Inhibition of human Nav1.5 sodium channels by strychnine and its analogs

Biochemical Pharmacology

Volumn 82, Issue 4, 2011, Pages 350-357

  Yuan, Chunhua ^a   Sun, Lirong ^a   Zhang, Meng ^a   Li, Shuji ^a   Wang, Xuemin ^a   Gao, Tianming ^a   Zhu, Xinhong ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Alkaloid; Arrhythmias; Icajine; Nav1.5 channel; Strychnine

Indexed keywords

ALKALOID DERIVATIVE; BRUCINE; BRUCINE N OXIDE; ICAJINE; ISOBRUCINE; ISOSTRYCHNINE; NOVACINE; SODIUM CHANNEL NAV1.5; STRYCHNINE; STRYCHNINE N OXIDE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; IC 50; MUSCLE CELL; PRIORITY JOURNAL; STEADY STATE; SUBSTITUTION REACTION;

ACTION POTENTIALS; ANIMALS; CELLS, CULTURED; FEMALE; HEK293 CELLS; HUMANS; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SEEDS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRYCHNINE; STRYCHNOS NUX-VOMICA;

EID: 79960352227     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.05.006     Document Type: Article

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