Cyclosporine A induces apoptosis of human lung adenocarcinoma cells via caspase-dependent pathway

Anticancer Research

Volumn 31, Issue 6, 2011, Pages 2129-2134

  Sato, Maki ^a   Tsujino, Ichiro ^a   Fukunaga, Makiko ^a   Mizumura, Kenji ^a   Gon, Yasuhiro ^a   Takahashi, Noriaki ^a   Hashimoto, Shu ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Caspase; Cyclosporine A; Human lung adenocarcinoma cell; Lung transplantation

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYCLOSPORIN A; CYTOCHROME C; LIPOCORTIN 5;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL COUNT; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LUNG ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; WESTERN BLOTTING;

ADENOCARCINOMA; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL LINE, TUMOR; CYCLOSPORINE; CYTOCHROMES C; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; ISOENZYMES; LUNG NEOPLASMS; MITOCHONDRIA;

EID: 79960447528     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. OPTN/SRTR Annual Report chapter index VII; http://www.ustransplant.org/ annual-reports/current/
2. Shiraishi T, Okada Y, Sekine Y, Chida M, Bando T, Minami M, Oto T, Nagayasu T, Date H and Kondo T: Registry of the Japanese Society of Lung and Heart-Lung Transplantation: the official Japanese lung transplantation report 2008. Gen Thorac Cardiovasc Surg 57: 395-401, 2009.
3. Lyu DM and Zamora MR: Medical complications of lung transplantation. Proc Am Thorac Soc 6: 101-107, 2009.
4. Mitruka SN, Won A, McCurry KR, Zeevi A, McKaveney T, Venkataramanan R, Iacono A, Griffith BP and Burckart GJ: In the lung aerosol cyclosporine provides a regional concentration advantage over intramuscular cyclosporine. J Heart and Lung Transplantation 19: 969-975, 2000.
5. Letsou GV, Safi HJ, Reardon MJ, Ergenoglu M, Li Z, Klonaris CN, Baldwin JC, Gilbert BE and Waldrep JC: Pharmacokinetics of liposomal aerosolized cyclosporine A for pulmonary immunosuppression. Ann Thorac Surg 68: 2044-2048, 1999. (Pubitemid 30027822)
6. Arcasoy SM, Hersh C, Christie JD, Zisman D, Pochettino A, Rosengard BR, Blumenthal NP, Palevsky HI, Bavaria JE and Kotloff RM: Bronchogenic carcinoma complicating lung transplantation. J Heart and Lung Transplantation 20: 1044-1053, 2001. (Pubitemid 32930109)
7. Mathew J and Kratzke RA: Lung cancer and lung transplantation. J Thorac Oncol 4: 753-760, 2009.
8. Collins J, Kazerooni EA, Lacomis J, McAdams HP, Leung AN, Shiau M, Semenkovich J and Love RB: Bronchogenic carcinoma after transplantation: frequency, clinical characteristics, and imaging findings. Radiology 224: 131-138, 2002. (Pubitemid 34685511)
9. Roy MK, Takenaka M, Kobori M, Nakahara K, Isobe S and Tsushida T: Apoptosis, necrosis and cell proliferation-inhibition by cyclosporine A in U937 cells (a human monocytic cell line). Pharmacol Res 53: 293-302, 2006. (Pubitemid 43247543)
10. Duraj, Takacsova X, Sedlak J, Sulikova M, Hunakova L, Bies J and Chorvath B: PSC833 induces apoptosis in drug-sensitive human leukemia cell line and modulates resistance to paclitaxel in its multidrug-resistanat variant. Anticancer Res 20: 4627-4632, 2000. (Pubitemid 32141828)
11. Lopes EC, Garcia M, Benavides F, Shen J, Conti CJ, Alvarez E and Hajos SE: Multidrug resistance modulators PSC833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype. Leuk Res 27: 413-423, 2003. (Pubitemid 36287203)
12. Ito C, Ribeiro RC, Behm FG, Raimondi SC, Pui CH and Campana D: Cyclosporin A induces apoptosis in childhood acute lymphoblastic leukemia cells. Blood 91: 1001-1007, 1998. (Pubitemid 28078304)
13. Ciechomska I, Legat M, Golab J, Wesolowska A, Kurzaj Z, Mackiewicz A and Kaminska B: Cyclosporine A and its non-immunosuppressive derivative NIM811 induce apoptosis of malignant melanoma cells in vitro and in vivo studies. Int J Cancer 117: 59-67, 2005. (Pubitemid 41262760)
14. Zupanska A, Dziembowska M, Ellert-Miklaszewska A, Gaweda-Walerych K and Kaminska B: Cyclosporine A induces growth arrest or programmed cell death of human glioma cells. Neurochem Int 47(6): 430-441, 2005. (Pubitemid 41242624)
15. Mosieniak G, Figiel I and Kaminska B: CyclosporinA, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor. J Neurochem 68(3): 1142-1149, 1997. (Pubitemid 27086219)
16. Hojo M, Morimoto T, Maluccio M, Asano T, Morimoto K, Lagman M, Shimbo T and Suthanthiran M: Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature 397: 530-534, 1999.
17. Keenan RJ, Zeevi A, Iacono AT, Spichty KJ, Cai JZ, Yousem SA, Ohori NP, Paradis IL, Kawai A and Griffith BP: Efficacy of inhaled cyclosporine in lung transplant recipients with refractory rejection: correlation of intragraft cytokine gene expression with pulmonary function and histologic characteristics. Surgery 118: 385-391, 1995.
18. Iacono AT, Corcoran TE, Griffith BP, Grgurich WF, Smith DA, Zeevi A, Smaldone GC, McCurry KR, Johnson BA and Dauber JH: Aerosol cyclosporine therapy in lung transplant recipients with bronchiolitis obliterans. Eur Respir J 23: 384-390, 2004. (Pubitemid 38344373)
19. Iacono AT, Johnson BA, Grgurich WF, Youssef JG, Corcoran TE, Seiler DA, Dauber JH, Smaldone GC, Zeevi A, Yousem SA, Fung JJ, Burckart GJ, McCurry KR and Griffith BP: A randomized trial of inhaled cyclosporine in lung-transplant recipients. N Engl J Med 354: 141-150, 2006. (Pubitemid 43076711)
20. Hami M, Mojahedi MJ, Naghibi M, Shakeri MT and Sharifipour F: Cyclosporine trough levels and its side effects in kidney transplant recipients. Transplantation 4: 153-157, 2010.
21. Narula AS, Murthy MSN, Patrulu KSK and Saxena VK: Routine cyclosporine concentration-C2 level monitoring. Med J Armed Forces India 60: 326-328, 2004.
22. Hishita T, Tada-Oikawa S, Tohyama K, Miura Y, Nishihara T, Tohyama Y, Yoshida Y, Uchiyama T and Kawanishi S: Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39. Cancer Research 61: 2878-2884, 2001. (Pubitemid 32691929)
23. Chauhan D, Pandey P, Ogata A, Teoh G, Krett N, Halgren R, Rosen S, Kufe D, Kharbanda S and Anderson K: Cytochrome c-dependent and -independent induction of apoptosis in multiple myeloma cells. J Biol Chem 272: 29995-29997, 1997. (Pubitemid 27512191)
24. Juin P, Hueber AO, Littlewood T and Evan G: c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes Dev 13: 1367-1381, 1999. (Pubitemid 29270243)
25. Bossy Wetzel E and Green DR: Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J Biol Chem 274: 17484-17490, 1999.
26. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES and Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997. (Pubitemid 27508237)
27. Nagata S: Apoptosis by death factor. Cell 88: 355-365, 1997.
28. Cain K, Brown DG, Langlais C and Cohen GM: Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. J Biol Chem 274: 22686-22692, 1999.
29. Chandra D, Choy G, Deng X, Bhatia B, Daniel P and Tang DG: Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death. Mol Cell Biol 24: 6592-6607, 2004. (Pubitemid 38944340)
30. Ashkenazi A and Dixit VM: Death receptors: signaling and modulation. Science 281: 1305-1308, 1998.
31. Boesen-de Cock JG, Tepper AD, Vries E, van Blitterswijk WJ and Borst J: Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation. J Biol Chem 274: 14255-14261, 1999.
32. Debatin KM, Poncet D and Kroemer G: Chemotherapy: targeting the mitochondria cell death pathway. Oncogene 21: 8786-8803, 2002. (Pubitemid 36132400)
33. Johnston JB, Kabore AF, Strutinsky J, Hu X, Paul JT, Kropp DM, Kuschak B, Begleiter A and Gibson SB: Role of the TRAIL/AP02-L death receptors in chlorambucil- and fludarabine-induced apoptosis in chronic lymphocytic leukemia. Oncogene 22: 8356-8369, 2003. (Pubitemid 37485528)
34. Lacour S, Micheau O, Hammann A, Drouineaud V, Tschopp J, Solary E and Dimanche-Boitrel MT: Chemotherapy enhances TNF-related apoptosis-including ligand DISC assembly in HT29 human colon cancer cells. Oncogene 22: 1807-1816, 2003.
35. Perkins CL, Fang G, Kim CN and Bhalla KN: The role of APAF-1, caspase-9, and BID proteins in etoposide-or paclitaxel-induced mitochondrial events during apoptosis. Cancer Res 60: 1645-1653, 2000. (Pubitemid 30183437)
36. Soengas MS, Alarcón RM, Yoshida H, Giaccia AJ, Hakem R, Mak TW and Lowe SW: Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284: 156-159, 1999. (Pubitemid 29282071)
37. Srinivasula SM, Ahmad M, Guo Y, Zhan Y, Lazebnik Y, Fernandes-Alnemri T and Alnemri ES: Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res 59: 999-1002, 1999. (Pubitemid 29135957)
38. Costantini P, Bruey JM, Castedo M, Métivier D, Loeffler M, Susin SA, Ravagnan L, Zamzami N, Garrido C and Kroemer G: Pre-processed caspase-9 contained in mitochondria participates in apoptosis. Cell Death and Differentiation 9: 82-88, 2002. (Pubitemid 34071995)
39. Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM and Mak TW: differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352, 1998. (Pubitemid 28376078)