New insights into the therapeutic inhibition of voltage-gated sodium channels

Channels

Volumn 2, Issue 1, 2008, Pages 1-3

  Ahern, Christopher A ^a   Eastwood, Amy L ^b   Dougherty, Dennis A ^b   Horn, Richard ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b California Institute of Technology   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Ab initio; Anti arrhythmic; Cation ; In vivo nonsense suppression; Local anesthetic; Voltage gated sodium channel

Indexed keywords

AROMATIC COMPOUND; BENZOCAINE; CATION; FLECAINIDE; LIDOCAINE; LIDOCAINE ETHOBROMIDE; LIGAND; LOCAL ANESTHETIC AGENT; PHENYLALANINE; PHENYLALANINE DERIVATIVE; QUINIDINE; TYROSINE; VOLTAGE GATED SODIUM CHANNEL; ANTIARRHYTHMIC AGENT; SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL BINDING; DRUG BINDING; DRUG MECHANISM; ELECTRICITY; FLUORINATION; HYDROPHOBICITY; MUTATION; NERVE EXCITABILITY; PH; PKA; BINDING SITE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; HUMAN; METABOLISM; PHYSIOLOGY; SKELETAL MUSCLE;

ANESTHETICS, LOCAL; ANTI-ARRHYTHMIA AGENTS; BINDING SITES; CATIONS; ELECTROSTATICS; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MUSCLE, SKELETAL; MUTATION; SODIUM CHANNELS;

EID: 55749105731     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.2.1.6007     Document Type: Article

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