Block of voltage-operated sodium channels by 2, 6-dimethylphenol, a structural analogue of lidocaine's aromatic tail

British Journal of Pharmacology

Volumn 137, Issue 2, 2002, Pages 285-293

  Haeseler, Gertrud ^a   Bufler, Johannes ^a   Merken, Sarah ^a   Dengler, Reinhard ^a   Aronson, Jeffrey ^a   Leuwer, Martin ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Binding site; Lidocaine; Local anaesthetic; Sodium channels; Structure; Voltage operated

Indexed keywords

2,6 XYLENOL; BUPIVACAINE; ETIDOCAINE; ISOPROTEIN; LIDOCAINE; LOCAL ANESTHETIC AGENT; PHENOL DERIVATIVE; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL MEMBRANE DEPOLARIZATION; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; IC 50; KIDNEY CELL; MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKELETAL MUSCLE; SODIUM CURRENT; STEADY STATE; STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS; VOLTAGE CLAMP;

CELL LINE; HUMANS; LIDOCAINE; RECEPTORS, GABA-A; SODIUM CHANNEL BLOCKERS; STRUCTURE-ACTIVITY RELATIONSHIP; XYLENES;

EID: 0036739176     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704854     Document Type: Article

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