Suppression of apoptosis by PIF1 helicase in human tumor cells

Cancer Research

Volumn 71, Issue 14, 2011, Pages 4998-5008

  Gagou, Mary E ^a   Ganesh, Anil ^a   Thompson, Ruth ^a   Phear, Geraldine ^a   Sanders, Cyril ^a   Meuth, Mark ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CHECKPOINT KINASE 1; CYCLIN E; GEMCITABINE; HELICASE; HELICASE PIF1; HISTONE H2AX; HYDROXYUREA; PROTEIN P21; PROTEIN P53; SMALL INTERFERING RNA; THYMIDINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER GROWTH; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL SUBPOPULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; GENE FUNCTION; HUMAN; HUMAN CELL; ONCOGENE; PIF1 GENE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; TUMOR CELL;

APOPTOSIS; CASPASE 3; COLORECTAL NEOPLASMS; DNA HELICASES; DNA REPLICATION; G1 PHASE; HCT116 CELLS; HEK293 CELLS; HUMANS; PROTEIN KINASES; RNA, SMALL INTERFERING; S PHASE; THYMIDINE; TRANSFECTION;

EID: 79960435701     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-4404     Document Type: Article

References (34)

1. Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, et al. The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 1995;83:655-66.
2. Kudlow BA, Kennedy BK, Monnat RJ. Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol 2007;8:394-404. (Pubitemid 46643238)
3. Kitao S, Shimamoto A, Goto M, Miller RW, Smithson WA, Lindor NM, et al. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome. Nat Genet 1999;22:82-4. (Pubitemid 29214810)
4. Wu L, Hickson ID. DNA helicases required for homologous recombination and repair of damaged replication forks. Annu Rev Genet 2006;40:279-306. (Pubitemid 44956787)
5. - genomes having tandemly arrayed repeats units in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 1983;80:5345-9.
6. Schulz VP, Zakian VA. The Saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation. Cell 1994;76:145-55. (Pubitemid 24035288)
7. Budd M, Reis CC, Smith S, Myung K, Campbell JL. Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase d. Mol Cell Biol 2006;26:2490-500.
8. Ivessa AS, Zhou J-Q, Zakian VA. The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 2000;100:479-89.
9. Ribeyre C, Lopes J, Boule P, Piazza P, Guedin A, Zakian VA, et al. The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. PLoS Genet 2009;5:e1000475.
10. Ivessa AS, Zhou JQ, Schulz VP, Monson EK, Zakian VA. The Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev 2002;16:1383-96. (Pubitemid 34615091)
11. Mateyak MK, Zakian VA. Human Pif helicase is cell cycle regulated and associates with telomerase. Cell Cycle 2006;5:2796-804. (Pubitemid 44901742)
12. Futami K, Shimamoto A, Furuichi Y. Mitochondrial and nuclear localization of human Pif1 helicase. Biol Pharm Bull 2007;30:1685-92. (Pubitemid 47403245)
13. Snow ES, Mateyak M, Paderova J, Wakeham A, Iorio C, Zakian VA,, et al. Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Mol Cell Biol 2007;27:1017-26. (Pubitemid 46174564)
14. George T, Wen Q, Griffiths R, Ganesh A, Meuth M, Sanders CM. Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks. Nucleic Acids Res 2009;37:6491-502.
15. Rodriguez R, Meuth M. Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell 2006;17:402-12. (Pubitemid 43049492)
16. Gagou ME, Zuazua-Villar P, Meuth M. Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. Mol Biol Cell 2010;21:739-52.
17. Bolderson E, Scorah J, Helleday T, Smythe C, Meuth M. ATM is required for the cellular response to thymidine induced replication fork stress. Hum Mol Genet 2004;13:2937-45. (Pubitemid 39585226)
18. O'Neill RR, Mitchell LG, Merril CR, Rasband WS. Use of image analysis to quantitate changes in form of mitochondrial DNA after x-irradiation. Appl Theor Electrophor 1989;1:163-7.
19. Pfaffl MW. A new mathematical model for relative quantification in real time RT-PCR. Nucleic Acids Res 2001;29:e45.
20. Untergasser A, Nijveen H, Rao X, Bisseling T, Geurts R, Leunissen JAM. Primer3Plus, an enhanced web interface to Primer3. Nucleic Acids Res 2007;35:W71-4.
21. Rosen S, Skaletsky HJ. Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Miserner S, eds. Bioinformatics methods and protocols: methods in molecular biology. Totowa, NJ: Humana Press; 2000. p. 365-86.
22. Hautbergue GM, Hung ML, Walsh MJ, Snijders AP, Chang CT, Jones R, et al. UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA. Curr Biol 2009;19:1918-24.
23. Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003;300:1542-8. (Pubitemid 36682880)
24. Wen Q, Scorah J, Phear G, Rodgers G, Rodgers S, Meuth M. A mutant allele of MRE11 found in mismatch repair deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. Mol Biol Cell 2008;19:1693-705. (Pubitemid 351805121)
25. Zou Y, Liu Y, Wu X, Shell SM. Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J Cell Physiol 2006;208:267-73. (Pubitemid 43993416)
26. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 2008;133:2110-8.
27. Meuth M. Chk1 suppressed cell death. Cell Div 2010;5:21.
28. Sanders CM. Human Pif1 helicase is a G-quadruplex DNA binding protein with G-quadruplex DNA unwinding activity. Biochem J 2010;430:119-28.
29. Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006;444:633-7. (Pubitemid 44864442)
30. Di Micco R, Fumagalli M, Cicalese A, Bensimon A, Maestro R, Pelicci PG, et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006;444:638-42. (Pubitemid 44864443)
31. Gong Z, Kim J-E, Leung CCY, Glover JNM, Chen J. Bach1/FancJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell 2010;37:438-46.
32. London TB, Barber LJ, Mosedale G, Kelly GP, Balasubramanian S, Hickson ID, et al. FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Bio Chem 2008;283:36132-9.
33. Rodriguez R, Gagou ME, Meuth M. Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45. Cell Death Differ 2008;15:889-98. (Pubitemid 351524431)
34. Aggarwal M, Sommers JA, Shoemaker RH, Brosh RM. Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) in the cellular response to DNA damage or replication stress. Proc Natl Acad Sci U S A 2011;108:1525-30.