Synthesis, in vitro antifungal activity and mechanism of action of four sterol hydrazone analogues against the dimorphic fungus Paracoccidioides brasiliensis

Steroids

Volumn 76, Issue 10-11, 2011, Pages 1069-1081

  Visbal, Gonzalo ^a   San Blas, Gioconda ^a   Maldonado, Alexis ^a   Álvarez Aular, Álvaro ^a   Capparelli, Mario V ^b   Murgich, Juan ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

Fungal inhibition; Hydrazones; Methyl transferase; Paracoccidioides brasiliensis

Indexed keywords

20 HYDRAZONE IMIDAZOLIN 2 YL 5ALPHA PREGNAN 3BETA OL; 20 HYDRAZONE PYRIDIN 2 YL 5ALPHA PREGNAN 3BETA OL; 20 PIPERIDIN 2 YL 5ALPHA PREGNAN 3BETA 20 DIOL; 22 HYDRAZONE IMIDAZOLIN 2 YL CHOL 5 ENE 3BETA OL; 22 HYDRAZONE PYRIDIN 2 YL CHOL 5 ENE 3BETA OL; 22 PIPERIDIN 2 YL PREGNAN 3BETA,22 DIOL; 22 PIPERIDIN 3 YL PREGNAN 3BETA,22 DIOL; ANTIFUNGAL AGENT; AZACOSTEROL; BRASICASTEROL; DELTA 24 STEROL METHYL TRANSFERASE; ERGOSTEROL; HYDRAZONE DERIVATIVE; LANOSTEROL; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG SYNTHESIS; ENZYME INHIBITION; FUNGUS GROWTH; IN VITRO STUDY; NONHUMAN; PARACOCCIDIOIDES BRASILIENSIS; X RAY;

ANTIFUNGAL AGENTS; CRYSTALLOGRAPHY, X-RAY; HYDRAZONES; MOLECULAR STRUCTURE; PARACOCCIDIOIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

FUNGI; PARACOCCIDIOIDES BRASILIENSIS;

EID: 79960455074     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.04.012     Document Type: Article

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