In the lung aerosol cyclosporine provides a regional concentration advantage over intramuscular cyclosporine

Journal of Heart and Lung Transplantation

Volumn 19, Issue 10, 2000, Pages 969-975

  Mitruka, Surindra N ^a   Won, Alvina ^a   McCurry, Kenneth R ^a   Zeevi, Adriana ^b   McKaveney, Teresa ^a   Venkataramanan, Raman ^a   Iacono, Aldo ^a   Griffith, Bartley P ^a   Burckart, Gilbert J ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN;

AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUNG; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMAL; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAMUSCULAR; LUNG; RATS; RATS, INBRED LEW; SUPPORT, U.S. GOV'T, P.H.S.; TISSUE DISTRIBUTION;

EID: 0033810531     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-2498(00)00176-5     Document Type: Article

References (29)

1. Heart-lung transplantation; successful therapy for patients with pulmonary vascular disease
2. The registry of the international society for heart and lung transplantaion; sixteenth official report-1999
3. Acute pulmonary allograft rejection; mechanisms, diagnosis, and management
4. Single lung transplantation; a temporal look at rejection, infection and survival
5. Management of lung transplant rejection
6. A decade of lung transplantation
7. Analysis of risk factors for the development of bronchiolitis obliterans syndrome
8. Obliterative bronchiolitis after lung and heart-lung transplantation; an analysis of risk factors and management
9. Treatment of presumed and proven acute rejection following six months of lung transplant survival
10. Airway obstruction and bronchiolitis obliterans after lung transplantation
11. Development of bronchiolitis obliterans syndrome in recipients of heart-lung transplantations-early risk factors
12. Local immunosuppression of cardiac transplants in rats enhances survival
13. Graft rejection can be treated effectively by local immunosuppression
14. Prolongation of heterotopic heart allograft survival by local delivery of continuous low-dose cyclosporine therapy
15. Local immunosuppression of the vascularized graft
16. Aerosolized cyclosporine as single agent immunotherapy in canine lung allografts
17. Immunosuppression with aerosolized cyclosporine for prevention of lung rejection in a rat model
18. Improved immunosuppression with aerosolized cyclosporine in experimental pulmonary transplantation
19. Aerosol cyclosporine prevents acute allograft rejection in experimental lung transplantation
20. Aerosolized cyclosporine in lung recipients with refractory chronic rejection
21. Efficacy of inhaled cyclosporine in lung transplant recipients with refractory rejection; correlation of intragraft cytokine gene expression with pulmonary function and histologic characteristics
22. Dose-related reversal of acute lung rejection by aerosolized cyclosporine
23. A method for repeated evaluation of pulmonary performance in unanesthetized, unrestrained Guinea pigs and its application to detect effects of sulfuric acid mist inhalation
24. Liquid-chromatographic determination of Cyclosporin-A in blood and plasma
25. Lung allograft rejection in the rat. II.Specific immunological properties of lung grafts
26. Correlation of blood levels and tissue levels of cyclosporine with the histologic features of cyclosporine toxicity