridoma (Larchmt) 27: 353-360, 2008.
    • (2008) Hybridoma , vol.27 , pp. 353-360
    • Ahmadvand, D.1    Rasaee, M.J.2    Rahbarizadeh, F.3    Mohammadi, M.4
  • 94
    • 18744427000 scopus 로고    scopus 로고
    • Targeting of immunoliposomes to endothelial cells using a single-chain Fv fragment directed against human endoglin (CD105)
    • DOI 10.1016/j.bbamem.2004.03.007, PII S0005273604000859
    • Volkel T, Holig P, Merdan T, Muller R and Kontermann RE: Targeting of immunoliposomes to endothelial cells using a single-chain Fv fragment directed against human endoglin (CD105). Biochim Biophys Acta 1663: 158-166, 2004. (Pubitemid 38625590)
    • (2004) Biochimica et Biophysica Acta - Biomembranes , vol.1663 , Issue.1-2 , pp. 158-166
    • Volkel, T.1    Holig, P.2    Merdan, T.3    Muller, R.4    Kontermann, R.E.5
  • 95
    • 0032971818 scopus 로고    scopus 로고
    • Induction of lasting complete regression of preformed distinct solid tumors by targeting the tumor vasculature using two new anti-endoglin monoclonal antibodies
    • Matsuno F, Haruta Y, Kondo M, Tsai H, Barcos M and Seon BK: Induction of lasting complete regression of preformed distinct solid tumors by targeting the tumor vasculature using two new anti-endoglin monoclonal antibodies. Clin Cancer Res 5: 371-382, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 371-382
    • Matsuno, F.1    Haruta, Y.2    Kondo, M.3    Tsai, H.4    Barcos, M.5    Seon, B.K.6
  • 96
    • 0030858765 scopus 로고    scopus 로고
    • Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin
    • Seon BK, Matsuno F, Haruta Y, Kondo M and Barcos M: Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin. Clin Cancer Res 3: 1031-1044, 1997.
    • (1997) Clin Cancer Res , vol.3 , pp. 1031-1044
    • Seon, B.K.1    Matsuno, F.2    Haruta, Y.3    Kondo, M.4    Barcos, M.5
  • 97
    • 0035503538 scopus 로고    scopus 로고
    • Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide
    • Takahashi N, Haba A, Matsuno F and Seon BK: Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Cancer Res 61: 7846-7854, 2001. (Pubitemid 33049374)
    • (2001) Cancer Research , vol.61 , Issue.21 , pp. 7846-7854
    • Takahashi, N.1    Haba, A.2    Matsuno, F.3    Seon, B.K.4
  • 98
    • 42149083332 scopus 로고    scopus 로고
    • Anti-tumor activity of an anti-endoglin monoclonal antibody is enhanced in immunocompetent mice
    • DOI 10.1002/ijc.23314
    • Tsujie M, Tsujie T, Toi H, Uneda S, Shiozaki K, Tsai H and Seon BK: Antitumor activity of an anti-endoglin monoclonal antibody is enhanced in immunocompetent mice. Int J Cancer 122: 2266-2273, 2008. (Pubitemid 351542330)
    • (2008) International Journal of Cancer , vol.122 , Issue.10 , pp. 2266-2273
    • Tsujie, M.1    Tsujie, T.2    Toi, H.3    Uneda, S.4    Shiozaki, K.5    Tsai, H.6    Seon, B.K.7
  • 99
    • 39049176805 scopus 로고    scopus 로고
    • Effective anti-angiogenic therapy of established tumors in mice by naked anti-human endoglin (CD105) antibody: Differences in growth rate and therapeutic response between tumors growing at different sites
    • Tsujie M, Uneda S, Tsai H and Seon BK: Effective anti-angiogenic therapy of established tumors in mice by naked anti-human endoglin (CD105) antibody: differences in growth rate and therapeutic response between tumors growing at different sites. Int J Oncol 29: 1087-1094, 2006.
    • (2006) Int J Oncol , vol.29 , pp. 1087-1094
    • Tsujie, M.1    Uneda, S.2    Tsai, H.3    Seon, B.K.4
  • 100
    • 68249147445 scopus 로고    scopus 로고
    • Anti-endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature
    • Uneda S, Toi H, Tsujie T, Tsujie M, Harada N, Tsai H and Seon BK: Anti-endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature. Int J Cancer 125: 1446-1453, 2009.
    • (2009) Int J Cancer , vol.125 , pp. 1446-1453
    • Uneda, S.1    Toi, H.2    Tsujie, T.3    Tsujie, M.4    Harada, N.5    Tsai, H.6    Seon, B.K.7
  • 104
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1: 27-31, 1995.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1


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