Differential effects of tityus bahiensis scorpion venom on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium currents

Neurotoxicity Research

Volumn 19, Issue 1, 2011, Pages 102-114

  Moraes, Eder R ^a   Kalapothakis, Evanguedes ^a   Naves, Lígia A ^a   Kushmerick, Christopher ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Electrophysiology; Neurotoxin; Scorpion; Sodium channel

Indexed keywords

SCORPION VENOM; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.8; SODIUM CHANNEL NAV1.9; TETRODOTOXIN; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CHANNEL GATING; CONTROLLED STUDY; HEART MUSCLE CELL; MALE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; POISONOUS SCORPION; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SODIUM CURRENT; SPINAL GANGLION; TITYUS BAHIENSIS;

ANIMALS; CELLS, CULTURED; DRUG RESISTANCE; GANGLIA, SPINAL; ION CHANNEL GATING; MALE; RATS; RATS, WISTAR; SCORPION VENOMS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN;

RATTUS; SCORPIONES; TITYUS BAHIENSIS;

EID: 78650572359     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12640-009-9144-8     Document Type: Article

References (47)

1. LM Alvarenga CR Diniz C Granier C Chávez-Olórtegui 2002 Induction of neutralizing antibodies against Tityus serrulatus scorpion toxins by immunization with a mixture of defined synthetic epitopes Toxicon 40 89 95 1:CAS:528:DC%2BD3MXnsFGisbs%3D 10.1016/S0041-0101(01)00197-0 11602284
2. CM Armstrong F Bezanilla 1974 Charge movement associated with the opening and closing of the activation gates of the Na channels J Gen Physiol 63 533 552 1:CAS:528:DyaE2cXkvVygtrk%3D 10.1085/jgp.63.5.533 4824995
3. B Becerril M Corona FI Coronas F Zamudio ES Calderon-Aranda PL Fletcher BM Martin LD Possani 1996 Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus Biochem J 313 Pt 3 753 760 1:CAS:528:DyaK28XhtV2itrc%3D 8611151
4. L Bonilha F Cendes E Ghizoni RJ Vieira LM Li 2004 Epilepsy due to a destructive brain lesion caused by a scorpion sting Arch Neurol 61 1294 1296 10.1001/archneur.61.8.1294 15313850
5. A Borges LD Sousa J Espinoza MM Melo RG Santos E Kalapothakis D Valadares C Chávez-Olórtegui 2008 Characterization of Tityus scorpion venoms using synaptosome binding assays and reactivity towards Venezuelan and Brazilian antivenoms Toxicon 51 66 79 1:CAS:528:DC%2BD1cXltV2itw%3D%3D 10.1016/j.toxicon.2007.08.006 17920649
6. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254 1:CAS:528:DyaE28XksVehtrY%3D 10.1016/0003-2697(76)90527- 3 942051
7. W Bucherl 1953 Scorpions and scorpionism in Brazil. 2. Effect of the venom of Tityus serrulatus and T. bahiensis on mice Mem Inst Butantan 25 83 108 1:STN:280:DyaG2M%2FgsFSqug%3D%3D 13193519
8. MD Cahalan 1975 Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom J Physiol 244 511 534 1:STN:280:DyaE2M7ptFGhtA%3D%3D 1079869
9. + channels in rat vagal afferent neurons Toxicon 43 401 406 1:CAS:528:DC%2BD2cXisFChu7w%3D 10.1016/j.toxicon.2004.01.012 15051403
10. FV Campos B Chanda PSL Beirão F Bezanilla 2007 beta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channel J Gen Physiol 130 257 268 1:CAS:528:DC%2BD2sXhtFWhs7nL 10.1085/jgp.200609719 17698594
11. WA Catterall 1980 Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes Annu Rev Pharmacol Toxicol 20 15 43 1:CAS:528:DyaL3cXktVWmtLo%3D 10.1146/annurev.pa.20.040180.000311 6247957
12. WA Catterall 2000 From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels Neuron 26 13 25 1:CAS:528:DC%2BD3cXjtFSksbY%3D 10.1016/S0896-6273(00)81133-2 10798388
13. WA Catterall AL Goldin SG Waxman 2003 International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels Pharmacol Rev 55 575 578 1:CAS:528:DC%2BD2cXhtlWktg%3D%3D 10.1124/pr.55.4.7 14657413
14. S Cestèle WA Catterall 2000 Molecular mechanisms of neurotoxin action on voltage-gated sodium channels Biochimie 82 883 892 10.1016/S0300-9084(00)01174-3 11086218
15. S Cestèle Y Qu JC Rogers H Rochat T Scheuer WA Catterall 1998 Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II Neuron 21 919 931 10.1016/S0896-6273(00)80606-6 9808476
16. S Cestèle V Yarov-Yarovoy Y Qu F Sampieri T Scheuer WA Catterall 2006 Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin J Biol Chem 281 21332 21344 10.1074/jbc.M603814200 16679310
17. J-S Choi A Hudmon SG Waxman SD Dib-Hajj 2006 Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons J Neurophysiol 96 97 108 1:CAS:528:DC%2BD28Xnt1Cmsr4%3D 10.1152/jn.00854.2005 16598065
18. AP Corrado A Antonio CR Diniz 1968 Brazilian scorpion venom (Tityus serrulatus), an unusual sympathetic postganglionic stimulant J Pharmacol Exp Ther 164 253 258 1:CAS:528:DyaF1MXhtVSmsQ%3D%3D 5699086
19. B Coste N Osorio F Padilla M Crest P Delmas 2004 Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neurons Mol Cell Neurosci 26 123 134 1:CAS:528:DC%2BD2cXjs1Chur0%3D 10.1016/j.mcn.2004.01.015 15121184
20. 2+ currents, and mechanically activated cation currents in different populations of DRG neurons J Gen Physiol 129 57 77 1:CAS:528:DC%2BD2sXhtF2qsbc%3D 10.1085/jgp.200609665 17190903
21. RCR de la Vega LD Possani 2007 Novel paradigms on scorpion toxins that affects the activating mechanism of sodium channels Toxicon 49 171 180 10.1016/j.toxicon.2006.09.016 17081580
22. + channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles Biophys J 83 2595 2609 1:CAS:528:DC%2BD38Xos1Crsbo%3D 10.1016/S0006-3495(02) 75270-3 12414693
23. MV Gomez CR Diniz 1966 Separation of toxic components from the Brazilian scorpion Tityus serrulatus venom Mem Inst Butantan 33 899 902 1:CAS:528:DyaF1MXksVKqsQ%3D%3D 6002970
24. M Gueron R Ilia S Sofer 1992 The cardiovascular system after scorpion envenomation. A review J Toxicol Clin Toxicol 30 245 258 1:STN:280: DyaK383mvFeqsg%3D%3D 10.3109/15563659209038636 1588674
25. OP Hamill A Marty E Neher B Sakmann FJ Sigworth 1981 Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Pflugers Arch 391 85 100 1:STN:280:DyaL38%2FjslWrug%3D%3D 10.1007/BF00656997 6270629
26. + current affects resting potential and response to depolarization in simulated spinal sensory neurons J Neurophysiol 86 1351 1364 1:CAS:528:DC%2BD3MXntFGmtbY%3D 11535682
27. SR Ikeda GG Schofield 1987 Tetrodotoxin-resistant sodium current of rat nodose neurones: monovalent cation selectivity and divalent cation block J Physiol 389 255 270 1:CAS:528:DyaL2sXktlOhtrc%3D 2445974
28. + flow dependence J Gen Physiol 124 27 42 1:CAS:528: DC%2BD2cXmtlSit7k%3D 10.1085/jgp.200409054 15226363
29. RM Leão JS Cruz CR Diniz MN Cordeiro PS Beirão 2000 Inhibition of neuronal high-voltage activated calcium channels by the omega-phoneutria nigriventer Tx3-3 peptide toxin Neuropharmacology 39 1756 1767 10.1016/S0028-3908(99)00267-1 10884557
30. MED Lima MF Martin CR Diniz H Rochat 1986 Tityus serrulatus toxin VII bears pharmacological properties of both beta-toxin and insect toxin from scorpion venoms Biochem Biophys Res Commun 139 296 302 10.1016/S0006-291X(86) 80112-7 2429652
31. SKG Maier RE Westenbroek TT Yamanushi H Dobrzynski MR Boyett WA Catterall T Scheuer 2003 An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node Proc Natl Acad Sci USA 100 3507 3512 1:CAS:528:DC%2BD3sXisVCnu7Y%3D 10.1073/pnas.2627986100 12631690
32. + channels in isolated single cultured rat myocardial cells Am J Physiol 245 C381 C387 1:CAS:528:DyaL2cXhtVSkt7o%3D 6314819
33. MBS Mesquita T Moraes-Santos MFD Moraes 2003 Centrally injected tityustoxin produces the systemic manifestations observed in severe scorpion poisoning Toxicol Appl Pharmacol 187 58 66 1:CAS:528:DC%2BD3sXhvFert78%3D 10.1016/S0041-008X(02)00036-4 12628585
34. EB Nascimento KA Costa CM Bertollo ACP Oliveira LTS Rocha ALS Souza MBA Glória T Moraes-Santos MM Coelho 2005 Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus Toxicon 45 585 593 1:CAS:528:DC%2BD2MXitlShtbk%3D 10.1016/j.toxicon.2004.12.020 15777954
35. DG Nascimento B Rates DM Santos T Verano-Braga A Barbosa-Silva AAA Dutra I Biondi MF Martin-Eauclaire MED Lima AMC Pimenta 2006 Moving pieces in a taxonomic puzzle: venom 2D-LC/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones) Toxicon 47 628 639 1:CAS:528:DC%2BD28XktVWntbo%3D 10.1016/j.toxicon.2006.01.015 16551474
36. AK Nishikawa CP Caricati ML Lima MCD Santos TL Kipnis VR Eickstedt I Knysak MHD Silva HG Higashi WDD Silva 1994 Antigenic cross-reactivity among the venoms from several species of Brazilian scorpions Toxicon 32 989 998 1:CAS:528:DyaK2cXlt1Oms78%3D 10.1016/0041-0101(94)90377-8 7985203
37. EA Nunan MFD Moraes VN Cardoso T Moraes-Santos 2003 Effect of age on body distribution of Tityustoxin from Tityus serrulatus scorpion venom in rats Life Sci 73 319 325 1:CAS:528:DC%2BD3sXjvFantr4%3D 10.1016/S0024-3205(03)00264-9 12757839
38. C Oliva IS Cohen RT Mathias 1988 Calculation of time constants for intracellular diffusion in whole cell patch clamp configuration Biophys J 54 791 799 1:STN:280:DyaL1M3gslKksg%3D%3D 10.1016/S0006-3495(88)83017-0 3242629
39. AM Pimenta M Martin-Eauclaire H Rochat SG Figueiredo E Kalapothakis LC Afonso MED Lima 2001 Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae) Toxicon 39 1009 1019 1:CAS:528:DC%2BD3MXit1ars7o%3D 10.1016/S0041-0101(00)00240-3 11223090
40. LD Possani E Merino M Corona F Bolivar B Becerril 2000 Peptides and genes coding for scorpion toxins that affect ion-channels Biochimie 82 861 868 1:CAS:528:DC%2BD3cXovFahtr8%3D 10.1016/S0300-9084(00)01167-6 11086216
41. + channel alpha subunit J Biol Chem 271 15950 15962 1:CAS:528:DyaK28XktFaitLY%3D 10.1074/jbc.271.27.15950 8663157
42. + current and NaV1.9 subunit in myenteric sensory neurons J Neurosci 23 2715 2725 1:CAS:528:DC%2BD3sXjtFCnt70%3D 12684457
43. AM Rush TR Cummins SG Waxman 2007 Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons J Physiol 579 1 14 1:CAS:528:DC%2BD2sXjsVyksb0%3D 10.1113/jphysiol.2006.121483 17158175
44. CY Saab TR Cummins SD Dib-Hajj SG Waxman 2002 Molecular determinant of Na(v)1.8 sodium channel resistance to the venom from the scorpion Leiurus quinquestriatus hebraeus Neurosci Lett 331 79 82 1:CAS:528:DC%2BD38XnsVajurY%3D 10.1016/S0304-3940(02)00860-1 12361845
45. C Trequattrini FZ Zamudio A Petris G Prestipino LD Possani F Franciolini 1995 Tityus bahiensis toxin IV-5b selectively affects Na channel inactivation in chick dorsal root ganglion neurons Comp Biochem Physiol A Physiol 112 21 28 1:STN:280:DyaK28%2FhtlSjuw%3D%3D 10.1016/0300-9629(95)00096-P 7553331
46. J Wang S-W Ou Y-J Wang M Kameyama A Kameyama Z-H Zong 2009 Analysis of four novel variants of Nav1.5/SCN5A cloned from the brain Neurosci Res 64 339 347 1:CAS:528:DC%2BD1MXnt1Gmtrk%3D 10.1016/j.neures.2009.04.003 19376164
47. Y Wu Z Cao H Yi D Jiang X Mao H Liu W Li 2004 Simulation of the interaction between ScyTx and small conductance calcium-activated potassium channel by docking and MM-PBSA Biophys J 87 105 112 1:CAS:528: DC%2BD2cXmtVemuro%3D 10.1529/biophysj.103.039156 15240449