Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica

Journal of Ethnopharmacology

Volumn 88, Issue 2-3, 2003, Pages 205-214

  Yin, Wu ^a   Wang, Tian Shan ^a   Yin, Fang Zhou ^a   Cai, Bao Chang ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Analgesic; Anti inflammatory; Brucine; Brucine N oxide; Strychnos nux vomica

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ACETIC ACID DERIVATIVE; AMINE OXIDE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; BRUCINE; BRUCINE N OXIDE; BRUCINE N-OXIDE; CARRAGEENAN; DRUG DERIVATIVE; FORMALDEHYDE; FREUND ADJUVANT; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; PROSTAGLANDIN E2; SEROTONIN; STRYCHNINE; STRYCHNOS NUX VOMICA EXTRACT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BLOOD; BLOOD VESSEL PERMEABILITY; CAPILLARY PERMEABILITY; CHEMISTRY; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG STRUCTURE; EDEMA; EXTRACTION; FEMALE; HOT PLATE TEST; IATROGENIC DISEASE; ISOLATION AND PURIFICATION; MALE; MEDICINAL PLANT; MOUSE; MOUSE STRAIN; NONHUMAN; PAIN; PAW EDEMA; PLANT SEED; PLASMA; PROSTAGLANDIN RELEASE; PROTECTION; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE; STRYCHNOS NUX VOMICA; THERMAL STIMULATION; WRITHING TEST;

STRYCHNOS NUX-VOMICA;

EID: 0042831204     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(03)00224-1     Document Type: Article

References (30)

1. Adzu B., Amos S., Kapu S.D., Gamaniel K.S. Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis. Journal of Ethnopharmacology. 84:2003;169-173.
2. Al-Swayeh O.A., Clifford R.H., Del Soldato P., Moore P.K. A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin. British Journal of Pharmacology. 129:2000;343-350.
3. Bisset N.G., Phillipson J.D. The Asian species of Strychnos. Part IV. The alkaloids. Lloydia. 39:1976;263-325.
4. Cai B.-C., Hattori M., Namba T. Processing of nux vomica. II. Changes in alkaloid composition of the seeds of Strychnos nux-vomica on traditional drug-processing. Chemical and Pharmaceutical Bulletin (Tokyo). 38:1990;1295-1298.
5. Cai B.-C., Yang W.X., Zhu W.Y., Lu J.C., Ye D.J. Effect of processing on the extraction of alkaloids from Strychnos. Journal of Chinese Herbal Medicine. 18:1993;23-24.
6. Cai B.-C., He Y.W., Ding H.F., Ma C., Wu H. Determination of alkaloids and comparison of the acute toxicity of differently processed products of the seeds of Strychnos nux-vomica. Journal of Chinese Herbal Medicine. 19:1994;598-600.
7. Carmines E.L., Carchman R.A., Borzelleca J.F. A method for the evaluation of dose-effect data utilizing a programmable calculator. Journal of Environmental Pathology and Toxicology. 4:1980;23-30.
8. Colpaert F.C., Meert T., De Witte P., Schmitt P. Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat. Life Science. 31:1982;67-75.
9. Duarte J.D.G., Nakamura M., Ferreira S.H. Participation of the sympathetic system in acetic-induced writhing in mice. Brazilian Journal of Medicine and Biological Research. 21:1988;341-343.
10. Elisabetsky E., Amador T.A., Albuquerque R.R., Nunes D.S., Carvalho A.C.T. Analgesic activity of Psychotria colorata (wild ex R. et S.) Muell. Arg. Alkaloids. Journal of Ethnopharmacology. 48:1995;77-83.
11. Guizhi M. The long period clinical observation of the effect of Strychnos nux-vomica on Kaschin-Beck's disease. Chinese Journal of Regional Diseases Prevention and Therapy. 11:1996;120-124.
12. Hong Y., Abbott F.V. Peripheral opioid modulation of pain and inflammation in the formalin test. European Journal of Pharmacology. 227:1995;21-28.
13. Huijuan H. The anti-inflammatory effect of Ewei acid. Journal of Chinese Pharmaceutical University. 21:1990;279-284.
14. Jianyin Z., Huimin B., Chen M. Study on the effect of brucine and brucine N-oxide on platelet aggregation and blood clot formation. Jiangsu Journal of Chinese Traditional Medicine. 19:1998;41-42.
15. Kweifo-Okai G. Anti-inflammatory activity of a Ghanaian anti-arthritic herbal preparation. Journal of Ethnopharmacology. 33:1991;263-267.
16. 2. Journal of Jilin University Medical Science. 2:1976;24-26.
17. McMahon A.D. Observation and experiment with the efficacy of drugs: a warning example from a cohort of nonsteroidal anti-inflammatory and ulcer-healing drug users. American Journal of Epidemiology. 154:2001;557-562.
18. Mossa J.S., Rafatullah S., Galal A.M., Al-Yahya M.A. Pharmacological studies of Rhus retinorrhaea. International Journal of Pharmacognosy. 33:1995;242-246.
19. Oliva P., Aurilio C., Massimo F., Grella A., Maione S., Grella E., Scafuro M., Rossi F., Berrino L. The antinociceptive effect of tramadol in the formalin test is mediated by the serotonergic component. European Journal of Pharmacology. 445:2002;179-185.
20. Rocha G.M., Michea L.F., Peters E.M., Kirby M., Xu Y. Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells. Proceedings of the National Academy of Sciences of the United States of America. 98:2001;5317-5322.
21. Salvemini D., Wang Z.Q., Wyatt P.S., Bourdon D.M., Marino M.H., Manning P.T., Currie M.G. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. British Journal of Pharmacology. 118:1996;829-838.
22. Shibata M., Ohkubo T., Takahashi H., Inoki R. Modified formalin test: characteristic biphasic pain response. Pain. 38:1989;347-352.
23. Takada Y., Ihara H., Urano T., Takada A. Changes in blood and plasma serotonergic measurements in rats - effect of nicotine and/or exposure to different stresses. Thrombosis Research. 80:1995;307-316.
24. Takada A., Urano T., Yoshida M., Takada Y. Comparison of changes in serotonergic measures in whole blood or plasma and brain in rats given nicotine and/or stresses. Polish Journal of Pharmacology. 48:1996;173-177.
25. Tjolsen A., Berge O.G., Hunskaar S., Rosland J.H., Hole K. The formalin test: an evaluation of the method. Pain. 51:1992;5-17.
26. Warnhoff M. Simultaneous determination of norepinephrine, dopamine, 5-hydroxytryptamine and their main metabolites in rat brain, using high-performance liquid chromatography with electrochemical detection. Enzymatic hydrolysis of metabolites prior to chromatography. Journal of Chromatography. 307:1984;271-281.
27. Winter C.A., Risley E.A., Nuss G.W. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proceedings of the Society of Experimental Biology and Medicine. 111:1962;544-546.
28. Wu H., Cai B.-C., Zheng P.X., Zhao C.Z., Yuan Z.R. Effect of processing on the alkaloids in Strychnos nux-vomica. Journal of Chinese Herbal Medicine. 19:1994;277-279.
29. Yanna Z., Yumin S., Mengzhou B. The effect of brucine on central nervous system of mice. Journal of Henan Medical University. 27:1992;140-142.
30. Yong W. External effect of Strychnos nux-vomica on herpes zoster. Journal of Basic Chinese Herbal Medicine. 9:1975;52-56.