Salivary gland branching morphogenesis: A quantitative systems analysis of the Eda/Edar/NFkB paradigm

BMC Developmental Biology

Volumn 9, Issue 1, 2009, Pages

  Melnick, Michael ^a   Phair, Robert D ^b   Lapidot, Smadar A ^b   Jaskoll, Tina ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Integrative Bioinformatics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; ECTODYSPLASIN A; EDAR RECEPTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR 8; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; EDA PROTEIN, MOUSE; EDAR PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRANCHING MORPHOGENESIS; CONTROLLED STUDY; DNA POLYMORPHISM; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; ONTOGENY; PHENOTYPE; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SALIVARY GLAND; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE; ANIMAL; BIOLOGICAL MODEL; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MORPHOGENESIS; MOUSE STRAIN; PHYSIOLOGY; PRENATAL DEVELOPMENT;

MUS;

ANIMALS; ECTODYSPLASINS; EDAR RECEPTOR; FEMALE; MALE; MICE; MICE, INBRED STRAINS; MODELS, BIOLOGICAL; MORPHOGENESIS; NF-KAPPA B; PHENOTYPE; SALIVARY GLANDS; SIGNAL TRANSDUCTION;

EID: 67649580786     PISSN: None     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/1471-213X-9-32     Document Type: Article

References (95)

1. Tissue Interactions and Development. NK Wessells, Menlo Park: Benjamin/Cummings 1977
2. Do different branching epithelia use a conserved developmental mechanism? JA Davies, Bioessays 2002 24 937 48 12325126
3. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. BM Ferguson N Brockdorff E Formstone T Ngyuen JE Kronmiller J Zonana, Hum Mol Genet 1997 6 1589 94 9285798
4. The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. AK Srivastava J Pispa AJ Hartung Y Du S Ezer T Jenks T Shimada M Pekkanen ML Mikkola MS Ko I Thesleff J Kere D Schlessinger, Proc Natl Acad Sci USA 1997 94 13069 74 9371801
5. Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells. S Ezer M Bayés O Elomaa D Schlessinger J Kere, Hum Mol Genet 1999 8 2079 86 10484778
6. Anhidrotic ectodermal dysplasia (EDA) protein expressed in MCF-7 cells associates with cell membrane and induces rounding. S Ezer D Schlessinger A Srivastava J Kere, Hum Mol Genet 1997 6 1581 7 9285797
7. Soluble TNF-alpha receptors are constitutively shed and downregulate adhesion molecule expression in malignant gliomas. TC Chen DR Hinton BD Sippy FM Hofman, J Neuropathol Exp Neurol 1997 56 541 50 9143267
8. Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein. O Elomaa K Pulkkinen U Hannelius M Mikkola U Saarialho-Kere J Kere, Hum Mol Genet 2001 10 953 62 11309369
9. The Ectodysplasin and NFkappaB signalling pathways in odontogenesis. JM Courtney J Blackburn PT Sharpe, Arch Oral Biol 2005 50 159 63 15721144
10. The Edar subfamily in feather placode formation. CF Drew CM Lin TX Jiang G Blunt C Mou CM Choung DJ Headon, Dev Biol 2007 305 232 245 17362907 (Pubitemid 46589420)
11. TNF superfamily in skin appendage development. ML Mikkola, Cytokine Growth Factor Rev 2008 19 219 30 18495521
12. NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. R Schmidt-Ullrich DJ Tobin D Lenhard P Schneider R Paus C Scheidereit, Development 2006 133 1045 57 16481354
13. The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes. A Smahi G Courtois SH Rabia R Döffinger C Bodemer A Munnich JL Casanova A Isral, Hum Mol Genet 2002 11 2371 5 12351572
14. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. T Jaskoll YM Zhou G Trump M Melnick, Anat Rec A Discov Mol Cell Evol Biol 2003 271 322 31 12629675
15. Pleiotropic effect of Tabby gene on epidermal growth factor-containing cells of mouse submandibular gland. SR Blecher M Debertin JS Murphy, Anat Rec 1983 207 25 9 6605698
16. Clinical aspects of X-linked hypohidrotic ectodermal dysplasia. A Clarke DI Phillips R Brown PS Harper, Arch Dis Child 1987 62 989 96 2445301
17. Genes and genotypes affecting the teeth of the mouse. H Grüneberg, J Embryol Exp Morphol 1965 14 137 59 5893447
18. The glandular aspect of the tabby syndrome in the mouse. H Grüneberg, J Embryol Exp Morphol 1971 25 1 19 5548211
19. Oligodontia is associated with extra-oral ectodermal symptoms and low whole salivary flow rates. H Nordgarden JL Jensen K Storhaug, Oral Dis 2001 7 226 32 11575873
20. Salivary gland involvement in hypohidrotic ectodermal dysplasia. H Nordgarden S Johannessen K Storhaug JL Jensen, Oral Dis 1998 4 152 4 9680903
21. Salivary gland function in persons with ectodermal dysplasias. H Nordgarden K Storhaug SP Lyngstadaas JL Jensen, Eur J Oral Sci 2003 111 371 6 12974678
22. Recognizable Patterns of Human Malformation. DW Smith, Philadelphia: W.B. Saunders Company 1982 540 41
23. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. CY Cui T Hashimoto SI Grivennikov Y Piao SA Nedospasov D Schlessinger, Proc Natl Acad Sci USA 2006 103 9142 7 16738056
24. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. D Esibizione CY Cui D Schlessinger, Gene 2008 427 42 6 18848976
25. Shadow enhancers as a source of evolutionary novelty. JW Hong DA Hendrix MS L, Science 2008 321 1314 18772429
26. Enhancing gene regulation. GA Wray CC Babbitt, Science 2008 321 1300 1301 18772422
27. Differentiation and gene regulation: toward a holistic understanding of animal development: intercellular communication and transcriptional regulation are two sides of the same coin. A Michelson R Kopan, Curr Opin Genet Dev 2002 12 499 502 12200153 (Pubitemid 35013530)
28. Embryonic Salivary Gland Branching Morphogenesis. T Jaskoll M Melnick, Branching Morphogenesis Austin: Eurekah, Davies J, 2005
29. Mouse submandibular gland morphogenesis: a paradigm for embryonic signal processing. M Melnick T Jaskoll, Crit Rev Oral Biol Med 2000 11 199 215 12002815 (Pubitemid 30481380)
30. Salivary gland branching morphogenesis. VN Patel IT Rebustini MP Hoffman, Differentiation 2006 74 349 64 16916374
31. Salivary gland development. AS Tucker, Semin Cell Dev Biol 2007 18 237 44 17336109
32. The functional genomic response of developing embryonic submandibular glands to NF-kappa B inhibition. M Melnick H Chen Y Min Zhou T Jaskoll, BMC Dev Biol 2001 1 15 11716784
33. From genotype to phenotype: systems biology meets natural variation. PN Benfey T Mitchell-Olds, Science 2008 320 495 7 18436781
34. The genetics of brain wiring: from molecule to mind. KJ Mitchell, PLoS Biol 2007 5 e113 17439300
35. Expression of epidermal growth factor receptor in fetal mouse submandibular gland detected by a biotinyltyramide-based catalyzed signal amplification method. EW Gresik M Kashimata Y Kadoya R Mathews N Minami S Yamashina, J Histochem Cytochem 1997 45 1651 7 9389768
36. FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. T Jaskoll G Abichaker D Witcher FG Sala S Bellusci MK Hajihosseini M Melnick, BMC Dev Biol 2005 5 11 15972105
37. Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-R null mutations. T Jaskoll M Melnick, Anat Rec 1999 256 252 68 10521784
38. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. T Jaskoll D Witcher L Toreno P Bringas AM Moon M Melnick, Dev Biol 2004 268 457 69 15063181
39. Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. T Jaskoll YM Zhou Y Chai HP Makarenkova JM Collinson JD West MK Hajihosseini J Lee M Melnick, Cells Tissues Organs 2002 170 83 98 11731698
40. Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit. M Kashimata EW Gresik, Dev Dyn 1997 208 149 61 9022052
41. Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. M Melnick H Chen Y Zhou T Jaskoll, Anat Rec 2001 262 318 30 11241200
42. Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. M Melnick H Chen YM Zhou T Jaskoll, Cells Tissues Organs 2001 168 233 45 11275690
43. Modeling of signaling networks. SR Neves R Iyengar, Bioessays 2002 24 1110 7 12447976
44. Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis. T Jaskoll T Leo D Witcher M Ormestad J Astorga P Bringas Jr P Carlsson M Melnick, Dev Dyn 2004 229 722 32 15042696
45. Regulatory gene networks and the properties of the development process. EH Davidson DR McClay L Hood, Proc Natl Acad Sci 2003 100 1475 1480 12578984 (Pubitemid 36254470)
46. A genomic regulatory network for development. EH Davidson JP Rast P Oliveri A Ransick C Calestani CH Yuh T Minokawa G Amore V Hinman C Arenas-Mena O Otim CT Brown CB Livi PY Lee R Revilla AG Rust Z Pan MJ Schilstra PJ Clarke MI Arnone L Rowen RA Cameron DR McClay L Hood H Bolouri, Science 2002 295 1669 78 11872831
47. Global regulatory logic for specification of an embryonic cell lineage. P Oliveri Q Tu EH Davidson, Proc Natl Acad Sci USA 2008 105 5955 62 18413610
48. Kinetic modelling approaches to in vivo imaging. RD Phair T Misteli, Nat Rev Mol Cell Biol 2001 2 898 907 11733769 (Pubitemid 33674089)
49. A gene regulatory network subcircuit drives a dynamic pattern of gene expression. J Smith C Theodoris EH Davidson, Science 2007 318 794 7 17975065
50. Getting started in biological pathway construction and analysis. GA Viswanathan J Seto S Patil G Nudelman SC Sealfon, PLoS Comput Biol 2008 4 e16 18463709
51. Computational system biology. H Kitano, Nature 2002 420 206 210 12432404
52. Inferring genetic networks and identifying compound mode of action via expression profiling. TS Gardner D di Bernardo D Lorenz JJ Collins, Science 2003 301 102 5 12843395
53. A new approach to decoding life: systems biology. T Ideker T Galitski L Hood, Annu Rev Genomics Hum Genet 2001 2 343 72 11701654
54. Insights into the relation between mRNA and protein expression patterns: II. Experimental observations in Escherichia coli. PS Lee LB Shaw LH Choe A Mehra V Hatzimanikatis KH Lee, Biotechnol Bioeng 2003 84 834 41 14708124
55. Kinetic analysis of secretory protein traffic and characterization of golgi to plasma membrane transport intermediates in living cells. K Hirschberg CM Miller J Ellenberg JF Presley ED Siggia RD Phair J Lippincott-Schwartz, J Cell Biol 1998 143 285 503
56. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. YZ Lin SY Yao RA Veach TR Torgerson J Hawiger, J Biol Chem 1995 270 14255 8 7782278
57. Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model. M Melnick ES Mocarski G Abichaker J Huang T Jaskoll, BMC Dev Biol 2006 6 42 16959038
58. Unraveling transcription regulatory networks by protein-DNA and protein-protein interaction mapping. AJ Walhout, Genome Res 2006 16 1445 1454 17053092 (Pubitemid 44878484)
59. The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control. C Nerlov, Trends Cell Biol 2007 17 318 24 17658261
60. Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction. B Stein PC Cogswell AS Baldwin Jr, Mol Cell Biol 1993 13 3964 3974 8321203
61. Prediction of potential C/EBP/NF-kappaB composite elements using matrix-based search methods. E Shelest AE Kel E Göessling E Wingender, In Silico Biol 2003 3 71 9 12762847
62. The Variation of Animals and Plants Under Domestication. C Darwin, New York: D. Appleton Company 1897
63. Whole saliva in X-linked hypohidrotic ectodermal dysplasia. MO Lexner A Bardow JM Hertz L Almer B Nauntofte S Kreiborg, Int J Paediatr Dent 2007 17 155 62 17397458
64. Critical dynamics in genetic regulatory networks: examples from four kingdoms. E Balleza ER Alvarez-Buylla A Chaos S Kauffman I Shmulevich M Aldana, PLoS ONE 2008 3 e2456 18560561
65. Gene expression dynamics in the macrophage exhibit criticality. M Nykter ND Price M Aldana SA Ramsey SA Kauffman LE Hood O Yli-Harja I Shmulevich, Proc Natl Acad Sci USA 2008 105 1897 900 18250330
66. Perturbation avalanches and criticality in gene regulatory networks. P Rämö J Kesseli O Yli-Harja, J Theor Biol 2006 242 164 70 16574157
67. Why a simple model of genetic regulatory networks describes the distribution of avalanches in gene expression data. R Serra M Villani A Graudenzi SA Kauffman, J Theor Biol 2007 246 449 60 17316697
68. Eukaryotic cells are dynamically ordered or critical but not chaotic. I Shmulevich SA Kauffman M Aldana, Proc Natl Acad Sci USA 2005 102 13439 44 16155121
69. The origins of order. SA Kauffman, New York: Oxford University Press 1993
70. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. WC Sha HC Liou EI Tuomanen D Baltimore, Cell 1995 80 321 330 7834752
71. Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. R Schmidt-Ullrich T Aebischer J Hülsken W Birchmeier U Klemm C Scheidereit, Development 2001 128 3843 53 11585809
72. Epistasis: too often neglected in complex trait studies? O Carlborg CS Haley, Nat Rev Genetics 2004 5 618 25
73. Quantitative morphological signatures define local signaling networks regulating cell morphology. C Bakal J Aach G Church N Perrimon, Science 2007 316 1753 6 17588932
74. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. KA Janes JG Albeck S Gaudet PK Sorger DA Lauffenburger MB Yaffe, Science 2005 310 1646 53 16339439
75. Attractors and democratic dynamics. Y Bar-Yam D Harmon B de Bivort, Science 2009 323 1016 1017 19229023
76. Integrating computational and biochemical studies to explore mechanisms in NF-B signaling. JD Kearns A Hoffmann, Journal of Biological Chemistry 2009 284 5493 5443
77. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. J Pispa M Pummila PA Barker I Thesleff ML Mikkola, Hum Mol Genet 2008 17 3380 91 18689798
78. A systematic approach to detecting transcription factors in response to environmental stresses. LH Lin HC Lee WH Li BS Chen, BMC Bioinformatics 2007 8 473 18067669
79. Cell-to-cell stochastic variation in gene expression is a complex genetic trait. J Ansel H Bottin C Rodriguez-Beltran C Damon M Nagarajan S Fehrmann J François G Yvert, PLoS Genet 2008 4 e1000049 18404214
80. Syndromes of the Head and Neck. RJ Gorlin MM Cohen LS Levin, New York: Oxford University Press 1990
81. Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. MP Harris N Rohner H Schwarz S Perathoner P Konstantinidis C Nusslein-Volhard, PLoS Genet 2008 4 e1000206 18833299
82. An alternatively spliced Muc10 glycoprotein ligand for putative L-selectin binding during mouse embryonic submandibular gland morphogenesis. M Melnick H Chen Y Zhou T Jaskoll, Arch Oral Biol 2001 46 745 57 11389866
83. Mouse submandibular gland mucin: embryo-specific mRNA and protein species. T Jaskoll H Chen PC Denny PA Denny M Melnick, Mech Dev 1998 74 179 83 9651522
84. The formulation and testing of models. M Berman, Ann N Y Acad Sci 1963 10 182 94
85. Compartmental analysis in biology and medicine. JA Jacquez, Ann Arbor, Michigan: BioMedWare Publishing 1996
86. Enzyme kinetics: behavior and analysis of rapid equlibrium and steady state systems. IH Segel, New York: John Wiley and Sons Inc 1975
87. MATCH: A tool for searching transcription factor binding sites in DNA sequences. AE Kel E Gössling I Reuter E Cheremushkin OV Kel-Margoulis E Wingender, Nucleic Acids Res 2003 31 3576 3579 12824369 (Pubitemid 37442201)
88. P-Match: transcription factor binding site search by combining patterns and weight matrices. DS Chekmenev C Haid AE Kel, Nucleic Acids Res 2005 33 W432 7 15980505
89. Biometry. R Sokal FJ Rohlf, New York: Freeman 1981
90. Tumor necrosis factor-alpha-induced proliferation of human Mo7e leukemic cells occurs via activation of nuclear factor kappaB transcription factor. RY Liu C Fan NE Olashaw X Wang KS Zuckerman, J Biol Chem 1999 274 13877 85 10318796
91. Fuzzy logic and neural network handbook. C Chen ed, New York: McGraw-Hill 1996
92. Probabilistic neural network for classification, mapping, or associative memory. D Specht, Proceeding of the IEEE International Conference on Neural Networks 1988 1 525 32
93. Generalization accuracy of probabilistic neural networks captured with back-propagation networks. D Specht P Shapiro, Proceeding of the IEEE International Joint Conference on Neural Networks 1991 1 887 92
94. Genetic Algorithms in Search, Optimization, and Machine Learning. DE Goldberg, Reading, Mass: Addison-Wesley 1989
95. Adaptation in Natural and Artificial Systems. JH Holland, Ann Arbor: University of Michigan Press 1975