A mouse model linking viral hepatitis and salivary gland dysfunction

Oral Diseases

Volumn 15, Issue 8, 2009, Pages 587-595

  Kasman, L M ^a   London, L L ^a,b   London, S D ^a,b   Pilgrim, M J ^a,c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c School of Business and Public Management   (United States)

Author keywords

Cytomegalovirus; Hepatitis; Hyposalivation; Xerostomia

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; AQUAPORIN 5; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; GENOMIC DNA; INTERLEUKIN 12P40; INTERLEUKIN 12P70; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 5; PILOCARPINE; RANTES; TUMOR NECROSIS FACTOR RECEPTOR;

ACUTE DISEASE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BAGG ALBINO MOUSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; HYPOSALIVATION; IMMUNOBLOTTING; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIALOADENITIS; SPLENECTOMY; TISSUE INJURY; TISSUE LEVEL; UREA NITROGEN BLOOD LEVEL; VIRUS HEPATITIS; VIRUS TITRATION; XEROSTOMIA;

ANALYSIS OF VARIANCE; ANIMALS; AQUAPORIN 5; DISEASE MODELS, ANIMAL; FEMALE; HEPATITIS, VIRAL, ANIMAL; HERPESVIRIDAE INFECTIONS; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MUROMEGALOVIRUS; SALIVATION; STATISTICS, NONPARAMETRIC; XEROSTOMIA;

EID: 70349952315     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2009.01600.x     Document Type: Article

References (50)

1. Andreu V, Mas A, Bruguera M et al (1998). Ecstasy: a common cause of severe acute hepatotoxicity. J Hepatol 29 : 394 397.
2. Astor F, Hanft K, Ciocon J (1999). Xerostomia: a prevalent condition in the elderly. Ear Nose Throat J 78 : 476 479.
3. Azuma M, Motegi K, Aota K, Hayashi Y, Sato M (1997). Role of cytokines in the destruction of acinar structure in Sjogren's syndrome salivary glands. Lab Invest 77 : 269 280.
4. Bachmanov AA, Reed DR, Beauchamp GK, Tordoff MG (2002). Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet 32 : 435 443.
5. Bolger G, Lapeyre N, Rheaume M et al (1999). Acute murine cytomegalovirus infection: a model for determining antiviral activity against CMV induced hepatitis. Antiviral Res 44 : 155 165.
6. Campbell AE (1999). Murine cytomegalovirus. In : Ahmed R, Chen I, eds. Persistent viral infections. John Wiley and Sons Ltd : New York, pp. 447 466.
7. Cavanaugh VJDY, Birkenbach MP, Slater JS, Campbell AE (2003). Vigorous innate and virus-specific cytotoxic T-lymphocyte responses to murine cytomegalovirus in the submaxillary salivary gland. J Virol 77 : 1703 1717.
8. Coates EA, Brennan D, Logan RM et al (2000). Hepatitis C infection and associated oral health problems. Aust Dent J 45 : 108 114.
9. Correia PN, Carpenter GH, Osailan SM, Paterson KL, Proctor GB (2008). Acute salivary gland hypofunction in the duct ligation model in the absence of inflammation. Oral Dis 14 : 520 528.
10. Donovan CE, Mark DA, He HZ et al (1999). NF-kappa B/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation. J Immunol 163 : 6827 6833.
11. Dykhuizen RS, Brunt PW, Atkinson P, Simpson JG, Smith CC (1995). Ecstasy induced hepatitis mimicking viral hepatitis. Gut 36 : 939 941.
12. Fidler H, Dhillon A, Gertner D, Burroughs A (1996). Chronic ecstasy (3,4-methylenedioxymetamphetamine) abuse: a recurrent and unpredictable cause of severe acute hepatitis. J Hepatol 25 : 563 566.
13. Fleck M, Kern ER, Zhou T, Lang B, Mountz JD (1998). Murine cytomegalovirus induces a Sjogren's syndrome-like disease in C57Bl/6-lpr/lpr mice. Arthritis Rheum 41 : 2175 2184.
14. Fleck M, Zhang HG, Kern ER, Hsu HC, Muller-Ladner U, Mountz JD (2001). Treatment of chronic sialadenitis in a murine model of Sjogren's syndrome by local fasL gene transfer. Arthritis Rheum 44 : 964 973.
15. Greenspan D (1996). Xerostomia: diagnosis and management. Oncology (Williston Park) 10 : 7 11. (Pubitemid 26132480)
16. Hamamdzic D, Harley RA, Hazen-Martin D, LeRoy EC (2001). MCMV induces neointima in IFN-gammaR-/- mice: Intimal cell apoptosis and persistent proliferation of myofibroblasts. BMC Musculoskelet Disord 2 : 3.
17. Hamamoto DT, Rhodus NL (2009). Methamphetamine abuse and dentistry. Oral Dis 15 : 27 37.
18. Henderson L, Muir M, Mills PR et al (2001). Oral health of patients with hepatitis C virus infection: a pilot study. Oral Dis 7 : 271 275.
19. Henson D (1972). Cytomegalovirus inclusion bodies in the gastrointestinal tract. Arch Pathol 93 : 477 482.
20. Henson D, Strano AJ (1972). Mouse cytomegalovirus. Necrosis of infected and morphologically normal submaxillary gland acinar cells during termination of chronic infection. Am J Pathol 68 : 183 202.
21. Hilliard BA, Mason N, Xu L et al (2002). Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J Clin Invest 110 : 843 850.
22. Karlmark KR, Wasmuth HE, Trautwein C, Tacke F (2008). Chemokine-directed immune cell infiltration in acute and chronic liver disease. Expert Rev Gastroenterol Hepatol 2 : 233 242.
23. Kasman LM (2005). CD13/aminopeptidase N and murine cytomegalovirus infection. Virology 334 : 1 9.
24. Krane CM, Melvin JE, Nguyen HV et al (2001). Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation. J Biol Chem 276 : 23413 23420.
25. Krmpotic A, Bubic I, Polic B, Lucin P, Jonjic S (2003). Pathogenesis of murine cytomegalovirus infection. Microbes Infect 5 : 1263 1277.
26. Lee SH, Gitas J, Zafer A et al (2001). Haplotype mapping indicates two independent origins for the Cmv1s susceptibility allele to cytomegalovirus infection and refines its localization within the Ly49 cluster. Immunogenetics 53 : 501 505.
27. Lee SH, Webb JR, Vidal SM (2002). Innate immunity to cytomegalovirus: the Cmv1 locus and its role in natural killer cell function. Microbes Infect 4 : 1491 1503.
28. Lee SH, Zafer A, de Repentigny Y et al (2003). Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J Exp Med 197 : 515 526.
29. Lin AL, Johnson DA, Wu Y, Wong G, Ebersole JL, Yeh CK (2001). Measuring short-term gamma-irradiation effects on mouse salivary gland function using a new saliva collection device. Arch Oral Biol 46 : 1085 1089.
30. Lins L, Almeida H, Vitvisk L, Carmo T, Parana R, Reis MG (2005). Detection of hepatitis C virus RNA in saliva is not related to oral health status or viral load. J Med Virol 77 : 216 220.
31. Liou HC, Jin Z, Tumang J, Andjelic S, Smith KA, Liou ML (1999). c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol 11 : 361 371.
32. Lucin PPI, Polic B, Jonjic S, Koszinowski UH (1992). Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands. J Virol 66 : 1977 1984.
33. Mang FW, Michieletti P, O'Rourke K et al (1997). Primary biliary cirrhosis, sicca complex, and dysphagia. Dysphagia 12 : 167 170.
34. Ohyama Y, Carroll VA, Deshmukh U, Gaskin F, Brown MG, Fu SM (2006). Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV: a novel model for human Sjogren's syndrome. J Immunol 177 : 7391 7397.
35. Pai SY, Ho IC (2002). c-Rel delivers a one-two punch in Th1 cell differentiation. J Clin Invest 110 : 741 742.
36. Pilgrim MJ, Kasman L, Grewal J et al (2007). A focused salivary gland infection with attenuated MCMV: an animal model with prevention of pathology associated with systemic MCMV infection. Exp Mol Pathol 82 : 269 279.
37. Reznik DA (2005). Oral manifestations of HIV diseases. Top HIV Med 13 : 143 148.
38. Scalzo AA, Fitzgerald NA, Simmons A, La Vista AB, Shellam GR (1990). Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen. J Exp Med 171 : 1469 1483.
39. Scalzo AA, Fitzgerald NA, Wallace CR et al (1992). The effect of the Cmv-1 resistance gene, which is linked to the natural killer cell gene complex, is mediated by natural killer cells. J Immunol 149 : 581 589.
40. Scalzo AA, Brown MG, Chu DT, Heusel JW, Yokoyama WM, Forbes CA (1999). Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci. Immunogenetics 49 : 238.
41. Ship J, Fischer D (1997). The relationship between dehydration and parotid salivary gland function in young and older healthy adults. J Gerontol A Biol Sci Med Sci 52 : M310 M319.
42. Smith J, Siddiqui A, Modica L et al (1999). Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands. J Interferon Cytokine Res 19 : 929 935.
43. Stoddart CA, Cardin RD, Boname JM, Manning WC, Abenes GB, Mocarski ES (1994). Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus. J Virol 68 : 6243 6253.
44. Towne JE, Harrod KS, Krane CM, Menon AG (2000). Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after acute viral infection. Am J Respir Cell Mol Biol 22 : 34 44.
45. Varani S, Landini MP (2002). Cytomegalovirus as a hepatotropic virus. Clin Lab 48 : 39 44.
46. Verbaan H, Carlson J, Eriksson S et al (1999). Extrahepatic manifestations of chronic hepatitis C infection and the interrelationship between primary Sjogren's syndrome and hepatitis C in Swedish patients. J Intern Med 245 : 127 132.
47. Wozniak KL, Arribas A, Leigh JE, Fidel PL Jr. (2002). Inhibitory effects of whole and parotid saliva on immunomodulators. Oral Microbiol Immunol 17 : 100 107.
48. Wu A, Chen Z, Tsokos M, O'Connell B, Ambudkar I, Baum B (1996). Interferon-gamma induced cell death in a cultured human salivary gland cell line. J Cell Physiol 167 : 297 304.
49. Yamano S, Atkinson JC, Baum BJ, Fox PC (1999). Salivary gland cytokine expression in NOD and normal BALB/c mice. Clin Immunol 92 : 265 275.
50. Zamara E, Galastri S, Aleffi S et al (2007). Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice. J Hepatol 46 : 230 238.