Inhibition of NF-κB by MG132 through ER stress-mediated induction of LAP and LIP

FEBS Letters

Volumn 585, Issue 14, 2011, Pages 2249-2254

  Nakajima, Shotaro ^a   Kato, Hironori ^a   Takahashi, Shuhei ^a   Johno, Hisashi ^a   Kitamura, Masanori ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

C EBP ; Endoplasmic reticulum (ER) stress; MG132; NF B; Unfolded protein response (UPR)

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CCAAT ENHANCER BINDING PROTEIN BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER ACTIVATING PROTEIN; LIVER ENRICHED INHIBITORY PROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; EPITHELIUM CELL; GENETIC TRANSFECTION; INHIBITION KINETICS; KIDNEY TUBULE CELL; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE; CYSTEINE PROTEINASE INHIBITORS; ENDOPLASMIC RETICULUM; LEUPEPTINS; NF-KAPPA B; RATS; STRESS, PHYSIOLOGICAL; TRANSCRIPTIONAL ACTIVATION; UNFOLDED PROTEIN RESPONSE;

EID: 79960344274     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.05.047     Document Type: Article

References (27)

1. D.H. Lee, and A.L. Goldberg Proteasome inhibitors: valuable new tools for cell biologists Trends Cell Biol. 8 1998 397 403 (Pubitemid 28458705)
2. E.D. Werner, J.L. Brodsky, and A.A. McCracken Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate Proc. Natl. Acad. Sci. USA 93 1996 13797 13801 (Pubitemid 26424200)
3. K.T. Bush, A.L. Goldberg, and S.K. Nigam Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance J. Biol. Chem. 272 1997 9086 9092 (Pubitemid 27154911)
4. T. Yoshida, T. Shiraishi, S. Nakata, M. Horinaka, M. Wakada, Y. Mizutani, T. Miki, and T. Sakai Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein Cancer Res. 65 2005 5662 5667 (Pubitemid 40911167)
5. D.P. Ramji, and P. Foka CCAAT/enhancer-binding proteins: structure, function and regulation Biochem. J. 365 2002 561 575 (Pubitemid 34864439)
6. C.A. Zahnow CCAAT/enhancer-binding protein β: its role in breast cancer and associations with receptor tyrosine kinases Expert Rev. Mol. Med. 11 2009 e12
7. C. Chen, E.E. Dudenhausen, Y.X. Pan, C. Zhong, and M.S. Kilberg Human CCAAT/enhancer-binding protein β gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence J. Biol. Chem. 279 2004 27948 27956 (Pubitemid 38900063)
8. B. Stein, P.C. Cogswell, and A.S. Baldwin Jr. Functional and physical associations between NF-κB and C/EBP family members: a Rel domain-bZIP interaction Mol. Cell. Biol. 13 1993 3964 3974 (Pubitemid 23187624)
9. S. Prösch, A.K. Heine, H.D. Volk, and D.H. Krüger CCAAT/enhancer-binding proteins α and β negatively influence the capacity of tumor necrosis factor α to up-regulate the human cytomegalovirus IE1/2 enhancer/promoter by nuclear factor κB during monocyte differentiation J. Biol. Chem. 276 2001 40712 40720
10. 5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP Nature 443 2006 548 552 (Pubitemid 44527286)
11. K. Ozawa, K. Kuwabara, M. Tamatani, K. Takatsuji, Y. Tsukamoto, S. Kaneda, H. Yanagi, D.M. Stern, Y. Eguchi, Y. Tsujimoto, S. Ogawa, and M. Tohyama 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death J. Biol. Chem. 274 1999 6397 6404 (Pubitemid 29111054)
12. S. Du, N. Hiramatsu, K. Hayakawa, A. Kasai, M. Okamura, T. Huang, J. Yao, M. Takeda, I. Araki, N. Sawada, A.W. Paton, J.C. Paton, and M. Kitamura Suppression of NF-κB by cyclosporin A and tacrolimus (FK506) via induction of the C/EBP family: implication for unfolded protein response J. Immunol. 182 2009 7201 7211
13. T. Iwawaki, and R. Akai Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators Biochem. Biophys. Res. Commun. 350 2006 709 715 (Pubitemid 44547905)
14. A.H. Lee, N.N. Iwakoshi, and L.H. Glimcher XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response Mol. Cell. Biol. 23 2003 7448 7459 (Pubitemid 37271447)
15. J. Shao, L. Qiao, R.C. Janssen, M. Pagliassotti, and J.E. Friedman Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio Diabetes 54 2005 976 984 (Pubitemid 40446311)
16. M. Kitamura Identification of an inhibitor targeting macrophage production of monocyte chemoattractant protein-1 as TGF-β 1 J. Immunol. 159 1997 1404 1411 (Pubitemid 127484119)
17. O. Bezy, C. Elabd, O. Cochet, R.K. Petersen, K. Kristiansen, C. Dani, G. Ailhaud, and E.Z. Amri Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein β, implicated in adipocyte differentiation J. Biol. Chem. 280 2005 11432 11438 (Pubitemid 40418452)
18. B.J. Rollins, E.D. Morrison, and C.D. Stiles Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties Proc. Natl. Acad. Sci. USA 85 1988 3738 3742
19. T. Katayama, K. Imaizumi, A. Honda, T. Yoneda, T. Kudo, M. Takeda, K. Mori, R. Rozmahel, P. Fraser, P.S. George-Hyslop, and M. Tohyama Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations J. Biol. Chem. 276 2001 43446 43454
20. X.Z. Wang, H.P. Harding, Y. Zhang, E.M. Jolicoeur, M. Kuroda, and D. Ron Cloning of mammalian Ire1 reveals diversity in the ER stress responses EMBO J. 17 1998 5708 5717 (Pubitemid 28445982)
21. S. Nakajima, N. Hiramatsu, K. Hayakawa, Y. Saito, H. Kato, T. Huang, J. Yao, A.W. Paton, J.C. Paton, and M. Kitamura Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt Mol. Cell. Biol. 31 2011 1710 1718
22. I.M. Verma, J.K. Stevenson, E.M. Schwarz, D.V. Antwerp, and S. Miyamoto Rel/NF-κB/IκB family: intimate tales of association and dissociation Genes Dev. 9 1995 2723 2735 (Pubitemid 3009952)
23. A.S. Lee The glucose-regulated proteins: stress induction and clinical applications Trends Biochem. Sci. 26 2001 504 510 (Pubitemid 32735452)
24. H. Yamazaki, N. Hiramatsu, K. Hayakawa, Y. Tagawa, M. Okamura, R. Ogata, T. Huang, S. Nakajima, J. Yao, A.W. Paton, J.C. Paton, and M. Kitamura Activation of the Akt-NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response J. Immunol. 183 2009 1480 1487
25. A. Zwergal, M. Quirling, B. Saugel, K.C. Huth, C. Sydlik, V. Poli, D. Neumeier, H.W. Ziegler-Heitbrock, and K. Brand C/EBPβ blocks p65 phosphorylation and thereby NF-κB-mediated transcription in TNF-tolerant cells J. Immunol. 177 2006 665 672 (Pubitemid 43939181)
26. A.S. Ahmed, J. Li, M. Ahmed, L. Hua, T. Yakovleva, M.H. Ossipov, G. Bakalkin, and A. Stark Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132 Arthritis Rheum. 62 2010 2160 2169
27. S. Inoue, H. Nakase, M. Matsuura, S. Mikami, S. Ueno, N. Uza, and T. Chiba The effect of proteasome inhibitor MG132 on experimental inflammatory bowel disease Clin. Exp. Immunol. 156 2009 172 182