Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis

Experimental and Molecular Pathology

Volumn 91, Issue 1, 2011, Pages 400-410

  Melnick, Michael ^a   Abichaker, George ^a   Htet, Khine ^a   Sedghizadeh Parish, P ^a   Jaskoll, Tina ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Amphiregulin; CMV induced pathology; COX 2; Cytomegalovirus; EGF receptor; ERK

Indexed keywords

AMPHIREGULIN; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; CYTOMEGALOVIRUS; DOWNSTREAM PROCESSING; DYSPLASIA; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HISTOPATHOLOGY; MOLECULAR PATHOLOGY; MOUSE; NEWBORN; NONHUMAN; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS ATTENUATION; VIRUS CELL INTERACTION; VIRUS PATHOGENESIS;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; BUTADIENES; CELL PROLIFERATION; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; GLYCOPROTEINS; HERPESVIRIDAE INFECTIONS; HOST-PATHOGEN INTERACTIONS; IMMUNOENZYME TECHNIQUES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUROMEGALOVIRUS; NITRILES; ORGAN CULTURE TECHNIQUES; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUBMANDIBULAR GLAND;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 79960426036     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2011.04.014     Document Type: Article

References (56)

1. Agulnik M., et al. Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands. J. Clin. Oncol. 2007, 25:3978-3984.
2. Andrei G., et al. Novel inhibitors of human CMV. Curr. Opin. Investig. Drugs 2008, 9:132-145.
3. Bai Y., et al. Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:10919-10924.
4. Chan G., et al. Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility. Proc. Natl. Acad. Sci. 2009, 106:22369-22374.
5. Chan G., et al. PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes. J. Immunol. 2010, 184:3213-3222.
6. Cheeran M.C., et al. Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin. Microbiol. Rev. 2009, 22:99-126.
7. Fuzzy Logic and Neural Network Handbook 1996, McGraw-Hill, New York. C. Chen (Ed.).
8. Correia-Silva Jde F., et al. Cytomegalovirus shedding in the oral cavity of allogeneic haematopoietic stem cell transplant patients. Oral Dis. 2007, 13:163-169.
9. Correia-Silva J.F., et al. Saliva as a source of HCMV DNA in allogeneic stem cell transplantation patients. Oral Dis. 2010, 16:210-216.
10. D'Alessio A., et al. Effects of the combined blockade of EGFR and ErbB-2 on signal transduction and regulation of cell cycle regulatory proteins in breast cancer cells. Breast Cancer Res. Treat. 2010, 123:387-396.
11. Djerf E.A., et al. ErbB receptor tyrosine kinases contribute to proliferation of malignant melanoma cells: inhibition by gefitinub. Melanoma Res. 2009, 19:156-166.
12. Favoni R.E., et al. Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural mesothelioma cell proliferation. Curr. Cancer Drug Targets 2010, 10:176-191.
13. Goldberg D.E. Genetics algorithms in search, optimization, and machine learning 1989, Addison-Wesley, Reading, Mass.
14. Hickinson D.M., et al. Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib. CTS J. 2009, 2:183-192.
15. Holbro T., et al. The ErbB receptors and their role in cancer progression. Exp. Cell Res. 2003, 284.
16. Holland J.H. Adaptation in Natural and Artificial Systems 1975, University of Michigan Press, Ann Arbor.
17. Hynes N.E., et al. The ErbB receptor tyrosine family as signal integrators. Endocr. Relat. Cancer 2001, 8:151-159.
18. Jaskoll T., et al. Cytomegalovirus inhibition of embryonic mouse tooth development: a model of the human amelogenesis imperfecta phenocopy. Arch. Oral Biol. 2008, 53:405-415.
19. Jaskoll T., et al. Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development. BMC Dev. Biol. 2008, 8:33.
20. Jaskoll T., et al. Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars. Cells Tissues Organs 2010, 192:221-239.
21. Jaskoll T., et al. CRTC1 expression during normal and abnormal salivary gland development supports a precursor cell origin for mucoepidermoid cancer. Gene Expr. Patterns 2011, 11:57-63.
22. Kasman L.M., et al. A mouse model linking viral hepatitis and salivary gland dysfunction. Oral Dis. 2009, 15:587-595.
23. Kenney N.J., et al. Induction of ductal morphogenesis and lobular hyperplasia by amphiregulin in the mouse mammary gland. Cell Growth Differ. 1996, 7:1769-1781.
24. Kim J.M., et al. The risk factors for cytomegalovirus syndrome and tissue-invasive cytomegalovirus disease in liver transplant recipients who have cytomegalovirus antigenemia. Transplant. Proc. 2010, 42:890-894.
25. Krmpotic A., et al. Pathogenesis of murine cytomegalovirus infection. Microbes Infect. 2003, 5:1263-1277.
26. Lagenaur L.A., et al. Structure and function of the murine cytomegalovirus sgg1 gene: a determinant of viral growth in salivary gland acinar cells. J. Virol. 1994, 68:7717-7727.
27. LeJeune S., et al. Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer. Cancer Res. 1993, 53:3597-3602.
28. Liu M., et al. EGFR signaling is required for TGF-β1-mediated COX-2 induction in human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 2007, 37:578-588.
29. Locati L.D., et al. Cetuximab in recurrent and/or metastatic salivary gland carcinomas: a phase II study. Oral Oncol. 2009, 45:574-578.
30. Lurje G., Lenz H.J. EGFR signaling and drug discovery. Oncology 2009, 77:400-410.
31. Melnick M., et al. The functional genomic response of developing embryonic submandibular glands to NF-kappa B inhibition. BMC Dev. Biol. 2001, 1:15.
32. Melnick M., et al. Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model. BMC Dev. Biol. 2006, 6:42.
33. Melnick M., et al. Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev. Biol. 2009, 9.
34. Mori T., Kato J. Cytomegalovirus infection/disease after hematopoietic stem cell transplantation. Int. J. Hematol. 2010, 91:588-595.
35. Nadeau J.H., Dudley A.M. Systems genetics. Science 2011, 331:1015.
36. Nichols W.G., Boeckh M. Recent advances in the therapy and prevention of CMV infections. J. Clin. Virol. 2000, 16:25-40.
37. Oshima H., et al. Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis. Cancer Sci. 2011, 102:713-719.
38. Piechocki M.P., et al. Gefitinib prevents cancer progression in mice expressing the activated rat HER2/neu. Int. J. Cancer 2008, 122:1722-1729.
39. Pilgrim M.J., et al. A focused salivary gland infection with attenuated MCMV: an animal model with prevention of pathology associated with systemic MCMV infection. Exp. Mol. Pathol. 2007, 82:269-279.
40. Reynolds R.P., et al. Experimental murine cytomegalovirus infection in severe combined immunodeficient mice. Lab. Anim. Sci. 1993, 43:291-295.
41. Rogers S.J., et al. Detriminants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck. J. Pathol. 2009, 218:122-130.
42. Saba N.F., et al. Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. Cancer Prev. Res. 2009, 2:823-829.
43. Sanchez V., Spector D.H. Subversion of cell cycle regulatory pathways. Curr. Top. Microbiol. Immunol. 2008, 325:243-262.
44. Schleiss M., Choo D. Mechanisms of congenital cytomegalovirus-induced deafness. Drug Discov. Today 2006, 3:105-113.
45. Schmader K., et al. Mouse cytomegalovirus reactivation in severe combined immune deficient mice after implantation of latently infected salivary gland. J. Infect. Dis. 1995, 172:531-534.
46. Schwegmann A., Brombacher F. Host-directed drug targeting of factors hijacked by pathogens. Sci. Signal. 2008, 1:re8.
47. Specht D. Probabilistic neural network for classification, mapping, or associative memory. Proc. IEEE Int. Conf. Neural Netw. 1988, 1:525-532.
48. Specht D., Shapiro P. Generalization accuracy of probabilistic neural networks captured with back-propagation networks. Proc. IEEE Int. Joint Conf. Neural Netw. 1991, 1:887-892.
49. Sturm O.E., et al. The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier. Sci. Signal. 2010, 3:ra90.
50. Subbaramaiah K., et al. Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. J. Biol. Chem. 2008, 283:33955-33968.
51. Trelle S., et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011, 342:c7086.
52. Wagner R.P., et al. AIDS-associated infections in salivary glands: autopsy survey of 60 cases. Clin. Infect. Dis. 1996, 22:369-371.
53. Willmarth N.E., Ethier S.P. Autocrine and juxtacrine effects of amphiregulin on the proleferative, invasive and migratory properties of normal and neoplastic human mammary epithelial cells. J. Biol. Chem. 2006, 281:37728-37737.
54. Willmarth N.E., et al. Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. Cell. Signal. 2009, 21:212-219.
55. Yahav D., et al. Antiviral prophylaxis in haematological patients: systematic review and meta-analysis. Eur. J. Cancer 2009, 45:3131-3148.
56. Yonesaka K., et al. Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers. Clin. Cancer Res. 2008, 14:6963-6973.